Campbell McInnes Department of Drug Discovery and Biomedical Sciences University of South Carolina Biography Publications Institution JoVE Articles Campbell McInnes has not added a biography. If you are Campbell McInnes and would like to personalize this page please email our Author Liaison for assistance. Publications Efficient Soluble Expression of Active Recombinant Human Cyclin A2 Mediated by E. Coli Molecular Chaperones Protein Expression and Purification. Sep, 2015 | Pubmed ID: 25956535 Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity Journal of Medicinal Chemistry. Jan, 2015 | Pubmed ID: 25454794 Quantification of the Effects of Ionic Strength, Viscosity, and Hydrophobicity on Protein-ligand Binding Affinity ACS Medicinal Chemistry Letters. Aug, 2014 | Pubmed ID: 25147617 Current Assessment of Polo-like Kinases As Anti-tumor Drug Targets Expert Opinion on Drug Discovery. Jul, 2014 | Pubmed ID: 24819909 Fragment Based Discovery of Arginine Isosteres Through REPLACE: Towards Non-ATP Competitive CDK Inhibitors Bioorganic & Medicinal Chemistry. Jan, 2014 | Pubmed ID: 24286762 Structural Characterization of the Binding Interactions of Various Endogenous Estrogen Metabolites with Human Estrogen Receptor α and β Subtypes: a Molecular Modeling Study PloS One. 2013 | Pubmed ID: 24098659 Optimization of Non-ATP Competitive CDK/cyclin Groove Inhibitors Through REPLACE-mediated Fragment Assembly Journal of Medicinal Chemistry. Feb, 2013 | Pubmed ID: 23323521 Targeting Subcellular Localization Through the Polo-box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype Molecular Cancer Therapeutics. Aug, 2012 | Pubmed ID: 22848093 Calpain 10 Homology Modeling with CYGAK and Increased Lipophilicity Leads to Greater Potency and Efficacy in Cells ACS Chemical Biology. Aug, 2012 | Pubmed ID: 22612451 PLK1 As an Oncology Target: Current Status and Future Potential Drug Discovery Today. Jul, 2011 | Pubmed ID: 21601650 Discovery and Characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine Transcriptional CDK Inhibitors As Anticancer Agents Chemistry & Biology. Oct, 2010 | Pubmed ID: 21035734 Structural and Functional Analysis of Cyclin D1 Reveals P27 and Substrate Inhibitor Binding Requirements ACS Chemical Biology. Dec, 2010 | Pubmed ID: 20843055 Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors Journal of Medicinal Chemistry. Jun, 2010 | Pubmed ID: 20462263 Design, Synthesis, and Evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines As Ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine Cyclin-dependent Kinase Inhibitors Journal of Medicinal Chemistry. Mar, 2010 | Pubmed ID: 20146435 Truncation and Optimisation of Peptide Inhibitors of Cyclin-dependent Kinase 2-cyclin a Through Structure-guided Design ChemMedChem. Jul, 2009 | Pubmed ID: 19472269 Functional Characterization and Identification of Mouse Rad51d Splice Variants BMC Molecular Biology. 2009 | Pubmed ID: 19327148 Non-ATP Competitive Protein Kinase Inhibitors As Anti-tumor Therapeutics Biochemical Pharmacology. May, 2009 | Pubmed ID: 19167366 Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases Journal of Medicinal Chemistry. Jan, 2009 | Pubmed ID: 19072652 Functional Characterization of the RAD51D E233G Genetic Variant Pharmacogenetics and Genomics. Feb, 2009 | Pubmed ID: 19033885 Progress in the Evaluation of CDK Inhibitors As Anti-tumor Agents Drug Discovery Today. Oct, 2008 | Pubmed ID: 18639646 Virtual Screening Strategies in Drug Discovery Current Opinion in Chemical Biology. Oct, 2007 | Pubmed ID: 17936059 REPLACE: a Strategy for Iterative Design of Cyclin-binding Groove Inhibitors Chembiochem : a European Journal of Chemical Biology. Dec, 2006 | Pubmed ID: 17051658 Inhibitors of Polo-like Kinase Reveal Roles in Spindle-pole Maintenance Nature Chemical Biology. Nov, 2006 | Pubmed ID: 17028581 Catch the Kinase Conformer Chemistry & Biology. Jul, 2006 | Pubmed ID: 16873016 Improved Lead-finding for Kinase Targets Using High-throughput Docking Current Opinion in Drug Discovery & Development. May, 2006 | Pubmed ID: 16729730 Structure-based Discovery and Optimization of Potential Cancer Therapeutics Targeting the Cell Cycle IDrugs : the Investigational Drugs Journal. Apr, 2006 | Pubmed ID: 16596481 Differential Binding of Inhibitors to Active and Inactive CDK2 Provides Insights for Drug Design Chemistry & Biology. Feb, 2006 | Pubmed ID: 16492568 Protein Structures in Virtual Screening: a Case Study with CDK2 Journal of Medicinal Chemistry. Jan, 2006 | Pubmed ID: 16392795 PharmaDiscovery 2005. Kinases in Drug Discovery IDrugs : the Investigational Drugs Journal. Jul, 2005 | Pubmed ID: 15973561 Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments That Accompany P53-binding Journal of Molecular Biology. Jul, 2005 | Pubmed ID: 15953616 Strategies for the Design of Potent and Selective Kinase Inhibitors Current Pharmaceutical Design. 2005 | Pubmed ID: 15892678 Progress in the Discovery of Polo-like Kinase Inhibitors Current Topics in Medicinal Chemistry. 2005 | Pubmed ID: 15853646 Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15681588 Design, Synthesis, Biological Activity and Structural Analysis of Cyclic Peptide Inhibitors Targeting the Substrate Recruitment Site of Cyclin-dependent Kinase Complexes Organic & Biomolecular Chemistry. Oct, 2004 | Pubmed ID: 15455144 Synthesis and Biological Activity of 2-anilino-4-(1H-pyrrol-3-yl) Pyrimidine CDK Inhibitors Bioorganic & Medicinal Chemistry Letters. Aug, 2004 | Pubmed ID: 15261277 Cambridge Healthtech Institute Fourth Annual Conference in Structure-based Drug Design IDrugs : the Investigational Drugs Journal. Jun, 2004 | Pubmed ID: 15197656 Structural Determinants of CDK4 Inhibition and Design of Selective ATP Competitive Inhibitors Chemistry & Biology. Apr, 2004 | Pubmed ID: 15123247 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors: Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity Journal of Medicinal Chemistry. Mar, 2004 | Pubmed ID: 15027857 Insights into Cyclin Groove Recognition: Complex Crystal Structures and Inhibitor Design Through Ligand Exchange Structure (London, England : 1993). Dec, 2003 | Pubmed ID: 14656438 Discovery of a Novel Family of CDK Inhibitors with the Program LIDAEUS: Structural Basis for Ligand-induced Disordering of the Activation Loop Structure (London, England : 1993). Apr, 2003 | Pubmed ID: 12679018 Peptidomimetic Design of CDK Inhibitors Targeting the Recruitment Site of the Cyclin Subunit Current Medicinal Chemistry. Anti-cancer Agents. Jan, 2003 | Pubmed ID: 12678915 Peptide Inhibitors of CDK2-cyclin A That Target the Cyclin Recruitment-site: Structural Variants of the C-terminal Phe Bioorganic & Medicinal Chemistry Letters. Sep, 2002 | Pubmed ID: 12182847 تطوير مثبطات البروتين البروتين التفاعلات استبدال من خلال: تطبيق لتصميم وتطوير غير ATP مثبطات معلمين تنافسي Padmavathy Nandha Premnath1, Sandra Craig1, Campbell McInnes1 1Department of Drug Discovery and Biomedical Sciences, University of South Carolina Biology
تطوير مثبطات البروتين البروتين التفاعلات استبدال من خلال: تطبيق لتصميم وتطوير غير ATP مثبطات معلمين تنافسي Padmavathy Nandha Premnath1, Sandra Craig1, Campbell McInnes1 1Department of Drug Discovery and Biomedical Sciences, University of South Carolina Biology
