Charles L. Sawyers

Publications

• A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation
  Nature Medicine. Oct, 2019  |   Pubmed ID: 31591597
• Herceptin: A First Assault on Oncogenes That Launched a Revolution
  Cell. Sep, 2019  |   Pubmed ID: 31519311
• FOXA1 Mutations Alter Pioneering Activity, Differentiation and Prostate Cancer Phenotypes
  Nature. 07, 2019  |   Pubmed ID: 31243370
• Publisher Correction: The Long Tail of Oncogenic Drivers in Prostate Cancer
  Nature Genetics. Jul, 2019  |   Pubmed ID: 31152158
• Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019  |   Pubmed ID: 31061129
• Amplifies Androgen Receptor Output in Human Prostate Cancer and Contributes to Antiandrogen Resistance
  ELife. Jan, 2019  |   Pubmed ID: 30644358
• Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade
  JAMA Oncology. Apr, 2019  |   Pubmed ID: 30589920
• SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2019  |   Pubmed ID: 30587545
• Strategies to Identify and Target Cells of Origin in Prostate Cancer
  Journal of the National Cancer Institute. Mar, 2019  |   Pubmed ID: 30312421
• American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives
  JCO Clinical Cancer Informatics. 12, 2018  |   Pubmed ID: 30652542
• Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer
  The Journal of Clinical Investigation. 10, 2018  |   Pubmed ID: 30179225
• Tumor Copy Number Alteration Burden is a Pan-cancer Prognostic Factor Associated with Recurrence and Death
  ELife. 09, 2018  |   Pubmed ID: 30178746
• Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer
  Cellular and Molecular Gastroenterology and Hepatology. 2018  |   Pubmed ID: 30109253
• Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes
  Nature Communications. 06, 2018  |   Pubmed ID: 29921838
• The Long Tail of Oncogenic Drivers in Prostate Cancer
  Nature Genetics. 05, 2018  |   Pubmed ID: 29610475
• Challenges in Validating Candidate Therapeutic Targets in Cancer
  ELife. 02, 2018  |   Pubmed ID: 29417929
• Targeting DNA Repair in Prostate Cancer
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 04, 2018  |   Pubmed ID: 29369701
• Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting
  European Urology. 05, 2018  |   Pubmed ID: 29258679
• Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity As a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer
  JAMA Oncology. Feb, 2018  |   Pubmed ID: 29121144
• Deletion of 3p13-14 Locus Spanning FOXP1 to SHQ1 Cooperates with PTEN Loss in Prostate Oncogenesis
  Nature Communications. 10, 2017  |   Pubmed ID: 29057879
• Regulation of the Glucocorticoid Receptor Via a BET-dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer
  ELife. 09, 2017  |   Pubmed ID: 28891793
• Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA Vs Guideline-Based Germline Testing
  JAMA. 09, 2017  |   Pubmed ID: 28873162
• Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making
  JCO Precision Oncology. Jul, 2017  |   Pubmed ID: 28825054
• ERF Mutations Reveal a Balance of ETS Factors Controlling Prostate Oncogenesis
  Nature. 06, 2017  |   Pubmed ID: 28614298
• Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions
  The New England Journal of Medicine. 05, 2017  |   Pubmed ID: 28538124
• SOX2 Promotes Lineage Plasticity and Antiandrogen Resistance in TP53- and RB1-deficient Prostate Cancer
  Science (New York, N.Y.). 01, 2017  |   Pubmed ID: 28059768
• Rb1 and Trp53 Cooperate to Suppress Prostate Cancer Lineage Plasticity, Metastasis, and Antiandrogen Resistance
  Science (New York, N.Y.). 01, 2017  |   Pubmed ID: 28059767
• Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells That Can Initiate Human Prostate Cancer and Predict Poor Outcome
  Cell Reports. 12, 2016  |   Pubmed ID: 27926864
• A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon
  PloS One. 2016  |   Pubmed ID: 27536883
• Facilitating a Culture of Responsible and Effective Sharing of Cancer Genome Data
  Nature Medicine. 05, 2016  |   Pubmed ID: 27149219
• Organoid Culture Systems for Prostate Epithelial and Cancer Tissue
  Nature Protocols. Feb, 2016  |   Pubmed ID: 26797458
• Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins
  Molecular Pharmaceutics. Feb, 2016  |   Pubmed ID: 26725682
• Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors
  Cell Reports. Dec, 2015  |   Pubmed ID: 26628377
• Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer
  Nature Reviews. Cancer. Dec, 2015  |   Pubmed ID: 26563462
• All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care Through the Global Alliance for Genomics and Health
  Cancer Discovery. Nov, 2015  |   Pubmed ID: 26526696
• Androgen Receptor Upregulation Mediates Radioresistance After Ionizing Radiation
  Cancer Research. Nov, 2015  |   Pubmed ID: 26432404
• Identification of an Oncogenic RAB Protein
  Science (New York, N.Y.). Oct, 2015  |   Pubmed ID: 26338797
• Integrative Clinical Genomics of Advanced Prostate Cancer
  Cell. May, 2015  |   Pubmed ID: 26000489
• Feedback Suppression of PI3Kα Signaling in PTEN-mutated Tumors is Relieved by Selective Inhibition of PI3Kβ
  Cancer Cell. Jan, 2015  |   Pubmed ID: 25544636
• Identifying Actionable Targets Through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling
  Molecular Cancer Therapeutics. Jan, 2015  |   Pubmed ID: 25381262
• MAGI-2 Scaffold Protein is Critical for Kidney Barrier Function
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014  |   Pubmed ID: 25271328
• Cabozantinib Resolves Bone Scans in Tumor-naïve Mice Harboring Skeletal Injuries
  Molecular Imaging. 2014  |   Pubmed ID: 25248353
• Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: a Policy Statement from the American Association for Cancer Research
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014  |   Pubmed ID: 25204554
• Organoid Cultures Derived from Patients with Advanced Prostate Cancer
  Cell. Sep, 2014  |   Pubmed ID: 25201530
• Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
  Cell. Sep, 2014  |   Pubmed ID: 25201529
• CDK9-mediated Transcription Elongation is Required for MYC Addiction in Hepatocellular Carcinoma
  Genes & Development. Aug, 2014  |   Pubmed ID: 25128497
• Copy Number Alteration Burden Predicts Prostate Cancer Relapse
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25024180
• Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade
  Cell. Dec, 2013  |   Pubmed ID: 24315100
• "N of 1" Case Reports in the Era of Whole-genome Sequencing
  The Journal of Clinical Investigation. Nov, 2013  |   Pubmed ID: 24135144
• Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers
  Cancer Discovery. Nov, 2013  |   Pubmed ID: 24027196
• Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-resistant Prostate Cancer
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2013  |   Pubmed ID: 24002508
• ETS Factors Reprogram the Androgen Receptor Cistrome and Prime Prostate Tumorigenesis in Response to PTEN Loss
  Nature Medicine. Aug, 2013  |   Pubmed ID: 23817021
• Perspective: Combined Forces
  Nature. Jun, 2013  |   Pubmed ID: 23803949
• Developing Standards for Breakthrough Therapy Designation in Oncology
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013  |   Pubmed ID: 23719260
• Overcoming Mutation-based Resistance to Antiandrogens with Rational Drug Design
  ELife. Apr, 2013  |   Pubmed ID: 23580326
• β4 Integrin Signaling Induces Expansion of Prostate Tumor Progenitors
  The Journal of Clinical Investigation. Feb, 2013  |   Pubmed ID: 23348745
• Imaging Tumor Burden in the Brain with 89Zr-Transferrin
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2013  |   Pubmed ID: 23236019
• The 2011 Gordon Wilson Lecture: Overcoming Resistance to Targeted Cancer Drugs
  Transactions of the American Clinical and Climatological Association. 2012  |   Pubmed ID: 23303979
• Annotating MYC Status with 89Zr-transferrin Imaging
  Nature Medicine. Oct, 2012  |   Pubmed ID: 23001181
• Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors
  Cancer Research. Dec, 2012  |   Pubmed ID: 22971343
• JNK and PTEN Cooperatively Control the Development of Invasive Adenocarcinoma of the Prostate
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012  |   Pubmed ID: 22753496
• Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-specific Antigen
  Cancer Discovery. Apr, 2012  |   Pubmed ID: 22576209
• Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-hairpin RNA Library Screening
  PloS One. 2012  |   Pubmed ID: 22509301
• Converting Cancer Therapies into Cures: Lessons from Infectious Diseases
  Cell. Mar, 2012  |   Pubmed ID: 22424221
• ARN-509: a Novel Anti-androgen for Prostate Cancer Treatment
  Cancer Research. Jan, 2012  |   Pubmed ID: 22266222
• Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-existing Resistance in Chronic Myeloid Leukemia
  PloS One. 2011  |   Pubmed ID: 22140458
• TMPRSS2-ERG Status in Circulating Tumor Cells As a Predictive Biomarker of Sensitivity in Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate
  European Urology. Nov, 2011  |   Pubmed ID: 21802835
• Noninvasive Measurement of Androgen Receptor Signaling with a Positron-emitting Radiopharmaceutical That Targets Prostate-specific Membrane Antigen
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011  |   Pubmed ID: 21606347
• Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-deficient Prostate Cancer
  Cancer Cell. May, 2011  |   Pubmed ID: 21575859
• FAS and NF-κB Signalling Modulate Dependence of Lung Cancers on Mutant EGFR
  Nature. Mar, 2011  |   Pubmed ID: 21430781
• MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to MTOR Inhibitors
  PloS One. 2011  |   Pubmed ID: 21394210
• ETV1 is a Lineage Survival Factor That Cooperates with KIT in Gastrointestinal Stromal Tumours
  Nature. Oct, 2010  |   Pubmed ID: 20927104
• Constitutively Active Androgen Receptor Splice Variants Expressed in Castration-resistant Prostate Cancer Require Full-length Androgen Receptor
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010  |   Pubmed ID: 20823238
• Integrative Genomic Profiling of Human Prostate Cancer
  Cancer Cell. Jul, 2010  |   Pubmed ID: 20579941
• Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion-positive Prostate Cancers
  Cancer Cell. May, 2010  |   Pubmed ID: 20478521
• Antitumour Activity of MDV3100 in Castration-resistant Prostate Cancer: a Phase 1-2 Study
  Lancet. Apr, 2010  |   Pubmed ID: 20398925
• Structure-activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-resistant Prostate Cancer (CRPC)
  Journal of Medicinal Chemistry. Apr, 2010  |   Pubmed ID: 20218717
• Clonal Hematopoiesis in Philadelphia Chromosome-negative Bone Marrow Cells of Chronic Myeloid Leukemia Patients Receiving Dasatinib
  Leukemia Research. Jun, 2010  |   Pubmed ID: 19804904
• Lessons Learned from the Development of Kinase Inhibitors
  Clinical Advances in Hematology & Oncology : H&O. Sep, 2009  |   Pubmed ID: 20020670
• Shifting Paradigms: the Seeds of Oncogene Addiction
  Nature Medicine. Oct, 2009  |   Pubmed ID: 19812578
• Proteasomal and Genetic Inactivation of the NF1 Tumor Suppressor in Gliomagenesis
  Cancer Cell. Jul, 2009  |   Pubmed ID: 19573811
• Finding and Drugging the Vulnerabilities of RAS-dependent Cancers
  Cell. May, 2009  |   Pubmed ID: 19490885
• Cooperativity of TMPRSS2-ERG with PI3-kinase Pathway Activation in Prostate Oncogenesis
  Nature Genetics. May, 2009  |   Pubmed ID: 19396167
• Development of a Second-generation Antiandrogen for Treatment of Advanced Prostate Cancer
  Science (New York, N.Y.). May, 2009  |   Pubmed ID: 19359544
• Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-sensitive and Castrate-resistant Prostate Cancer
  Cancer Research. Feb, 2009  |   Pubmed ID: 19176386
• Translational Research: Are We on the Right Track? 2008 American Society for Clinical Investigation Presidential Address
  The Journal of Clinical Investigation. Nov, 2008  |   Pubmed ID: 18982165
• The Nuclear Factor-kappaB Pathway Controls the Progression of Prostate Cancer to Androgen-independent Growth
  Cancer Research. Aug, 2008  |   Pubmed ID: 18701501
• A Prostatic Intraepithelial Neoplasia-dependent P27 Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression
  Cancer Cell. Aug, 2008  |   Pubmed ID: 18691549
• Targeting the Androgen Receptor Pathway in Prostate Cancer
  Current Opinion in Pharmacology. Aug, 2008  |   Pubmed ID: 18674639
• The Cancer Biomarker Problem
  Nature. Apr, 2008  |   Pubmed ID: 18385728
• Something Lost--something Gained: the ASCI Begins Its Second Century
  The Journal of Clinical Investigation. Apr, 2008  |   Pubmed ID: 18382722
• Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-deficient Glioblastoma
  PLoS Medicine. Jan, 2008  |   Pubmed ID: 18215105
• Sequential ABL Kinase Inhibitor Therapy Selects for Compound Drug-resistant BCR-ABL Mutations with Altered Oncogenic Potency
  The Journal of Clinical Investigation. Sep, 2007  |   Pubmed ID: 17710227
• Phosphorylation of the ATP-binding Loop Directs Oncogenicity of Drug-resistant BCR-ABL Mutants
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006  |   Pubmed ID: 17164333
• Biology of Progressive, Castration-resistant Prostate Cancer: Directed Therapies Targeting the Androgen-receptor Signaling Axis
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005  |   Pubmed ID: 16278481
• Inhibition of Drug-resistant Mutants of ABL, KIT, and EGF Receptor Kinases
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005  |   Pubmed ID: 16046538
• A Novel Pyridopyrimidine Inhibitor of Abl Kinase is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and is Effective Against STI571-resistant Bcr-abl Mutants
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003  |   Pubmed ID: 12684394