Charles L. Sawyers Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Charles L. Sawyers has not added a biography. If you are Charles L. Sawyers and would like to personalize this page please email our Author Liaison for assistance. Publications A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation Nature Medicine. Oct, 2019 | Pubmed ID: 31591597 Herceptin: A First Assault on Oncogenes That Launched a Revolution Cell. Sep, 2019 | Pubmed ID: 31519311 FOXA1 Mutations Alter Pioneering Activity, Differentiation and Prostate Cancer Phenotypes Nature. 07, 2019 | Pubmed ID: 31243370 Publisher Correction: The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. Jul, 2019 | Pubmed ID: 31152158 Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31061129 Amplifies Androgen Receptor Output in Human Prostate Cancer and Contributes to Antiandrogen Resistance ELife. Jan, 2019 | Pubmed ID: 30644358 Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade JAMA Oncology. Apr, 2019 | Pubmed ID: 30589920 SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2019 | Pubmed ID: 30587545 Strategies to Identify and Target Cells of Origin in Prostate Cancer Journal of the National Cancer Institute. Mar, 2019 | Pubmed ID: 30312421 American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives JCO Clinical Cancer Informatics. 12, 2018 | Pubmed ID: 30652542 Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer The Journal of Clinical Investigation. 10, 2018 | Pubmed ID: 30179225 Tumor Copy Number Alteration Burden is a Pan-cancer Prognostic Factor Associated with Recurrence and Death ELife. 09, 2018 | Pubmed ID: 30178746 Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 30109253 Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes Nature Communications. 06, 2018 | Pubmed ID: 29921838 The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. 05, 2018 | Pubmed ID: 29610475 Challenges in Validating Candidate Therapeutic Targets in Cancer ELife. 02, 2018 | Pubmed ID: 29417929 Targeting DNA Repair in Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 04, 2018 | Pubmed ID: 29369701 Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting European Urology. 05, 2018 | Pubmed ID: 29258679 Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity As a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer JAMA Oncology. Feb, 2018 | Pubmed ID: 29121144 Deletion of 3p13-14 Locus Spanning FOXP1 to SHQ1 Cooperates with PTEN Loss in Prostate Oncogenesis Nature Communications. 10, 2017 | Pubmed ID: 29057879 Regulation of the Glucocorticoid Receptor Via a BET-dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer ELife. 09, 2017 | Pubmed ID: 28891793 Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA Vs Guideline-Based Germline Testing JAMA. 09, 2017 | Pubmed ID: 28873162 Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making JCO Precision Oncology. Jul, 2017 | Pubmed ID: 28825054 ERF Mutations Reveal a Balance of ETS Factors Controlling Prostate Oncogenesis Nature. 06, 2017 | Pubmed ID: 28614298 Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions The New England Journal of Medicine. 05, 2017 | Pubmed ID: 28538124 SOX2 Promotes Lineage Plasticity and Antiandrogen Resistance in TP53- and RB1-deficient Prostate Cancer Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059768 Rb1 and Trp53 Cooperate to Suppress Prostate Cancer Lineage Plasticity, Metastasis, and Antiandrogen Resistance Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059767 Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells That Can Initiate Human Prostate Cancer and Predict Poor Outcome Cell Reports. 12, 2016 | Pubmed ID: 27926864 A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon PloS One. 2016 | Pubmed ID: 27536883 Facilitating a Culture of Responsible and Effective Sharing of Cancer Genome Data Nature Medicine. 05, 2016 | Pubmed ID: 27149219 Organoid Culture Systems for Prostate Epithelial and Cancer Tissue Nature Protocols. Feb, 2016 | Pubmed ID: 26797458 Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins Molecular Pharmaceutics. Feb, 2016 | Pubmed ID: 26725682 Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors Cell Reports. Dec, 2015 | Pubmed ID: 26628377 Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer Nature Reviews. Cancer. Dec, 2015 | Pubmed ID: 26563462 All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care Through the Global Alliance for Genomics and Health Cancer Discovery. Nov, 2015 | Pubmed ID: 26526696 Androgen Receptor Upregulation Mediates Radioresistance After Ionizing Radiation Cancer Research. Nov, 2015 | Pubmed ID: 26432404 Identification of an Oncogenic RAB Protein Science (New York, N.Y.). Oct, 2015 | Pubmed ID: 26338797 Integrative Clinical Genomics of Advanced Prostate Cancer Cell. May, 2015 | Pubmed ID: 26000489 Feedback Suppression of PI3Kα Signaling in PTEN-mutated Tumors is Relieved by Selective Inhibition of PI3Kβ Cancer Cell. Jan, 2015 | Pubmed ID: 25544636 Identifying Actionable Targets Through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling Molecular Cancer Therapeutics. Jan, 2015 | Pubmed ID: 25381262 MAGI-2 Scaffold Protein is Critical for Kidney Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25271328 Cabozantinib Resolves Bone Scans in Tumor-naïve Mice Harboring Skeletal Injuries Molecular Imaging. 2014 | Pubmed ID: 25248353 Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: a Policy Statement from the American Association for Cancer Research Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014 | Pubmed ID: 25204554 Organoid Cultures Derived from Patients with Advanced Prostate Cancer Cell. Sep, 2014 | Pubmed ID: 25201530 Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell. Sep, 2014 | Pubmed ID: 25201529 CDK9-mediated Transcription Elongation is Required for MYC Addiction in Hepatocellular Carcinoma Genes & Development. Aug, 2014 | Pubmed ID: 25128497 Copy Number Alteration Burden Predicts Prostate Cancer Relapse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25024180 Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade Cell. Dec, 2013 | Pubmed ID: 24315100 "N of 1" Case Reports in the Era of Whole-genome Sequencing The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24135144 Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers Cancer Discovery. Nov, 2013 | Pubmed ID: 24027196 Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-resistant Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2013 | Pubmed ID: 24002508 ETS Factors Reprogram the Androgen Receptor Cistrome and Prime Prostate Tumorigenesis in Response to PTEN Loss Nature Medicine. Aug, 2013 | Pubmed ID: 23817021 Perspective: Combined Forces Nature. Jun, 2013 | Pubmed ID: 23803949 Developing Standards for Breakthrough Therapy Designation in Oncology Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23719260 Overcoming Mutation-based Resistance to Antiandrogens with Rational Drug Design ELife. Apr, 2013 | Pubmed ID: 23580326 β4 Integrin Signaling Induces Expansion of Prostate Tumor Progenitors The Journal of Clinical Investigation. Feb, 2013 | Pubmed ID: 23348745 腫瘍負担 89Zr トランスフェリンと脳イメージング。 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2013 | Pubmed ID: 23236019 The 2011 Gordon Wilson Lecture: Overcoming Resistance to Targeted Cancer Drugs Transactions of the American Clinical and Climatological Association. 2012 | Pubmed ID: 23303979 Annotating MYC Status with 89Zr-transferrin Imaging Nature Medicine. Oct, 2012 | Pubmed ID: 23001181 Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors Cancer Research. Dec, 2012 | Pubmed ID: 22971343 JNK and PTEN Cooperatively Control the Development of Invasive Adenocarcinoma of the Prostate Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22753496 Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-specific Antigen Cancer Discovery. Apr, 2012 | Pubmed ID: 22576209 Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-hairpin RNA Library Screening PloS One. 2012 | Pubmed ID: 22509301 Converting Cancer Therapies into Cures: Lessons from Infectious Diseases Cell. Mar, 2012 | Pubmed ID: 22424221 ARN-509:、小説からの抗アンドロゲン前立腺癌治療のため。 Cancer Research. Jan, 2012 | Pubmed ID: 22266222 BCR-ABL キナーゼ ドメインの変異によって授与フィットネス慢性骨髄性白血病における既存の抵抗性のリスクを判断します。 PloS One. 2011 | Pubmed ID: 22140458 去勢抵抗性前立腺癌患者における感度の予測マーカーとして循環腫瘍細胞の TMPRSS2 ERG ステータス Abiraterone 酢酸で扱われます。 European Urology. Nov, 2011 | Pubmed ID: 21802835 非侵襲計測陽電子放出放射性医薬品とそのターゲット膜前立腺特異抗原シグナリング アンドロゲン受容体の。 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606347 前立腺癌における PTEN 欠損シグナリング PI3K とアンドロゲン受容体の相互フィードバック調節。 Cancer Cell. May, 2011 | Pubmed ID: 21575859 FAS と NF-κ シグナリング EGFR 変異肺癌の依存性を調節します。 Nature. Mar, 2011 | Pubmed ID: 21430781 MYC 前立腺腫瘍における AKT と協力して、mTOR 阻害剤への感度を変更します。 PloS One. 2011 | Pubmed ID: 21394210 ETV1は、消化管間質腫瘍におけるKITと協働してリネージュ生存因子である Nature. Oct, 2010 | Pubmed ID: 20927104 去勢抵抗性前立腺癌で表明した恒常活性アンドロゲン受容体スプライス亜種フルレングスのアンドロゲン受容体が必要です。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823238 統合的なゲノム人間の前立腺癌のプロファイリング。 Cancer Cell. Jul, 2010 | Pubmed ID: 20579941 フュージョン正前立腺癌における ERG とアンドロゲン受容体による転写調節機構座標。 Cancer Cell. May, 2010 | Pubmed ID: 20478521 去勢抵抗性前立腺癌における MDV3100 の抗腫瘍活性: フェーズ 1 2 研究。 Lancet. Apr, 2010 | Pubmed ID: 20398925 構造活性相関によるチオヒダントイン アンドロゲン受容体拮抗薬の去勢抵抗性前立腺癌 (CRPC) ため。 Journal of Medicinal Chemistry. Apr, 2010 | Pubmed ID: 20218717 フィラデルフィア染色体陰性骨髄細胞のダサチニブ慢性骨髄性白血病患者における栄養系造血。 Leukemia Research. Jun, 2010 | Pubmed ID: 19804904 キナーゼ阻害剤の開発からの教訓。 Clinical Advances in Hematology & Oncology : H&O. Sep, 2009 | Pubmed ID: 20020670 パラダイム シフト: がん遺伝子中毒の種子。 Nature Medicine. Oct, 2009 | Pubmed ID: 19812578 プロテアソームとグリオーマの NF1 腫瘍サプレッサーの遺伝的不活性化。 Cancer Cell. Jul, 2009 | Pubmed ID: 19573811 見つけると脆弱性の RAS 依存癌の薬漬けにします。 Cell. May, 2009 | Pubmed ID: 19490885 TMPRSS2 ERG の協同性 PI3 キナーゼ経路の活性化における前立腺 Egf と。 Nature Genetics. May, 2009 | Pubmed ID: 19396167 第 2 世代の抗アンドロゲン治療進行性前立腺癌のための開発。 Science (New York, N.Y.). May, 2009 | Pubmed ID: 19359544 ヒストン脱アセチル化酵素ホルモン感受性と去勢抵抗性前立腺癌におけるアンドロゲン受容体の機能に必要です。 Cancer Research. Feb, 2009 | Pubmed ID: 19176386 トランスレーショナルリサーチ: 我々 は正しい軌道に乗っているか。2008 アメリカの社会の臨床調査大統領のアドレス。 The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18982165 核要因 KappaB 経路アンドロゲン依存成長する前立腺癌の進行を制御します。 Cancer Research. Aug, 2008 | Pubmed ID: 18701501 前立腺上皮内腫瘍依存型 P27 Kip1 チェックポイントは老化を誘導して細胞増殖と癌の進行を阻害します。 Cancer Cell. Aug, 2008 | Pubmed ID: 18691549 前立腺癌におけるアンドロゲン受容体経路をターゲットします。 Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18674639 癌バイオ マーカーの問題。 Nature. Apr, 2008 | Pubmed ID: 18385728 失った--何か何かを得た:、ASCI の第 2 世紀が始まります。 The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18382722 ラパマイシンの抗腫瘍活性相における再発 PTEN 欠損膠芽腫患者に対する試験。 PLoS Medicine. Jan, 2008 | Pubmed ID: 18215105 逐次 ABL キナーゼ阻害剤療法変更後の発癌能と化合物の薬剤耐性 BCR-ABL 変異を選択します。 The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17710227 ATP 結合ループのリン酸化は薬剤耐性 BCR-ABL 変異体のアニオンを指示します。 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17164333 プログレッシブ、去勢抵抗性前立腺癌の生物学: アンドロゲン受容体シグナル伝達軸をターゲット療法を監督します。 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16278481 薬剤耐性変異株の ABL、キット、および EGF 受容体キナーゼの阻害です。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046538 新規 Pyridopyrimidine 阻害の Abl キナーゼ Bcr-abl ドリブン K562 細胞の Picomolar 阻害剤であり、STI571 耐性 Bcr-abl 変異体に対して効果的です。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003 | Pubmed ID: 12684394 遺伝子型と突然変異プロファイルを薬理学的応答に変換するツールとしての前立腺オルガノイド培養 Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research
遺伝子型と突然変異プロファイルを薬理学的応答に変換するツールとしての前立腺オルガノイド培養 Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research