Charles L. Sawyers Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Charles L. Sawyers has not added a biography. If you are Charles L. Sawyers and would like to personalize this page please email our Author Liaison for assistance. Publications A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation Nature Medicine. Oct, 2019 | Pubmed ID: 31591597 Herceptin: A First Assault on Oncogenes That Launched a Revolution Cell. Sep, 2019 | Pubmed ID: 31519311 FOXA1 Mutations Alter Pioneering Activity, Differentiation and Prostate Cancer Phenotypes Nature. 07, 2019 | Pubmed ID: 31243370 Publisher Correction: The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. Jul, 2019 | Pubmed ID: 31152158 Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31061129 Amplifies Androgen Receptor Output in Human Prostate Cancer and Contributes to Antiandrogen Resistance ELife. Jan, 2019 | Pubmed ID: 30644358 Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade JAMA Oncology. Apr, 2019 | Pubmed ID: 30589920 SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2019 | Pubmed ID: 30587545 Strategies to Identify and Target Cells of Origin in Prostate Cancer Journal of the National Cancer Institute. Mar, 2019 | Pubmed ID: 30312421 American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives JCO Clinical Cancer Informatics. 12, 2018 | Pubmed ID: 30652542 Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer The Journal of Clinical Investigation. 10, 2018 | Pubmed ID: 30179225 Tumor Copy Number Alteration Burden is a Pan-cancer Prognostic Factor Associated with Recurrence and Death ELife. 09, 2018 | Pubmed ID: 30178746 Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 30109253 Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes Nature Communications. 06, 2018 | Pubmed ID: 29921838 The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. 05, 2018 | Pubmed ID: 29610475 Challenges in Validating Candidate Therapeutic Targets in Cancer ELife. 02, 2018 | Pubmed ID: 29417929 Targeting DNA Repair in Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 04, 2018 | Pubmed ID: 29369701 Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting European Urology. 05, 2018 | Pubmed ID: 29258679 Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity As a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer JAMA Oncology. Feb, 2018 | Pubmed ID: 29121144 Deletion of 3p13-14 Locus Spanning FOXP1 to SHQ1 Cooperates with PTEN Loss in Prostate Oncogenesis Nature Communications. 10, 2017 | Pubmed ID: 29057879 Regulation of the Glucocorticoid Receptor Via a BET-dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer ELife. 09, 2017 | Pubmed ID: 28891793 Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA Vs Guideline-Based Germline Testing JAMA. 09, 2017 | Pubmed ID: 28873162 Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making JCO Precision Oncology. Jul, 2017 | Pubmed ID: 28825054 ERF Mutations Reveal a Balance of ETS Factors Controlling Prostate Oncogenesis Nature. 06, 2017 | Pubmed ID: 28614298 Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions The New England Journal of Medicine. 05, 2017 | Pubmed ID: 28538124 SOX2 Promotes Lineage Plasticity and Antiandrogen Resistance in TP53- and RB1-deficient Prostate Cancer Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059768 Rb1 and Trp53 Cooperate to Suppress Prostate Cancer Lineage Plasticity, Metastasis, and Antiandrogen Resistance Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059767 Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells That Can Initiate Human Prostate Cancer and Predict Poor Outcome Cell Reports. 12, 2016 | Pubmed ID: 27926864 A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon PloS One. 2016 | Pubmed ID: 27536883 Facilitating a Culture of Responsible and Effective Sharing of Cancer Genome Data Nature Medicine. 05, 2016 | Pubmed ID: 27149219 Organoid Culture Systems for Prostate Epithelial and Cancer Tissue Nature Protocols. Feb, 2016 | Pubmed ID: 26797458 Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins Molecular Pharmaceutics. Feb, 2016 | Pubmed ID: 26725682 Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors Cell Reports. Dec, 2015 | Pubmed ID: 26628377 Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer Nature Reviews. Cancer. Dec, 2015 | Pubmed ID: 26563462 All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care Through the Global Alliance for Genomics and Health Cancer Discovery. Nov, 2015 | Pubmed ID: 26526696 Androgen Receptor Upregulation Mediates Radioresistance After Ionizing Radiation Cancer Research. Nov, 2015 | Pubmed ID: 26432404 Identification of an Oncogenic RAB Protein Science (New York, N.Y.). Oct, 2015 | Pubmed ID: 26338797 Integrative Clinical Genomics of Advanced Prostate Cancer Cell. May, 2015 | Pubmed ID: 26000489 Feedback Suppression of PI3Kα Signaling in PTEN-mutated Tumors is Relieved by Selective Inhibition of PI3Kβ Cancer Cell. Jan, 2015 | Pubmed ID: 25544636 Identifying Actionable Targets Through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling Molecular Cancer Therapeutics. Jan, 2015 | Pubmed ID: 25381262 MAGI-2 Scaffold Protein is Critical for Kidney Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25271328 Cabozantinib Resolves Bone Scans in Tumor-naïve Mice Harboring Skeletal Injuries Molecular Imaging. 2014 | Pubmed ID: 25248353 Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: a Policy Statement from the American Association for Cancer Research Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014 | Pubmed ID: 25204554 Organoid Cultures Derived from Patients with Advanced Prostate Cancer Cell. Sep, 2014 | Pubmed ID: 25201530 Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell. Sep, 2014 | Pubmed ID: 25201529 CDK9-mediated Transcription Elongation is Required for MYC Addiction in Hepatocellular Carcinoma Genes & Development. Aug, 2014 | Pubmed ID: 25128497 Copy Number Alteration Burden Predicts Prostate Cancer Relapse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25024180 Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade Cell. Dec, 2013 | Pubmed ID: 24315100 "N of 1" Case Reports in the Era of Whole-genome Sequencing The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24135144 Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers Cancer Discovery. Nov, 2013 | Pubmed ID: 24027196 Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-resistant Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2013 | Pubmed ID: 24002508 ETS Factors Reprogram the Androgen Receptor Cistrome and Prime Prostate Tumorigenesis in Response to PTEN Loss Nature Medicine. Aug, 2013 | Pubmed ID: 23817021 Perspective: Combined Forces Nature. Jun, 2013 | Pubmed ID: 23803949 Developing Standards for Breakthrough Therapy Designation in Oncology Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23719260 Overcoming Mutation-based Resistance to Antiandrogens with Rational Drug Design ELife. Apr, 2013 | Pubmed ID: 23580326 β4 Integrin Signaling Induces Expansion of Prostate Tumor Progenitors The Journal of Clinical Investigation. Feb, 2013 | Pubmed ID: 23348745 89Zr Transferrin와 뇌에 종양 부담 이미징 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2013 | Pubmed ID: 23236019 The 2011 Gordon Wilson Lecture: Overcoming Resistance to Targeted Cancer Drugs Transactions of the American Clinical and Climatological Association. 2012 | Pubmed ID: 23303979 Annotating MYC Status with 89Zr-transferrin Imaging Nature Medicine. Oct, 2012 | Pubmed ID: 23001181 Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors Cancer Research. Dec, 2012 | Pubmed ID: 22971343 JNK and PTEN Cooperatively Control the Development of Invasive Adenocarcinoma of the Prostate Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22753496 Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-specific Antigen Cancer Discovery. Apr, 2012 | Pubmed ID: 22576209 Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-hairpin RNA Library Screening PloS One. 2012 | Pubmed ID: 22509301 Converting Cancer Therapies into Cures: Lessons from Infectious Diseases Cell. Mar, 2012 | Pubmed ID: 22424221 기대-509: 전립선 암 치료에 대 한 소설 Anti-androgen Cancer Research. Jan, 2012 | Pubmed ID: 22266222 피트 니스 BCR ABL 니 도메인 돌연변이 의해 수 여 만성 골수성 백혈병에서 기존의 저항의 위험을 결정 합니다 PloS One. 2011 | Pubmed ID: 22140458 거세 저항 전립선 암 환자에서 감도의 예측 Biomarker로 종양 세포를 순환에서 TMPRSS2-르 그 상태 Abiraterone 아세테이트로 치료 European Urology. Nov, 2011 | Pubmed ID: 21802835 안 드로 겐 수용 체 신호 양전자 방출 Radiopharmaceutical와 그 대상 전립선 특정 막 항 원 측정 비 침 투 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606347 PTEN 불충분 한 전립선 암 신호 PI3K 및 안 드로 겐 수용 체의 상호 피드백 규제 Cancer Cell. May, 2011 | Pubmed ID: 21575859 FAS와 NF κB 신호 변조 EGFR 돌연변이 폐 암 의존도 Nature. Mar, 2011 | Pubmed ID: 21430781 MYC는 AKT를 협력 하는 전립선 Tumorigenesis 고 감도 MTOR 억제제를 변경 PloS One. 2011 | Pubmed ID: 21394210 ETV1 키트와 함께 위장 Stromal 종양에 협조 하는 리니지 생존 요소 이다 Nature. Oct, 2010 | Pubmed ID: 20927104 Constitutively 활성 안 드로 겐 수용 체 결합 변종 거세 내성 전립선 암에 표현 된 전체 길이 안 드로 겐 수용 체가 필요 합니다 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823238 통합 게놈의 프로 파일링 인간의 전립선 암입니다 Cancer Cell. Jul, 2010 | Pubmed ID: 20579941 퓨전 양성 전립선 암에 르 그 및 안 드로 겐 수용 체에 의해 Transcriptional 규제를 조정 합니다 Cancer Cell. May, 2010 | Pubmed ID: 20478521 거세 저항 전립선 암에 Mdv3100의 Antitumour 활동: 1-2 단계 연구 Lancet. Apr, 2010 | Pubmed ID: 20398925 거세 저항 전립선 암 (CRPC)에 대 한 Thiohydantoin 안 드로 겐 수용 체 길 항 제에 대 한 구조 활동 관계 Journal of Medicinal Chemistry. Apr, 2010 | Pubmed ID: 20218717 Dasatinib를 받고 만성 골수성 백혈병 환자의 필라델피아 염색체 음수가 골 수 세포에서 클론 조 Leukemia Research. Jun, 2010 | Pubmed ID: 19804904 Kinase 억제제 개발으로부터 배운 교훈 Clinical Advances in Hematology & Oncology : H&O. Sep, 2009 | Pubmed ID: 20020670 패러다임 변화: Oncogene 중독의 씨앗 Nature Medicine. Oct, 2009 | Pubmed ID: 19812578 Proteasomal 및 Gliomagenesis에서 N F 1 종양 억제기 유전자 비활성화 Cancer Cell. Jul, 2009 | Pubmed ID: 19573811 찾기 및 RAS 종속 암의 취약점의 약물을 투여 합니다 Cell. May, 2009 | Pubmed ID: 19490885 Cooperativity TMPRSS2-르 그의 전립선 발암에 PI3 Kinase 통로 활성화 Nature Genetics. May, 2009 | Pubmed ID: 19396167 고급 전립선 암의 치료를 위해 2 세대 Antiandrogen의 개발 Science (New York, N.Y.). May, 2009 | Pubmed ID: 19359544 히스톤 Deacetylases는 호르몬에 민감하고 거세 내성 전립선 암에 안 드로 겐 수용 체 기능을 위해 필요 합니다 Cancer Research. Feb, 2009 | Pubmed ID: 19176386 변환 연구: 우리는 곧 정상 궤도에? 2008 임상 조사 대통령 주소를 위한 미국 사회입니다 The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18982165 핵 인자-kappaB 통로 안 드로 겐 독립적인 성장에 전립선 암의 진행을 제어합니다 Cancer Research. Aug, 2008 | Pubmed ID: 18701501 전립선 Intraepithelial 신 생물 종속 P27 Kip1 검사점 노화를 유도 하 고 세포 증식 및 암 진행을 억제 한다 Cancer Cell. Aug, 2008 | Pubmed ID: 18691549 전립선 암에 안 드로 겐 수용 체 통로 대상으로 합니다 Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18674639 암 Biomarker 문제입니다 Nature. Apr, 2008 | Pubmed ID: 18385728 뭔가 잃어버린-뭔가 얻었다:는 ASCI 시작 됩니다 자사의 두 번째 세기 The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18382722 단계에 Rapamycin의 Antitumor 활동 나 재발 PTEN 불충분 한 Glioblastoma 환자에 대 한 재판 PLoS Medicine. Jan, 2008 | Pubmed ID: 18215105 순차 ABL Kinase 억제제 치료 복합 약물 내성 BCR ABL 돌연변이 대 한 변경 된 금하는 효능을 선택합니다 The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17710227 ATP 바인딩 루프의 인 산화 약물 내성 BCR ABL 돌연변이 Oncogenicity 지시 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17164333 생물학의 진보, 거세 저항 하는 전립선 암: 치료 대상으로 안 드로 겐-수용 체 신호 축 감독 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16278481 ABL, 키트, 그리고 EGF 수용 체 Kinases 약물 내성 돌연변이의 억제 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046538 Abl 니의 소설 Pyridopyrimidine 억제제 Bcr Abl 구동 K562 셀 Picomolar 억제제 이며 STI571 내성 Bcr Abl 돌연변이 대해 효과적입니다 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003 | Pubmed ID: 12684394 약리학적 반응에 유전형과 돌연변이 단면도를 번역하는 공구로 전립선 오르가노이드 문화 Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research
약리학적 반응에 유전형과 돌연변이 단면도를 번역하는 공구로 전립선 오르가노이드 문화 Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research