Charles A. Parkos Department of Pathology University of Michigan Biography Publications Institution JoVE Articles Charles A. Parkos has not added a biography. If you are Charles A. Parkos and would like to personalize this page please email our Author Liaison for assistance. Publications Dysregulation of Intestinal Epithelial CFTR-dependent Cl Ion Transport and Paracellular Barrier Function Drives Gastrointestinal Symptoms of Food-induced Anaphylaxis in Mice Mucosal Immunology. 01, 2021 | Pubmed ID: 32576925 WD40 Repeat Protein 26 Negatively Regulates Formyl Peptide Receptor-1 Mediated Wound Healing in Intestinal Epithelial Cells The American Journal of Pathology. 10, 2020 | Pubmed ID: 32958140 Neutrophil Expressed CD47 Regulates CD11b/CD18-dependent Neutrophil Transepithelial Migration in the Intestine in Vivo Mucosal Immunology. Jun, 2020 | Pubmed ID: 32561828 Blocking Integrin αβ-mediated CD4 T Cell Recruitment to the Intestine and Liver Protects Mice from Western Diet-induced Non-alcoholic Steatohepatitis Journal of Hepatology. Nov, 2020 | Pubmed ID: 32540177 Western Diet-induced Increase in Colonic Bile Acids Compromises Epithelial Barrier in Nonalcoholic Steatohepatitis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 05, 2020 | Pubmed ID: 32275114 Desmocollin-2 Promotes Intestinal Mucosal Repair by Controlling Integrin-dependent Cell Adhesion and Migration Molecular Biology of the Cell. 03, 2020 | Pubmed ID: 31967937 Regulation of Neutrophil Function by Selective Targeting of Glycan Epitopes Expressed on the Integrin CD11b/CD18 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 02, 2020 | Pubmed ID: 31907993 Innate Immune Cell-epithelial Crosstalk During Wound Repair The Journal of Clinical Investigation. 07, 2019 | Pubmed ID: 31329162 Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 T-Cell Activation Frontiers in Immunology. 2019 | Pubmed ID: 30936879 Macrophage-dependent Neutrophil Recruitment is Impaired Under Conditions of Increased Intestinal Permeability in JAM-A-deficient Mice Mucosal Immunology. 05, 2019 | Pubmed ID: 30745566 Role of JAM-A Tyrosine Phosphorylation in Epithelial Barrier Dysfunction During Intestinal Inflammation Molecular Biology of the Cell. 03, 2019 | Pubmed ID: 30625033 Analysis of Leukocyte Transepithelial Migration Using an in Vivo Murine Colonic Loop Model JCI Insight. 10, 2018 | Pubmed ID: 30333307 Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Frontiers in Immunology. 2018 | Pubmed ID: 29881378 Role of Negative Regulation of Immune Signaling Pathways in Neutrophil Function Journal of Leukocyte Biology. Dec, 2017 | Pubmed ID: 29345376 Expression of Lewis-a Glycans on Polymorphonuclear Leukocytes Augments Function by Increasing Transmigration Journal of Leukocyte Biology. Sep, 2017 | Pubmed ID: 28600306 Defects in CD4+ T Cell LFA-1 Integrin-dependent Adhesion and Proliferation Protect Cd47-/- Mice from EAE Journal of Leukocyte Biology. 02, 2017 | Pubmed ID: 27965383 IL-17A-mediated Neutrophil Recruitment Limits Expansion of Segmented Filamentous Bacteria Mucosal Immunology. 05, 2017 | Pubmed ID: 27624780 Claudin-based Barrier Differentiation in the Colonic Epithelial Crypt Niche Involves Hopx/Klf4 and Tcf7l2/Hnf4-α Cascades Tissue Barriers. Jul-Sep, 2016 | Pubmed ID: 27583195 Pathobiology of Neutrophil-epithelial Interactions Immunological Reviews. 09, 2016 | Pubmed ID: 27558330 Deposition of Microparticles by Neutrophils Onto Inflamed Epithelium: a New Mechanism to Disrupt Epithelial Intercellular Adhesions and Promote Transepithelial Migration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 12, 2016 | Pubmed ID: 27553226 Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair Gastroenterology. 10, 2016 | Pubmed ID: 27436072 Redox Control of Cas Phosphorylation Requires Abl Kinase in Regulation of Intestinal Epithelial Cell Spreading and Migration American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2016 | Pubmed ID: 27418680 Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol Gastroenterology. 10, 2016 | Pubmed ID: 27342212 Neutrophil-Epithelial Interactions: A Double-Edged Sword The American Journal of Pathology. 06, 2016 | Pubmed ID: 27083514 Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation The American Journal of Pathology. Feb, 2016 | Pubmed ID: 26687991 Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage Journal of Immunology (Baltimore, Md. : 1950). Jan, 2016 | Pubmed ID: 26590314 Inflammation-induced Desmoglein-2 Ectodomain Shedding Compromises the Mucosal Barrier Molecular Biology of the Cell. Sep, 2015 | Pubmed ID: 26224314 HNF4α Regulates Claudin-7 Protein Expression During Intestinal Epithelial Differentiation The American Journal of Pathology. Aug, 2015 | Pubmed ID: 26216285 Annexin A1-containing Extracellular Vesicles and Polymeric Nanoparticles Promote Epithelial Wound Repair The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25664854 Junctional Adhesion Molecule A Promotes Epithelial Tight Junction Assembly to Augment Lung Barrier Function The American Journal of Pathology. Feb, 2015 | Pubmed ID: 25438062 Challenges in IBD Research: Update on Progress and Prioritization of the CCFA's Research Agenda Inflammatory Bowel Diseases. Mar, 2013 | Pubmed ID: 23448796 Targeting Epithelial Expressed Sialyl Lewis Glycans Improves Colonic Mucosal Wound Healing and Protects Against Colitis JCI Insight. | Pubmed ID: 32427587 Resolvin E1 is a Pro-repair Molecule That Promotes Intestinal Epithelial Wound Healing Proceedings of the National Academy of Sciences of the United States of America. | Pubmed ID: 32300016 Epithelial CD47 is Critical for Mucosal Repair in the Murine Intestine in Vivo Nature Communications. | Pubmed ID: 31676794 Formyl Peptide Receptor 2 Regulates Monocyte Recruitment to Promote Intestinal Mucosal Wound Repair FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. | Pubmed ID: 31585047 TNFα Promotes Mucosal Wound Repair Through Enhanced Platelet Activating Factor Receptor Signaling in the Epithelium Mucosal Immunology. | Pubmed ID: 30971752 Intracellular Desmoglein-2 Cleavage Sensitizes Epithelial Cells to Apoptosis in Response to Pro-inflammatory Cytokines Cell Death & Disease. | Pubmed ID: 29523777 Macrophage-derived IL-10 Mediates Mucosal Repair by Epithelial WISP-1 Signaling The Journal of Clinical Investigation. | Pubmed ID: 28783045 एक मुरीन डेक्सट्रान सोडियम सल्फेट-प्रेरित कोलाइटिस मॉडल में आंतों की सूजन के लिए व्यवस्थित स्कोरिंग विश्लेषण Vicky Garcia-Hernandez1, Philipp-Alexander Neumann2, Stefan Koch3,4, Renae Lyons1, Asma Nusrat1, Charles A. Parkos1 1Department of Pathology, University of Michigan, 2Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, 3Wallenberg Centre for Molecular Medicine, Linköping University, 4Department of Biomedical and Clinical Sciences (BKV), Linköping University JoVE 62135 Immunology and Infection मानकीकृत आंतों के लूप मॉडल का उपयोग करके चूहों में आंतों की पारगम्यता और न्यूट्रोफिल ट्रांसेपिथेलियल माइग्रेशन का कार्यात्मक मूल्यांकन Kevin Boerner1, Anny-Claude Luissint1, Charles A. Parkos1 1Department of Pathology, University of Michigan, Ann Arbor JoVE 62093 Immunology and Infection
एक मुरीन डेक्सट्रान सोडियम सल्फेट-प्रेरित कोलाइटिस मॉडल में आंतों की सूजन के लिए व्यवस्थित स्कोरिंग विश्लेषण Vicky Garcia-Hernandez1, Philipp-Alexander Neumann2, Stefan Koch3,4, Renae Lyons1, Asma Nusrat1, Charles A. Parkos1 1Department of Pathology, University of Michigan, 2Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, 3Wallenberg Centre for Molecular Medicine, Linköping University, 4Department of Biomedical and Clinical Sciences (BKV), Linköping University JoVE 62135 Immunology and Infection
मानकीकृत आंतों के लूप मॉडल का उपयोग करके चूहों में आंतों की पारगम्यता और न्यूट्रोफिल ट्रांसेपिथेलियल माइग्रेशन का कार्यात्मक मूल्यांकन Kevin Boerner1, Anny-Claude Luissint1, Charles A. Parkos1 1Department of Pathology, University of Michigan, Ann Arbor JoVE 62093 Immunology and Infection
