Christoph Winkler Department of Biological Sciences National University of Singapore Biography Publications Institution JoVE Articles Christoph Winkler has not added a biography. If you are Christoph Winkler and would like to personalize this page please email our Author Liaison for assistance. Publications A Vertebrate Specific and Essential Role for Sp7/osterix in Osteogenesis Revealed by Gene Knock-out in the Teleost Medaka Development (Cambridge, England). Dec, 2016 | Pubmed ID: 27993982 Transcriptional Enhancement of Smn Levels in Motoneurons is Crucial for Proper Axon Morphology in Zebrafish Scientific Reports. Jun, 2016 | Pubmed ID: 27273160 Trametes Versicolor Carboxylate Reductase Uncovered Monatshefte Fur Chemie. 2016 | Pubmed ID: 27069283 Live Imaging of Osteoclast Inhibition by Bisphosphonates in a Medaka Osteoporosis Model Disease Models & Mechanisms. Feb, 2016 | Pubmed ID: 26704995 An Adult Osteopetrosis Model in Medaka Reveals the Importance of Osteoclast Function for Bone Remodeling in Teleost Fish Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Dec, 2015 | Pubmed ID: 26334373 The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish PloS One. 2015 | Pubmed ID: 26121341 The Flatness of Lamellipodia Explained by the Interaction Between Actin Dynamics and Membrane Deformation Journal of Theoretical Biology. Sep, 2015 | Pubmed ID: 26002996 A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish G3 (Bethesda, Md.). Apr, 2015 | Pubmed ID: 25840430 Effect of Rubber Flooring on Dairy Cattle Stepping Behavior and Muscle Activity Journal of Dairy Science. Apr, 2015 | Pubmed ID: 25648801 Dmrt5 Controls Corticotrope and Gonadotrope Differentiation in the Zebrafish Pituitary Molecular Endocrinology (Baltimore, Md.). Feb, 2015 | Pubmed ID: 25489906 Nitrile As Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases Advanced Synthesis & Catalysis. May, 2014 | Pubmed ID: 26190962 Identification of a PRPF4 Loss-of-function Variant That Abrogates U4/U6.U5 Tri-snRNP Integration and is Associated with Retinitis Pigmentosa PloS One. 2014 | Pubmed ID: 25383878 Identification of Promiscuous Ene-reductase Activity by Mining Structural Databases Using Active Site Constellations Nature Communications. Jun, 2014 | Pubmed ID: 24954722 Bioreduction and Disproportionation of Cyclohex-2-enone Catalyzed by Ene-reductase OYE-1 in 'micro-aqueous' Organic Solvents Biotechnology Letters. Jun, 2014 | Pubmed ID: 24563324 Electron Tomography and Simulation of Baculovirus Actin Comet Tails Support a Tethered Filament Model of Pathogen Propulsion PLoS Biology. Jan, 2014 | Pubmed ID: 24453943 Osterix/Sp7 Regulates Biomineralization of Otoliths and Bone in Medaka (Oryzias Latipes) Matrix Biology : Journal of the International Society for Matrix Biology. Feb, 2014 | Pubmed ID: 24407212 NAD(P)H-independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates As the Hydrogen Donor Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2014 | Pubmed ID: 24382795 SMN Deficiency Alters Nrxn2 Expression and Splicing in Zebrafish and Mouse Models of Spinal Muscular Atrophy Human Molecular Genetics. Apr, 2014 | Pubmed ID: 24218366 Arp2/3 Complex is Essential for Actin Network Treadmilling As Well As for Targeting of Capping Protein and Cofilin Molecular Biology of the Cell. Sep, 2013 | Pubmed ID: 23885122 Overcoming Co-product Inhibition in the Nicotinamide Independent Asymmetric Bioreduction of Activated C=C-bonds Using Flavin-dependent Ene-reductases Biotechnology and Bioengineering. Dec, 2013 | Pubmed ID: 23794404 A Col10a1:nlGFP Transgenic Line Displays Putative Osteoblast Precursors at the Medaka Notochordal Sheath Prior to Mineralization Developmental Biology. Sep, 2013 | Pubmed ID: 23769979 Two Isoforms of Sister-Of-Mammalian Grainyhead Have Opposing Functions in Endothelial Cells and in Vivo Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2013 | Pubmed ID: 23685552 Anaplastic Lymphoma Kinase is Required for Neurogenesis in the Developing Central Nervous System of Zebrafish PloS One. 2013 | Pubmed ID: 23667670 Zebrafish Hoxd4a Acts Upstream of Meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis PloS One. 2013 | Pubmed ID: 23554940 Análisis De La Estructura Y Función De Larga Duración Midkine Revelan Nuevos Residuos Importantes Para La Embriogénesis Heparina Y Pez Cebra The Biochemical Journal. Feb, 2013 | Pubmed ID: 23418741 Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors Via Asymmetric Bioreduction of β-cyanoacrylate Esters Using Ene-reductases The Journal of Organic Chemistry. Feb, 2013 | Pubmed ID: 23316696 Dynamic Microtubules at the Vegetal Cortex Predict the Embryonic Axis in Zebrafish Development (Cambridge, England). Oct, 2012 | Pubmed ID: 22949618 The 1D4 Antibody Labels Outer Segments of Long Double Cone but Not Rod Photoreceptors in Zebrafish Investigative Ophthalmology & Visual Science. Jul, 2012 | Pubmed ID: 22743318 A Substrate-driven Approach to Determine Reactivities of α,β-unsaturated Carboxylic Esters Towards Asymmetric Bioreduction Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2012 | Pubmed ID: 22736443 Asymmetric Bioreduction of Activated Alkenes to Industrially Relevant Optically Active Compounds Journal of Biotechnology. Dec, 2012 | Pubmed ID: 22498437 Actin Branching in the Initiation and Maintenance of Lamellipodia Journal of Cell Science. Jun, 2012 | Pubmed ID: 22431015 Actin Filament Tracking in Electron Tomograms of Negatively Stained Lamellipodia Using the Localized Radon Transform Journal of Structural Biology. Apr, 2012 | Pubmed ID: 22387240 Conditional Ablation of Osteoblasts in Medaka Developmental Biology. Apr, 2012 | Pubmed ID: 22326228 The Popeye Domain Containing 2 (popdc2) Gene in Zebrafish is Required for Heart and Skeletal Muscle Development Developmental Biology. Mar, 2012 | Pubmed ID: 22290329 Rankl-induced Osteoclastogenesis Leads to Loss of Mineralization in a Medaka Osteoporosis Model Development (Cambridge, England). Jan, 2012 | Pubmed ID: 22096076 Mutant Prpf31 Causes Pre-mRNA Splicing Defects and Rod Photoreceptor Cell Degeneration in a Zebrafish Model for Retinitis Pigmentosa Molecular Neurodegeneration. Jul, 2011 | Pubmed ID: 21801444 Asymmetric Bioreduction of Alkenes Using Ene-reductases YersER and KYE1 and Effects of Organic Solvents Organic Letters. May, 2011 | Pubmed ID: 21510626 Combined in Vivo Imaging and Omics Approaches Reveal Metabolism of Icaritin and Its Glycosides in Zebrafish Larvae Molecular BioSystems. Jul, 2011 | Pubmed ID: 21445457 Systemic Splicing Factor Deficiency Causes Tissue-specific Defects: a Zebrafish Model for Retinitis Pigmentosa Human Molecular Genetics. Jan, 2011 | Pubmed ID: 21051334 Bioreduction of Alpha-methylcinnamaldehyde Derivatives: Chemo-enzymatic Asymmetric Synthesis of Lilial and Helional Dalton Transactions (Cambridge, England : 2003). Sep, 2010 | Pubmed ID: 20461254 Tgfbeta3 Regulation of Chondrogenesis and Osteogenesis in Zebrafish is Mediated Through Formation and Survival of a Subpopulation of the Cranial Neural Crest Mechanisms of Development. Jul-Aug, 2010 | Pubmed ID: 20406684 Accessibility of Host Cell Lineages to Medaka Stem Cells Depends on Genetic Background and Irradiation of Recipient Embryos Cellular and Molecular Life Sciences : CMLS. Apr, 2010 | Pubmed ID: 20238480 La Heterogénea Ribonucleoproteína Nuclear-R Es Necesaria Para El Desplazamiento Del MRNA De Beta-actina Axonal En Motoneuronas Espinales Human Molecular Genetics. May, 2010 | Pubmed ID: 20167579 Phylogenetic and Evolutionary Relationships and Developmental Expression Patterns of the Zebrafish Twist Gene Family Development Genes and Evolution. Jun, 2009 | Pubmed ID: 19565261 Osterix-mCherry Transgenic Medaka for in Vivo Imaging of Bone Formation Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jan, 2009 | Pubmed ID: 19097055 Genetic Analysis of Somite Formation in Laboratory Fish Models Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 21038770 Retinoic Acid and Cyp26b1 Are Critical Regulators of Osteogenesis in the Axial Skeleton Development (Cambridge, England). Nov, 2008 | Pubmed ID: 18927155 An Asymmetric Distribution of Positrons in the Galactic Disk Revealed by Gamma-rays Nature. Jan, 2008 | Pubmed ID: 18185581 Midkine-b Regulates Cell Specification at the Neural Plate Border in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jan, 2008 | Pubmed ID: 18058915 Influence of Verapamil on Tachycardia-induced Alterations of PP1 and PP2A in Rabbit Atrium Experimental and Clinical Cardiology. 2007 | Pubmed ID: 18651001 Effect of Verapamil on Tachycardia-induced Early Cellular Electrical Remodeling in Rabbit Atrium Naunyn-Schmiedeberg's Archives of Pharmacology. Dec, 2007 | Pubmed ID: 17874072 Inhibition of Primordial Germ Cell Proliferation by the Medaka Male Determining Gene Dmrt I BY BMC Developmental Biology. Aug, 2007 | Pubmed ID: 17760954 Pituitary-interrenal Interaction in Zebrafish Interrenal Organ Development Molecular Endocrinology (Baltimore, Md.). Feb, 2007 | Pubmed ID: 17082325 Discontinuous Organization and Specification of the Lateral Floor Plate in Zebrafish Developmental Biology. Jan, 2007 | Pubmed ID: 17045256 Tissue-specific Expression of Dmrt Genes in Embryos and Adults of the Platyfish Xiphophorus Maculatus Zebrafish. 2006 | Pubmed ID: 18377213 Structural and Functional Characterization of the Zebrafish Lamin B Receptor European Journal of Cell Biology. Aug, 2006 | Pubmed ID: 16759737 Dynamic Expression of Sparc Precedes Formation of Skeletal Elements in the Medaka (Oryzias Latipes) Gene. May, 2006 | Pubmed ID: 16545530 Her1 and Her13.2 Are Jointly Required for Somitic Border Specification Along the Entire Axis of the Fish Embryo Developmental Biology. May, 2006 | Pubmed ID: 16545363 Comparative Analysis of Her Genes During Fish Somitogenesis Suggests a Mouse/chick-like Mode of Oscillation in Medaka Development Genes and Evolution. Jun, 2006 | Pubmed ID: 16544152 Radioactive 26Al from Massive Stars in the Galaxy Nature. Jan, 2006 | Pubmed ID: 16397491 Identification and Comparative Expression Analysis of a Second Wt1 Gene in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2006 | Pubmed ID: 16292775 Reduced U SnRNP Assembly Causes Motor Axon Degeneration in an Animal Model for Spinal Muscular Atrophy Genes & Development. Oct, 2005 | Pubmed ID: 16204184 Medial Floor Plate Formation in Zebrafish Consists of Two Phases and Requires Trunk-derived Midkine-a Genes & Development. Apr, 2005 | Pubmed ID: 15833916 Hedgehog and Retinoid Signalling Confines Nkx2.2b Expression to the Lateral Floor Plate of the Zebrafish Trunk Mechanisms of Development. Jan, 2005 | Pubmed ID: 15582776 The Lamina-associated Polypeptide 2 (LAP2) Genes of Zebrafish and Chicken: No LAP2alpha Isoform is Synthesised by Non-mammalian Vertebrates European Journal of Cell Biology. Aug, 2004 | Pubmed ID: 15506564 Her7 and Hey1, but Not Lunatic Fringe Show Dynamic Expression During Somitogenesis in Medaka (Oryzias Latipes) Gene Expression Patterns : GEP. Sep, 2004 | Pubmed ID: 15261833 Developmentally Regulated and Non-sex-specific Expression of Autosomal Dmrt Genes in Embryos of the Medaka Fish (Oryzias Latipes) Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210205 Activation of the Mouse Oct4 Promoter in Medaka Embryonic Stem Cells and Its Use for Ablation of Spontaneous Differentiation Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210197 Las Mutaciones Que Afectan Al Desarrollo De Retina En Medaka Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210178 Las Mutaciones Que Afectan La Formación Somitas En La Medaka (Oryzias Latipes) Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210175 Una Sistemática De Todo El Genoma En Busca De Mutaciones Que Afectan a La Organogénesis En Medaka, Oryzias Latipes Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210174 Characterization of Hey BHLH Genes in Teleost Fish Development Genes and Evolution. Nov, 2003 | Pubmed ID: 14593478 Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-specific Gene Duplication Genome Research. Jun, 2003 | Pubmed ID: 12743018 The Lamina-associated Polypeptide 2 (LAP2) Isoforms Beta, Gamma and Omega of Zebrafish: Developmental Expression and Behavior During the Cell Cycle Journal of Cell Science. Jun, 2003 | Pubmed ID: 12734396 The Pro-opiomelanocortin Gene of the Zebrafish (Danio Rerio) Biochemical and Biophysical Research Communications. Apr, 2003 | Pubmed ID: 12684052 A Duplicated Copy of DMRT1 in the Sex-determining Region of the Y Chromosome of the Medaka, Oryzias Latipes Proceedings of the National Academy of Sciences of the United States of America. Sep, 2002 | Pubmed ID: 12193652 El tratamiento de drogas y Tingsheng Yu1,2, Christoph Winkler1,2 1Department of Biological Sciences, National University of Singapore, 2NUS Centre for Bioimaging Sciences (CBIS), National University of Singapore Developmental Biology
El tratamiento de drogas y Tingsheng Yu1,2, Christoph Winkler1,2 1Department of Biological Sciences, National University of Singapore, 2NUS Centre for Bioimaging Sciences (CBIS), National University of Singapore Developmental Biology