Christophe Prehaud

Virology Department

Institut Pasteur, Viral Neuroimmunology Laboratory

Christophe Prehaud

Christophe Prehaud obtained his Ph.D. degree in 1984 at Paris University (UPMC) on a molecular and genetic study of the Rabies virus glycoprotein (RABV-G). Then, he moved to Oxford-UK (NERC Institute of Virology) as a European Economic Community (EEC) postdoc fellow before undertaking a post doc training in Australia (CSIRO). He joined Institut Pasteur (Paris, France) in 1994 where he works with Dr Monique Lafon in her research unit (Viral NeuroImmunology) on the Neuron-Rabies Virus interaction. Since then, their work demonstrated the key role of the RABV-G in the neuron survival phenotype of virulent RABV strains and allowed to identify the serine-threonine microtubule associated serine-threonine kinase MAST2 as neuronal protein partner of RABV-G. From this basic research project, they identify a short polypeptide molecule that can trigger neuronal survival and axonal neuroregeneration. The use, delivery and optimization of this molecule is currently developed in a translational research program by using in vivo models as well as in cellulo human neuronal cells and BBB-minibrain models.

Publications

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

1Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, 2Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, 3Institut Pasteur, PFIA, DTPS

JoVE 59220


 Neuroscience