Christophe Prehaud Virology Department Institut Pasteur, Viral Neuroimmunology Laboratory Biography Publications Institution JoVE Articles Christophe Prehaud Christophe Prehaud obtained his Ph.D. degree in 1984 at Paris University (UPMC) on a molecular and genetic study of the Rabies virus glycoprotein (RABV-G). Then, he moved to Oxford-UK (NERC Institute of Virology) as a European Economic Community (EEC) postdoc fellow before undertaking a post doc training in Australia (CSIRO). He joined Institut Pasteur (Paris, France) in 1994 where he works with Dr Monique Lafon in her research unit (Viral NeuroImmunology) on the Neuron-Rabies Virus interaction. Since then, their work demonstrated the key role of the RABV-G in the neuron survival phenotype of virulent RABV strains and allowed to identify the serine-threonine microtubule associated serine-threonine kinase MAST2 as neuronal protein partner of RABV-G. From this basic research project, they identify a short polypeptide molecule that can trigger neuronal survival and axonal neuroregeneration. The use, delivery and optimization of this molecule is currently developed in a translational research program by using in vivo models as well as in cellulo human neuronal cells and BBB-minibrain models. Publications Innovative in Cellulo Method As an Alternative to in Vivo Neurovirulence Test for the Characterization and Quality Control of Human Live Yellow Fever Virus Vaccines: A Pilot Study Biologicals : Journal of the International Association of Biological Standardization. May, 2018 | Pubmed ID: 29580693 Ein menschliches Blut-Hirn-Schnittstellenmodell Barriere Kreuzungen durch Krankheitserreger oder Medikamente und ihre Wechselwirkungen mit dem Gehirn zu studieren Anaelle da Costa*1, Christophe Prehaud*1, Florian Bakoa1, Philippe Afonso2, Pierre-Emmanuel Ceccaldi2, Pierre Lafaye3, Monique Lafon1 1Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, 2Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, 3Institut Pasteur, PFIA, DTPS JoVE 59220 Neuroscience
Ein menschliches Blut-Hirn-Schnittstellenmodell Barriere Kreuzungen durch Krankheitserreger oder Medikamente und ihre Wechselwirkungen mit dem Gehirn zu studieren Anaelle da Costa*1, Christophe Prehaud*1, Florian Bakoa1, Philippe Afonso2, Pierre-Emmanuel Ceccaldi2, Pierre Lafaye3, Monique Lafon1 1Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, 2Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, 3Institut Pasteur, PFIA, DTPS JoVE 59220 Neuroscience
