Christopher J. Brown

Publications

• Simultaneous Measurement of P53:Mdm2 and P53:Mdm4 Protein-protein Interactions in Whole Cells Using Fluorescence Labelled Foci
  Scientific Reports. Nov, 2019  |   Pubmed ID: 31784573
• Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties
  Molecules (Basel, Switzerland). Jun, 2019  |   Pubmed ID: 31226791
• Monitoring Flux in Signalling Pathways Through Measurements of 4EBP1-mediated EIF4F Complex Assembly
  BMC Biology. 05, 2019  |   Pubmed ID: 31118010
• Structural Insights Reveal a Recognition Feature for Tailoring Hydrocarbon Stapled-peptides Against the Eukaryotic Translation Initiation Factor 4E Protein
  Chemical Science. Feb, 2019  |   Pubmed ID: 30881679
• Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery
  Scientific Reports. 05, 2017  |   Pubmed ID: 28496125
• Stapled Peptides with Improved Potency and Specificity That Activate P53
  ACS Chemical Biology. Mar, 2013  |   Pubmed ID: 23214419
• C-terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms
  PloS One. 2011  |   Pubmed ID: 21904608
• Stabilizing the EIF4G1 α-helix Increases Its Binding Affinity with EIF4E: Implications for Peptidomimetic Design Strategies
  Journal of Molecular Biology. Jan, 2011  |   Pubmed ID: 21094167