Christopher Aiken

Publications

• RING Domain Mutations Uncouple TRIM5α Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating
  Journal of Virology. Feb, 2012  |   Pubmed ID: 22114335
• Maturation-induced Cloaking of Neutralization Epitopes on HIV-1 Particles
  PLoS Pathogens. Sep, 2011  |   Pubmed ID: 21931551
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  Nature. Apr, 2011  |   Pubmed ID: 21512569
• Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter-hexamer Interfaces
  PLoS Pathogens. Mar, 2011  |   Pubmed ID: 21455494
• Structure of the HIV-1 Full-length Capsid Protein in a Conformationally Trapped Unassembled State Induced by Small-molecule Binding
  Journal of Molecular Biology. Feb, 2011  |   Pubmed ID: 21146540
• Small-molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization
  Journal of Virology. Jan, 2011  |   Pubmed ID: 20962083
• HIV Nuclear Entry: Clearing the Fog
  Viruses. May, 2010  |   Pubmed ID: 21994675
• TRIM5alpha Disrupts the Structure of Assembled HIV-1 Capsid Complexes in Vitro
  Journal of Virology. Jul, 2010  |   Pubmed ID: 20410272
• Anti-HIV Activity of Defective Cyanovirin-N Mutants is Restored by Dimerization
  The Journal of Biological Chemistry. Apr, 2010  |   Pubmed ID: 20147291
• Structural Convergence Between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function
  Cell. Nov, 2009  |   Pubmed ID: 19914170
• Cell-free Assays for HIV-1 Uncoating
  Methods in Molecular Biology (Clifton, N.J.). 2009  |   Pubmed ID: 19020817
• Cyclophilin A-dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells
  Journal of Virology. Dec, 2008  |   Pubmed ID: 18829762
• Biochemical Characterization of a Recombinant TRIM5alpha Protein That Restricts Human Immunodeficiency Virus Type 1 Replication
  Journal of Virology. Dec, 2008  |   Pubmed ID: 18799573
• Proteasomal Degradation of TRIM5alpha During Retrovirus Restriction
  PLoS Pathogens. May, 2008  |   Pubmed ID: 18497858
• Nef Enhances HIV-1 Infectivity Via Association with the Virus Assembly Complex
  Virology. Apr, 2008  |   Pubmed ID: 18191978
• Escape from the Dominant HLA-B27-restricted Cytotoxic T-lymphocyte Response in Gag is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication
  Journal of Virology. Nov, 2007  |   Pubmed ID: 17804494
• Analysis of Human Cell Heterokaryons Demonstrates That Target Cell Restriction of Cyclosporine-resistant Human Immunodeficiency Virus Type 1 Mutants is Genetically Dominant
  Journal of Virology. Nov, 2007  |   Pubmed ID: 17715216
• Maturation-dependent Human Immunodeficiency Virus Type 1 Particle Fusion Requires a Carboxyl-terminal Region of the Gp41 Cytoplasmic Tail
  Journal of Virology. Sep, 2007  |   Pubmed ID: 17609279
• A Mutation in Alpha Helix 3 of CA Renders Human Immunodeficiency Virus Type 1 Cyclosporin A Resistant and Dependent: Rescue by a Second-site Substitution in a Distal Region of CA
  Journal of Virology. Apr, 2007  |   Pubmed ID: 17267487
• Selective Restriction of Nef-defective Human Immunodeficiency Virus Type 1 by a Proteasome-dependent Mechanism
  Journal of Virology. Feb, 2007  |   Pubmed ID: 17108041
• Analysis of HIV-1-X4 Fusion with Immature Dendritic Cells Identifies a Specific Restriction That is Independent of CXCR4 Levels
  The Journal of Investigative Dermatology. Feb, 2007  |   Pubmed ID: 16917492
• Viral and Cellular Factors That Regulate HIV-1 Uncoating
  Current Opinion in HIV and AIDS. May, 2006  |   Pubmed ID: 19372808
• Human Immunodeficiency Virus Type 1 Resistance to the Small Molecule Maturation Inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic Acid is Conferred by a Variety of Single Amino Acid Substitutions at the CA-SP1 Cleavage Site in Gag
  Journal of Virology. Dec, 2006  |   Pubmed ID: 17035324
• Saturation of TRIM5 Alpha-mediated Restriction of HIV-1 Infection Depends on the Stability of the Incoming Viral Capsid
  Virology. Jul, 2006  |   Pubmed ID: 16624363
• Evidence for a Functional Link Between Uncoating of the Human Immunodeficiency Virus Type 1 Core and Nuclear Import of the Viral Preintegration Complex
  Journal of Virology. Apr, 2006  |   Pubmed ID: 16571788
• A Mutation in the Human Immunodeficiency Virus Type 1 Gag Protein Destabilizes the Interaction of the Envelope Protein Subunits Gp120 and Gp41
  Journal of Virology. Mar, 2006  |   Pubmed ID: 16474147
• Maturation of the Viral Core Enhances the Fusion of HIV-1 Particles with Primary Human T Cells and Monocyte-derived Macrophages
  Virology. Mar, 2006  |   Pubmed ID: 16375941
• Inhibition of HIV-1 Maturation Via Drug Association with the Viral Gag Protein in Immature HIV-1 Particles
  The Journal of Biological Chemistry. Dec, 2005  |   Pubmed ID: 16251182
• Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells
  Journal of Virology. Sep, 2005  |   Pubmed ID: 16140737
• Betulinic Acid Derivatives As HIV-1 Antivirals
  Trends in Molecular Medicine. Jan, 2005  |   Pubmed ID: 15649820
• Structural Requirements for Recognition of the Human Immunodeficiency Virus Type 1 Core During Host Restriction in Owl Monkey Cells
  Journal of Virology. Jan, 2005  |   Pubmed ID: 15613315
• The Sequence of the CA-SP1 Junction Accounts for the Differential Sensitivity of HIV-1 and SIV to the Small Molecule Maturation Inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic Acid
  Retrovirology. 2004  |   Pubmed ID: 15225375
• Nef Stimulates Human Immunodeficiency Virus Type 1 Replication in Primary T Cells by Enhancing Virion-associated Gp120 Levels: Coreceptor-dependent Requirement for Nef in Viral Replication
  Journal of Virology. Jun, 2004  |   Pubmed ID: 15163722
• Coupling of Human Immunodeficiency Virus Type 1 Fusion to Virion Maturation: a Novel Role of the Gp41 Cytoplasmic Tail
  Journal of Virology. Apr, 2004  |   Pubmed ID: 15016865
• Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein
  Journal of Virology. Mar, 2004  |   Pubmed ID: 14963157
• Bifunctional Anti-human Immunodeficiency Virus Type 1 Small Molecules with Two Novel Mechanisms of Action
  Antimicrobial Agents and Chemotherapy. Feb, 2004  |   Pubmed ID: 14742233
• Small-molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation
  Journal of Virology. Jan, 2004  |   Pubmed ID: 14694123
• Nef Does Not Affect the Efficiency of Human Immunodeficiency Virus Type 1 Fusion with Target Cells
  Journal of Virology. Oct, 2003  |   Pubmed ID: 12970449
• Disassembly of Human Immunodeficiency Virus Type 1 Cores in Vitro Reveals Association of Nef with the Subviral Ribonucleoprotein Complex
  Journal of Virology. Apr, 2003  |   Pubmed ID: 12634398
• Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability is Crucial for Viral Replication
  Journal of Virology. Jun, 2002  |   Pubmed ID: 11991995
• Nef-mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes
  Journal of Virology. May, 2002  |   Pubmed ID: 11932428