Christopher Nicchitta Department of Cell Biology Duke University School of Medicine Biography Publications Institution JoVE Articles Christopher Nicchitta has not added a biography. If you are Christopher Nicchitta and would like to personalize this page please email our Author Liaison for assistance. Publications Simple and Inexpensive Ribosome Profiling Analysis of MRNA Translation Methods (San Diego, Calif.). Jul, 2015 | Pubmed ID: 26164698 LOCAL TRANSLATION. Comment on "Principles of ER Cotranslational Translocation Revealed by Proximity-specific Ribosome Profiling" Science (New York, N.Y.). Jun, 2015 | Pubmed ID: 26068841 Diversity and Selectivity in MRNA Translation on the Endoplasmic Reticulum Nature Reviews. Molecular Cell Biology. Apr, 2015 | Pubmed ID: 25735911 A Novel Ribosomopathy Caused by Dysfunction of RPL10 Disrupts Neurodevelopment and Causes X-linked Microcephaly in Humans Genetics. Oct, 2014 | Pubmed ID: 25316788 The Unfolded Protein Response Triggers Selective MRNA Release from the Endoplasmic Reticulum Cell. Sep, 2014 | Pubmed ID: 25215492 De Novo Translation Initiation on Membrane-bound Ribosomes As a Mechanism for Localization of Cytosolic Protein MRNAs to the Endoplasmic Reticulum RNA (New York, N.Y.). Oct, 2014 | Pubmed ID: 25142066 Multifunctional Roles for the Protein Translocation Machinery in RNA Anchoring to the Endoplasmic Reticulum The Journal of Biological Chemistry. Sep, 2014 | Pubmed ID: 25063809 Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells PloS One. 2013 | Pubmed ID: 24039668 Rare Codons Regulate KRas Oncogenesis Current Biology : CB. Jan, 2013 | Pubmed ID: 23246410 Premature Translational Termination Products Are Rapidly Degraded Substrates for MHC Class I Presentation PloS One. 2012 | Pubmed ID: 23251665 Desplazamiento De Células Falciformes Eritrocito MicroRNAs En Plasmodium Falciparum Inhibe Traducción Del Parásito Y Contribuye a La Resistencia De La Malaria Cell Host & Microbe. Aug, 2012 | Pubmed ID: 22901539 Glycoprotein 96 Perpetuates the Persistent Inflammation of Rheumatoid Arthritis Arthritis and Rheumatism. Nov, 2012 | Pubmed ID: 22777994 Development of a Grp94 Inhibitor Journal of the American Chemical Society. Jun, 2012 | Pubmed ID: 22642269 The Enduring Enigma of Nuclear Translation The Journal of Cell Biology. Apr, 2012 | Pubmed ID: 22472436 Primary Role for Endoplasmic Reticulum-bound Ribosomes in Cellular Translation Identified by Ribosome Profiling The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22199352 Hierarchical Regulation of MRNA Partitioning Between the Cytoplasm and the Endoplasmic Reticulum of Mammalian Cells Molecular Biology of the Cell. Jul, 2011 | Pubmed ID: 21613539 Polysome Profiling of the Malaria Parasite Plasmodium Falciparum Molecular and Biochemical Parasitology. Sep, 2011 | Pubmed ID: 21605599 Out with the Old, in with the New? Comparing Methods for Measuring Protein Degradation Cell Biology International. May, 2011 | Pubmed ID: 21476986 Analyzing MRNA Localization to the Endoplasmic Reticulum Via Cell Fractionation Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21431749 Re-examination of CD91 Function in GRP94 (glycoprotein 96) Surface Binding, Uptake, and Peptide Cross-presentation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010 | Pubmed ID: 21048103 Gp93, the Drosophila GRP94 Ortholog, is Required for Gut Epithelial Homeostasis and Nutrient Assimilation-coupled Growth Control Developmental Biology. Mar, 2010 | Pubmed ID: 20044986 Glioblastoma Proto-oncogene SEC61gamma is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress Cancer Research. Dec, 2009 | Pubmed ID: 19920201 Efficient Cross-priming of Antiviral CD8+ T Cells by Antigen Donor Cells is GRP94 Independent Journal of Immunology (Baltimore, Md. : 1950). Oct, 2009 | Pubmed ID: 19752220 Heat Shock Protein 96 is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily Via TLR2 Signaling Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19342676 Cell Biology: How to Combat Stress Nature. Feb, 2009 | Pubmed ID: 19194438 The Exception That Reinforces the Rule: Crosspriming by Cytosolic Peptides That Escape Degradation Immunity. Jun, 2008 | Pubmed ID: 18549799 Redundancy Renders the Glycoprotein 96 Receptor Scavenger Receptor A Dispensable for Cross Priming in Vivo Immunology. Dec, 2008 | Pubmed ID: 18489571 Analysis of MRNA Partitioning Between the Cytosol and Endoplasmic Reticulum Compartments of Mammalian Cells Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18369985 Signal Sequence- and Translation-independent MRNA Localization to the Endoplasmic Reticulum RNA (New York, N.Y.). Mar, 2008 | Pubmed ID: 18192611 Divergent Regulation of Protein Synthesis in the Cytosol and Endoplasmic Reticulum Compartments of Mammalian Cells Molecular Biology of the Cell. Feb, 2008 | Pubmed ID: 18077556 In Vitro and Tissue Culture Methods for Analysis of Translation Initiation on the Endoplasmic Reticulum Methods in Enzymology. 2007 | Pubmed ID: 17923230 The DRiP Hypothesis Decennial: Support, Controversy, Refinement and Extension Trends in Immunology. Aug, 2006 | Pubmed ID: 16815756 Interaction of TLR2 and TLR4 Ligands with the N-terminal Domain of Gp96 Amplifies Innate and Adaptive Immune Responses The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16754684 Identification of Novel Quaternary Domain Interactions in the Hsp90 Chaperone, GRP94 Protein Science : a Publication of the Protein Society. Jun, 2006 | Pubmed ID: 16731965 Synthesis of Hsp90 Dimerization Modulators Bioorganic & Medicinal Chemistry Letters. Jul, 2006 | Pubmed ID: 16621545 MRNA Translation is Compartmentalized to the Endoplasmic Reticulum Following Physiological Inhibition of Cap-dependent Translation RNA (New York, N.Y.). May, 2006 | Pubmed ID: 16540694 Pathways for Compartmentalizing Protein Synthesis in Eukaryotic Cells: the Template-partitioning Model Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Dec, 2005 | Pubmed ID: 16333319 Enhancement of Cancer Radiation Therapy by Use of Adenovirus-mediated Secretable Glucose-regulated Protein 94/gp96 Expression Cancer Research. Oct, 2005 | Pubmed ID: 16230366 Stable Ribosome Binding to the Endoplasmic Reticulum Enables Compartment-specific Regulation of MRNA Translation Molecular Biology of the Cell. Dec, 2005 | Pubmed ID: 16221886 HDAC6 Regula La Acetilación De Hsp90 Y Activación De Acompañante Dependiente Del Receptor De Glucocorticoides Molecular Cell. May, 2005 | Pubmed ID: 15916966 Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/cotranslocation The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15716279 Catheter-mediated Subselective Intracoronary Gene Delivery to the Rabbit Heart: Introduction of a Novel Method The Journal of Gene Medicine. May, 2005 | Pubmed ID: 15651066 The Messenger and the Message: Gp96 (GRP94)-peptide Interactions in Cellular Immunity Cell Stress & Chaperones. 2004 | Pubmed ID: 15633290 Adenosine Nucleotides and the Regulation of GRP94-client Protein Interactions Biochemistry. Jul, 2004 | Pubmed ID: 15236592 Glucose-regulated Protein 94/glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production in Vivo Journal of Immunology (Baltimore, Md. : 1950). Apr, 2004 | Pubmed ID: 15034032 Scavenger Receptor-A Mediates Gp96/GRP94 and Calreticulin Internalization by Antigen-presenting Cells The EMBO Journal. Nov, 2003 | Pubmed ID: 14609958 Structure of the N-terminal Domain of GRP94. Basis for Ligand Specificity and Regulation The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12970348 Come Forth CD1d: Hsp110 in the Regulation of Intestinal Epithelial CD1d Expression The Journal of Clinical Investigation. Sep, 2003 | Pubmed ID: 12952910 Partitioning and Translation of MRNAs Encoding Soluble Proteins on Membrane-bound Ribosomes RNA (New York, N.Y.). Sep, 2003 | Pubmed ID: 12923260 GRP94/gp96 Elicits ERK Activation in Murine Macrophages. A Role for Endotoxin Contamination in NF-kappa B Activation and Nitric Oxide Production The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12805368 Re-evaluating the Role of Heat-shock Protein-peptide Interactions in Tumour Immunity Nature Reviews. Immunology. May, 2003 | Pubmed ID: 12766764 ISO: a Critical Evaluation of the Role of Peptides in Heat Shock/chaperone Protein-mediated Tumor Rejection Current Opinion in Immunology. Feb, 2003 | Pubmed ID: 12495739 GRP94 (gp96) and GRP94 N-terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression The Journal of Experimental Medicine. Dec, 2002 | Pubmed ID: 12461080 A Platform for Compartmentalized Protein Synthesis: Protein Translation and Translocation in the ER Current Opinion in Cell Biology. Aug, 2002 | Pubmed ID: 12383790 GRP94-associated Enzymatic Activities. Resolution by Chromatographic Fractionation The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11983709 Cutting Edge: CD91-independent Cross-presentation of GRP94(gp96)-associated Peptides Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11970968 Endoplasmic Reticulum-bound Ribosomes Reside in Stable Association with the Translocon Following Termination of Protein Synthesis The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11964406 Métodos para investigar el papel de Regulación de pequeños ARN ribosomal y ocupación de Gregory LaMonte*1,2, Katelyn A. Walzer*1,2, Joshua Lacsina3, Christopher Nicchitta3, Jen-Tsan Chi1,2 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, 2Center for Genomic and Computational Biology, Duke University School of Medicine, 3Department of Cell Biology, Duke University School of Medicine Immunology and Infection
Métodos para investigar el papel de Regulación de pequeños ARN ribosomal y ocupación de Gregory LaMonte*1,2, Katelyn A. Walzer*1,2, Joshua Lacsina3, Christopher Nicchitta3, Jen-Tsan Chi1,2 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, 2Center for Genomic and Computational Biology, Duke University School of Medicine, 3Department of Cell Biology, Duke University School of Medicine Immunology and Infection