Chuan-ju Liu Department of Orthopaedic Surgery & Department of Cell Biology NYU School of Medicine Biography Publications Institution JoVE Articles Chuan-ju LiuProfessor of Orthopaedic Surgery and Cell Biology Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS. Publications Progranulin Promotes Diabetic Fracture Healing in Mice with Type 1 Diabetes Annals of the New York Academy of Sciences. Aug, 2019 | Pubmed ID: 31423598 Fexofenadine Inhibits TNF Signaling Through Targeting to Cytosolic Phospholipase A2 and is Therapeutic Against Inflammatory Arthritis Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31302596 Progranulin: A Conductor of Receptors Orchestra, a Chaperone of Lysosomal Enzymes and a Therapeutic Target for Multiple Diseases Cytokine & Growth Factor Reviews. 02, 2019 | Pubmed ID: 30733059 Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review JBJS Reviews. Jan, 2019 | Pubmed ID: 30694878 Targeting Tumor Necrosis Factor Receptors in Ankylosing Spondylitis Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30008173 Brain-penetrant Heat Shock Protein Amplifier Arimoclomol Enhances GCase Activity in in Vitro Gaucher Disease Models EBioMedicine. 12, 2018 | Pubmed ID: 30522930 Progranulin Associates with Hexosaminidase A and Ameliorates GM2 Ganglioside Accumulation and Lysosomal Storage in Tay-Sachs Disease Journal of Molecular Medicine (Berlin, Germany). Dec, 2018 | Pubmed ID: 30341570 Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956284 Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor Arthritis & Rheumatology (Hoboken, N.J.). 11, 2018 | Pubmed ID: 29750395 Molecular Regulations and Therapeutic Targets of Gaucher Disease Cytokine & Growth Factor Reviews. 06, 2018 | Pubmed ID: 29699937 P204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice EBioMedicine. Mar, 2018 | Pubmed ID: 29472103 Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease EBioMedicine. Feb, 2018 | Pubmed ID: 29396296 Multifunctional Molecule ERp57: From Cancer to Neurodegenerative Diseases Pharmacology & Therapeutics. 01, 2018 | Pubmed ID: 28723413 Progranulin: A Key Player in Autoimmune Diseases Cytokine. 01, 2018 | Pubmed ID: 27527809 Progranulin Derivative Atsttrin Protects Against Early Osteoarthritis in Mouse and Rat Models Arthritis Research & Therapy. Dec, 2017 | Pubmed ID: 29258611 Progranulin Acts As a Shared Chaperone and Regulates Multiple Lysosomal Enzymes Genes & Diseases. Sep, 2017 | Pubmed ID: 28944282 Foxo4- and Stat3-dependent IL-10 Production by Progranulin in Regulatory T Cells Restrains Inflammatory Arthritis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2017 | Pubmed ID: 28011648 Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease EBioMedicine. Nov, 2016 | Pubmed ID: 27789271 Association Between Progranulin and Gaucher Disease EBioMedicine. Sep, 2016 | Pubmed ID: 27515686 Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling Arthritis & Rheumatology (Hoboken, N.J.). 12, 2016 | Pubmed ID: 27428882 Extracellular Matrix Protein 1, a Direct Targeting Molecule of Parathyroid Hormone-related Peptide, Negatively Regulates Chondrogenesis and Endochondral Ossification Via Associating with Progranulin Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27075243 Progranulin Suppresses Titanium Particle Induced Inflammatory Osteolysis by Targeting TNFα Signaling Scientific Reports. Feb, 2016 | Pubmed ID: 26864916 Does Progranulin Account for the Opposite Effects of Etanercept and Infliximab/adalimumab in Osteoarthritis?: Comment on Olson Et Al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture" Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2016 | Pubmed ID: 26519939 Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice Scientific Reports. Mar, 2015 | Pubmed ID: 25777988 Overexpression of ADAMTS-7 Leads to Accelerated Initiation and Progression of Collagen-induced Arthritis in Mice Molecular and Cellular Biochemistry. Jun, 2015 | Pubmed ID: 25742929 Progranulin Protects Against Osteoarthritis Through Interacting with TNF-α and β-Catenin Signalling Annals of the Rheumatic Diseases. Dec, 2015 | Pubmed ID: 25169730 Progranulin Facilitates Conversion and Function of Regulatory T Cells Under Inflammatory Conditions PloS One. 2014 | Pubmed ID: 25393765 PGRN Protects Against Colitis Progression in Mice in an IL-10 and TNFR2 Dependent Manner Scientific Reports. Nov, 2014 | Pubmed ID: 25387791 ADAMTS-18: a Metalloproteinase with Multiple Functions Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896365 Three TNFR-binding Domains of PGRN Act Independently in Inhibition of TNF-alpha Binding and Activity Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896343 Progranulin Inhibition of TNFα Immunology and Cell Biology. Feb, 2014 | Pubmed ID: 24518982 Progranulin Directly Binds to the CRD2 and CRD3 of TNFR Extracellular Domains FEBS Letters. Nov, 2013 | Pubmed ID: 24070898 ADAMTS-7 Forms a Positive Feedback Loop with TNF-α in the Pathogenesis of Osteoarthritis Annals of the Rheumatic Diseases. Dec, 2013 | Pubmed ID: 23928557 The Promotion of Bone Healing by Progranulin, a Downstream Molecule of BMP-2, Through Interacting with TNF/TNFR Signaling Biomaterials. Sep, 2013 | Pubmed ID: 23746860 Progranulin Deficiency Exaggerates, Whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice FEBS Letters. Jun, 2013 | Pubmed ID: 23669357 Prevention of Atrophic Nonunion by the Systemic Administration of Parathyroid Hormone (PTH 1-34) in an Experimental Animal Model Journal of Orthopaedic Trauma. Dec, 2012 | Pubmed ID: 22932751 PROGRANULIN: Un Fattore Di Crescita, Un Romanzo TNFR Ligando E Un Obiettivo Di Droga Pharmacology & Therapeutics. Jan, 2012 | Pubmed ID: 22008260 GEP Costituisce Un Ciclo Di Feedback Negativo Con MyoD E Agisce Come Un Mediatore Romanzo Nel Controllo Della Differenziazione Del Muscolo Scheletrico Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 22179841 PROGRANULIN: Un Promettente Bersaglio Terapeutico Per L'artrite Reumatoide FEBS Letters. Dec, 2011 | Pubmed ID: 21550343 Il Fattore Di Crescita Progranulin Si Lega Ai Recettori TNF Ed è Terapeutico Contro L'artrite Infiammatoria Nei Topi Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393509 Proteina Oligomerica Della Matrice Della Cartilagine Inibisce La Muscolatura Liscia Vascolare Calcificazione Interagendo Con Bone Morphogenetic Protein-2 Circulation Research. Apr, 2011 | Pubmed ID: 21350216 Il Ruolo Di ADAMTSs Nel Trattamento Dell'artrite Protein & Cell. Jan, 2010 | Pubmed ID: 21203996 GEP, Un Fattore Di Sviluppo Locale, è Fondamentale Per Odontogenesis E Amelogenesi International Journal of Biological Sciences. 2010 | Pubmed ID: 21152114 Metalloproteinasi Di Matrice Che Associano E Fendere Bone Morphogenetic Protein-2 in Vitro Sono Elevati Nel Tessuto Mancato Consolidamento Di Frattura Ipertrofica Journal of Orthopaedic Trauma. Sep, 2010 | Pubmed ID: 20736794 Interazione Tra Proteina Oligomerica Della Matrice Della Cartilagine E Proteina Extracellulare 1 Media Crescita Ossea Endocondrale Matrix Biology : Journal of the International Society for Matrix Biology. May, 2010 | Pubmed ID: 20138147 Granulin Epithelin Precursore: Un Osso Morfogenetico Della Proteina 2-inducible Fattore Di Crescita Che Attiva La Segnalazione Di Erk1/2 E Fattore Di Trascrizione DonBeo in Chondrogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2010 | Pubmed ID: 20124436 Proteina Oligomerica Della Matrice Della Cartilagine Mantiene Il Fenotipo Contrattile Delle Cellule Muscolari Lisce Vascolari Interagendo Con Alpha(7)beta(1) Integrina Circulation Research. Feb, 2010 | Pubmed ID: 20019333 Livelli Di Espressione Di BMP-7 E Diversi Antagonisti BMP Possono Svolgere Un Ruolo Fondamentale in Una Frattura Non Sindacali: Uno Studio Pilota Clinical Orthopaedics and Related Research. Dec, 2009 | Pubmed ID: 19597895 ADAMTS-7, Un Bersaglio Diretto Di PTHrP, Regola Negativamente Endocondrale Crescita Ossea Da Associare E Inattivare Il Fattore Di Crescita GEP Molecular and Cellular Biology. Aug, 2009 | Pubmed ID: 19487464 MicroRNA in Skeletogenesis Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273234 MiR-199a, Un'osso Morfogenetico Proteina 2-reattiva MicroRNA, Regola Chondrogenesis Via Targeting Diretto a Smad1 The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19251704 ADAMTS-7 Media Muscolatura Liscia Vascolare Migrazione E Neointima Formazione Delle Cellule Nelle Arterie Ratto Palloncino-ferito Circulation Research. Mar, 2009 | Pubmed ID: 19168437 Il Ruolo Di ADAMTS-7 E ADAMTS-12 Nella Patogenesi Dell'artrite Nature Clinical Practice. Rheumatology. Jan, 2009 | Pubmed ID: 19098927 P204, Una Proteina Famiglia P200, Come Regolatore Multifunzionale Di Proliferazione Cellulare E La Differenziazione Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027346 Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-macroglobulin Osteoarthritis and Cartilage. Nov, 2008 | Pubmed ID: 18485748 P204 Proteine Supera L'inibizione Del Core Binding Factor Alpha-1-mediata Osteogeniche Differenziazione Da Proteine Helix-loop-helix Id Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287524 RbAp48 è Un Mediatore Critico Controllando L'attività Trasformante Del Papillomavirus Umano Di Tipo 16 in Cancro Cervicale The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17616526 IFI16 Inibisce La Proliferazione Delle Cellule E Tumorigenicity Delle Cellule Di Tumore Osseo E Cartilagine Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569615 Attivazione Trascrizionale Della Proteina Oligomerica Della Matrice Della Cartilagine Da Fattori Di Trascrizione Sox9, Sox5 E Sox6 E P300/CBP Coattivatori Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17485346 La Proteina Del Retinoblastoma è Un Mediatore Essenziale Dell'osteogenesi Che Lega La Proteina P204 Al Fattore Di Trascrizione Cbfa1 Aumentando Così La Sua Attività The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17439944 Interazioni Proteina-proteina E Localizzazione Di Membrana Del Trasportatore Soluto Organico Umano American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2007 | Pubmed ID: 17332473 Proteina Oligomerica Della Matrice Della Cartilagine Associa Precursore Granulin-epithelin (GEP) E Potenzia La Proliferazione Di Condrociti GEP-stimolata The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17307734 ADAMTS-12 Associa E Degrada La Proteina Oligomerica Della Matrice Della Cartilagine The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16611630 ADAMTS-7: Metalloproteinase Che Direttamente Si Lega a E Degrada La Proteina Oligomerica Della Matrice Della Cartilagine FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16585064 P204 Proteine Supera L'inibizione Della Differenziazione Delle Cellule Di Carcinoma Embrionale Murino P19 Alla Battendo Miociti Cardiaci Da Proteine Id The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556596 P204 è Necessaria Per La Differenziazione Delle Cellule Di Carcinoma Embrionale Murino P19 Per Battere I Miociti Cardiaci: Sua Espressione Viene Attivato Mediante Le Proteine Cardiache Gata4, NKX 2.5 E Tbx5 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556595 Siero Interleukin-6 Come Marcatore Di Infezione PERIPROTESICHE Anca Totale E Artroplastica Di Ginocchio The Journal of Bone and Joint Surgery. American Volume. Sep, 2005 | Pubmed ID: 16140805 La Proteina Interferone-inducible P204 Agisce Come Un Coactivator Transcriptional Di Cbfa1 E Aumenta La Differenziazione Degli Osteoblasti The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15557274 Fattore Di Leucemia O Linfoma-correlato, Un POZ Dominio Contenenti Repressore Trascrizionale, Interagisce Con Istone Deacetylase-1 E Inibisce La Chondrogenesis E L'espressione Genica Di Cartilagine Oligomerica Della Matrice Proteica The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15337766 Un Elemento Silenziatore Nel Gene Per La Proteina Oligomerica Della Matrice Della Cartilagine Regola L'espressione Di Specifiche Di Condrociti Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2004 | Pubmed ID: 15183430 Associazione Di 16 KDa Subunità C Della Pompa Protonica Vacuolare Con Ileale Na +-dipendente Bile Acid Transporter: Interazione Proteina-proteina E Il Traffico Intracellulare The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14752118 Modulazione Del Canale Cardiaco Del Sodio Nav1.5 Da Fibroblast Growth Factor Fattore Omologhe 1B The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12401812 La Proteina P204 MyoD-inducible Supera L'inibizione Del Myoblast Differenziazione Da Proteine Id Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940648 Un saggio di assenza di stasse reattiva (DARTS) di affinità dei farmaci semi-quantitativa per studiare l'interazione tra Rapamicina e mTOR Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemistry Istituzione di un modello chirurgicamente indotta nei topi per indagare il ruolo protettivo di progranulina in osteoartrite Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioengineering Modificato lievito-sistema del doppio ibrido per identificare proteine che interagiscono con il fattore di crescita progranulina Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biology
Un saggio di assenza di stasse reattiva (DARTS) di affinità dei farmaci semi-quantitativa per studiare l'interazione tra Rapamicina e mTOR Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemistry
Istituzione di un modello chirurgicamente indotta nei topi per indagare il ruolo protettivo di progranulina in osteoartrite Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioengineering
Modificato lievito-sistema del doppio ibrido per identificare proteine che interagiscono con il fattore di crescita progranulina Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biology