Chunzhang Yang Neuro-Oncology Branch, Center for Cancer Research National Cancer Institute Biography Publications Institution JoVE Articles Chunzhang Yang has not added a biography. If you are Chunzhang Yang and would like to personalize this page please email our Author Liaison for assistance. Publications Vorinostat Suppresses Hypoxia Signaling by Modulating Nuclear Translocation of Hypoxia Inducible Factor 1 Alpha Oncotarget. Aug, 2017 | Pubmed ID: 28915577 Anthracyclines Suppress Pheochromocytoma Cell Characteristics, Including Metastasis, Through Inhibition of the Hypoxia Signaling Pathway Oncotarget. Apr, 2017 | Pubmed ID: 28423608 The P38 Signaling Pathway Mediates Quiescence of Glioma Stem Cells by Regulating Epidermal Growth Factor Receptor Trafficking Oncotarget. May, 2017 | Pubmed ID: 28410196 Chemosensitivity of IDH1 Mutant Gliomas Due to an Impairment in PARP1-mediated DNA Repair Cancer Research. Feb, 2017 | Pubmed ID: 28202508 Novel Insights into the Polycythemia-paraganglioma-somatostatinoma Syndrome Endocrine-related Cancer. Dec, 2016 | Pubmed ID: 27679736 ZEB1 Expression is Increased in IDH1-mutant Lower-grade Gliomas Journal of Neuro-oncology. Oct, 2016 | Pubmed ID: 27568035 HIF2A Gain-of-function Mutations Detected in Duodenal Gangliocytic Paraganglioma Endocrine-related Cancer. May, 2016 | Pubmed ID: 27130043 Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism Molecular Therapy. Nucleic Acids. Apr, 2016 | Pubmed ID: 27115839 Hypotaurine Evokes a Malignant Phenotype in Glioma Through Aberrant Hypoxic Signaling Oncotarget. Mar, 2016 | Pubmed ID: 26934654 Somatic Gain-of-function HIF2A Mutations in Sporadic Central Nervous System Hemangioblastomas Journal of Neuro-oncology. Feb, 2016 | Pubmed ID: 26514359 Somatic IDH1 Mutation in a Pituitary Adenoma of a Patient with Maffucci Syndrome Journal of Neurosurgery. Jun, 2016 | Pubmed ID: 26473790 Somatic Mosaicism of EPAS1 Mutations in the Syndrome of Paraganglioma and Somatostatinoma Associated with Polycythemia Human Genome Variation. 2015 | Pubmed ID: 27081557 Hypoxia and Glioblastoma Therapy Aging. Aug, 2015 | Pubmed ID: 26298282 Potential Therapeutic Target for Malignant Paragangliomas: ATP Synthase on the Surface of Paraganglioma Cells American Journal of Cancer Research. 2015 | Pubmed ID: 26101719 Activation of Hypoxia Signaling Induces Phenotypic Transformation of Glioma Cells: Implications for Bevacizumab Antiangiogenic Therapy Oncotarget. May, 2015 | Pubmed ID: 25957416 Inhibition of Protein Phosphatase 2A with the Small Molecule LB100 Overcomes Cell Cycle Arrest in Osteosarcoma After Cisplatin Treatment Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 25942376 Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma Molecular Cancer Therapeutics. Jul, 2015 | Pubmed ID: 25939762 LB100, a Small Molecule Inhibitor of PP2A with Potent Chemo- and Radio-sensitizing Potential Cancer Biology & Therapy. 2015 | Pubmed ID: 25897893 New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma International Journal of Medical Sciences. 2015 | Pubmed ID: 25678837 Mutant Glucocerebrosidase in Gaucher Disease Recruits Hsp27 to the Hsp90 Chaperone Complex for Proteasomal Degradation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25583479 Fab Fragment Glycosylated IgG May Play a Central Role in Placental Immune Evasion Human Reproduction (Oxford, England). Feb, 2015 | Pubmed ID: 25505012 Germ-line PHD1 and PHD2 Mutations Detected in Patients with Pheochromocytoma/paraganglioma-polycythemia Journal of Molecular Medicine (Berlin, Germany). Jan, 2015 | Pubmed ID: 25263965 Cell Transcriptional State Alters Genomic Patterns of DNA Double-strand Break Repair in Human Astrocytes Nature Communications. Dec, 2014 | Pubmed ID: 25517576 A Morphologic and Semi-quantitative Technique to Analyze Synthesis and Release of Specific Proteins in Cells BMC Cell Biology. 2014 | Pubmed ID: 25476158 Ocular Manifestations of Hypoxia-Inducible Factor-2α Paraganglioma-Somatostatinoma-Polycythemia Syndrome Ophthalmology. Aug, 2014 | Pubmed ID: 25109928 Von Hippel-lindau Disease Associated Pulmonary Carcinoid with Cranial Metastasis The Journal of Clinical Endocrinology and Metabolism. Aug, 2014 | Pubmed ID: 24878057 Maotai Ameliorates Diethylnitrosamine-initiated Hepatocellular Carcinoma Formation in Mice PloS One. 2014 | Pubmed ID: 24690765 De Novo VHL Germline Mutation Detected in a Patient with Mild Clinical Phenotype of Von Hippel-Lindau Disease Journal of Neurosurgery. Aug, 2014 | Pubmed ID: 24678776 Tumor Derived Vasculogenesis in Von Hippel-Lindau Disease-associated Tumors Scientific Reports. Feb, 2014 | Pubmed ID: 24531117 Celastrol Increases Glucocerebrosidase Activity in Gaucher Disease by Modulating Molecular Chaperones Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24351928 Overexpression of Arginine Transporter CAT-1 is Associated with Accumulation of L-arginine and Cell Growth in Human Colorectal Cancer Tissue PloS One. 2013 | Pubmed ID: 24040099 Hypoxia-inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction Journal of the National Cancer Institute. Sep, 2013 | Pubmed ID: 23940289 Novel Compound VHL Heterozygosity (VHL T124A/L188V) Associated with Congenital Polycythaemia British Journal of Haematology. Sep, 2013 | Pubmed ID: 23772956 Histone Deacetylase Inhibitors Are Neuroprotective and Preserve NGF-mediated Cell Survival Following Traumatic Brain Injury Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23754423 Characterization of the Blood-brain Barrier of Metastatic and Primary Malignant Neoplasms Journal of Neurosurgery. Aug, 2013 | Pubmed ID: 23621605 First Report of Bilateral Pheochromocytoma in the Clinical Spectrum of HIF2A-related Polycythemia-paraganglioma Syndrome The Journal of Clinical Endocrinology and Metabolism. May, 2013 | Pubmed ID: 23539726 Novel Homozygous VHL Mutation in Exon 2 is Associated with Congenital Polycythemia but Not with Cancer Blood. May, 2013 | Pubmed ID: 23538339 New Syndrome of Paraganglioma and Somatostatinoma Associated with Polycythemia Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2013 | Pubmed ID: 23509317 Regulation and Dysregulation of Astrocyte Activation and Implications in Tumor Formation Cellular and Molecular Life Sciences : CMLS. Feb, 2013 | Pubmed ID: 23420481 Novel HIF2A Mutations Disrupt Oxygen Sensing, Leading to Polycythemia, Paragangliomas, and Somatostatinomas Blood. Mar, 2013 | Pubmed ID: 23361906 Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt Tumor Progression Cell Reports. Jan, 2013 | Pubmed ID: 23318261 Histone Deacetylase Inhibitors Increase Glucocerebrosidase Activity in Gaucher Disease by Modulation of Molecular Chaperones Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23277556 A Novel EPAS1/HIF2A Germline Mutation in a Congenital Polycythemia with Paraganglioma Journal of Molecular Medicine (Berlin, Germany). Apr, 2013 | Pubmed ID: 23090011 An Innovative Approach to the Treatment of Gaucher Disease and Possibly Other Metabolic Disorders of the Brain Journal of Inherited Metabolic Disease. May, 2013 | Pubmed ID: 22814681 CNTF Receptor Subunit α As a Marker for Glioma Tumor-initiating Cells and Tumor Grade: Laboratory Investigation Journal of Neurosurgery. Dec, 2012 | Pubmed ID: 23061382 Somatic HIF2A Gain-of-function Mutations in Paraganglioma with Polycythemia The New England Journal of Medicine. Sep, 2012 | Pubmed ID: 22931260 Missense Mutations in the Human SDHB Gene Increase Protein Degradation Without Altering Intrinsic Enzymatic Function FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2012 | Pubmed ID: 22835832 Neuronatin in a Subset of Glioblastoma Multiforme Tumor Progenitor Cells is Associated with Increased Cell Proliferation and Shorter Patient Survival PloS One. 2012 | Pubmed ID: 22624064 β-Catenin Signaling Initiates the Activation of Astrocytes and Its Dysregulation Contributes to the Pathogenesis of Astrocytomas Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22505738 Histone Deacetylase Inhibitors Prevent the Degradation and Restore the Activity of Glucocerebrosidase in Gaucher Disease Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22160715 Proteomic Identification of Glutamine Synthetase As a Differential Marker for Oligodendrogliomas and Astrocytomas Journal of Neurosurgery. Oct, 2011 | Pubmed ID: 21682567 Missense Mutations in the NF2 Gene Result in the Quantitative Loss of Merlin Protein and Minimally Affect Protein Intrinsic Function Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21383154 Carbon Dioxide Influence on Nitric Oxide Production in Endothelial Cells and Astrocytes: Cellular Mechanisms Brain Research. Apr, 2011 | Pubmed ID: 21362408 Decreased Glucocerebrosidase Activity in Gaucher Disease Parallels Quantitative Enzyme Loss Due to Abnormal Interaction with TCP1 and C-Cbl Proceedings of the National Academy of Sciences of the United States of America. Dec, 2010 | Pubmed ID: 21098288 Cystic Fibrosis Transmembrane Conductance Regulator Expression in Human Spinal and Sympathetic Ganglia Laboratory Investigation; a Journal of Technical Methods and Pathology. Jun, 2009 | Pubmed ID: 19333236 Evaluering af In Vitro DNA skader med Comet Assay Yanxin Lu1,2, Yang Liu1, Chunzhang Yang1 1Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, 2Basic Medical Science Department, Zunyi Medical College-Zhuhai Campus JoVE 56450 Cancer Research
Evaluering af In Vitro DNA skader med Comet Assay Yanxin Lu1,2, Yang Liu1, Chunzhang Yang1 1Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, 2Basic Medical Science Department, Zunyi Medical College-Zhuhai Campus JoVE 56450 Cancer Research