Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 타입-1 당뇨병 Mellitus에 대 한 치료로 Leptin의 사용: 대위법 Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 제 1 형 당뇨병에 대 한 저항에서 유전학의 역할 Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 증가 Superoxide Pyruvate 효소 결핍 복잡 한 섬유 아 세포에 축적 Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 마른 Ncb5or Null 생쥐에서 당뇨병의 개발 Endoplasmic 그물 및 베타 세포에서 산화 스트레스의 발현에 연결 됩니다 Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 인간의 췌 장 β 세포 선 Βlox5의 면역 중재 Apoptotic 죽음에 미토 콘 드리 아의 역할 PloS One. 2011 | Pubmed ID: 21738580 대 식 세포와 T 세포에 의해 초과 생산 Autoreactivity의 유도 대 한 중요 하 고 제 1 형 당뇨병 Diabetes. Aug, 2011 | Pubmed ID: 21715554 Polymicrobial 패 혈 증 중 골 수에서 호 동원 CXCL12 신호에 따라 달라 집니다 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 Β-cell 함수의 점진적 침식 타입-1 당뇨병의 끄 덕 임 마우스 모델에서 혈당 발병을 앞 Diabetes. Aug, 2011 | Pubmed ID: 21659497 CXC 리간드 수용 체 10/CXC 3 신호 Murine 신생아 패 혈 증에에 대 한 응답에서에 대 한 중요 한 역할 Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 패 혈 증 2 차 감염으로 사망에 영향을 주는 타고 난 면제에 초기 변경 유도 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 Mt-Nd2(a) 췌 장 β-세포 수준에서 끄 덕 쥐의 면역 타입 1 당뇨병에 대 한 수정 저항 Diabetes. Jan, 2011 | Pubmed ID: 20980458 NADPH 산화 효소 결핍, Th 혈통 지 조절 Autoimmunity 변조 Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 인간의 타입-1 당뇨병 이해 하기 Nonobese 당뇨병 쥐의 사용 Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 셀룰러 동원 된 면역 고갈 Immunoregulation를 부여 하 고 자가 면역 당뇨병 Nonobese 당뇨병 쥐에 되돌립니다 Diabetes. Oct, 2009 | Pubmed ID: 19628781 평가 하는 베타 세포 인슐린 분 비로 배아 줄기 세포 분화에 대 한 프로토콜 특정 그리고 비 침 투 적인 기자로 인슐린 II-GFP를 사용 하 여 Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 타입-1 당뇨병 아키타 쥐의 마음에 부 교감 신경 기능 장애의 개발에 SREBP-1의 역할 Circulation Research. Jul, 2009 | Pubmed ID: 19423844 마우스 미토 콘 드리 아 반응 산소 종의 생산의 정량화, 지역화 및 조직 특이성 장 24 Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTK Thymic 선택 Autoreactive T 세포의 조절 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 T1D 예방에서 증가 선생님 소산의 역할 Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 자유 래 디 칼-중재 당뇨병에 저항 유전자 자연 면역의 공통점 Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 Mt-Nd2a I 및 III 미토 콘 드 리아 복합물에 의해 반응 산소 종의 생산을 억제 합니다 The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 Mertk가 Apoptotic 세포 유도 된 T 세포 허용 오차에 대 한 필요 합니다 The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Autoreactive T 세포 응답: 오래 된 천 적 추구 새로운 기술 Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 Mt-Nd2 관련 된 핵과 미토 콘 드리 아 상호 작용 증가 미토 콘 드리 아 반응 산소 종의 생산으로 이어집니다 The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 Apoptotic 세포 수지상 세포에서 NF KappaB 활성화의 메 르 티로신 키 니 아 제 종속 봉쇄를 유도 Blood. Jan, 2007 | Pubmed ID: 17008547 CD4 T 세포 DR4-DQ8-제한 응답 및 타입-1 당뇨병 민감성의 Modulatory 역할 Diabetes. Dec, 2006 | Pubmed ID: 17130492 Humanized 끄 덕 생쥐에서 T 세포 HLA A * 0201 제한 Autoantigens 타입-1 당뇨병을 잠재적인 임상 관련성 인식 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 자연 면역 연구를 위한 Murine 모델의 유틸리티 타입 1 당뇨병 Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 Cytokine 유도 파괴 ALR/Lt 쥐에서 췌 장 독도의 저항을 기본 메커니즘 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 주요 조직 적합성 복잡 한 연결 된 당뇨병 민감성 끄 덕/Lt 쥐에서: Subcongenic 분석 Localizes 복잡 한 H2(g7) Diabetogenic H 2 D 끝에 Idd16의 구성 요소 Diabetes. May, 2005 | Pubmed ID: 15855353 프로테아좀 억제 달라져 포도 당 자극 (프로) 인슐린 분 비와 췌 장 {베타}에서 매출-셀 The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 루 게 릭 병/Lt: 새로운 타입-2 당뇨병 마우스 모델 낮은 자유 래 디 칼 잠재력을 청소와 관련 된 Diabetes. Feb, 2004 | Pubmed ID: 14749277 ALR/Lt 생쥐에서 제 1 형 당뇨병, 자가 면역 중재 Diabetogenic 스트레스에 대 한 방어와 끄 덕 관련 스트레인에 대 한 저항 유전자 분석 Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 Rodent Models for the Study of Type 2 Diabetes in Children (juvenile Diabesity) Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 인슐린 의존 하는 당뇨병 Mellitus에 섬 이식 연구에 새로운 마우스 모델 Transplantation. Apr, 2002 | Pubmed ID: 11981430 당뇨병 방지 ALR/Lt 생쥐에서 호 초과 생산 유전자 제어 Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 살아있는 췌장 조직 조각에서 아일렛 기능 및 아슬레 면역 세포 상호 작용을 관찰 Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection 세포 독성 T Lymphocytes에 의해 베타 세포 죽음의 중재를 평가하는 방법 Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection
살아있는 췌장 조직 조각에서 아일렛 기능 및 아슬레 면역 세포 상호 작용을 관찰 Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
세포 독성 T Lymphocytes에 의해 베타 세포 죽음의 중재를 평가하는 방법 Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection