Clive N. Svendsen The Board of Governors Regenerative Medicine Institute Cedars-Sinai Medical Center Biography Publications Institution JoVE Articles Clive N. Svendsen has not added a biography. If you are Clive N. Svendsen and would like to personalize this page please email our Author Liaison for assistance. Publications Development of Physiologically Responsive Human IPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD International Journal of Molecular Sciences. Feb, 2020 | Pubmed ID: 32093254 Rejuvenating the Blood and Bone Marrow to Slow Aging-associated Cognitive Decline and Alzheimer's Disease Communications Biology. Feb, 2020 | Pubmed ID: 32054965 IPSC Modeling of Young-onset Parkinson's Disease Reveals a Molecular Signature of Disease and Novel Therapeutic Candidates Nature Medicine. Feb, 2020 | Pubmed ID: 31988461 Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support Frontiers in Neuroscience. 2019 | Pubmed ID: 31316341 Human IPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications Cell Stem Cell. 06, 2019 | Pubmed ID: 31173718 Young Bone Marrow Transplantation Preserves Learning and Memory in Old Mice Communications Biology. 2019 | Pubmed ID: 30820468 In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival Proteomics. 02, 2019 | Pubmed ID: 30515959 Report of the International Conference on Manufacturing and Testing of Pluripotent Stem Cells Biologicals : Journal of the International Association of Biological Standardization. Nov, 2018 | Pubmed ID: 30150108 Stem Cell Transplantation for Amyotrophic Lateral Sclerosis Current Opinion in Neurology. 10, 2018 | Pubmed ID: 30080719 Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 29930984 Inducible Expression of GDNF in Transplanted IPSC-Derived Neural Progenitor Cells Stem Cell Reports. 06, 2018 | Pubmed ID: 29706501 Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex As a Strategy to Treat Amyotrophic Lateral Sclerosis Stem Cells (Dayton, Ohio). 07, 2018 | Pubmed ID: 29656478 Human IPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development Stem Cell Reports. 04, 2018 | Pubmed ID: 29576540 Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 Huntington Modeling Improves with Age Nature Neuroscience. 03, 2018 | Pubmed ID: 29476127 The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations Cell Systems. Jan, 2018 | Pubmed ID: 29199020 Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium Scientific Reports. 09, 2017 | Pubmed ID: 28878359 Concise Review: Stem Cells for Corneal Wound Healing Stem Cells (Dayton, Ohio). 10, 2017 | Pubmed ID: 28748596 Patients with ALS Show Highly Correlated Progression Rates in Left and Right Limb Muscles Neurology. Jul, 2017 | Pubmed ID: 28600459 Ex Vivo Gene Therapy for the Treatment of Neurological Disorders Progress in Brain Research. 2017 | Pubmed ID: 28552237 Modeling Psychomotor Retardation Using IPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier Cell Stem Cell. 06, 2017 | Pubmed ID: 28526555 Huntington's Disease IPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits Cell Reports. May, 2017 | Pubmed ID: 28514657 Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies Stem Cells Translational Medicine. 06, 2017 | Pubmed ID: 28225193 Ferumoxytol Labeling of Human Neural Progenitor Cells for Diagnostic Cellular Tracking in the Porcine Spinal Cord with Magnetic Resonance Imaging Stem Cells Translational Medicine. 01, 2017 | Pubmed ID: 28170192 An Isogenic Blood-brain Barrier Model Comprising Brain Endothelial Cells, Astrocytes, and Neurons Derived from Human Induced Pluripotent Stem Cells Journal of Neurochemistry. 03, 2017 | Pubmed ID: 27935037 Modeling Huntington׳s Disease with Patient-derived Neurons Brain Research. 02, 2017 | Pubmed ID: 26459990 A Model of Recurrent Concussion That Leads to Long-term Motor Deficits, CTE-like Tauopathy and Exacerbation of an ALS Phenotype The Journal of Trauma and Acute Care Surgery. 12, 2016 | Pubmed ID: 27602892 Transcriptome and Proteome Characterization of Surface Ectoderm Cells Differentiated from Human IPSCs Scientific Reports. Aug, 2016 | Pubmed ID: 27550649 ALS Disrupts Spinal Motor Neuron Maturation and Aging Pathways Within Gene Co-expression Networks Nature Neuroscience. 09, 2016 | Pubmed ID: 27428653 Cell Freezing Protocol Suitable for ATAC-Seq on Motor Neurons Derived from Human Induced Pluripotent Stem Cells Scientific Reports. 05, 2016 | Pubmed ID: 27146274 Human Neural Progenitors Differentiate into Astrocytes and Protect Motor Neurons in Aging Rats Experimental Neurology. 06, 2016 | Pubmed ID: 27032721 Modeling ALS with Motor Neurons Derived from Human Induced Pluripotent Stem Cells Nature Neuroscience. Apr, 2016 | Pubmed ID: 27021939 In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2016 | Pubmed ID: 26666451 Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26611598 Regenerative Cellular Therapies for Neurologic Diseases Brain Research. May, 2016 | Pubmed ID: 26239912 In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging Is Not Enhanced by Ferritin Expression Cell Transplantation. 2016 | Pubmed ID: 26160767 Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model ENeuro. May-Jun, 2015 | Pubmed ID: 26464984 Quantitative High-throughput Gene Expression Profiling of Human Striatal Development to Screen Stem Cell-derived Medium Spiny Neurons Molecular Therapy. Methods & Clinical Development. 2015 | Pubmed ID: 26417608 Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells Stem Cells Translational Medicine. Sep, 2015 | Pubmed ID: 26185257 Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord Neurosurgery. Oct, 2015 | Pubmed ID: 26134596 Human IPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model Stem Cells (Dayton, Ohio). Aug, 2015 | Pubmed ID: 25869002 HD IPSC-derived Neural Progenitors Accumulate in Culture and Are Susceptible to BDNF Withdrawal Due to Glutamate Toxicity Human Molecular Genetics. Jun, 2015 | Pubmed ID: 25740845 Kuwanon V Inhibits Proliferation, Promotes Cell Survival and Increases Neurogenesis of Neural Stem Cells PloS One. 2015 | Pubmed ID: 25706719 A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy Translational Vision Science & Technology. Feb, 2015 | Pubmed ID: 25694843 Astrocytes Show Reduced Support of Motor Neurons with Aging That is Accelerated in a Rodent Model of ALS Neurobiology of Aging. Feb, 2015 | Pubmed ID: 25443290 Targeting ATM Ameliorates Mutant Huntingtin Toxicity in Cell and Animal Models of Huntington's Disease Science Translational Medicine. Dec, 2014 | Pubmed ID: 25540325 Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis After Suppression of Mutant SOD1 in the Motor Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2014 | Pubmed ID: 25411487 Reliable Generation of Induced Pluripotent Stem Cells from Human Lymphoblastoid Cell Lines Stem Cells Translational Medicine. Dec, 2014 | Pubmed ID: 25298370 Differentiation of Human Limbal-derived Induced Pluripotent Stem Cells into Limbal-like Epithelium Stem Cells Translational Medicine. Sep, 2014 | Pubmed ID: 25069777 In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Bioluminescence Imaging Journal of Neuroscience Methods. May, 2014 | Pubmed ID: 24675049 The Past, Present and Future of Stem Cell Clinical Trials for ALS Experimental Neurology. Mar, 2014 | Pubmed ID: 24613827 Human Induced Pluripotent Stem Cells Are a Novel Source of Neural Progenitor Cells (iNPCs) That Migrate and Integrate in the Rodent Spinal Cord The Journal of Comparative Neurology. Mar, 2014 | Pubmed ID: 24610630 Patient-Derived Skeletal Dysplasia IPSCs Display Abnormal Chondrogenic Marker Expression and Regulation by BMP2 and TGFβ1 Stem Cells and Development. Apr, 2014 | Pubmed ID: 24559391 Neonatal Immune-tolerance in Mice Does Not Prevent Xenograft Rejection Experimental Neurology. Apr, 2014 | Pubmed ID: 24440640 Ocular Changes in TgF344-AD Rat Model of Alzheimer's Disease Investigative Ophthalmology & Visual Science. Jan, 2014 | Pubmed ID: 24398104 Glial Cell Line-derived Neurotrophic Factor-secreting Human Neural Progenitors Show Long-term Survival, Maturation into Astrocytes, and No Tumor Formation Following Transplantation into the Spinal Cord of Immunocompromised Rats Neuroreport. Apr, 2014 | Pubmed ID: 24284956 Stimulation of GABA-induced Ca2+ Influx Enhances Maturation of Human Induced Pluripotent Stem Cell-derived Neurons PloS One. 2013 | Pubmed ID: 24278369 A Simple Alkaline Method for Decellularizing Human Amniotic Membrane for Cell Culture PloS One. 2013 | Pubmed ID: 24236148 Targeting RNA Foci in IPSC-derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion Science Translational Medicine. Oct, 2013 | Pubmed ID: 24154603 Back to the Future: How Human Induced Pluripotent Stem Cells Will Transform Regenerative Medicine Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23945396 EZ Spheres: a Stable and Expandable Culture System for the Generation of Pre-rosette Multipotent Stem Cells from Human ESCs and IPSCs Stem Cell Research. May, 2013 | Pubmed ID: 23474892 Intermittent Hypoxia and Stem Cell Implants Preserve Breathing Capacity in a Rodent Model of Amyotrophic Lateral Sclerosis American Journal of Respiratory and Critical Care Medicine. Mar, 2013 | Pubmed ID: 23220913 The in Vitro Survival of Human Monosomies and Trisomies As Embryonic Stem Cells Stem Cell Research. Nov, 2012 | Pubmed ID: 22892439 Rapid Genetic Targeting of Pial Surface Neural Progenitors and Immature Neurons by Neonatal Electroporation Neural Development. 2012 | Pubmed ID: 22776033 Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-repeat-expansion-associated Phenotypes Cell Stem Cell. Aug, 2012 | Pubmed ID: 22748968 Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy PloS One. 2012 | Pubmed ID: 22723941 Stem Cell Transplantation for Motor Neuron Disease: Current Approaches and Future Perspectives Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2011 | Pubmed ID: 21904789 Blood-brain Barrier Modeling with Co-cultured Neural Progenitor Cell-derived Astrocytes and Neurons Journal of Neurochemistry. Nov, 2011 | Pubmed ID: 21854389 Induced Pluripotent Stem Cells: a New Revolution for Clinical Neurology? Lancet Neurology. Apr, 2011 | Pubmed ID: 21435601 Gene Therapy-mediated Delivery of Targeted Cytotoxins for Glioma Therapeutics Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21030678 Stem Cell Biologists Sure Play a Mean Pinball Nature Biotechnology. Apr, 2010 | Pubmed ID: 20379177 Generación de un chip de barrera hematoencefálica basada en iPSC humana Srikanth Jagadeesan1,2,3, Michael J. Workman4, Anna Herland5,6, Clive N. Svendsen4, Gad D. Vatine1,2,3 1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet JoVE 60925 Developmental Biology
Generación de un chip de barrera hematoencefálica basada en iPSC humana Srikanth Jagadeesan1,2,3, Michael J. Workman4, Anna Herland5,6, Clive N. Svendsen4, Gad D. Vatine1,2,3 1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet JoVE 60925 Developmental Biology
