Clive N. Svendsen Regenerative Medicine Institute Cedars-Sinai Medical Center Biography Publications Institution JoVE Articles Clive N. Svendsen has not added a biography. If you are Clive N. Svendsen and would like to personalize this page please email our Author Liaison for assistance. Publications In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Bioluminescence Imaging Journal of Neuroscience Methods. May, 2014 | Pubmed ID: 24675049 The Past, Present and Future of Stem Cell Clinical Trials for ALS Experimental Neurology. Mar, 2014 | Pubmed ID: 24613827 Human Induced Pluripotent Stem Cells Are a Novel Source of Neural Progenitor Cells (iNPCs) That Migrate and Integrate in the Rodent Spinal Cord The Journal of Comparative Neurology. Mar, 2014 | Pubmed ID: 24610630 Patient-Derived Skeletal Dysplasia IPSCs Display Abnormal Chondrogenic Marker Expression and Regulation by BMP2 and TGFβ1 Stem Cells and Development. Apr, 2014 | Pubmed ID: 24559391 Neonatal Immune-tolerance in Mice Does Not Prevent Xenograft Rejection Experimental Neurology. Apr, 2014 | Pubmed ID: 24440640 Ocular Changes in TgF344-AD Rat Model of Alzheimer's Disease Investigative Ophthalmology & Visual Science. Jan, 2014 | Pubmed ID: 24398104 Glial Cell Line-derived Neurotrophic Factor-secreting Human Neural Progenitors Show Long-term Survival, Maturation into Astrocytes, and No Tumor Formation Following Transplantation into the Spinal Cord of Immunocompromised Rats Neuroreport. Apr, 2014 | Pubmed ID: 24284956 Stimulation of GABA-induced Ca2+ Influx Enhances Maturation of Human Induced Pluripotent Stem Cell-derived Neurons PloS One. 2013 | Pubmed ID: 24278369 A Simple Alkaline Method for Decellularizing Human Amniotic Membrane for Cell Culture PloS One. 2013 | Pubmed ID: 24236148 Targeting RNA Foci in IPSC-derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion Science Translational Medicine. Oct, 2013 | Pubmed ID: 24154603 Back to the Future: How Human Induced Pluripotent Stem Cells Will Transform Regenerative Medicine Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23945396 Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2013 | Pubmed ID: 23712039 EZ Spheres: a Stable and Expandable Culture System for the Generation of Pre-rosette Multipotent Stem Cells from Human ESCs and IPSCs Stem Cell Research. May, 2013 | Pubmed ID: 23474892 Intermittent Hypoxia and Stem Cell Implants Preserve Breathing Capacity in a Rodent Model of Amyotrophic Lateral Sclerosis American Journal of Respiratory and Critical Care Medicine. Mar, 2013 | Pubmed ID: 23220913 The in Vitro Survival of Human Monosomies and Trisomies As Embryonic Stem Cells Stem Cell Research. Nov, 2012 | Pubmed ID: 22892439 Gene Expression Changes in the MAPK Pathway in Both Fragile X and Down Syndrome Human Neural Progenitor Cells American Journal of Stem Cells. Jun, 2012 | Pubmed ID: 22822472 Rapid Genetic Targeting of Pial Surface Neural Progenitors and Immature Neurons by Neonatal Electroporation Neural Development. 2012 | Pubmed ID: 22776033 Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy PloS One. 2012 | Pubmed ID: 22723941 Gonadectomy and Dehydroepiandrosterone (DHEA) Do Not Modulate Disease Progression in the G93A Mutant SOD1 Rat Model of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. May, 2012 | Pubmed ID: 22409357 Clinical Translation of Stem Cells in Neurodegenerative Disorders Cell Stem Cell. Feb, 2012 | Pubmed ID: 22305565 BDNF-, IGF-1- and GDNF-secreting Human Neural Progenitor Cells Rescue Amyloid β-induced Toxicity in Cultured Rat Septal Neurons Neurochemical Research. Jan, 2012 | Pubmed ID: 21909955 Stem Cell Transplantation for Motor Neuron Disease: Current Approaches and Future Perspectives Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2011 | Pubmed ID: 21904789 Blood-brain Barrier Modeling with Co-cultured Neural Progenitor Cell-derived Astrocytes and Neurons Journal of Neurochemistry. Nov, 2011 | Pubmed ID: 21854389 Human Neural Stem Cells Enhance Structural Plasticity and Axonal Transport in the Ischaemic Brain Brain : a Journal of Neurology. Jun, 2011 | Pubmed ID: 21616972 Induced Pluripotent Stem Cells: a New Revolution for Clinical Neurology? Lancet Neurology. Apr, 2011 | Pubmed ID: 21435601 Transplantation of Human Glial-restricted Neural Precursors into Injured Spinal Cord Promotes Functional and Sensory Recovery Without Causing Allodynia Cytotherapy. Jan, 2011 | Pubmed ID: 20735167 Gene Therapy-mediated Delivery of Targeted Cytotoxins for Glioma Therapeutics Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21030678 Real Time Imaging of Human Progenitor Neurogenesis PloS One. 2010 | Pubmed ID: 20949053 Stem Cell Model of Spinal Muscular Atrophy Archives of Neurology. Jun, 2010 | Pubmed ID: 20558385 Stem Cell Biologists Sure Play a Mean Pinball Nature Biotechnology. Apr, 2010 | Pubmed ID: 20379177 Human Stem Cells and Drug Screening: Opportunities and Challenges Nature Reviews. Drug Discovery. May, 2010 | Pubmed ID: 20339370 Ex Vivo Delivery of GDNF Maintains Motor Function and Prevents Neuronal Loss in a Transgenic Mouse Model of Huntington's Disease Experimental Neurology. Jul, 2010 | Pubmed ID: 20227407 Acute Glial Activation by Stab Injuries Does Not Lead to Overt Damage or Motor Neuron Degeneration in the G93A Mutant SOD1 Rat Model of Amyotrophic Lateral Sclerosis Experimental Neurology. Feb, 2010 | Pubmed ID: 20005223 Chromosome 7 and 19 Trisomy in Cultured Human Neural Progenitor Cells PloS One. 2009 | Pubmed ID: 19898616 A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells Developmental Neuroscience. 2009 | Pubmed ID: 19738365 Induced Pluripotent Stem Cells from a Spinal Muscular Atrophy Patient Nature. Jan, 2009 | Pubmed ID: 19098894 Regionally Specified Human Neural Progenitor Cells Derived from the Mesencephalon and Forebrain Undergo Increased Neurogenesis Following Overexpression of ASCL1 Stem Cells (Dayton, Ohio). Feb, 2009 | Pubmed ID: 19008346 Lesion-induced Increase in Survival and Migration of Human Neural Progenitor Cells Releasing GDNF Cell Transplantation. 2008 | Pubmed ID: 19044202 Isolating, Expanding, and Infecting Human and Rodent Fetal Neural Progenitor Cells Current Protocols in Stem Cell Biology. Sep, 2008 | Pubmed ID: 18819085 Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1 Stem Cells (Dayton, Ohio). Dec, 2008 | Pubmed ID: 18802035 Direct Muscle Delivery of GDNF with Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2008 | Pubmed ID: 18797452 Long-term Vision Rescue by Human Neural Progenitors in a Rat Model of Photoreceptor Degeneration Investigative Ophthalmology & Visual Science. Jul, 2008 | Pubmed ID: 18579765 GDNF-secreting Human Neural Progenitor Cells Increase Tyrosine Hydroxylase and VMAT2 Expression in MPTP-treated Cynomolgus Monkeys Cell Transplantation. 2008 | Pubmed ID: 18522241 Combining Growth Factor and Stem Cell Therapy for Amyotrophic Lateral Sclerosis Trends in Neurosciences. Apr, 2008 | Pubmed ID: 18329734 A Novel Serum-free Method for Culturing Human Prenatal Retinal Pigment Epithelial Cells Investigative Ophthalmology & Visual Science. Feb, 2008 | Pubmed ID: 18235029 Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells Stem Cells and Development. Feb, 2008 | Pubmed ID: 18225979 Human Neural Progenitor Cells Over-expressing IGF-1 Protect Dopamine Neurons and Restore Function in a Rat Model of Parkinson's Disease Experimental Neurology. Jan, 2008 | Pubmed ID: 18061591 A High Concentration of Epidermal Growth Factor Increases the Growth and Survival of Neurogenic Radial Glial Cells Within Human Neurosphere Cultures Stem Cells (Dayton, Ohio). Feb, 2008 | Pubmed ID: 18032704 GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS PloS One. 2007 | Pubmed ID: 17668067 Lentiviral Vector-mediated Genetic Modification of Human Neural Progenitor Cells for Ex Vivo Gene Therapy Journal of Neuroscience Methods. Jul, 2007 | Pubmed ID: 17397931 Protection of Visual Functions by Human Neural Progenitors in a Rat Model of Retinal Disease PloS One. 2007 | Pubmed ID: 17396165 Sexual Dimorphism in Disease Onset and Progression of a Rat Model of ALS Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. Feb, 2007 | Pubmed ID: 17364431 Over-expression of Alpha-synuclein in Human Neural Progenitors Leads to Specific Changes in Fate and Differentiation Human Molecular Genetics. Mar, 2007 | Pubmed ID: 17309880 Differentiating Embryonic Neural Progenitor Cells Induce Blood-brain Barrier Properties Journal of Neurochemistry. Apr, 2007 | Pubmed ID: 17254017 Control of Neurogenesis and Tyrosine Hydroxylase Expression in Neural Progenitor Cells Through BHLH Proteins and Nurr1 Experimental Neurology. Feb, 2007 | Pubmed ID: 17034791 Low Concentrations of Extracellular FGF-2 Are Sufficient but Not Essential for Neurogenesis from Human Neural Progenitor Cells Molecular and Cellular Neurosciences. Sep, 2006 | Pubmed ID: 16860999 Glutamate Enhances Proliferation and Neurogenesis in Human Neural Progenitor Cell Cultures Derived from the Fetal Cortex The European Journal of Neuroscience. Aug, 2006 | Pubmed ID: 16848797 Musashi1 Antigen Expression in Human Fetal Germinal Matrix Development Experimental Neurology. Oct, 2006 | Pubmed ID: 16777095 Massively Parallel Signature Sequencing Profiling of Fetal Human Neural Precursor Cells Stem Cells and Development. Apr, 2006 | Pubmed ID: 16646669 Human Progenitor Cells Isolated from the Developing Cortex Undergo Decreased Neurogenesis and Eventual Senescence Following Expansion in Vitro Experimental Cell Research. Jul, 2006 | Pubmed ID: 16631163 Crossroads in GDNF Therapy for Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2006 | Pubmed ID: 16470786 EGF and FGF-2 Responsiveness of Rat and Mouse Neural Precursors Derived from the Embryonic CNS Brain Research Bulletin. Dec, 2005 | Pubmed ID: 16325008 5-Bromo-2'-deoxyuridine is Selectively Toxic to Neuronal Precursors in Vitro The European Journal of Neuroscience. Dec, 2005 | Pubmed ID: 16324131 A New Tool in the Battle Against Alzheimer's Disease and Aging: Ex Vivo Gene Therapy Rejuvenation Research. 2005 | Pubmed ID: 16144466 Human Retinal Progenitor Cells Grown As Neurospheres Demonstrate Time-dependent Changes in Neuronal and Glial Cell Fate Potential Annals of the New York Academy of Sciences. May, 2005 | Pubmed ID: 15965111 GDNF Delivery Using Human Neural Progenitor Cells in a Rat Model of ALS Human Gene Therapy. Apr, 2005 | Pubmed ID: 15871682 Stem Cells in the Injured Spinal Cord: Reducing the Pain and Increasing the Gain Nature Neuroscience. Mar, 2005 | Pubmed ID: 15746908 Intraputamenal Infusion of Glial Cell Line-derived Neurotrophic Factor in PD: a Two-year Outcome Study Annals of Neurology. Feb, 2005 | Pubmed ID: 15668979 Rotenone-induced Caspase 9/3-independent and -dependent Cell Death in Undifferentiated and Differentiated Human Neural Stem Cells Journal of Neurochemistry. Feb, 2005 | Pubmed ID: 15659217 Requirement for Neurogenesis to Proceed Through the Division of Neuronal Progenitors Following Differentiation of Epidermal Growth Factor and Fibroblast Growth Factor-2-responsive Human Neural Stem Cells Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 15342944 Combining Growth Factors, Stem Cells, and Gene Therapy for the Aging Brain Annals of the New York Academy of Sciences. Jun, 2004 | Pubmed ID: 15246984 Heparin Stabilizes FGF-2 and Modulates Striatal Precursor Cell Behavior in Response to EGF Experimental Neurology. Aug, 2004 | Pubmed ID: 15246840 Human Neural Stem Cell Transplants Improve Motor Function in a Rat Model of Huntington's Disease The Journal of Comparative Neurology. Jul, 2004 | Pubmed ID: 15211462 Stem Cells As a Potential Treatment of Neurological Disorders Current Opinion in Pharmacology. Feb, 2004 | Pubmed ID: 15018846 Differentiation and Migration of Long Term Expanded Human Neural Progenitors in a Partial Lesion Model of Parkinson's Disease The International Journal of Biochemistry & Cell Biology. Apr, 2004 | Pubmed ID: 15010333 Stem Cells for Parkinson Disease and ALS: Replacement or Protection? Nature Medicine. Mar, 2004 | Pubmed ID: 14991036 Mitotic and Neurogenic Effects of Dehydroepiandrosterone (DHEA) on Human Neural Stem Cell Cultures Derived from the Fetal Cortex Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14973190 Using Human Neural Stem Cells to Model Neurological Disease Nature Reviews. Genetics. Feb, 2004 | Pubmed ID: 14735124 FGF-dependent Generation of Oligodendrocytes by a Hedgehog-independent Pathway Development (Cambridge, England). Dec, 2003 | Pubmed ID: 14660548 Gene Expression in Human Neural Stem Cells: Effects of Leukemia Inhibitory Factor Journal of Neurochemistry. Jul, 2003 | Pubmed ID: 12807438 Direct Brain Infusion of Glial Cell Line-derived Neurotrophic Factor in Parkinson Disease Nature Medicine. May, 2003 | Pubmed ID: 12669033 Stem Cells for Neurodegenerative Disorders: Where Can We Go from Here? BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 2002 | Pubmed ID: 12463763 Neurospheres Modified to Produce Glial Cell Line-derived Neurotrophic Factor Increase the Survival of Transplanted Dopamine Neurons Journal of Neuroscience Research. Sep, 2002 | Pubmed ID: 12205689 The Amazing Astrocyte Nature. May, 2002 | Pubmed ID: 11986650 Neuronal Target Genes of the Neuron-restrictive Silencer Factor in Neurospheres Derived from Fetuses with Down's Syndrome: a Gene Expression Study Lancet. Jan, 2002 | Pubmed ID: 11830198 Een cGMP-toepassing Uitbreiding Methode voor Aggregaten van menselijke neurale stamcellen en stamcellen afgeleid uit pluripotente stamcellen of foetaal hersenweefsel Brandon C. Shelley1, Geneviève Gowing1, Clive N. Svendsen1 1Regenerative Medicine Institute, Cedars-Sinai Medical Center JoVE 51219 Neuroscience
Een cGMP-toepassing Uitbreiding Methode voor Aggregaten van menselijke neurale stamcellen en stamcellen afgeleid uit pluripotente stamcellen of foetaal hersenweefsel Brandon C. Shelley1, Geneviève Gowing1, Clive N. Svendsen1 1Regenerative Medicine Institute, Cedars-Sinai Medical Center JoVE 51219 Neuroscience