Constance Cepko Howard Hughes Medical Institute Harvard Medical School Biography Publications Institution JoVE Articles Constance Cepko has not added a biography. If you are Constance Cepko and would like to personalize this page please email our Author Liaison for assistance. Publications Gene Expression Changes Within Müller Glial Cells in Retinitis Pigmentosa Molecular Vision. 2012 | Pubmed ID: 22665967 Emerging Gene Therapies for Retinal Degenerations The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2012 | Pubmed ID: 22573664 Transcription Factor Olig2 Defines Subpopulations of Retinal Progenitor Cells Biased Toward Specific Cell Fates Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22543161 Loss of Daylight Vision in Retinal Degeneration: Are Oxidative Stress and Metabolic Dysregulation to Blame? The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22074929 Identification of a Retina-specific Otx2 Enhancer Element Active in Immature Developing Photoreceptors Developmental Biology. Dec, 2011 | Pubmed ID: 21963459 Restraint of Angiogenesis by Zinc Finger Transcription Factor CTCF-dependent Chromatin Insulation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21896759 Anterograde or Retrograde Transsynaptic Labeling of CNS Neurons with Vesicular Stomatitis Virus Vectors Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21825165 A Class of Human Proteins That Deliver Functional Proteins into Mammalian Cells in Vitro and in Vivo Chemistry & Biology. Jul, 2011 | Pubmed ID: 21802004 NeuroD Factors Regulate Cell Fate and Neurite Stratification in the Developing Retina The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2011 | Pubmed ID: 21593321 Conditional Expression of the TVA Receptor Allows Clonal Analysis of Descendents from Cre-expressing Progenitor Cells Developmental Biology. May, 2011 | Pubmed ID: 21397594 An Isoform-specific SnoN1-FOXO1 Repressor Complex Controls Neuronal Morphogenesis and Positioning in the Mammalian Brain Neuron. Mar, 2011 | Pubmed ID: 21382553 Analysis of Thyroid Response Element Activity During Retinal Development PloS One. 2010 | Pubmed ID: 21060789 Neuroscience. Seeing the Light of Day Science (New York, N.Y.). Jul, 2010 | Pubmed ID: 20651144 Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein ACS Chemical Biology. Aug, 2010 | Pubmed ID: 20545362 A Common Progenitor for Retinal Astrocytes and Oligodendrocytes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2010 | Pubmed ID: 20371817 Transcriptional Role of Cyclin D1 in Development Revealed by a Genetic-proteomic Screen Nature. Jan, 2010 | Pubmed ID: 20090754 Alternative Splicing Produces High Levels of Noncoding Isoforms of BHLH Transcription Factors During Development Genes & Development. Feb, 2010 | Pubmed ID: 20080942 Robust Marking of Photoreceptor Cells and Pinealocytes with Several Reporters Under Control of the Crx Gene Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2009 | Pubmed ID: 19882727 Development and Diversification of Retinal Amacrine Interneurons at Single Cell Resolution Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19470466 Development and Neurogenic Potential of Müller Glial Cells in the Vertebrate Retina Progress in Retinal and Eye Research. Jul, 2009 | Pubmed ID: 19465144 Developmental Sources of Conservation and Variation in the Evolution of the Primate Eye Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19451636 Identification of Genes Expressed Preferentially in the Developing Peripheral Margin of the Optic Cup Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2009 | Pubmed ID: 19449303 HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas Science (New York, N.Y.). Jan, 2009 | Pubmed ID: 19131628 Stimulation of the Insulin/mTOR Pathway Delays Cone Death in a Mouse Model of Retinitis Pigmentosa Nature Neuroscience. Jan, 2009 | Pubmed ID: 19060896 Temporal Requirement of the Alternative-splicing Factor Sfrs1 for the Survival of Retinal Neurons Development (Cambridge, England). Dec, 2008 | Pubmed ID: 18987029 Thyroid Hormone Components Are Expressed in Three Sequential Waves During Development of the Chick Retina BMC Developmental Biology. 2008 | Pubmed ID: 18854032 A Core Paired-type and POU Homeodomain-containing Transcription Factor Program Drives Retinal Bipolar Cell Gene Expression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2008 | Pubmed ID: 18667607 The Transcriptome of Retinal Müller Glial Cells The Journal of Comparative Neurology. Jul, 2008 | Pubmed ID: 18465787 Dicer Inactivation Leads to Progressive Functional and Structural Degeneration of the Mouse Retina The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2008 | Pubmed ID: 18463241 Light-activated Channels Targeted to ON Bipolar Cells Restore Visual Function in Retinal Degeneration Nature Neuroscience. Jun, 2008 | Pubmed ID: 18432197 Analysis of Gene Function in the Retina Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18370205 Ultrasound-guided in Utero Injections Allow Studies of the Development and Function of the Eye Developmental Dynamics : an Official Publication of the American Association of Anatomists. Apr, 2008 | Pubmed ID: 18351670 Individual Retinal Progenitor Cells Display Extensive Heterogeneity of Gene Expression PloS One. 2008 | Pubmed ID: 18270576 Identification of Molecular Markers of Bipolar Cells in the Murine Retina The Journal of Comparative Neurology. Apr, 2008 | Pubmed ID: 18260140 Temporal Order of Bipolar Cell Genesis in the Neural Retina Neural Development. 2008 | Pubmed ID: 18215319 The Cis-regulatory Logic of the Mammalian Photoreceptor Transcriptional Network PloS One. 2007 | Pubmed ID: 17653270 A Typology of Photoreceptor Gene Expression Patterns in the Mouse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17620597 Requirement of Histone Deacetylase Activity for the Expression of Critical Photoreceptor Genes BMC Developmental Biology. 2007 | Pubmed ID: 17603891 Local Retinal Circuits of Melanopsin-containing Ganglion Cells Identified by Transsynaptic Viral Tracing Current Biology : CB. Jun, 2007 | Pubmed ID: 17524644 Molecular Heterogeneity of Developing Retinal Ganglion and Amacrine Cells Revealed Through Single Cell Gene Expression Profiling The Journal of Comparative Neurology. Jun, 2007 | Pubmed ID: 17444492 Automatic Correspondence of Tags and Genes (ACTG): a Tool for the Analysis of SAGE, MPSS and SBS Data Bioinformatics (Oxford, England). Apr, 2007 | Pubmed ID: 17277333 Cellular Responses to Photoreceptor Death in the Rd1 Mouse Model of Retinal Degeneration Investigative Ophthalmology & Visual Science. Feb, 2007 | Pubmed ID: 17251487 Controlled Expression of Transgenes Introduced by in Vivo Electroporation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17209010 Notch Activity Permits Retinal Cells to Progress Through Multiple Progenitor States and Acquire a Stem Cell Property Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17148603 Wnt2b/beta-catenin-mediated Canonical Wnt Signaling Determines the Peripheral Fates of the Chick Eye Development (Cambridge, England). Aug, 2006 | Pubmed ID: 16854977 DILA Neurons in the Dorsal Spinal Cord Are the Product of Terminal and Non-terminal Asymmetric Progenitor Cell Divisions, and Require Mash1 for Their Development Development (Cambridge, England). Jun, 2006 | Pubmed ID: 16690754 Notch 1 Inhibits Photoreceptor Production in the Developing Mammalian Retina Development (Cambridge, England). Mar, 2006 | Pubmed ID: 16452096 RCAS-RNAi: a Loss-of-function Method for the Developing Chick Retina BMC Developmental Biology. 2006 | Pubmed ID: 16426460 Effect of Gene Expression on Cone Survival in Retinitis Pigmentosa Retina (Philadelphia, Pa.). Dec, 2005 | Pubmed ID: 16374320 Retinoic Acid Regulates the Expression of Dorsoventral Topographic Guidance Molecules in the Chick Retina Development (Cambridge, England). Dec, 2005 | Pubmed ID: 16251210 A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-cone Syndrome PLoS Genetics. Aug, 2005 | Pubmed ID: 16110338 A POU Factor Binding Site Upstream of the Chx10 Homeobox Gene is Required for Chx10 Expression in Subsets of Retinal Progenitor Cells and Bipolar Cells Developmental Biology. May, 2005 | Pubmed ID: 15893976 The Rod Photoreceptor Pattern is Set at the Optic Vesicle Stage and Requires Spatially Restricted CVax Expression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2005 | Pubmed ID: 15772342 Synaptogenesis and Outer Segment Formation Are Perturbed in the Neural Retina of Crx Mutant Mice BMC Neuroscience. 2005 | Pubmed ID: 15676071 Methionine Adenosyltransferase:adrenergic-cAMP Mechanism Regulates a Daily Rhythm in Pineal Expression The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15504733 Transdifferentiation of the Retina into Pigmented Cells in Ocular Retardation Mice Defines a New Function of the Homeodomain Gene Chx10 Development (Cambridge, England). Oct, 2004 | Pubmed ID: 15459106 Genomic Analysis of Mouse Retinal Development PLoS Biology. Sep, 2004 | Pubmed ID: 15226823 Genetic Analysis of the Homeodomain Transcription Factor Chx10 in the Retina Using a Novel Multifunctional BAC Transgenic Mouse Reporter Developmental Biology. Jul, 2004 | Pubmed ID: 15223342 A Role for Ligand-gated Ion Channels in Rod Photoreceptor Development Neuron. Mar, 2004 | Pubmed ID: 15046720 Rb Regulates Proliferation and Rod Photoreceptor Development in the Mouse Retina Nature Genetics. Apr, 2004 | Pubmed ID: 14991054 Inner Retinal Abnormalities in a Mouse Model of Leber's Congenital Amaurosis The Journal of Comparative Neurology. Feb, 2004 | Pubmed ID: 14730587 Electroporation and RNA Interference in the Rodent Retina in Vivo and in Vitro Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14603031 Thyroid Hormone and Retinal Development: an Emerging Field Thyroid : Official Journal of the American Thyroid Association. Nov, 2003 | Pubmed ID: 14651785 Prox1 Function Controls Progenitor Cell Proliferation and Horizontal Cell Genesis in the Mammalian Retina Nature Genetics. May, 2003 | Pubmed ID: 12692551 MicroSAGE is Highly Representative and Reproducible but Reveals Major Differences in Gene Expression Among Samples Obtained from Similar Tissues Genome Biology. 2003 | Pubmed ID: 12620102 Irx4-mediated Regulation of Slit1 Expression Contributes to the Definition of Early Axonal Paths Inside the Retina Development (Cambridge, England). Mar, 2003 | Pubmed ID: 12571096 Stem Cells That Know Their Place Nature Neuroscience. Dec, 2002 | Pubmed ID: 12447376 The Dorsal-ventral Axis of the Neural Retina is Divided into Multiple Domains of Restricted Gene Expression Which Exhibit Features of Lineage Compartments Developmental Biology. Nov, 2002 | Pubmed ID: 12413898 The Chicken RaxL Gene Plays a Role in the Initiation of Photoreceptor Differentiation Development (Cambridge, England). Dec, 2002 | Pubmed ID: 12403708 Ena/VASP Proteins Regulate Cortical Neuronal Positioning Current Biology : CB. Apr, 2002 | Pubmed ID: 11937025 The Mouse Crx 5'-upstream Transgene Sequence Directs Cell-specific and Developmentally Regulated Expression in Retinal Photoreceptor Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002 | Pubmed ID: 11880494 Mutations in the Inosine Monophosphate Dehydrogenase 1 Gene (IMPDH1) Cause the RP10 Form of Autosomal Dominant Retinitis Pigmentosa Human Molecular Genetics. Mar, 2002 | Pubmed ID: 11875050 Sox-9 and CDachsund-2 Expression in the Developing Chick Telencephalon Mechanisms of Development. Mar, 2002 | Pubmed ID: 11850191 Profile of the Genes Expressed in the Human Peripheral Retina, Macula, and Retinal Pigment Epithelium Determined Through Serial Analysis of Gene Expression (SAGE) Proceedings of the National Academy of Sciences of the United States of America. Jan, 2002 | Pubmed ID: 11756676 Viral spåra genetiskt definierad neurala kretsar Kevin Beier1, Constance Cepko2 1Department of Genetics, Harvard Medical School, 2Howard Hughes Medical Institute, Harvard Medical School JoVE 4253 Neuroscience
Viral spåra genetiskt definierad neurala kretsar Kevin Beier1, Constance Cepko2 1Department of Genetics, Harvard Medical School, 2Howard Hughes Medical Institute, Harvard Medical School JoVE 4253 Neuroscience