Daryl A. Bosco Department of Neurology University of Massachusetts Chan Medical School Biography Publications Institution JoVE Articles Daryl A. Bosco has not added a biography. If you are Daryl A. Bosco and would like to personalize this page please email our Author Liaison for assistance. Publications Interactions Between FUS and the C-terminal Domain of Nup62 Are Sufficient for Their Co-phase Separation into Amorphous Assemblies Journal of Molecular Biology. Mar, 2023 | Pubmed ID: 36690069 Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons International Journal of Molecular Sciences. Dec, 2022 | Pubmed ID: 36555655 Excessive Release of Inorganic Polyphosphate by ALS/FTD Astrocytes Causes Non-cell-autonomous Toxicity to Motoneurons Neuron. 05, 2022 | Pubmed ID: 35276083 ALS-linked PFN1 Variants Exhibit Loss and Gain of Functions in the Context of Formin-induced Actin Polymerization Proceedings of the National Academy of Sciences of the United States of America. 06, 2021 | Pubmed ID: 34074767 Interactions Between ALS-linked FUS and Nucleoporins Are Associated with Defects in the Nucleocytoplasmic Transport Pathway Nature Neuroscience. 08, 2021 | Pubmed ID: 34059832 The RNA-binding Protein FUS/TLS Undergoes Calcium-mediated Nuclear Egress During Excitotoxic Stress and is Required for MRNA Processing The Journal of Biological Chemistry. 06, 2019 | Pubmed ID: 31092554 Translation Dysregulation in Neurodegenerative Disorders Proceedings of the National Academy of Sciences of the United States of America. 12, 2018 | Pubmed ID: 30504142 ALS-linked FUS Exerts a Gain of Toxic Function Involving Aberrant P38 MAPK Activation Scientific Reports. 03, 2017 | Pubmed ID: 28273913 Structural Basis for Mutation-induced Destabilization of Profilin 1 in ALS Proceedings of the National Academy of Sciences of the United States of America. Jun, 2015 | Pubmed ID: 26056300 Functions of FUS/TLS from DNA Repair to Stress Response: Implications for ALS ASN Neuro. Jun, 2014 | Pubmed ID: 25289647 Identification of a Misfolded Region in Superoxide Dismutase 1 That is Exposed in Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25164820 Amyotrophic Lateral Sclerosis-linked FUS/TLS Alters Stress Granule Assembly and Dynamics Molecular Neurodegeneration. Aug, 2013 | Pubmed ID: 24090136 Wild-type and Mutant SOD1 Share an Aberrant Conformation and a Common Pathogenic Pathway in ALS Nature Neuroscience. Nov, 2010 | Pubmed ID: 20953194 Genetic Determinants of Amyotrophic Lateral Sclerosis As Therapeutic Targets CNS & Neurological Disorders Drug Targets. Dec, 2010 | Pubmed ID: 20942785 Mutant FUS Proteins That Cause Amyotrophic Lateral Sclerosis Incorporate into Stress Granules Human Molecular Genetics. Nov, 2010 | Pubmed ID: 20699327 Imagerie intravitale de l’expression de protéines fluorescentes chez des souris présentant un traumatisme crânien à crâne fermé et une fenêtre crânienne à l’aide d’un microscope à deux photons Jianjun Zhong1,2, Georgia Gunner3, Nils Henninger1, Dorothy P. Schafer3, Daryl A. Bosco1 1Department of Neurology, University of Massachusetts Chan Medical School, 2Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 3Department of Neurobiology, University of Massachusetts Chan Medical School JoVE 64701 Neuroscience Cellules humaines de type microglie : différenciation à partir de cellules souches pluripotentes induites et dosage in vitro de la phagocytose sur cellules vivantes à l’aide de synaptosomes humains Salome Funes1,2, Daryl A. Bosco1 1Department of Neurology, University of Massachusetts Chan Medical School, 2Translation Science Program, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School JoVE 64323 Neuroscience
Imagerie intravitale de l’expression de protéines fluorescentes chez des souris présentant un traumatisme crânien à crâne fermé et une fenêtre crânienne à l’aide d’un microscope à deux photons Jianjun Zhong1,2, Georgia Gunner3, Nils Henninger1, Dorothy P. Schafer3, Daryl A. Bosco1 1Department of Neurology, University of Massachusetts Chan Medical School, 2Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 3Department of Neurobiology, University of Massachusetts Chan Medical School JoVE 64701 Neuroscience
Cellules humaines de type microglie : différenciation à partir de cellules souches pluripotentes induites et dosage in vitro de la phagocytose sur cellules vivantes à l’aide de synaptosomes humains Salome Funes1,2, Daryl A. Bosco1 1Department of Neurology, University of Massachusetts Chan Medical School, 2Translation Science Program, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School JoVE 64323 Neuroscience
