David D. Shock Laboratory of Structural Biology NIEHS, National Institutes of Health Biography Publications Institution JoVE Articles David D. Shock has not added a biography. If you are David D. Shock and would like to personalize this page please email our Author Liaison for assistance. Publications Observing a DNA Polymerase Choose Right from Wrong Cell. Jul, 2013 | Pubmed ID: 23827680 Insights into the Conformation of Aminofluorene-deoxyguanine Adduct in a DNA Polymerase Active Site The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23798703 Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction Journal of the American Chemical Society. May, 2013 | Pubmed ID: 23647366 Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β Biochemistry. Oct, 2012 | Pubmed ID: 23043620 Stereospecific Formation of a Ternary Complex of (S)-α,β-fluoromethylene-dATP with DNA Pol β Chembiochem : a European Journal of Chemical Biology. Mar, 2012 | Pubmed ID: 22315190 Binary Complex Crystal Structure of DNA Polymerase β Reveals Multiple Conformations of the Templating 8-oxoguanine Lesion Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22178760 Metal-induced DNA Translocation Leads to DNA Polymerase Conformational Activation Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22169953 Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20952393 Base Excision Repair and Design of Small Molecule Inhibitors of Human DNA Polymerase β Cellular and Molecular Life Sciences : CMLS. Nov, 2010 | Pubmed ID: 20844920 Synthesis and Biological Evaluation of Fluorinated Deoxynucleotide Analogs Based on Bis-(difluoromethylene)triphosphoric Acid Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20724659 DNA Polymerase Beta Substrate Specificity: Side Chain Modulation of the "A-rule" The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19759017 Alpha,beta-difluoromethylene Deoxynucleoside 5'-triphosphates: a Convenient Synthesis of Useful Probes for DNA Polymerase Beta Structure and Function Organic Letters. May, 2009 | Pubmed ID: 19351147 Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates As Noncleavable Substrates for DNA Polymerases: Isolation, Characterization, and Stability Studies of Novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT Journal of Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18811136 Structures of DNA Polymerase Beta with Active-site Mismatches Suggest a Transient Abasic Site Intermediate During Misincorporation Molecular Cell. May, 2008 | Pubmed ID: 18471977 Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/apyrimidinic Endonuclease 1 and DNA Polymerase Beta The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17355977 Structure of DNA Polymerase Beta with a Benzo[c]phenanthrene Diol Epoxide-adducted Template Exhibits Mutagenic Features Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17079493 Magnesium-induced Assembly of a Complete DNA Polymerase Catalytic Complex Structure (London, England : 1993). Apr, 2006 | Pubmed ID: 16615916 Nucleotide-induced DNA Polymerase Active Site Motions Accommodating a Mutagenic DNA Intermediate Structure (London, England : 1993). Aug, 2005 | Pubmed ID: 16084394 DNA Polymerase Lambda Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15749700 DNA Polymerase Beta and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15561706 Influence of DNA Structure on DNA Polymerase Beta Active Site Function: Extension of Mutagenic DNA Intermediates The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15145936 Localization of the Deoxyribose Phosphate Lyase Active Site in Human DNA Polymerase Iota by Controlled Proteolysis The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12777390 Rapid Segmental and Subdomain Motions of DNA Polymerase Beta The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12458221 Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12370169 Molecular Basis of CIB Binding to the Integrin Alpha IIb Cytoplasmic Domain The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12023286 Loss of DNA Polymerase Beta Stacking Interactions with Templating Purines, but Not Pyrimidines, Alters Catalytic Efficiency and Fidelity The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11756435 Steady-state Pré-steady-state, e Single-turnover Medição, Kinetic para DNA glicosilase Atividade Akira Sassa1, William A. Beard1, David D. Shock1, Samuel H. Wilson1 1Laboratory of Structural Biology, NIEHS, National Institutes of Health JoVE 50695 Chemistry
Steady-state Pré-steady-state, e Single-turnover Medição, Kinetic para DNA glicosilase Atividade Akira Sassa1, William A. Beard1, David D. Shock1, Samuel H. Wilson1 1Laboratory of Structural Biology, NIEHS, National Institutes of Health JoVE 50695 Chemistry