David K Cole Division of Infection and Immunity and Systems Immunity Research Institute Cardiff University Biography Publications Institution JoVE Articles David K Cole has not added a biography. If you are David K Cole and would like to personalize this page please email our Author Liaison for assistance. Publications Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase The Journal of Biological Chemistry. Jan, 2017 | Pubmed ID: 27903649 Hotspot Autoimmune T Cell Receptor Binding Underlies Pathogen and Insulin Peptide Cross-reactivity The Journal of Clinical Investigation. Sep, 2016 | Pubmed ID: 27525441 Hotspot Autoimmune T Cell Receptor Binding Underlies Pathogen and Insulin Peptide Cross-reactivity The Journal of Clinical Investigation. Jun, 2016 | Pubmed ID: 27183389 A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26917722 T-cell Libraries Allow Simple Parallel Generation of Multiple Peptide-specific Human T-cell Clones Journal of Immunological Methods. Mar, 2016 | Pubmed ID: 26826277 Direct Molecular Mimicry Enables Off-target Cardiovascular Toxicity by an Enhanced Affinity TCR Designed for Cancer Immunotherapy Scientific Reports. Jan, 2016 | Pubmed ID: 26758806 Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers Journal of Immunology (Baltimore, Md. : 1950). Dec, 2015 | Pubmed ID: 26553072 Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide The Journal of Biological Chemistry. Jul, 2015 | Pubmed ID: 26085090 More Tricks with Tetramers: a Practical Guide to Staining T Cells with Peptide-MHC Multimers Immunology. Sep, 2015 | Pubmed ID: 26076649 The Promise of γδ T Cells and the γδ T Cell Receptor for Cancer Immunotherapy Cellular & Molecular Immunology. Nov, 2015 | Pubmed ID: 25864915 The Ultimate Mix and Match: Making Sense of HLA Alleles and Peptide Repertoires Immunology and Cell Biology. Jul, 2015 | Pubmed ID: 25823993 A Molecular Switch in Immunodominant HIV-1-specific CD8 T-cell Epitopes Shapes Differential HLA-restricted Escape Retrovirology. Feb, 2015 | Pubmed ID: 25808313 Naive CD8⁺ T-cell Precursors Display Structured TCR Repertoires and Composite Antigen-driven Selection Dynamics Immunology and Cell Biology. Aug, 2015 | Pubmed ID: 25801351 Structural Basis for Ineffective T-cell Responses to MHC Anchor Residue-improved "heteroclitic" Peptides European Journal of Immunology. Feb, 2015 | Pubmed ID: 25471691 Antibody Stabilization of Peptide-MHC Multimers Reveals Functional T Cells Bearing Extremely Low-affinity TCRs Journal of Immunology (Baltimore, Md. : 1950). Jan, 2015 | Pubmed ID: 25452566 Recurrence of Melanoma Following T Cell Treatment: Continued Antigen Expression in a Tumor That Evades T Cell Recruitment Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2015 | Pubmed ID: 25363716 Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance Cell. Oct, 2014 | Pubmed ID: 25284152 Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2014 | Pubmed ID: 24600035 The Versatility of the αβ T-cell Antigen Receptor Protein Science : a Publication of the Protein Society. Mar, 2014 | Pubmed ID: 24375592 T-cell Receptor (TCR)-peptide Specificity Overrides Affinity-enhancing TCR-major Histocompatibility Complex Interactions The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24196962 Cellular-level Versus Receptor-level Response Threshold Hierarchies in T-cell Activation Frontiers in Immunology. 2013 | Pubmed ID: 24046768 Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough Frontiers in Immunology. 2013 | Pubmed ID: 23847615 Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native PMHC Docking Mode Frontiers in Immunology. 2013 | Pubmed ID: 23805144 T-cell Receptor Specificity Maintained by Altered Thermodynamics The Journal of Biological Chemistry. Jun, 2013 | Pubmed ID: 23698002 Peptide Length Determines the Outcome of TCR/peptide-MHCI Engagement Blood. Feb, 2013 | Pubmed ID: 23255554 Human β-cell Killing by Autoreactive Preproinsulin-specific CD8 T Cells is Predominantly Granule-mediated with the Potency Dependent Upon T-cell Receptor Avidity Diabetes. Jan, 2013 | Pubmed ID: 22936177 Minimal Conformational Plasticity Enables TCR Cross-reactivity to Different MHC Class II Heterodimers Scientific Reports. 2012 | Pubmed ID: 22953050 T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22952231 The Molecular Determinants of CD8 Co-receptor Function Immunology. Oct, 2012 | Pubmed ID: 22804746 TCR/pMHC Optimized Protein Crystallization Screen Journal of Immunological Methods. Aug, 2012 | Pubmed ID: 22705983 Modification of the Carboxy-terminal Flanking Region of a Universal Influenza Epitope Alters CD4⁺ T-cell Repertoire Selection Nature Communications. Feb, 2012 | Pubmed ID: 22314361 Structural Basis for the Killing of Human Beta Cells by CD8(+) T Cells in Type 1 Diabetes Nature Immunology. Jan, 2012 | Pubmed ID: 22245737 Structural and Biophysical Determinants of αβ T-cell Antigen Recognition Immunology. Jan, 2012 | Pubmed ID: 22044041 The Multiple Roles of the CD8 Coreceptor in T Cell Biology: Opportunities for the Selective Modulation of Self-reactive Cytotoxic T Cells Journal of Leukocyte Biology. Dec, 2011 | Pubmed ID: 21954283 Correlation of in Situ Mechanosensitive Responses of the Moraxella Catarrhalis Adhesin UspA1 with Fibronectin and Receptor CEACAM1 Binding Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21876142 Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21677135 Real Time Detection of Peptide-MHC Dissociation Reveals That Improvement of Primary MHC-binding Residues Can Have a Minimal, or No, Effect on Stability Molecular Immunology. Jan, 2011 | Pubmed ID: 21130497 Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection PLoS Pathogens. Nov, 2010 | Pubmed ID: 21124993 Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010 | Pubmed ID: 20639478 MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20190139 T Cell Receptor Cross-reactivity Directed by Antigen-dependent Tuning of Peptide-MHC Molecular Flexibility Immunity. Dec, 2009 | Pubmed ID: 20064447 ELISPOT and Functional T Cell Analyses Using HLA Mono-specific Target Cells Journal of Immunological Methods. Oct, 2009 | Pubmed ID: 19729014 Peptide-major Histocompatibility Complex Dimensions Control Proximal Kinase-phosphatase Balance During T Cell Activation The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19628870 Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19605354 Tricks with Tetramers: How to Get the Most from Multimeric Peptide-MHC Immunology. Feb, 2009 | Pubmed ID: 19125886 Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-cell Receptor Nature Medicine. Dec, 2008 | Pubmed ID: 18997777 Detection of Low Avidity CD8(+) T Cell Populations with Coreceptor-enhanced Peptide-major Histocompatibility Complex Class I Tetramers Journal of Immunological Methods. Sep, 2008 | Pubmed ID: 18675271 T Cell Receptor Engagement of Peptide-major Histocompatibility Complex Class I Does Not Modify CD8 Binding Molecular Immunology. May, 2008 | Pubmed ID: 18243322 Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17540778 Human TCR-binding Affinity is Governed by MHC Class Restriction Journal of Immunology (Baltimore, Md. : 1950). May, 2007 | Pubmed ID: 17442956 Functional and Biophysical Characterization of an HLA-A*6801-restricted HIV-specific T Cell Receptor European Journal of Immunology. Feb, 2007 | Pubmed ID: 17273992 Computational Design and Crystal Structure of an Enhanced Affinity Mutant Human CD8 Alphaalpha Coreceptor Proteins. Apr, 2007 | Pubmed ID: 17243170 Crystal Structure of HLA-A*2402 Complexed with a Telomerase Peptide European Journal of Immunology. Jan, 2006 | Pubmed ID: 16323248 Crystallization and Preliminary X-ray Structural Studies of a High-affinity CD8alphaalpha Co-receptor to PMHC Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Mar, 2005 | Pubmed ID: 16511019 CD8: Adhesion Molecule, Co-receptor and Immuno-modulator Cellular & Molecular Immunology. Apr, 2004 | Pubmed ID: 16212893 Characterization of the Heptad Repeat Regions, HR1 and HR2, and Design of a Fusion Core Structure Model of the Spike Protein from Severe Acute Respiratory Syndrome (SARS) Coronavirus Biochemistry. Nov, 2004 | Pubmed ID: 15518555 Construct Design, Biophysical, and Biochemical Characterization of the Fusion Core from Mouse Hepatitis Virus (a Coronavirus) Spike Protein Protein Expression and Purification. Nov, 2004 | Pubmed ID: 15477089 Biochemical, Biophysical and Preliminary X-ray Crystallographic Analyses of the Fusion Core of Sendai Virus F Protein Acta Crystallographica. Section D, Biological Crystallography. Sep, 2004 | Pubmed ID: 15333939 Complex Assembly, Crystallization and Preliminary X-ray Crystallographic Studies of MHC H-2Kd Complexed with an HBV-core Nonapeptide Acta Crystallographica. Section D, Biological Crystallography. Aug, 2004 | Pubmed ID: 15272181 SARS Coronavirus Induces Apoptosis in Vero E6 Cells Journal of Medical Virology. Jul, 2004 | Pubmed ID: 15170624 Crystallization and Preliminary Crystallographic Analysis of the Fusion Core from Two New Zoonotic Paramyxoviruses, Nipah Virus and Hendra Virus Acta Crystallographica. Section D, Biological Crystallography. Jun, 2004 | Pubmed ID: 15159588 Following the Rule: Formation of the 6-helix Bundle of the Fusion Core from Severe Acute Respiratory Syndrome Coronavirus Spike Protein and Identification of Potent Peptide Inhibitors Biochemical and Biophysical Research Communications. Jun, 2004 | Pubmed ID: 15158473 Basis for Fusion Inhibition by Peptides: Analysis of the Heptad Repeat Regions of the Fusion Proteins from Nipah and Hendra Viruses, Newly Emergent Zoonotic Paramyxoviruses Biochemical and Biophysical Research Communications. Mar, 2004 | Pubmed ID: 14975752 Med användning av röntgenkristallografi, Biophysics, och Funktionella analyser för att bestämma de mekanismer som styr T-cellsreceptorigenkänning of Cancer Antigens Bruce J. MacLachlan*1, Alexander Greenshields-Watson*1, Georgina H Mason*1, Andrea J Schauenburg1, Valentina Bianchi1,2,3, Pierre J Rizkallah1, Andrew K Sewell1, Anna Fuller1, David K Cole1 1Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, 2Department of Oncology, University Hospital of Lausanne (CHUV), 3Ludwig Insitutue for Cancer Research, Lausanne Branch, University of Lausanne Immunology and Infection
Med användning av röntgenkristallografi, Biophysics, och Funktionella analyser för att bestämma de mekanismer som styr T-cellsreceptorigenkänning of Cancer Antigens Bruce J. MacLachlan*1, Alexander Greenshields-Watson*1, Georgina H Mason*1, Andrea J Schauenburg1, Valentina Bianchi1,2,3, Pierre J Rizkallah1, Andrew K Sewell1, Anna Fuller1, David K Cole1 1Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University, 2Department of Oncology, University Hospital of Lausanne (CHUV), 3Ludwig Insitutue for Cancer Research, Lausanne Branch, University of Lausanne Immunology and Infection
