David Brough

Publications

• Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome
  Stroke. May, 2019  |   Pubmed ID: 31009361
• Cathelicidin is a "fire Alarm", Generating Protective NLRP3-dependent Airway Epithelial Cell Inflammatory Responses During Infection with Pseudomonas Aeruginosa
  PLoS Pathogens. Apr, 2019  |   Pubmed ID: 30978238
• The Three Cytokines IL-1β, IL-18, and IL-1α Share Related but Distinct Secretory Routes
  The Journal of Biological Chemistry. May, 2019  |   Pubmed ID: 30940725
• Microglial Priming As Trained Immunity in the Brain
  Neuroscience. 05, 2019  |   Pubmed ID: 29292078
• Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data
  Genes. Nov, 2018  |   Pubmed ID: 30501127
• Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 Via Metabolic Reprogramming
  ACS Nano. Dec, 2018  |   Pubmed ID: 30444603
• Chloride Regulates Dynamic NLRP3-dependent ASC Oligomerization and Inflammasome Priming
  Proceedings of the National Academy of Sciences of the United States of America. 10, 2018  |   Pubmed ID: 30232264
• USP7 and USP47 Deubiquitinases Regulate NLRP3 Inflammasome Activation
  EMBO Reports. 10, 2018  |   Pubmed ID: 30206189
• Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?
  SLAS Discovery : Advancing Life Sciences R & D. Dec, 2018  |   Pubmed ID: 29969573
• Targeting the IL33-NLRP3 Axis Improves Therapy for Experimental Cerebral Malaria
  Proceedings of the National Academy of Sciences of the United States of America. 07, 2018  |   Pubmed ID: 29954866
• Development of a Characterised Tool Kit for the Interrogation of NLRP3 Inflammasome-dependent Responses
  Scientific Reports. Apr, 2018  |   Pubmed ID: 29618797
• Redefining the Ancestral Origins of the Interleukin-1 Superfamily
  Nature Communications. 03, 2018  |   Pubmed ID: 29559685
• Synthesis and Antibacterial Activities of Enamine Derivatives of Dehydroacetic Acid
  Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents. 2018  |   Pubmed ID: 29527108
• Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome
  ChemMedChem. 02, 2018  |   Pubmed ID: 29331080
• Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI
  Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. Mar, 2018  |   Pubmed ID: 29064155
• CRISPR/Cas9 Mediated Mutation of Mouse IL-1α Nuclear Localisation Sequence Abolishes Expression
  Scientific Reports. 12, 2017  |   Pubmed ID: 29213066
• Boron-Based Inhibitors of the NLRP3 Inflammasome
  Cell Chemical Biology. Nov, 2017  |   Pubmed ID: 28943355
• An Emerging Case for Membrane Pore Formation As a Common Mechanism for the Unconventional Secretion of FGF2 and IL-1β
  Journal of Cell Science. Oct, 2017  |   Pubmed ID: 28871048
• Salmonella Typhimurium-induced IL-1 Release from Primary Human Monocytes Requires NLRP3 and Can Occur in the Absence of Pyroptosis
  Scientific Reports. 07, 2017  |   Pubmed ID: 28761045
• Unconventional Pathways of Secretion Contribute to Inflammation
  International Journal of Molecular Sciences. Jan, 2017  |   Pubmed ID: 28067797
• Inflammasomes As Therapeutic Targets for Alzheimer's Disease
  Brain Pathology (Zurich, Switzerland). 03, 2017  |   Pubmed ID: 28009077
• P2X7 Receptor-dependent Tuning of Gut Epithelial Responses to Infection
  Immunology and Cell Biology. 02, 2017  |   Pubmed ID: 27559003
• Fenamate NSAIDs Inhibit the NLRP3 Inflammasome and Protect Against Alzheimer's Disease in Rodent Models
  Nature Communications. 2016  |   Pubmed ID: 27509875
• Inflammasomes Link Vascular Disease with Neuroinflammation and Brain Disorders
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 10, 2016  |   Pubmed ID: 27486046
• Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 27221482
• Inhibiting the Inflammasome: A Chemical Perspective
  Journal of Medicinal Chemistry. Mar, 2016  |   Pubmed ID: 26422006
• Novel Perspectives on Non-canonical Inflammasome Activation
  ImmunoTargets and Therapy. 2015  |   Pubmed ID: 27471719
• Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
  Frontiers in Immunology. 2015  |   Pubmed ID: 26635802
• Potassium Efflux Fires the Canon: Potassium Efflux As a Common Trigger for Canonical and Noncanonical NLRP3 Pathways
  European Journal of Immunology. Oct, 2015  |   Pubmed ID: 26332156
• Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage
  The Journal of Biological Chemistry. Oct, 2015  |   Pubmed ID: 26324708
• Interleukin-1 As a Pharmacological Target in Acute Brain Injury
  Experimental Physiology. Dec, 2015  |   Pubmed ID: 26096539
• P2X7R Activation Drives Distinct IL-1 Responses in Dendritic Cells Compared to Macrophages
  Cytokine. Aug, 2015  |   Pubmed ID: 26068648
• Interleukin-1α and Brain Inflammation
  IUBMB Life. May, 2015  |   Pubmed ID: 25906979
• AIM2 and NLRC4 Inflammasomes Contribute with ASC to Acute Brain Injury Independently of NLRP3
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015  |   Pubmed ID: 25775556
• Apoptosis-associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 During Macrophage Swelling
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015  |   Pubmed ID: 25552542
• Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome
  The Journal of Biological Chemistry. Dec, 2014  |   Pubmed ID: 25371210
• The NLRP3 Inflammasome is Released As a Particulate Danger Signal That Amplifies the Inflammatory Response
  Nature Immunology. Aug, 2014  |   Pubmed ID: 24952504
• Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death
  The Journal of Biological Chemistry. Jun, 2014  |   Pubmed ID: 24790078
• The Role of Inflammation and Interleukin-1 in Acute Cerebrovascular Disease
  Journal of Inflammation Research. Aug, 2013  |   Pubmed ID: 24062616
• Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion Via a Caspase-1-independent Pathway
  The Journal of Biological Chemistry. Oct, 2013  |   Pubmed ID: 24022484
• Microglia and Macrophages Differentially Modulate Cell Death After Brain Injury Caused by Oxygen-glucose Deprivation in Organotypic Brain Slices
  Glia. May, 2013  |   Pubmed ID: 23404620
• Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion Via Assembly of the Inflammasome
  The Journal of Biological Chemistry. Jan, 2013  |   Pubmed ID: 23209292
• NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation After Injury
  Frontiers in Immunology. 2012  |   Pubmed ID: 23024646
• Interleukin-1 Receptor Antagonist is Beneficial After Subarachnoid Haemorrhage in Rat by Blocking Haem-driven Inflammatory Pathology
  Disease Models & Mechanisms. Nov, 2012  |   Pubmed ID: 22679224
• Inhibition of Calpain Blocks the Phagosomal Escape of Listeria Monocytogenes
  PloS One. 2012  |   Pubmed ID: 22563421
• Obese Mice Exhibit an Altered Behavioural and Inflammatory Response to Lipopolysaccharide
  Disease Models & Mechanisms. Sep, 2012  |   Pubmed ID: 22328591
• Sphingosine Regulates the NLRP3-inflammasome and IL-1β Release from Macrophages
  European Journal of Immunology. Mar, 2012  |   Pubmed ID: 22105559
• Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria Monocytogenes During Growth in Vitro and in Vivo
  Infection and Immunity. Jan, 2012  |   Pubmed ID: 22025520
• Interleukin-1α Expression Precedes IL-1β After Ischemic Brain Injury and is Localised to Areas of Focal Neuronal Loss and Penumbral Tissues
  Journal of Neuroinflammation. Dec, 2011  |   Pubmed ID: 22206506
• Efficient Discovery of Anti-inflammatory Small-molecule Combinations Using Evolutionary Computing
  Nature Chemical Biology. Dec, 2011  |   Pubmed ID: 22020553
• Understanding the Mechanism of IL-1β Secretion
  Cytokine & Growth Factor Reviews. Aug, 2011  |   Pubmed ID: 22019906
• Regulation of Interleukin-1 in Acute Brain Injury
  Trends in Pharmacological Sciences. Oct, 2011  |   Pubmed ID: 21788085
• Nuclear Retention of IL-1 Alpha by Necrotic Cells: a Mechanism to Dampen Sterile Inflammation
  European Journal of Immunology. Nov, 2009  |   Pubmed ID: 19839011
• Pannexin-1-dependent Caspase-1 Activation and Secretion of IL-1beta is Regulated by Zinc
  European Journal of Immunology. Feb, 2009  |   Pubmed ID: 19130485
• The Dynamics and Mechanisms of Interleukin-1alpha and Beta Nuclear Import
  Traffic (Copenhagen, Denmark). Jan, 2009  |   Pubmed ID: 18939951
• Neuronal Injury Induces the Release of Pro-interleukin-1beta from Activated Microglia in Vitro
  Brain Research. Oct, 2008  |   Pubmed ID: 18722361
• A Selective, Non-peptide Caspase-1 Inhibitor, VRT-018858, Markedly Reduces Brain Damage Induced by Transient Ischemia in the Rat
  Neuropharmacology. Oct, 2007  |   Pubmed ID: 17845807
• Mechanisms of Regulation for Interleukin-1beta in Neurodegenerative Disease
  Neuropharmacology. Jun, 2007  |   Pubmed ID: 17428507
• Caspase-1-dependent Processing of Pro-interleukin-1beta is Cytosolic and Precedes Cell Death
  Journal of Cell Science. Mar, 2007  |   Pubmed ID: 17284521
• The Structural Integrity of the Endoplasmic Reticulum, and Its Possible Regulation by Inositol 1,3,4,5-tetrakisphosphate
  Cell Calcium. Aug, 2005  |   Pubmed ID: 16023721
• Interleukin-18 Induces Expression and Release of Cytokines from Murine Glial Cells: Interactions with Interleukin-1 Beta
  Journal of Neurochemistry. Jun, 2003  |   Pubmed ID: 12787061
• Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1 Beta and IL-1 Alpha from Murine Macrophages
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003  |   Pubmed ID: 12626557
• Role of P2X7 Receptors in Ischemic and Excitotoxic Brain Injury in Vivo
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2003  |   Pubmed ID: 12621313
• Extracellular ATP and P2X7 Receptors in Neurodegeneration
  European Journal of Pharmacology. Jul, 2002  |   Pubmed ID: 12151017
• Purinergic (P2X7) Receptor Activation of Microglia Induces Cell Death Via an Interleukin-1-independent Mechanism
  Molecular and Cellular Neurosciences. Feb, 2002  |   Pubmed ID: 11860279
• Priming of Macrophages with Lipopolysaccharide Potentiates P2X7-mediated Cell Death Via a Caspase-1-dependent Mechanism, Independently of Cytokine Production
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11706016