David Cribbs Institute for Brain Aging and Dementia University of California, Irvine (UCI) Biography Publications Institution JoVE Articles David Cribbs has not added a biography. If you are David Cribbs and would like to personalize this page please email our Author Liaison for assistance. Publications Delivery of a DNA Vaccine for Alzheimer's Disease by Electroporation Versus Gene Gun Generates Potent and Similar Immune Responses Neuro-degenerative Diseases. Feb, 2012 | Pubmed ID: 22301697 Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-catenin Pathway Function in an Alzheimer's Disease Model Journal of Immunology (Baltimore, Md. : 1950). Dec, 2011 | Pubmed ID: 22095718 Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease PloS One. 2011 | Pubmed ID: 22046234 Frontal Cortex Neuropathology in Dementia Pugilistica Journal of Neurotrauma. Oct, 2011 | Pubmed ID: 22017610 Therapeutic Modulation of Cerebral Microhemorrhage in a Mouse Model of Cerebral Amyloid Angiopathy Stroke; a Journal of Cerebral Circulation. Nov, 2011 | Pubmed ID: 21903962 Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease-like Pathology and Cognitive Decline The American Journal of Pathology. Aug, 2011 | Pubmed ID: 21704011 Cancer-testis Antigen, BORIS Based Vaccine Delivered by Dendritic Cells is Extremely Effective Against a Very Aggressive and Highly Metastatic Mouse Mammary Carcinoma Cellular Immunology. 2011 | Pubmed ID: 21641588 An Amyloid β(42)-dependent Deficit in Anandamide Mobilization is Associated with Cognitive Dysfunction in Alzheimer's Disease Neurobiology of Aging. May, 2011 | Pubmed ID: 21546126 Restricted V Gene Usage and VH/VL Pairing of Mouse Humoral Response Against the N-terminal Immunodominant Epitope of the Amyloid β Peptide Molecular Immunology. Nov-Dec, 2010 | Pubmed ID: 20970857 Aging and Cerebrovascular Dysfunction: Contribution of Hypertension, Cerebral Amyloid Angiopathy, and Immunotherapy Annals of the New York Academy of Sciences. Oct, 2010 | Pubmed ID: 20955427 Anti-11[E]-pyroglutamate-modified Amyloid β Antibodies Cross-react with Other Pathological Aβ Species: Relevance for Immunotherapy Journal of Neuroimmunology. Dec, 2010 | Pubmed ID: 20864186 Reductions in Amyloid-beta-derived Neuroinflammation, with Minocycline, Restore Cognition but Do Not Significantly Affect Tau Hyperphosphorylation Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20555131 Low Concentrations of Anti-Aβ Antibodies Generated in Tg2576 Mice by DNA Epitope Vaccine Fused with 3C3d Molecular Adjuvant Do Not Affect AD Pathology Human Gene Therapy. Nov, 2010 | Pubmed ID: 20528468 Linear and Conformation Specific Antibodies in Aged Beagles After Prolonged Vaccination with Aggregated Abeta Neurobiology of Disease. Sep, 2010 | Pubmed ID: 20451612 Abeta DNA Vaccination for Alzheimer's Disease: Focus on Disease Prevention CNS & Neurological Disorders Drug Targets. Apr, 2010 | Pubmed ID: 20205639 Immunization with Amyloid-beta Attenuates Inclusion Body Myositis-like Myopathology and Motor Impairment in a Transgenic Mouse Model The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2009 | Pubmed ID: 19439591 A Fibril-specific, Conformation-dependent Antibody Recognizes a Subset of Abeta Plaques in Alzheimer Disease, Down Syndrome and Tg2576 Transgenic Mouse Brain Acta Neuropathologica. Oct, 2009 | Pubmed ID: 19360426 Active and Passive Abeta-immunotherapy: Preclinical and Clinical Studies and Future Directions: Part II CNS & Neurological Disorders Drug Targets. Apr, 2009 | Pubmed ID: 19355929 Active and Passive Abeta-immunotherapy: Preclinical and Clinical Studies and Future Directions: Part I CNS & Neurological Disorders Drug Targets. Mar, 2009 | Pubmed ID: 19275632 Blocking Abeta42 Accumulation Delays the Onset and Progression of Tau Pathology Via the C Terminus of Heat Shock Protein70-interacting Protein: a Mechanistic Link Between Abeta and Tau Pathology The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2008 | Pubmed ID: 19020010 DNA Epitope Vaccine Containing Complement Component C3d Enhances Anti-amyloid-beta Antibody Production and Polarizes the Immune Response Towards a Th2 Phenotype Journal of Neuroimmunology. Dec, 2008 | Pubmed ID: 18838175 Gene Expression Changes in the Course of Normal Brain Aging Are Sexually Dimorphic Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008 | Pubmed ID: 18832152 Mannan-Abeta28 Conjugate Prevents Abeta-plaque Deposition, but Increases Microhemorrhages in the Brains of Vaccinated Tg2576 (APPsw) Mice Journal of Neuroinflammation. 2008 | Pubmed ID: 18823564 Cross-regulatory Protein-protein Interactions Between Hox and Pax Transcription Factors Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18755899 Timing of Wingless Signalling Distinguishes Maxillary and Antennal Identities in Drosophila Melanogaster Development (Cambridge, England). Jul, 2008 | Pubmed ID: 18508864 Reducing AD-like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine - a Novel Immunotherapeutic Strategy PloS One. 2008 | Pubmed ID: 18461171 Exercise Alters the Immune Profile in Tg2576 Alzheimer Mice Toward a Response Coincident with Improved Cognitive Performance and Decreased Amyloid Journal of Neuroinflammation. 2008 | Pubmed ID: 18400101 A Two-year Study with Fibrillar Beta-amyloid (Abeta) Immunization in Aged Canines: Effects on Cognitive Function and Brain Abeta The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2008 | Pubmed ID: 18385314 Amyloid-beta Peptide Binds to Microtubule-associated Protein 1B (MAP1B) Neurochemistry International. May, 2008 | Pubmed ID: 18079022 Immunostimulant Adjuvant Patch Enhances Humoral and Cellular Immune Responses to DNA Immunization DNA and Cell Biology. Jan, 2008 | Pubmed ID: 17961074 Experimental Investigation of Antibody-mediated Clearance Mechanisms of Amyloid-beta in CNS of Tg-SwDI Transgenic Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2007 | Pubmed ID: 18057195 Alzheimer's Disease Peptide Epitope Vaccine Reduces Insoluble but Not Soluble/oligomeric Abeta Species in Amyloid Precursor Protein Transgenic Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2007 | Pubmed ID: 18003852 Phagocytosis of Amyloid-beta and Inflammation: Two Faces of Innate Immunity in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Jul, 2007 | Pubmed ID: 17656824 Anti-A Beta 1-11 Antibody Binds to Different Beta-amyloid Species, Inhibits Fibril Formation, and Disaggregates Preformed Fibrils but Not the Most Toxic Oligomers The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17545160 Distinct Roles for Mediator Cdk8 Module Subunits in Drosophila Development The EMBO Journal. Feb, 2007 | Pubmed ID: 17290221 Elicitation of T Cell Responses to Histologically Unrelated Tumors by Immunization with the Novel Cancer-testis Antigen, Brother of the Regulator of Imprinted Sites Journal of Immunology (Baltimore, Md. : 1950). Jan, 2007 | Pubmed ID: 17182597 External Force-assisted Cell Positioning Inside Microfluidic Devices Biomedical Microdevices. Feb, 2007 | Pubmed ID: 17091393 Abeta-immunotherapy for Alzheimer's Disease Using Mannan-amyloid-Beta Peptide Immunoconjugates DNA and Cell Biology. Oct, 2006 | Pubmed ID: 17132088 Reduction of Soluble Abeta and Tau, but Not Soluble Abeta Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17056594 Relapsing Polychondritis with Features of Dementia with Lewy Bodies Acta Neuropathologica. Aug, 2006 | Pubmed ID: 16832629 The Specification of a Highly Derived Arthropod Appendage, the Drosophila Labial Palps, Requires the Joint Action of Selectors and Signaling Pathways Development Genes and Evolution. Jul-Aug, 2006 | Pubmed ID: 16773339 Novel Approaches for Immunotherapeutic Intervention in Alzheimer's Disease Neurochemistry International. Jul, 2006 | Pubmed ID: 16765487 Antitumor Efficacy of DNA Vaccination to the Epigenetically Acting Tumor Promoting Transcription Factor BORIS and CD80 Molecular Adjuvant Journal of Cellular Biochemistry. Aug, 2006 | Pubmed ID: 16741971 Immunization with Fibrillar Abeta(1-42) in Young and Aged Canines: Antibody Generation and Characteristics, and Effects on CSF and Brain Abeta Vaccine. Apr, 2006 | Pubmed ID: 16460841 Prototype Alzheimer's Disease Epitope Vaccine Induced Strong Th2-type Anti-Abeta Antibody Response with Alum to Quil A Adjuvant Switch Vaccine. Mar, 2006 | Pubmed ID: 16368167 Novel Abeta Peptide Immunogens Modulate Plaque Pathology and Inflammation in a Murine Model of Alzheimer's Disease Journal of Neuroinflammation. 2005 | Pubmed ID: 16332263 A Microfluidic Culture Platform for CNS Axonal Injury, Regeneration and Transport Nature Methods. Aug, 2005 | Pubmed ID: 16094385 Homeotic Proboscipedia Function Modulates Hedgehog-mediated Organizer Activity to Pattern Adult Drosophila Mouthparts Developmental Biology. Feb, 2005 | Pubmed ID: 15680366 Prototype Alzheimer's Disease Vaccine Using the Immunodominant B Cell Epitope from Beta-amyloid and Promiscuous T Cell Epitope Pan HLA DR-binding Peptide Journal of Immunology (Baltimore, Md. : 1950). Feb, 2005 | Pubmed ID: 15661919 Patterned Cell Culture Inside Microfluidic Devices Lab on a Chip. Jan, 2005 | Pubmed ID: 15616747 Mimotopes of Conformational Epitopes in Fibrillar Beta-amyloid Journal of Neuroimmunology. Nov, 2004 | Pubmed ID: 15465592 Abeta Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates Via the Proteasome Neuron. Aug, 2004 | Pubmed ID: 15294141 Caspase-mediated Degeneration in Alzheimer's Disease The American Journal of Pathology. Aug, 2004 | Pubmed ID: 15277211 Microfluidic Multicompartment Device for Neuroscience Research Langmuir : the ACS Journal of Surfaces and Colloids. Mar, 2003 | Pubmed ID: 20725530 Generation and Characterization of the Humoral Immune Response to DNA Immunization with a Chimeric Beta-amyloid-interleukin-4 Minigene European Journal of Immunology. Dec, 2003 | Pubmed ID: 14635031 Immunization with a Vaccine That Combines the Expression of MUC1 and B7 Co-stimulatory Molecules Prolongs the Survival of Mice and Delays the Appearance of Mouse Mammary Tumors Clinical & Experimental Metastasis. 2003 | Pubmed ID: 14598882 Fas and Fas Ligand Are Associated with Neuritic Degeneration in the AD Brain and Participate in Beta-amyloid-induced Neuronal Death Neurobiology of Disease. Apr, 2003 | Pubmed ID: 12742739 Adjuvant-dependent Modulation of Th1 and Th2 Responses to Immunization with Beta-amyloid International Immunology. Apr, 2003 | Pubmed ID: 12663680 The Induction of the TNFalpha Death Domain Signaling Pathway in Alzheimer's Disease Brain Neurochemical Research. Feb, 2003 | Pubmed ID: 12608703 Importance of IgG2c Isotype in the Immune Response to Beta-amyloid in Amyloid Precursor Protein/transgenic Mice Neuroscience Letters. Feb, 2003 | Pubmed ID: 12565127 Evidence for a Direct Functional Antagonism of the Selector Genes Proboscipedia and Eyeless in Drosophila Head Development Development (Cambridge, England). Feb, 2003 | Pubmed ID: 12490563 Beta-amyloid Deposition and Neurofibrillary Tangle Association with Caspase Activation in Down Syndrome Neuroscience Letters. Sep, 2002 | Pubmed ID: 12213643 Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to Man Cell. Jul, 2002 | Pubmed ID: 12150923 The Drosophila Gene Taranis Encodes a Novel Trithorax Group Member Potentially Linked to the Cell Cycle Regulatory Apparatus Genetics. Feb, 2002 | Pubmed ID: 11861561 A P-insertion Screen Identifying Novel X-linked Essential Genes in Drosophila Mechanisms of Development. Jan, 2002 | Pubmed ID: 11744370 Номера для плазмы Склеивание PDMS для недорогих Изготовление микрожидкостных устройств Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Cristina Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 410 Biology Подготовка E18 корковых нейронов крысы за раздробленности в микрожидкостных устройств Joseph Harris1, Hyuna Lee1, Christina Tu Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 305 Biology Изготовление микрожидкостных Устройство для дробления Нейрон Сома и Аксоны Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Christina Tu2, David Cribbs3, Noo Li Jeon1, Carl Cotman3 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 261 Biology
Номера для плазмы Склеивание PDMS для недорогих Изготовление микрожидкостных устройств Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Cristina Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 410 Biology
Подготовка E18 корковых нейронов крысы за раздробленности в микрожидкостных устройств Joseph Harris1, Hyuna Lee1, Christina Tu Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 305 Biology
Изготовление микрожидкостных Устройство для дробления Нейрон Сома и Аксоны Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Christina Tu2, David Cribbs3, Noo Li Jeon1, Carl Cotman3 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 261 Biology
