David Lillicrap

Publications

• Bispecific Antibody Therapy in Hemophilia
  The New England Journal of Medicine. Jul, 2017  |   Pubmed ID: 28691560
• Biological Considerations of Plasma-derived and Recombinant Factor VIII Immunogenicity
  Blood. Jun, 2017  |   Pubmed ID: 28432221
• Utility of Factor VIII and Factor VIII to Von Willebrand Factor Ratio in Identifying 277 Unselected Carriers of Hemophilia A
  American Journal of Hematology. Jun, 2017  |   Pubmed ID: 28249352
• Summary Report of the First International Conference on Inhibitors in Haemophilia A
  Blood Transfusion = Trasfusione Del Sangue. Nov, 2016  |   Pubmed ID: 27893354
• Life in the Shadow of a Dominant Partner: the FVIII-VWF Association and Its Clinical Implications for Hemophilia A
  Blood. Oct, 2016  |   Pubmed ID: 27587878
• Functional Characterisation of the Type 1 Von Willebrand Disease Candidate VWF Gene Variants: P.M771I, P.L881R and P.P1413L
  Blood Transfusion = Trasfusione Del Sangue. Jul, 2016  |   Pubmed ID: 27483487
• How Much Do We Really Know About Von Willebrand Disease?
  Current Opinion in Hematology. Sep, 2016  |   Pubmed ID: 27428891
• Gene Therapy for Coagulation Disorders
  Circulation Research. Apr, 2016  |   Pubmed ID: 27126652
• Concurrent Influenza Vaccination Reduces Anti-FVIII Antibody Responses in Murine Hemophilia A
  Blood. Jun, 2016  |   Pubmed ID: 27034428
• Clinical and Laboratory Variability in a Cohort of Patients Diagnosed with Type 1 VWD in the United States
  Blood. May, 2016  |   Pubmed ID: 26862110
• Recombinant Factor VIII Fc (rFVIIIFc) Fusion Protein Reduces Immunogenicity and Induces Tolerance in Hemophilia A Mice
  Cellular Immunology. Mar, 2016  |   Pubmed ID: 26775174
• War and Peace: Factor VIII and the Adaptive Immune Response
  Cellular Immunology. Mar, 2016  |   Pubmed ID: 26676073
• To Clear or to Fear: An Innate Perspective on Factor VIII Immunity
  Cellular Immunology. Mar, 2016  |   Pubmed ID: 26547364
• Foreword
  European Journal of Haematology. Dec, 2015  |   Pubmed ID: 26679391
• Transgene-host Cell Interactions Mediate Significant Influences on the Production, Stability, and Function of Recombinant Canine FVIII
  Molecular Therapy. Methods & Clinical Development. 2015  |   Pubmed ID: 26636112
• Journal of Thrombosis and Haemostasis. Special Issue: State of the Art 2015. Preface
  Journal of Thrombosis and Haemostasis : JTH. Jun, 2015  |   Pubmed ID: 26149009
• Introduction to a Series of Reviews on Inherited Bleeding Disorders
  Blood. Mar, 2015  |   Pubmed ID: 25712995
• Alloantibodies to Therapeutic Factor VIII in Hemophilia A: the Role of Von Willebrand Factor in Regulating Factor VIII Immunogenicity
  Haematologica. Feb, 2015  |   Pubmed ID: 25638804
• Rapid Acquisition of Immunologic Tolerance to Factor VIII and Disappearance of Anti-factor VIII IgG4 After Prophylactic Therapy in a Hemophilia A Patient with High-titer Factor VIII Inhibitor
  Journal of Pediatric Hematology/oncology. May, 2015  |   Pubmed ID: 25411864
• Syntaxin-binding Protein 5 Exocytosis Regulation: Differential Role in Endothelial Cells and Platelets
  The Journal of Clinical Investigation. Oct, 2014  |   Pubmed ID: 25244090
• Analysis of the Role of Von Willebrand Factor, Platelet Glycoprotein VI-, and α2β1-mediated Collagen Binding in Thrombus Formation
  Blood. Sep, 2014  |   Pubmed ID: 25051961
• FVIII Stabilization: VWF D'D3 Will Do
  Blood. Jul, 2014  |   Pubmed ID: 25035147
• Omental Implantation of BOECs in Hemophilia Dogs Results in Circulating FVIII Antigen and a Complex Immune Response
  Blood. Jun, 2014  |   Pubmed ID: 24829206
• A Novel Cell-sheet Technology That Achieves Durable Factor VIII Delivery in a Mouse Model of Hemophilia A
  PloS One. 2013  |   Pubmed ID: 24358271
• Von Willebrand Disease: Advances in Pathogenetic Understanding, Diagnosis, and Therapy
  Hematology. American Society of Hematology. Education Program. 2013  |   Pubmed ID: 24319188
• Genetic Sequence Analysis of Inherited Bleeding Diseases
  Blood. Nov, 2013  |   Pubmed ID: 24124085
• Von Willebrand Disease: Advances in Pathogenetic Understanding, Diagnosis, and Therapy
  Blood. Nov, 2013  |   Pubmed ID: 24065240
• Endogenous Factor VIII Synthesis from the Intron 22-inverted F8 Locus May Modulate the Immunogenicity of Replacement Therapy for Hemophilia A
  Nature Medicine. Oct, 2013  |   Pubmed ID: 24037092
• The Canadian "National Program for Hemophilia Mutation Testing" Database: a Ten-year Review
  American Journal of Hematology. Dec, 2013  |   Pubmed ID: 23913812
• Introduction to a Series of Reviews on Cancer-associated Thrombotic Disease
  Blood. Sep, 2013  |   Pubmed ID: 23798712
• The C-type Lectin Receptor CLEC4M Binds, Internalizes, and Clears Von Willebrand Factor and Contributes to the Variation in Plasma Von Willebrand Factor Levels
  Blood. Jun, 2013  |   Pubmed ID: 23529928
• Alloantibodies in Von Willebrand Disease
  Blood. Aug, 2013  |   Pubmed ID: 23297130
• The Future of Hemostasis Management
  Pediatric Blood & Cancer. 2013  |   Pubmed ID: 23109347
• A Complex Substitute: Antibody Therapy for Hemophilia
  Nature Medicine. Oct, 2012  |   Pubmed ID: 23042345
• The World Federation of Hemophilia and Research
  Haemophilia : the Official Journal of the World Federation of Hemophilia. Jul, 2012  |   Pubmed ID: 22726078
• Von Willebrand Disease: Clinical and Laboratory Lessons Learned from the Large Von Willebrand Disease Studies
  American Journal of Hematology. Feb, 2012  |   Pubmed ID: 22389132
• Solulin Increases Clot Stability in Whole Blood from Humans and Dogs with Hemophilia
  Blood. Apr, 2012  |   Pubmed ID: 22234684
• The Diagnosis and Management of Von Willebrand Disease in Canada
  Seminars in Thrombosis and Hemostasis. Jul, 2011  |   Pubmed ID: 22102195
• Therapeutic Consequences for Misdiagnosis of Type 2N Von Willebrand Disease
  Pediatric Blood & Cancer. Dec, 2011  |   Pubmed ID: 21425451
• Pathologic Mechanisms of Type 1 VWD Mutations R1205H and Y1584C Through in Vitro and in Vivo Mouse Models
  Blood. Apr, 2011  |   Pubmed ID: 21346256
• Frequency of Platelet Type Versus Type 2B Von Willebrand Disease. An International Registry-based Study
  Thrombosis and Haemostasis. Mar, 2011  |   Pubmed ID: 21301777
• A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2011  |   Pubmed ID: 21285959
• Early Intraoperative Blood Collection Does Not Affect Complete Blood Counts, Von Willebrand Factor or Factor VIII Levels in Normal Children
  Journal of Pediatric Hematology/oncology. Jan, 2011  |   Pubmed ID: 21178707
• Functional Analysis of Three Recombinant A1-VWF Domain Mutants in Comparison to Wild Type and Plasma-derived VWF Facilitates Subtyping in Type 2 Von Willebrand Disease
  Thrombosis Research. Feb, 2011  |   Pubmed ID: 21094983
• Challenges and Innovations in the Treatment of Bleeding Disorders
  Thrombosis Research. Jan, 2011  |   Pubmed ID: 21056903
• Hierarchical Scaffold Design for Mesenchymal Stem Cell-based Gene Therapy of Hemophilia B
  Biomaterials. Jan, 2011  |   Pubmed ID: 20864158
• Eradication of Neutralizing Antibodies to Factor VIII in Canine Hemophilia A After Liver Gene Therapy
  Blood. Dec, 2010  |   Pubmed ID: 20876851
• Functional Characterization of a 13-bp Deletion (c.-1522_-1510del13) in the Promoter of the Von Willebrand Factor Gene in Type 1 Von Willebrand Disease
  Blood. Nov, 2010  |   Pubmed ID: 20696945
• Improvements in Factor Concentrates
  Current Opinion in Hematology. Sep, 2010  |   Pubmed ID: 20613509
• Characterization of Viability and Proliferation of Alginate-poly-L-lysine-alginate Encapsulated Myoblasts Using Flow Cytometry
  Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Aug, 2010  |   Pubmed ID: 20586078
• Mutation-specific Hemostatic Variability in Mice Expressing Common Type 2B Von Willebrand Disease Substitutions
  Blood. Jun, 2010  |   Pubmed ID: 20371742
• [Application Studies on the Gene Diagnosis and Carrier Detection of Hemophilia A by Using Polymerase Chain Reaction-conformation Sensitive Gel Electrophoresis]
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Aug, 2009  |   Pubmed ID: 20017302
• A Murine Model for Induction of Long-term Immunologic Tolerance to Factor VIII Does Not Require Persistent Detectable Levels of Plasma Factor VIII and Involves Contributions from Foxp3+ T Regulatory Cells
  Blood. Jul, 2009  |   Pubmed ID: 19458355
• Recombinant and Plasma-derived Factor VIII Products Induce Distinct Splenic Cytokine Microenvironments in Hemophilia A Mice
  Blood. Jul, 2009  |   Pubmed ID: 19411636
• Anti-CD3 Prevents Factor VIII Inhibitor Development in Hemophilia A Mice by a Regulatory CD4+CD25+-dependent Mechanism and by Shifting Cytokine Production to Favor a Th1 Response
  Blood. Jan, 2009  |   Pubmed ID: 18815284
• The Role of Molecular Genetics in Diagnosing Von Willebrand Disease
  Seminars in Thrombosis and Hemostasis. Sep, 2008  |   Pubmed ID: 19085649
• ADAMTS13 Cleavage Efficiency is Altered by Mutagenic And, to a Lesser Extent, Polymorphic Sequence Changes in the A1 and A2 Domains of Von Willebrand Factor
  British Journal of Haematology. Nov, 2008  |   Pubmed ID: 18986390
• Extending Half-life in Coagulation Factors: Where Do We Stand?
  Thrombosis Research. 2008  |   Pubmed ID: 18929522
• Coagulation Factors--molecular Attributes and Their Clinical Impact
  Thrombosis Research. 2008  |   Pubmed ID: 18929520
• Von Willebrand Disease
  Pediatric Clinics of North America. Apr, 2008  |   Pubmed ID: 18381092
• Efficacy and Safety of a New-class Hemostatic Drug Candidate, AV513, in Dogs with Hemophilia A
  Blood. Jan, 2008  |   Pubmed ID: 17978172
• Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained in Vivo Factor VIII Expression from Lentivirally Engineered Endothelial Progenitors
  Stem Cells (Dayton, Ohio). Oct, 2007  |   Pubmed ID: 17615271
• Distinguishing Between Non-identical Twins: Platelet Type and Type 2B Von Willebrand Disease
  British Journal of Haematology. Sep, 2007  |   Pubmed ID: 17608761
• Von Willebrand Disease - Phenotype Versus Genotype: Deficiency Versus Disease
  Thrombosis Research. 2007  |   Pubmed ID: 17490730
• Von Willebrand: the Scientist, the Disease, the Factor, and the Treatment
  Thrombosis Research. 2007  |   Pubmed ID: 17482240
• Theories of Blood Coagulation
  Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses. May-Jun, 2007  |   Pubmed ID: 17475978
• Correction of the Bleeding Time in Von Willebrand Factor (VWF)-deficient Mice Using Murine VWF
  Blood. Mar, 2007  |   Pubmed ID: 17312004
• The Mutational Spectrum of Type 1 Von Willebrand Disease: Results from a Canadian Cohort Study
  Blood. Jan, 2007  |   Pubmed ID: 17190853
• Adenovirus-induced Thrombocytopenia: the Role of Von Willebrand Factor and P-selectin in Mediating Accelerated Platelet Clearance
  Blood. Apr, 2007  |   Pubmed ID: 17148587
• The Role of Immunomodulation in the Management of Factor VIII Inhibitors
  Hematology. American Society of Hematology. Education Program. 2006  |   Pubmed ID: 17124093
• Genetic Testing for Von Willebrand Disease: the Canadian Experience
  Seminars in Thrombosis and Hemostasis. Jul, 2006  |   Pubmed ID: 16862529
• Inhibitor Development in Hemophiliacs: the Roles of Genetic Versus Environmental Factors
  Seminars in Thrombosis and Hemostasis. Jun, 2006  |   Pubmed ID: 16804830
• Multiyear Therapeutic Benefit of AAV Serotypes 2, 6, and 8 Delivering Factor VIII to Hemophilia A Mice and Dogs
  Blood. Jul, 2006  |   Pubmed ID: 16522813
• Efficient Lentiviral Transduction and Improved Engraftment of Human Bone Marrow Mesenchymal Cells
  Stem Cells (Dayton, Ohio). Apr, 2006  |   Pubmed ID: 16339997
• Aminoglycoside Suppression of Nonsense Mutations in Severe Hemophilia
  Blood. Nov, 2005  |   Pubmed ID: 16051741
• Identification and Functional Characterization of a Novel 27-bp Deletion in the Macroglycopeptide-coding Region of the GPIBA Gene Resulting in Platelet-type Von Willebrand Disease
  Blood. Jun, 2005  |   Pubmed ID: 15705799
• Cell Type-specific Regulation of Von Willebrand Factor Expression by the E4BP4 Transcriptional Repressor
  Blood. Feb, 2005  |   Pubmed ID: 15498853
• Heterogeneity of the Immune Response to Adenovirus-mediated Factor VIII Gene Therapy in Different Inbred Hemophilic Mouse Strains
  The Journal of Gene Medicine. Dec, 2004  |   Pubmed ID: 15493040
• Molecular Modeling of the Von Willebrand Factor A2 Domain and the Effects of Associated Type 2A Von Willebrand Disease Mutations
  Journal of Molecular Modeling. Aug, 2004  |   Pubmed ID: 15322948
• Reliability and Reproducibility of Classification of Children As "bleeders" Versus "non-bleeders" Using a Questionnaire for Significant Mucocutaneous Bleeding
  Journal of Pediatric Hematology/oncology. Aug, 2004  |   Pubmed ID: 15284585
• Naked DNA Transfer of Factor VIII Induced Transgene-specific, Species-independent Immune Response in Hemophilia A Mice
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2004  |   Pubmed ID: 15233948
• A Novel Type 2A Von Willebrand Factor Mutation Located at the Last Nucleotide of Exon 26 (3538G>A) Causes Skipping of 2 Nonadjacent Exons
  Blood. Nov, 2004  |   Pubmed ID: 15226181
• Preclinical Animal Models for Hemophilia Gene Therapy: Predictive Value and Limitations
  Seminars in Thrombosis and Hemostasis. Apr, 2004  |   Pubmed ID: 15118932
• Helper-dependent Adenoviral Vectors Mediate Therapeutic Factor VIII Expression for Several Months with Minimal Accompanying Toxicity in a Canine Model of Severe Hemophilia A
  Blood. Feb, 2004  |   Pubmed ID: 14512318
• Sustained Phenotypic Correction of Canine Hemophilia A Using an Adeno-associated Viral Vector
  Blood. Sep, 2003  |   Pubmed ID: 12738670
• Founder Von Willebrand Factor Haplotype Associated with Type 1 Von Willebrand Disease
  Blood. Jul, 2003  |   Pubmed ID: 12649144
• Therapeutic Factor VIII Levels and Negligible Toxicity in Mouse and Dog Models of Hemophilia A Following Gene Therapy with High-capacity Adenoviral Vectors
  Blood. Mar, 2003  |   Pubmed ID: 12406898
• Gene Expression: Overview and Clinical Implications
  Vox Sanguinis. Aug, 2002  |   Pubmed ID: 12617108
• A Survey of Recommendations by Gynecologists in Canada Regarding Oral Contraceptive Use in the Perioperative Period
  American Journal of Obstetrics and Gynecology. Dec, 2002  |   Pubmed ID: 12501060
• The Canine Factor VIII 3'-untranslated Region and a Concatemeric Hepatocyte Nuclear Factor 1 Regulatory Element Enhance Factor VIII Transgene Expression in Vivo
  Human Gene Therapy. Sep, 2002  |   Pubmed ID: 12228013
• A 4% Solution of Bovine Serum Albumin May Be Used in Place of Factor VIII:C Deficient Plasma in the Control Sample in the Nijmegen Modification of the Bethesda Factor VIII:C Inhibitor Assay
  Thrombosis and Haemostasis. Aug, 2002  |   Pubmed ID: 12195715
• Dangerous Liaisons: the Role of "danger" Signals in the Immune Response to Gene Therapy
  Blood. Aug, 2002  |   Pubmed ID: 12149189
• Aberrant Splicing and Premature Termination of Transcription of the FVIII Gene As a Cause of Severe Canine Hemophilia A: Similarities with the Intron 22 Inversion Mutation in Human Hemophilia
  Thrombosis and Haemostasis. Apr, 2002  |   Pubmed ID: 12008949
• Recombinant Factor IX Recovery and Inhibitor Safety: a Canadian Post-licensure Surveillance Study
  Thrombosis and Haemostasis. Mar, 2002  |   Pubmed ID: 11916075
• Genetic Basis of Familial Meniere's Disease
  The Journal of Otolaryngology. Feb, 2002  |   Pubmed ID: 11883436