Dean A. Lee Center for Childhood Cancer and Blood Disease Nationwide Children's Hospital Biography Publications Institution JoVE Articles Dean A. Lee has not added a biography. If you are Dean A. Lee and would like to personalize this page please email our Author Liaison for assistance. Publications Aggressive Natural Killer-cell Leukemia mutational Landscape and Drug Profiling Highlight JAK-STAT Signaling As Therapeutic Target Nature Communications. Apr, 2018 | Pubmed ID: 29674644 Inhibiting TGF-beta Signaling Preserves the Function of Highly Activated, in Vitro Expanded Natural Killer Cells in AML and Colon Cancer Models PloS One. 2018 | Pubmed ID: 29342200 Ex Vivo-expanded NK Cells from Blood and Ascites of Ovarian Cancer Patients Are Cytotoxic Against Autologous Primary Ovarian Cancer Cells Cancer Immunology, Immunotherapy : CII. Apr, 2018 | Pubmed ID: 29299659 Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood Are Cytotoxic Against Primary Breast Cancer Cells Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb/Mar, 2018 | Pubmed ID: 29189387 Venous Thromboembolism in Pediatric Hematopoietic Cell Transplant: A Multicenter Cohort Study Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Feb, 2018 | Pubmed ID: 29128552 Radiotherapy Enhances Natural Killer Cell Cytotoxicity and Localization in Pre-clinical Canine Sarcomas and First-in-dog Clinical Trial Journal for Immunotherapy of Cancer. Dec, 2017 | Pubmed ID: 29254507 Phase 1 Clinical Trial Using MbIL21 Ex Vivo-expanded Donor-derived NK Cells After Haploidentical Transplantation Blood. 10, 2017 | Pubmed ID: 28835441 Ex Vivo Expanded Natural Killer Cells from Breast Cancer Patients and Healthy Donors Are Highly Cytotoxic Against Breast Cancer Cell Lines and Patient-derived Tumours Breast Cancer Research : BCR. Jul, 2017 | Pubmed ID: 28668076 IL-18/IL-15/IL-12 Synergy Induces Elevated and Prolonged IFN-γ Production by Ex Vivo Expanded NK Cells Which is Not Due to Enhanced STAT4 Activation Molecular Immunology. Aug, 2017 | Pubmed ID: 28644973 Interferon Gamma Induces Changes in Natural Killer (NK) Cell Ligand Expression and Alters NK Cell-Mediated Lysis of Pediatric Cancer Cell Lines Frontiers in Immunology. 2017 | Pubmed ID: 28428785 The Histone Deacetylase Inhibitor Valproic Acid Inhibits NKG2D Expression in Natural Killer Cells Through Suppression of STAT3 and HDAC3 Scientific Reports. Mar, 2017 | Pubmed ID: 28338101 Natural Killer Cells in Malignant Hematology: A Primer for the Non-immunologist Blood Reviews. Mar, 2017 | Pubmed ID: 27665023 NK細胞療法:造血幹細胞移植後の病気の再発を対象に Immunotherapy. Feb, 2012 | Pubmed ID: 22329587 膜結合型IL-21ヒトナチュラルキラー細胞の持続的なex Vivoでの増殖を促進する PloS One. 2012 | Pubmed ID: 22279576 高度なB-リンパ系悪性腫瘍のために自家造血幹細胞移植患者における疾病管理を強化するためにCD19主導T細胞を注入する Human Gene Therapy. Jan, 2012 | Pubmed ID: 22107246 IL-21シグナルとCD19特異的T細胞を再プログラミングするB-系列の悪性腫瘍の養子免疫療法を改善することができます Cancer Research. May, 2011 | Pubmed ID: 21558388 取得、準備、および養子免疫療法のためのヒトNK細胞の機能評価 Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20686960 ヒトT細胞の特異性をリダイレクトするためにキメラ抗原受容体を導入するためのハイスループットMicroelectroporationデバイス Biomedical Microdevices. Oct, 2010 | Pubmed ID: 20574820 B細胞悪性腫瘍の同種細胞治療のための腫瘍特異的ヒトT細胞を生成するためのCD19リダイレクトとAlloanergizationを組み合わせる Cancer Research. May, 2010 | Pubmed ID: 20424114 B系統の悪性腫瘍の治療のためにCD19特異的T細胞を生成するPiggyBacトランスポゾン/トランスポゾンシステム Human Gene Therapy. Apr, 2010 | Pubmed ID: 19905893 EBV +リンパ増殖性疾患難治性LCHのために長時間の化学療法後 Pediatric Blood & Cancer. Mar, 2008 | Pubmed ID: 17243127 MLLの複合転位から生じるCUGBP1の中断によるC / EBPbeta抑制 Cancer Genetics and Cytogenetics. Sep, 2007 | Pubmed ID: 17854664 ロタウイルスワクチン The New England Journal of Medicine. Apr, 2006 | Pubmed ID: 16625014 T(8; 21)と子供の肺炎などの提示顆粒球肉腫、急性骨髄性白血病:蛍光in Situハイブリダイゼーションによる診断 Journal of Pediatric Hematology/oncology. Jul, 2004 | Pubmed ID: 15218417 腫瘍特異的ヒトCD4 +制御性T細胞とそのリガンド:免疫療法のための含意 Immunity. Jan, 2004 | Pubmed ID: 14738769 HLAクラスIIライゲーションによって活性化単球を培養すると活性化された末梢Tリンパ球はアポトーシスを起こす Cellular Immunology. Oct, 2003 | Pubmed ID: 14698144 Cas9 Ribonucleoproteins を使用してノックアウト プライマリおよび拡張された人間の NK 細胞の生成 Meisam Naeimi Kararoudi1, Hamid Dolatshad2, Prashant Trikha1, Syed-Rehan A. Hussain3, Ezgi Elmas1, Jennifer A. Foltz1, Jena E. Moseman1, Aarohi Thakkar1, Robin J. Nakkula1, Margaret Lamb1, Nitin Chakravarti1, K. John McLaughlin3, Dean A. Lee1 1Center for Childhood Cancer and Blood Disease, Nationwide Children's Hospital, 2Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, 3Center for Clinical and Translational Research, Nationwide Children's Hospital Research Institute JoVE 58237 Immunology and Infection 拡大、精製、及びヒト末梢血NK細胞の機能的評価 Srinivas S. Somanchi1, Vladimir V. Senyukov1, Cecele J. Denman1, Dean A. Lee1 1Division of Pediatrics, MD Anderson Cancer Center - University of Texas JoVE 2540 Immunology and Infection
Cas9 Ribonucleoproteins を使用してノックアウト プライマリおよび拡張された人間の NK 細胞の生成 Meisam Naeimi Kararoudi1, Hamid Dolatshad2, Prashant Trikha1, Syed-Rehan A. Hussain3, Ezgi Elmas1, Jennifer A. Foltz1, Jena E. Moseman1, Aarohi Thakkar1, Robin J. Nakkula1, Margaret Lamb1, Nitin Chakravarti1, K. John McLaughlin3, Dean A. Lee1 1Center for Childhood Cancer and Blood Disease, Nationwide Children's Hospital, 2Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, 3Center for Clinical and Translational Research, Nationwide Children's Hospital Research Institute JoVE 58237 Immunology and Infection
拡大、精製、及びヒト末梢血NK細胞の機能的評価 Srinivas S. Somanchi1, Vladimir V. Senyukov1, Cecele J. Denman1, Dean A. Lee1 1Division of Pediatrics, MD Anderson Cancer Center - University of Texas JoVE 2540 Immunology and Infection