Derek J. Wilson Department of Chemistry York University Biography Publications Institution JoVE Articles Derek J. Wilson has not added a biography. If you are Derek J. Wilson and would like to personalize this page please email our Author Liaison for assistance. Publications Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif Biochemistry. Dec, 2016 | Pubmed ID: 27959512 Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic Biochemistry. Dec, 2016 | Pubmed ID: 27933795 Hydrogen Deuterium Exchange Mass Spectrometry in Biopharmaceutical Discovery and Development - A Review Analytica Chimica Acta. Oct, 2016 | Pubmed ID: 27662755 Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) As a Probe of Protein Conformation in Solution Journal of the American Society for Mass Spectrometry. Jun, 2016 | Pubmed ID: 26965162 Signal Transducer and Activator of Transcription 3 (STAT3) Inhibitor, S3I-201, Acts As a Potent and Non-selective Alkylating Agent Oncotarget. Apr, 2016 | Pubmed ID: 26942696 Conformational Dynamics and Allostery in Pyruvate Kinase The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26879751 Dimerization of the Type IV Pilin from Pseudomonas Aeruginosa Strain K122-4 Results in Increased Helix Stability As Measured by Time-resolved Hydrogen-deuterium Exchange Structural Dynamics (Melville, N.Y.). Jan, 2016 | Pubmed ID: 26798830 Comparing Equilibrium and Kinetic Protein Unfolding Using Time-resolved Electrospray-coupled Ion Mobility Mass Spectrometry The Analyst. Oct, 2015 | Pubmed ID: 26115375 Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble PloS One. 2015 | Pubmed ID: 25767879 Pre-equilibration Kinetic Size-exclusion Chromatography with Mass Spectrometry Detection (peKSEC-MS) for Label-free Solution-based Kinetic Analysis of Protein-small Molecule Interactions The Analyst. Feb, 2015 | Pubmed ID: 25611307 Unambiguous Characterization of Analytical Markers in Complex, Seized Opiate Samples Using an Enhanced Ion Mobility Trace Detector-mass Spectrometer Analytical Chemistry. Nov, 2014 | Pubmed ID: 25302672 Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25288792 Kinetic Size-exclusion Chromatography with Mass Spectrometry Detection: an Approach for Solution-based Label-free Kinetic Analysis of Protein-small Molecule Interactions Analytical Chemistry. Oct, 2014 | Pubmed ID: 25275785 An Improved Rapid Mixing Device for Time-resolved Electrospray Mass Spectrometry Measurements ChemistryOpen. Jun, 2014 | Pubmed ID: 25050229 Oxidative Protein Labeling with Analysis by Mass Spectrometry for the Study of Structure, Folding, and Dynamics Antioxidants & Redox Signaling. Jul, 2014 | Pubmed ID: 24512178 Characterizing Rapid, Activity-linked Conformational Transitions in Proteins Via Sub-second Hydrogen Deuterium Exchange Mass Spectrometry The FEBS Journal. Nov, 2013 | Pubmed ID: 23663649 Measuring Kinetic Isotope Effects in Enzyme Reactions Using Time-resolved Electrospray Mass Spectrometry Analytical Chemistry. Apr, 2013 | Pubmed ID: 23461634 An Electrospray Ms-coupled Microfluidic Device for Sub-second Hydrogen/deuterium Exchange Pulse-labelling Reveals Allosteric Effects in Enzyme Inhibition Lab on a Chip. Jul, 2013 | Pubmed ID: 23426018 Conformer Selection and Intensified Dynamics During Catalytic Turnover in Chymotrypsin Angewandte Chemie (International Ed. in English). Sep, 2012 | Pubmed ID: 22936643 Time-resolved Mass Spectrometry for Monitoring Millisecond Time-scale Solution-phase Processes European Journal of Mass Spectrometry (Chichester, England). 2012 | Pubmed ID: 22641726 Specific Disruption of Transthyretin(105-115) Fibrilization Using "stabilizing" Inhibitors of Transthyretin Amyloidogenesis Biochemistry. Apr, 2012 | Pubmed ID: 22482799 Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-enabled Subsecond H/D Exchange Mass Spectrometry Analytical Chemistry. Apr, 2012 | Pubmed ID: 22458633 Kinetic Capillary Electrophoresis with Mass-spectrometry Detection (KCE-MS) Facilitates Label-free Solution-based Kinetic Analysis of Protein-small Molecule Binding Chembiochem : a European Journal of Chemical Biology. Nov, 2011 | Pubmed ID: 22012742 Understanding and Optimizing Electrospray Ionization Techniques for Proteomic Analysis Expert Review of Proteomics. Apr, 2011 | Pubmed ID: 21501013 Rational Manipulation of Amyloidogenesis Using an Atomic Level Map of Peptide-fibril Interactions Biochemistry. Jul, 2010 | Pubmed ID: 20560641 A Microfluidic Reactor for Rapid, Low-pressure Proteolysis with On-chip Electrospray Ionization Rapid Communications in Mass Spectrometry : RCM. Feb, 2010 | Pubmed ID: 20049884 Binding Interactions in Early- and Late-stage Amyloid Aggregates of TTR(105-115) Biophysical Chemistry. Sep, 2009 | Pubmed ID: 19501449 A Versatile Microfluidic Chip for Millisecond Time-scale Kinetic Studies by Electrospray Mass Spectrometry Journal of the American Society for Mass Spectrometry. Jan, 2009 | Pubmed ID: 18845447 Hydrogen/deuterium Scrambling During Quadrupole Time-of-flight MS/MS Analysis of a Zinc-binding Protein Domain Analytical Chemistry. Jan, 2007 | Pubmed ID: 17194133 Protein Folding Mechanisms Studied by Time-resolved Electrospray Mass Spectrometry BioTechniques. Feb, 2006 | Pubmed ID: 16526400 Ultrarapid Desalting of Protein Solutions for Electrospray Mass Spectrometry in a Microchannel Laminar Flow Device Analytical Chemistry. Nov, 2005 | Pubmed ID: 16255586 Pulsed Hydrogen Exchange and Electrospray Charge-state Distribution As Complementary Probes of Protein Structure in Kinetic Experiments: Implications for Ubiquitin Folding Biochemistry. Jun, 2005 | Pubmed ID: 15952769 Kinetic Unfolding Mechanism of the Inducible Nitric Oxide Synthase Oxygenase Domain Determined by Time-resolved Electrospray Mass Spectrometry Biochemistry. Feb, 2005 | Pubmed ID: 15709740 Subunit Disassembly and Unfolding Kinetics of Hemoglobin Studied by Time-resolved Electrospray Mass Spectrometry Biochemistry. Nov, 2004 | Pubmed ID: 15544350 Mechanistic Studies on Enzymatic Reactions by Electrospray Ionization MS Using a Capillary Mixer with Adjustable Reaction Chamber Volume for Time-resolved Measurements Analytical Chemistry. May, 2004 | Pubmed ID: 15117195 A Capillary Mixer with Adjustable Reaction Chamber Volume for Millisecond Time-resolved Studies by Electrospray Mass Spectrometry Analytical Chemistry. Dec, 2003 | Pubmed ID: 16465695 Zeitaufgelöste Elektrospray-Ionisations Wasserstoff-Deuterium-Austausch-Massenspektrometrie zur Struktur Protein Studium und Dynamik Cristina Lento1, Shaolong Zhu1, Kerene A. Brown1, Ruth Knox1, Peter Liuni1, Derek J. Wilson1,2,3 1Department of Chemistry, York University, 2The Centre for Research in Mass Spectrometry, York University, 3The Centre for Research on Biomolecular Interactions, York University JoVE 55464 Biochemistry
Zeitaufgelöste Elektrospray-Ionisations Wasserstoff-Deuterium-Austausch-Massenspektrometrie zur Struktur Protein Studium und Dynamik Cristina Lento1, Shaolong Zhu1, Kerene A. Brown1, Ruth Knox1, Peter Liuni1, Derek J. Wilson1,2,3 1Department of Chemistry, York University, 2The Centre for Research in Mass Spectrometry, York University, 3The Centre for Research on Biomolecular Interactions, York University JoVE 55464 Biochemistry