Dirk Grimm Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty University of Heidelberg Biography Publications Institution JoVE Articles Dirk Grimm has not added a biography. If you are Dirk Grimm and would like to personalize this page please email our Author Liaison for assistance. Publications Determination of AAV Properties by Single Amino Acids: Go(o)d is in the Details Molecular Therapy. Methods & Clinical Development. Dec, 2022 | Pubmed ID: 36212908 Semirational Bioengineering of AAV Vectors with Increased Potency and Specificity for Systemic Gene Therapy of Muscle Disorders Science Advances. 09, 2022 | Pubmed ID: 36129972 In Vivo Adenine Base Editing Reverts C282Y and Improves Iron Metabolism in Hemochromatosis Mice Nature Communications. 09, 2022 | Pubmed ID: 36064805 Boosters for Adeno-associated Virus Vector (AAV) (r)evolution Cytotherapy. Aug, 2022 | Pubmed ID: 35999132 Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning Pathogens (Basel, Switzerland). Jul, 2022 | Pubmed ID: 35890005 Intranasal Application of Adeno-associated Viruses: a Systematic Review Translational Research : the Journal of Laboratory and Clinical Medicine. Oct, 2022 | Pubmed ID: 35597541 Identification of Adeno-associated Virus Variants for Gene Transfer into Human Neural Cell Types by Parallel Capsid Screening Scientific Reports. 05, 2022 | Pubmed ID: 35589936 Right on Target: The Next Class of Efficient, Safe, and Specific RNAi Triggers Molecular Therapy. Nucleic Acids. Jun, 2022 | Pubmed ID: 35505965 Natural Killer Cells Act As an Extrinsic Barrier for in Vivo Reprogramming Development (Cambridge, England). 04, 2022 | Pubmed ID: 35420133 Ex vivo and In vivo Suppression of SARS-CoV-2 with Combinatorial AAV/RNAi Expression Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. 05, 2022 | Pubmed ID: 35038579 An RNA Interference/Adeno-Associated Virus Vector-Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus Hepatology Communications. 04, 2022 | Pubmed ID: 34719133 Breaking the Sound Barrier: Towards Next-generation AAV Vectors for Gene Therapy of Hearing Disorders Hearing Research. 01, 2022 | Pubmed ID: 33268240 Cas9-specific Immune Responses Compromise Local and Systemic AAV CRISPR Therapy in Multiple Dystrophic Canine Models Nature Communications. 11, 2021 | Pubmed ID: 34819506 Adeno-Associated Viruses (AAV) and Host Immunity - A Race Between the Hare and the Hedgehog Frontiers in Immunology. 2021 | Pubmed ID: 34777364 Lentiviral and Adeno-associated Vectors Efficiently Transduce Mouse T Lymphocytes when Targeted to Murine CD8 Molecular Therapy. Methods & Clinical Development. Dec, 2021 | Pubmed ID: 34729380 Neutralizing Antibody Evasion and Transduction with Purified Extracellular Vesicle-Enveloped Adeno-Associated Virus Vectors Human Gene Therapy. 12, 2021 | Pubmed ID: 34445894 The Angiopoietin-Tie2 Pathway Regulates Purkinje Cell Dendritic Morphogenesis in a Cell-autonomous Manner Cell Reports. 08, 2021 | Pubmed ID: 34407407 Membrane-destabilizing Ionizable Phospholipids: Novel Components for Organ-selective MRNA Delivery and CRISPR-Cas Gene Editing Signal Transduction and Targeted Therapy. 05, 2021 | Pubmed ID: 34035211 A Versatile In Vivo System to Study Myc in Cell Reprogramming Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34019296 Best of Most Possible Worlds: Hybrid Gene Therapy Vectors Based on Parvoviruses and Heterologous Viruses Molecular Therapy : the Journal of the American Society of Gene Therapy. 12, 2021 | Pubmed ID: 33831556 Characterization of the GBoV1 Capsid and Its Antibody Interactions Viruses. 02, 2021 | Pubmed ID: 33672786 A Universal Protocol for Isolating Retinal ON Bipolar Cells Across Species Via Fluorescence-activated Cell Sorting Molecular Therapy. Methods & Clinical Development. Mar, 2021 | Pubmed ID: 33665228 'Hit and Run' Therapy Averts Macular Degeneration Nature Biomedical Engineering. 02, 2021 | Pubmed ID: 33580229 Optogenetic Control of Neisseria Meningitidis Cas9 Genome Editing Using an Engineered, Light-switchable Anti-CRISPR Protein Nucleic Acids Research. 03, 2021 | Pubmed ID: 33330940 Production, Processing, and Characterization of Synthetic AAV Gene Therapy Vectors Biotechnology Journal. Jan, 2021 | Pubmed ID: 32975881 Identification of a Myotropic AAV by Massively Parallel in Vivo Evaluation of Barcoded Capsid Variants Nature Communications. 10, 2020 | Pubmed ID: 33116134 Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 32651911 Computational Design of Anti-CRISPR Proteins with Improved Inhibition Potency Nature Chemical Biology. 07, 2020 | Pubmed ID: 32284602 Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity Journal of Virology. 05, 2020 | Pubmed ID: 32213611 Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening Molecular Therapy : the Journal of the American Society of Gene Therapy. 04, 2020 | Pubmed ID: 32105604 Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template IScience. Jan, 2020 | Pubmed ID: 31887661 Distinct Transduction of Muscle Tissue in Mice After Systemic Delivery of AAVpo1 Vectors Gene Therapy. 04, 2020 | Pubmed ID: 31624368 Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome The Pediatric Infectious Disease Journal. 09, 2019 | Pubmed ID: 31033910 Cell-specific CRISPR-Cas9 Activation by MicroRNA-dependent Expression of Anti-CRISPR Proteins Nucleic Acids Research. 07, 2019 | Pubmed ID: 30982889 Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30912043 Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses Molecular Therapy. Methods & Clinical Development. Mar, 2019 | Pubmed ID: 30766894 A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses ACS Synthetic Biology. 01, 2019 | Pubmed ID: 30513195 Impact of the Assembly-Activating Protein on Molecular Evolution of Synthetic Adeno-Associated Virus Capsids Human Gene Therapy. 01, 2019 | Pubmed ID: 29978729 Engineered Anti-CRISPR Proteins for Optogenetic Control of CRISPR-Cas9 Nature Methods. 11, 2018 | Pubmed ID: 30377362 AAVvector-mediated in Vivo Reprogramming into Pluripotency Nature Communications. 07, 2018 | Pubmed ID: 29985406 High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious Journal of Molecular Biology. 08, 2018 | Pubmed ID: 29782834 Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology Biotechnology Journal. Sep, 2018 | Pubmed ID: 29316283 Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1 Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 29379413 Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution Human Gene Therapy. 11, 2017 | Pubmed ID: 28835125 Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells Journal of Virology. 10, 2017 | Pubmed ID: 28768875 Next-generation AAV Vectors for Clinical Use: an Ever-accelerating Race Virus Genes. Oct, 2017 | Pubmed ID: 28762205 Plasmodium Berghei EXP-1 Interacts with Host Apolipoprotein H During Plasmodium Liver-stage Development Proceedings of the National Academy of Sciences of the United States of America. Feb, 2017 | Pubmed ID: 28137845 TALEN/CRISPR-mediated Engineering of a Promoterless Anti-viral RNAi Hairpin into an Endogenous MiRNA Locus Nucleic Acids Research. 01, 2017 | Pubmed ID: 27614072 Blocking Sense-strand Activity Improves Potency, Safety and Specificity of Anti-hepatitis B Virus Short Hairpin RNA EMBO Molecular Medicine. 09, 2016 | Pubmed ID: 27473329 Death Receptor-based Enrichment of Cas9-expressing Cells BMC Biotechnology. Feb, 2016 | Pubmed ID: 26883910 Zinc Finger Nuclease-based Double-strand Breaks Attenuate Malaria Parasites and Reveal Rare Microhomology-mediated End Joining Genome Biology. Nov, 2015 | Pubmed ID: 26573820 AAV8-mediated in Vivo Overexpression of MiR-155 Enhances the Protective Capacity of Genetically Attenuated Malarial Parasites Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2014 | Pubmed ID: 25189739 포유류 Argonaute 단백질 유전자 침묵 중재에 식 결정 요인 Nucleic Acids Research. Dec, 2011 | Pubmed ID: 22210886 마우스 간 항상성 및 재생성에 성숙한 Hepatocytes의 운명 추적 The Journal of Clinical Investigation. Dec, 2011 | Pubmed ID: 22105172 복용량 독을 만들 수 있습니다: RNAi Overexpression으로 인 한 불리 한 in Vivo 독성에서 배운 교훈 Silence. 2011 | Pubmed ID: 22029761 가, 또는 안가 고, 그것은 질문-경력 및 생활 6 개인 반사 어떻게 지리적 이동성에 영향을 수 있습니다 BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Oct, 2011 | Pubmed ID: 21858845 셀룰러 네트워크는 제어 부족: 글로벌 Dysregulation 인간의 병 리와 치료에 RNAi 기계 Progress in Molecular Biology and Translational Science. 2011 | Pubmed ID: 21846572 세포질 RNA 간섭 메커니즘입니다. 서 문입니다 Progress in Molecular Biology and Translational Science. 2011 | Pubmed ID: 21846566 작은 머리 핀 Rnas의 열역학적 안정성 높은 다른 포유류 Argonautes의 로딩 프로세스를 영향을 줍니다 Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21576459 Argonaute 단백질 RNAi 효능, 독성, 그리고 성인 마우스 간에서 지 속성에 대 한 주요 결정 요인이.입니다 The Journal of Clinical Investigation. Sep, 2010 | Pubmed ID: 20697157 41 명의 호스트와 6 개의 RNA 바이러스: 바이러스 성 작은 Rnas와 작은 RNA 범유럽 척추 동물 및 무척 추 동물 시스템의 변조 PLoS Pathogens. Feb, 2010 | Pubmed ID: 20169186 낮은 수준의 ShRNA 세포 독성 성인 쥐에 있는 MYC 유도 된 간세포 암 종에 기여할 수 있다 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2010 | Pubmed ID: 19844192 작은 입을 RNAs: 최신의 Advanced Drug Delivery Reviews. Jul, 2009 | Pubmed ID: 19427885 조직 관련 투표 소 2 차 발기인에서 ShRNA 표현의 효과적이 고 안전한 RNAi 치료입니다 Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2008 | Pubmed ID: 18665161 간장 지방산 운송업 자 단백질 5 in Vivo의 입을 다이어트 유발 비 알코올 지방산 간 질환을 취소 하 고 혈당을 향상 시킵니다 The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18524776 교배 및 Adeno 관련 바이러스의 로직에서 Multispecies 통해 체 외 in Vivo 유전자 치료 벡터 진화 Journal of Virology. Jun, 2008 | Pubmed ID: 18400866 간장 Parenchymal 대체 이식된 Allogeneic Hepatocytes에 의해 쥐에 있는 골 수 이식 용이 하 게 하 고 CD4 세포에 의해 중재 Hepatology (Baltimore, Md.). Feb, 2008 | Pubmed ID: 18220289 Rnai의 치료 응용 프로그램: 마지막으로 황금 시간대에 대 한 준비를 대상으로 하는 Mrna는? The Journal of Clinical Investigation. Dec, 2007 | Pubmed ID: 18060021 RNAi 및 유전자 치료: 상호적인 매력 Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2007 | Pubmed ID: 18024667 망막 색소 상피에 생 유전자의 신속 하 고 안정적인 최저 Human Gene Therapy. Oct, 2007 | Pubmed ID: 17892416 조합 RNAi: 진화 하는 대상에 대 한 경주에 대 한 승리 전략? Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2007 | Pubmed ID: 17311009 2 하이브리드 화면 Adeno 제휴해 바이러스 2와 8에 대 한 Uncoating 요인으로 B와 L Cathepsins를 식별합니다 Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2007 | Pubmed ID: 17235311 37/67-Kilodalton Laminin 수용 체 Adeno 제휴해 바이러스 Serotypes 8, 2, 3, 및 9에 대 한 수용 체가 이다 Journal of Virology. Oct, 2006 | Pubmed ID: 16973587 생쥐 세포 MicroRNA/짧은 헤어핀 RNA 통로의 Oversaturation 때문에 사망자 Nature. May, 2006 | Pubmed ID: 16724069 심장 유전자 이동을 Transcriptional 및 Transductional Adeno 제휴해 바이러스 성 벡터의 대상으로 하 여 향상 되었습니다 Cardiovascular Research. Apr, 2006 | Pubmed ID: 16448634 간 변환 재조합 Adeno 제휴해 바이러스는 주로 제한 Capsid, Serotype 하지 유전자 형 벡터 Journal of Virology. Jan, 2006 | Pubmed ID: 16352567 플라스 미드 시퀀스 생체 조건에서 식 카세트의 절단에 의해 유지 관리 및 Transgenes의 지 속성을 증가 했다 Human Gene Therapy. May, 2005 | Pubmed ID: 15916481 짧은 헤어핀 RNA 식 Adeno 제휴해 바이러스 벡터 Methods in Enzymology. 2005 | Pubmed ID: 15644194 Pseudotyped Adeno 제휴해 바이러스 벡터 간 유전자 치료에 대 한 전 임상 생체 조건 평가 Blood. Oct, 2003 | Pubmed ID: 12791653 도우미 바이러스 무료, 광학 제어 및 2 플라스 미드 기반의 생산 Serotypes 1 ~ 6의 Adeno 제휴해 바이러스 벡터의 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2003 | Pubmed ID: 12788658 유전자에 대 한 생산 방법 Adeno 제휴해 바이러스 Serotypes 기반 벡터를 전송 Methods (San Diego, Calif.). Oct, 2002 | Pubmed ID: 12413413 기본 인간의 세포 RAAV 2 중재 유전자 이동 및 리포터 유전자 발현의 기간에 그들의 자화 율에 차이가 있습니다 Journal of Virological Methods. Sep, 2002 | Pubmed ID: 12270659 아데노 관련 바이러스(AAV) 캡시드 변이체의 엔지니어링, 바코드 및 스크리닝을 통한 차세대 유전자 치료 벡터의 분리 Kleopatra Rapti1,2, Olena Maiakovska1,2, Jonas Becker1,2, Joanna Szumska1,2, Margarita Zayas1,2, Felix Bubeck1,2, Jixin Liu1,2, Emma Gerstmann1,2, Chiara Krämer1,2, Ellen Wiedtke1,2, Dirk Grimm1,2,3,4,5 1Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, 2BioQuant Center, BQ0030, University of Heidelberg, 3Cluster of Excellence CellNetworks, 4German Center for Infection Research (DZIF), 5German Center for Cardiovascular Research (DZHK) JoVE 64389 Bioengineering 유전자 가족 걸어갔다 통해 공학 및 합성 Adeno-관련 바이러스의 진화 (AAV) 유전자 치료 벡터 Eike Kienle*1, Elena Senís*1, Kathleen Börner2, Dominik Niopek1, Ellen Wiedtke1, Stefanie Grosse1, Dirk Grimm1 1Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University, 2Department of Infectious Diseases, Virology, Heidelberg University JoVE 3819 Immunology and Infection
아데노 관련 바이러스(AAV) 캡시드 변이체의 엔지니어링, 바코드 및 스크리닝을 통한 차세대 유전자 치료 벡터의 분리 Kleopatra Rapti1,2, Olena Maiakovska1,2, Jonas Becker1,2, Joanna Szumska1,2, Margarita Zayas1,2, Felix Bubeck1,2, Jixin Liu1,2, Emma Gerstmann1,2, Chiara Krämer1,2, Ellen Wiedtke1,2, Dirk Grimm1,2,3,4,5 1Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, 2BioQuant Center, BQ0030, University of Heidelberg, 3Cluster of Excellence CellNetworks, 4German Center for Infection Research (DZIF), 5German Center for Cardiovascular Research (DZHK) JoVE 64389 Bioengineering
유전자 가족 걸어갔다 통해 공학 및 합성 Adeno-관련 바이러스의 진화 (AAV) 유전자 치료 벡터 Eike Kienle*1, Elena Senís*1, Kathleen Börner2, Dominik Niopek1, Ellen Wiedtke1, Stefanie Grosse1, Dirk Grimm1 1Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University, 2Department of Infectious Diseases, Virology, Heidelberg University JoVE 3819 Immunology and Infection
