Edward R. O'Brien

Libin Cardiovascular Institute of Alberta

University of Calgary

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Publications

Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality Via Cathepsin B: a Novel Therapeutic Opportunity for Arterial Repair
Diabetes. Apr, 2014 | Pubmed ID: 24296714
Circulating Endothelial Progenitor Cells and In-stent Restenosis: Friend, Foe, or None of the Above?
The Canadian Journal of Cardiology. Jan, 2014 | Pubmed ID: 24290519
The Evolution of Coronary Stents: a Brief Review
The Canadian Journal of Cardiology. Jan, 2014 | Pubmed ID: 24286961
Giant Saphenous Vein Graft Aneurysm Presenting As ST-elevation Myocardial Infarction
Circulation Journal : Official Journal of the Japanese Circulation Society. 2014 | Pubmed ID: 24284922
Heat Shock Protein 27 Attenuates Neointima Formation and Accelerates Reendothelialization After Arterial Injury and Stent Implantation: Importance of Vascular Endothelial Growth Factor Up-regulation
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2014 | Pubmed ID: 24142570
Heat Shock Protein-27 Attenuates Foam Cell Formation and Atherogenesis by Down-regulating Scavenger Receptor-A Expression Via NF-κB Signaling
Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 23939398
The Effect of Statins on Circulating Endothelial Progenitor Cells in Humans: a Systematic Review
Journal of Cardiovascular Pharmacology. Nov, 2013 | Pubmed ID: 23933855
Serum Heat Shock Protein 27 Levels Represent a Potential Therapeutic Target for Atherosclerosis: Observations from a Human Cohort and Treatment of Female Mice
Journal of the American College of Cardiology. Oct, 2013 | Pubmed ID: 23764828
Response to Letter Regarding Article, "Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry"
Circulation. Cardiovascular Interventions. Apr, 2013 | Pubmed ID: 23591426
Neuroimmune Guidance Cue Semaphorin 3E is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention
Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2013 | Pubmed ID: 23430613
Chronic Over-expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: a Combined Histological and Mechanical Assessment of Aortic Lesions
PloS One. 2013 | Pubmed ID: 23409070
Circulating Endothelial Progenitor Cells in HIV Infection: a Systematic Review
Trends in Cardiovascular Medicine. Aug, 2013 | Pubmed ID: 23395428
Extracellular HSP27 Acts As a Signaling Molecule to Activate NF-κB in Macrophages
Cell Stress & Chaperones. Jan, 2013 | Pubmed ID: 22851137
Percutaneous Coronary Intervention with or Without On-site Coronary Artery Bypass Surgery: a Systematic Review and Meta-analysis
International Journal of Cardiology. Jul, 2013 | Pubmed ID: 22240768
Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry
Circulation. Cardiovascular Interventions. Dec, 2012 | Pubmed ID: 23149331
Natural History and Management of Aortocoronary Saphenous Vein Graft Aneurysms: a Systematic Review of Published Cases
Circulation. Oct, 2012 | Pubmed ID: 23109515
Reduction in Mortality As a Result of Direct Transport from the Field to a Receiving Center for Primary Percutaneous Coronary Intervention
Journal of the American College of Cardiology. Oct, 2012 | Pubmed ID: 23017532
Transradial Versus Transfemoral Artery Approach for Coronary Angiography and Percutaneous Coronary Intervention in the Extremely Obese
JACC. Cardiovascular Interventions. Aug, 2012 | Pubmed ID: 22917453
Transbrachial Insertion of an Intra-aortic Balloon Pump for High-risk Percutaneous Coronary Intervention
Clinical Research in Cardiology : Official Journal of the German Cardiac Society. Oct, 2012 | Pubmed ID: 22552835
Infective Endocarditis Presenting As ST-elevation Myocardial Infarction: an Angiographic Diagnosis
The Canadian Journal of Cardiology. Jul-Aug, 2012 | Pubmed ID: 22381910
Circulating Endothelial Progenitor Cell Levels Are Not Reduced in HIV-infected Men
The Journal of Infectious Diseases. Mar, 2012 | Pubmed ID: 22238473
Coronary Stent Fracture
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Aug, 2011 | Pubmed ID: 21444617
Pre-procedural Atorvastatin Mobilizes Endothelial Progenitor Cells: Clues to the Salutary Effects of Statins on Healing of Stented Human Arteries
PloS One. 2011 | Pubmed ID: 21283543
Cardiovascular Complications of Salmonella Enteritidis Infection
The Canadian Journal of Cardiology. Oct, 2010 | Pubmed ID: 20931102
Heat Shock Protein 27: Clue to Understanding Estrogen-mediated Atheroprotection?
Trends in Cardiovascular Medicine. Feb, 2010 | Pubmed ID: 20656216
Delayed Re-endothelialization with Rapamycin-coated Stents is Rescued by the Addition of a Glycogen Synthase Kinase-3beta Inhibitor
Cardiovascular Research. May, 2010 | Pubmed ID: 20167573
Primary Percutaneous Coronary Angioplasty with and Without Eptifibatide in ST-segment Elevation Myocardial Infarction: a Safety and Efficacy Study of Integrilin-facilitated Versus Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction (ASSIST)
Circulation. Cardiovascular Interventions. Aug, 2009 | Pubmed ID: 20031736
Heat Shock Protein 27 Protects Against Atherogenesis Via an Estrogen-dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation
Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2009 | Pubmed ID: 19729610
Inhibition of Endothelial Progenitor Cell Glycogen Synthase Kinase-3beta Results in Attenuated Neointima Formation and Enhanced Re-endothelialization After Arterial Injury
Cardiovascular Research. Jul, 2009 | Pubmed ID: 19454488
Extracellular Release of the Atheroprotective Heat Shock Protein 27 is Mediated by Estrogen and Competitively Inhibits AcLDL Binding to Scavenger Receptor-A
Circulation Research. Jul, 2008 | Pubmed ID: 18566345
Letter by Hibbert Et Al Regarding Article, "Smooth Muscle Cells Healing Atherosclerotic Plaque Disruptions Are of Local, Not Blood, Origin in Apolipoprotein E Knockout Mice"
Circulation. Apr, 2008 | Pubmed ID: 18427139
Contribution of Recipient-derived Cells in Allograft Neointima Formation and the Response to Stent Implantation
PloS One. 2008 | Pubmed ID: 18365026
A Citywide Protocol for Primary PCI in ST-segment Elevation Myocardial Infarction
The New England Journal of Medicine. Jan, 2008 | Pubmed ID: 18199862
Discovery of NM23-H2 As an Estrogen Receptor Beta-associated Protein: Role in Estrogen-induced Gene Transcription and Cell Migration
The Journal of Steroid Biochemistry and Molecular Biology. Jan, 2008 | Pubmed ID: 17964137
The Interaction and Cellular Localization of HSP27 and ERbeta Are Modulated by 17beta-estradiol and HSP27 Phosphorylation
Molecular and Cellular Endocrinology. May, 2007 | Pubmed ID: 17350752
NM23-H2, an Estrogen Receptor Beta-associated Protein, Shows Diminished Expression with Progression of Atherosclerosis
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Feb, 2007 | Pubmed ID: 17272673
Comparison of Early Mortality of Paramedic-diagnosed ST-segment Elevation Myocardial Infarction with Immediate Transport to a Designated Primary Percutaneous Coronary Intervention Center to That of Similar Patients Transported to the Nearest Hospital
The American Journal of Cardiology. Nov, 2006 | Pubmed ID: 17134623
Comparison of Processing and Sectioning Methodologies for Arteries Containing Metallic Stents
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jun, 2006 | Pubmed ID: 16714423
Regulation of Components of the Brain and Cardiac Renin-angiotensin Systems by 17beta-estradiol After Myocardial Infarction in Female Rats
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2006 | Pubmed ID: 16455770
Combined Angioplasty and Pharmacological Intervention Versus Thrombolysis Alone in Acute Myocardial Infarction (CAPITAL AMI Study)
Journal of the American College of Cardiology. Aug, 2005 | Pubmed ID: 16053952
Modulation of Estrogen Signaling by the Novel Interaction of Heat Shock Protein 27, a Biomarker for Atherosclerosis, and Estrogen Receptor Beta: Mechanistic Insight into the Vascular Effects of Estrogens
Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2005 | Pubmed ID: 15662019
17beta-estradiol Downregulates Tissue Angiotensin-converting Enzyme and ANG II Type 1 Receptor in Female Rats
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2005 | Pubmed ID: 15550614
Novel Antiinflammatory Vascular Benefits of Systemic and Stent-based Delivery of Ethylisopropylamiloride
Circulation. Dec, 2004 | Pubmed ID: 15505102
C-kit-immunopositive Vascular Progenitor Cells Populate Human Coronary In-stent Restenosis but Not Primary Atherosclerotic Lesions
American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2004 | Pubmed ID: 15277195
Antagonism of the Alpha4 Integrin Subunit Attenuates the Acute Inflammatory Response to Stent Implantation Yet is Insufficient to Prevent Late Intimal Formation
Journal of Leukocyte Biology. Jun, 2004 | Pubmed ID: 15020653
Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction: Cost Analysis of the Canadian STAT Study
Circulation. Nov, 2003 | Pubmed ID: 14597591

A Novel Stretching plattform for applikasjoner i celler og vev mechanobiology

Dominique Tremblay¹, Charles M. Cuerrier^1,2, Lukasz Andrzejewski¹, Edward R. O'Brien³, Andrew E. Pelling^1,4,5

¹Centre for Interdisciplinary NanoPhysics, Department of Physics, University of Ottawa, ²University of Ottawa Heart Institue, University of Ottawa, ³Libin Cardiovascular Institute of Alberta, University of Calgary, ⁴Department of Biology, University of Ottawa, ⁵Institute for Science, Society and Policy, University of Ottawa

JoVE 51454

Dr. Edward R. O'Brien has not added a biography.

Publications

A Novel Stretching plattform for applikasjoner i celler og vev mechanobiology

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