Eric B. Kmiec Gene Editing Institute, Helen F. Graham Cancer Center and Research Institute Christiana Care Health Services Biography Publications Institution JoVE Articles Eric B. Kmiec has not added a biography. If you are Eric B. Kmiec and would like to personalize this page please email our Author Liaison for assistance. Publications CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome Molecular Therapy. Nucleic Acids. Jun, 2017 | Pubmed ID: 28624204 To Cleave or Not to Cleave: Therapeutic Gene Editing with and Without Programmable Nucleases Nature Reviews. Drug Discovery. Apr, 2017 | Pubmed ID: 28303022 Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides PloS One. 2017 | Pubmed ID: 28052104 Analyses of Point Mutation Repair and Allelic Heterogeneity Generated by CRISPR/Cas9 and Single-stranded DNA Oligonucleotides Scientific Reports. Sep, 2016 | Pubmed ID: 27609304 Genetic Spell-checking: Gene Editing Using Single-stranded DNA Oligonucleotides Plant Biotechnology Journal. Feb, 2016 | Pubmed ID: 26402400 Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems PloS One. 2015 | Pubmed ID: 26053390 Is the Age of Genetic Surgery Finally Upon Us? Surgical Oncology. Jun, 2015 | Pubmed ID: 25936245 The Position of DNA Cleavage by TALENs and Cell Synchronization Influences the Frequency of Gene Editing Directed by Single-stranded Oligonucleotides PloS One. 2014 | Pubmed ID: 24788536 Enrichment of Breast Cancer Stem-like Cells by Growth on Electrospun Polycaprolactone-chitosan Nanofiber Scaffolds International Journal of Nanomedicine. 2014 | Pubmed ID: 24570583 Combinatorial Gene Editing in Mammalian Cells Using SsODNs and TALENs Scientific Reports. Jan, 2014 | Pubmed ID: 24445749 Electrospun Fiber Membranes Enable Proliferation of Genetically Modified Cells International Journal of Nanomedicine. 2013 | Pubmed ID: 23467983 DNA Damage Response Pathway and Replication Fork Stress During Oligonucleotide Directed Gene Editing Molecular Therapy. Nucleic Acids. Apr, 2012 | Pubmed ID: 23343929 Proliferation of Genetically Modified Human Cells on Electrospun Nanofiber Scaffolds Molecular Therapy. Nucleic Acids. 2012 | Pubmed ID: 23212298 Oligonucleotide Delivery by Nucleofection Does Not Rescue the Reduced Proliferation Phenotype of Gene-edited Cells Nucleic Acid Therapeutics. Dec, 2012 | Pubmed ID: 23072627 Modifications of P53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin Journal of Molecular Neuroscience : MN. Oct, 2011 | Pubmed ID: 21465263 Strand Bias Influences the Mechanism of Gene Editing Directed by Single-stranded DNA Oligonucleotides Nucleic Acids Research. Jun, 2011 | Pubmed ID: 21343181 Gene Editing Activity on Extrachromosomal Arrays in C. Elegans Transgenics Gene. Apr, 2011 | Pubmed ID: 21241788 A Stable G-quartet Binds to a Huntingtin Protein Fragment Containing Expanded Polyglutamine Tracks Journal of Neuroscience Research. Feb, 2010 | Pubmed ID: 19705452 DNA Breakage Associated with Targeted Gene Alteration Directed by DNA Oligonucleotides Mutation Research. Oct, 2009 | Pubmed ID: 19463835 Regulation of Targeted Gene Repair by Intrinsic Cellular Processes BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2009 | Pubmed ID: 19204988 DNA Breakage and Induction of DNA Damage Response Proteins Precede the Appearance of Visible Mutant Huntingtin Aggregates Journal of Neuroscience Research. Feb, 2009 | Pubmed ID: 18831068 DNA Replication, Cell Cycle Progression and the Targeted Gene Repair Reaction Cell Cycle (Georgetown, Tex.). May, 2008 | Pubmed ID: 18424915 G-rich Oligonucleotides Alter Cell Cycle Progression and Induce Apoptosis Specifically in OE19 Esophageal Tumor Cells Oligonucleotides. 2008 | Pubmed ID: 18321162 Genetic Conversion of an SMN2 Gene to SMN1: a Novel Approach to the Treatment of Spinal Muscular Atrophy Experimental Cell Research. Feb, 2008 | Pubmed ID: 18078930 Recovery of Cell Cycle Delay Following Targeted Gene Repair by Oligonucleotides DNA Repair. Oct, 2007 | Pubmed ID: 17560837 Manipulation of Cell Cycle Progression Can Counteract the Apparent Loss of Correction Frequency Following Oligonucleotide-directed Gene Repair BMC Molecular Biology. Feb, 2007 | Pubmed ID: 17284323 Reduction of Gene Repair by Selenomethionine with the Use of Single-stranded Oligonucleotides BMC Molecular Biology. Jan, 2007 | Pubmed ID: 17257432 Multiple Roles for MSH2 in the Repair of a Deletion Mutation Directed by Modified Single-stranded Oligonucleotides Gene. Jan, 2007 | Pubmed ID: 17113727 Targeted Gene Repair Activates Chk1 and Chk2 and Stalls Replication in Corrected Cells DNA Repair. Apr, 2006 | Pubmed ID: 16414312 A Tolerance of DNA Heterology in the Mammalian Targeted Gene Repair Reaction Oligonucleotides. 2005 | Pubmed ID: 16201904 Reaction Parameters of Targeted Gene Repair in Mammalian Cells Molecular Biotechnology. Mar, 2005 | Pubmed ID: 15767697 Gene Repair in Mammalian Cells is Stimulated by the Elongation of S Phase and Transient Stalling of Replication Forks DNA Repair. Apr, 2005 | Pubmed ID: 15725625 Fluorescent Detection and Isolation of DNA Variants Using Stabilized RecA-coated Oligonucleotides Discovery Medicine. Apr, 2004 | Pubmed ID: 20705000 Double Displacement Loops (double D-loops) Are Templates for Oligonucleotide-directed Mutagenesis and Gene Repair Oligonucleotides. 2004 | Pubmed ID: 15665595 Camptothecin Enhances the Frequency of Oligonucleotide-directed Gene Repair in Mammalian Cells by Inducing DNA Damage and Activating Homologous Recombination Nucleic Acids Research. 2004 | Pubmed ID: 15466591 Modified Single-stranded Oligonucleotides Inhibit Aggregate Formation and Toxicity Induced by Expanded Polyglutamine Journal of Molecular Neuroscience : MN. 2004 | Pubmed ID: 15456939 Enhanced Oligonucleotide-directed Gene Targeting in Mammalian Cells Following Treatment with DNA Damaging Agents Experimental Cell Research. Oct, 2004 | Pubmed ID: 15383324 DNA Replication and Transcription Direct a DNA Strand Bias in the Process of Targeted Gene Repair in Mammalian Cells Journal of Cell Science. Aug, 2004 | Pubmed ID: 15265980 Genetic Re-engineering of Saccharomyces Cerevisiae RAD51 Leads to a Significant Increase in the Frequency of Gene Repair in Vivo Nucleic Acids Research. 2004 | Pubmed ID: 15087488 Enhancement of in Vivo Targeted Nucleotide Exchange by Nonspecific Carrier DNA Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 14769964 Fluorescent Detection and Isolation of DNA Variants Using Stabilized RecA-coated Oligonucleotides Genome Research. Jan, 2004 | Pubmed ID: 14672976 The Effect of Hydroxyurea and Trichostatin a on Targeted Nucleotide Exchange in Yeast and Mammalian Cells Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 14751821 Reduction of Htt Inclusion Formation in Strains of Saccharomyces Cerevisiae Deficient in Certain DNA Repair Functions: a Statistical Analysis of Phenotype Experimental Cell Research. Nov, 2003 | Pubmed ID: 14597407 Nuclease Activity of Saccharomyces Cerevisiae Mre11 Functions in Targeted Nucleotide Alteration Applied and Environmental Microbiology. Oct, 2003 | Pubmed ID: 14532083 Targeted Nucleotide Exchange in the CAG Repeat Region of the Human HD Gene Biochemical and Biophysical Research Communications. Oct, 2003 | Pubmed ID: 14521962 Targeted Gene Repair -- in the Arena The Journal of Clinical Investigation. Sep, 2003 | Pubmed ID: 12952907 The Development and Regulation of Gene Repair Nature Reviews. Genetics. Sep, 2003 | Pubmed ID: 12951569 Targeted Nucleotide Repair of Cyc1 Mutations in Saccharomyces Cerevisiae Directed by Modified Single-stranded DNA Oligonucleotides Genetics. Feb, 2003 | Pubmed ID: 12618392 The Synaptic Complex of RecA Protein Participates in Hybridization and Inverse Strand Exchange Reactions Biochemistry. Mar, 2003 | Pubmed ID: 12614159 Efficiency of Chimeraplast Gene Targeting by Direct Nuclear Injection Using a GFP Recovery Assay Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2003 | Pubmed ID: 12597913 DNA Pairing is an Important Step in the Process of Targeted Nucleotide Exchange Nucleic Acids Research. Feb, 2003 | Pubmed ID: 12560486 Nucleotide Replacement at Two Sites Can Be Directed by Modified Single-stranded Oligonucleotides in Vitro and in Vivo Biomolecular Engineering. Jan, 2003 | Pubmed ID: 12485680 Targeted Nucleotide Exchange in Saccharomyces Cerevisiae Directed by Short Oligonucleotides Containing Locked Nucleic Acids Chemistry & Biology. Oct, 2002 | Pubmed ID: 12401492 Rad51p and Rad54p, but Not Rad52p, Elevate Gene Repair in Saccharomyces Cerevisiae Directed by Modified Single-stranded Oligonucleotide Vectors Nucleic Acids Research. Jul, 2002 | Pubmed ID: 12087156 The 'biased' Evolution of Targeted Gene Repair Current Opinion in Molecular Therapeutics. Apr, 2002 | Pubmed ID: 12044039 Strand Bias in Targeted Gene Repair is Influenced by Transcriptional Activity Molecular and Cellular Biology. Jun, 2002 | Pubmed ID: 11997519 Targeted Gene Repair and Its Application to Neurodegenerative Disorders Neuron. Feb, 2002 | Pubmed ID: 11856524 Стандартная методология для изучения на месте мутагенность как функция Точечная мутация ремонта, катализируемые ТРИФОСФАТЫ/Cas9 и SsODN в клетках человека Natalia Rivera-Torres1,2, Eric B. Kmiec1,2 1Gene Editing Institute, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health Services, 2Department of Medical Sciences, University of Delaware JoVE 56195 Genetics
Стандартная методология для изучения на месте мутагенность как функция Точечная мутация ремонта, катализируемые ТРИФОСФАТЫ/Cas9 и SsODN в клетках человека Natalia Rivera-Torres1,2, Eric B. Kmiec1,2 1Gene Editing Institute, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health Services, 2Department of Medical Sciences, University of Delaware JoVE 56195 Genetics
