Articles by Erin Hussey in JoVE
Het onderzoeken van de Kenmerken van episodisch geheugen met behulp van Event-related potentials bij patiënten met de ziekte van Alzheimer Erin Hussey1, Brandon Ally1 1Department of Neurology, Vanderbilt University De methodologie voor het verzamelen van high-density event-related mogelijke gegevens, terwijl patiënten met de ziekte van Alzheimer het uitvoeren van een erkenning van het geheugen taak is beoordeeld. Dit protocol zal onder meer afhankelijk voorbereiding, kwaliteitsborging, data-acquisitie en data-analyse.
Other articles by Erin Hussey on PubMed
Using Mental Imagery to Improve Memory in Patients With Alzheimer Disease: Trouble Generating or Remembering the Mind's Eye? Alzheimer Disease and Associated Disorders. Sep, 2011 | Pubmed ID: 21946012 This study was conducted to understand whether patients with mild Alzheimer disease (AD) could use general or self-referential mental imagery to improve their recognition of visually presented words. Experiment 1 showed that, unlike healthy controls, patients generally did not benefit from either type of imagery. To help determine whether the patients' inability to benefit from mental imagery at encoding was due to poor memory or due to an impairment in mental imagery, participants performed 4 imagery tasks with varying imagery and cognitive demands. Experiment 2 showed that patients successfully performed basic visual imagery, but degraded semantic memory, coupled with visuospatial and executive functioning deficits, impaired their ability to perform more complex types of imagery. Given that patients with AD can perform basic mental imagery, our results suggest that episodic memory deficits likely prevent AD patients from storing or retrieving general mental images generated during encoding. Overall, the results of both experiments suggest that neurocognitive deficits do not allow patients with AD to perform complex mental imagery, which may be most beneficial to improving memory. However, our data also suggest that intact basic mental imagery and rehearsal could possibly be helpful if used in a rehabilitation multisession intervention approach.
Gist-based Conceptual Processing of Pictures Remains Intact in Patients with Amnestic Mild Cognitive Impairment Neuropsychology. Jan, 2012 | Pubmed ID: 22229341 Objective: The picture superiority effect, better memory for pictures compared to words, has been found in young adults, healthy older adults, and, most recently, in patients with Alzheimer's disease and mild cognitive impairment. Although the picture superiority effect is widely found, there is still debate over what drives this effect. One main question is whether it is enhanced perceptual or conceptual information that leads to the advantage for pictures over words. In this experiment, we examined the picture superiority effect in healthy older adults and patients with amnestic mild cognitive impairment (MCI) to better understand the role of gist-based conceptual processing. Method: We had participants study three exemplars of categories as either words or pictures. In the test phase, participants were again shown pictures or words and were asked to determine whether the item was in the same category as something they had studied earlier or whether it was from a new category. Results: We found that all participants demonstrated a robust picture superiority effect, better performance for pictures than for words. Conclusions: These results suggest that the gist-based conceptual processing of pictures is preserved in patients with MCI. While in healthy older adults preserved recollection for pictures could lead to the picture superiority effect, in patients with MCI it is most likely that the picture superiority effect is a result of spared conceptually based familiarity for pictures, perhaps combined with their intact ability to extract and use gist information. (PsycINFO Database Record (c) 2012 APA, all rights reserved).