In JoVE (2)
Other Publications (1)
Articles by Erin McNulty in JoVE
Transabdominal Ultrasound for Pregnancy Diagnosis in Reeves' Muntjac Deer Kelly D. Walton1, Erin McNulty1, Amy V. Nalls1, Candace K. Mathiason1 1Department of Microbiology, Immunology, and Pathology, Colorado State University Transabdominal ultrasound is described as an effective, noninvasive means for assessing reproductive status in Reeves' muntjac deer. These methods can be used to achieve early pregnancy diagnosis and to evaluate fetal viability. Future applications of this technique include estimation of gestational age and effects of maternal disease on fetal development.
Milk Collection Methods for Mice and Reeves' Muntjac Deer Kassandra Willingham1, Erin McNulty1, Kelly Anderson1, Jeanette Hayes-Klug1, Amy Nalls1, Candace Mathiason1 1Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University Milk collection from animal models facilitates various research avenues: understanding passive immunity, identifying pathogens responsible for vertical transmission and, through the use of transgenic mice, even commercial production of proteins found in human breast milk. Here we illustrate a simple method for milk collection in mice and Reeves’ muntjac deer.
Other articles by Erin McNulty on PubMed
Mother to Offspring Transmission of Chronic Wasting Disease in Reeves' Muntjac Deer PloS One. 2013 | Pubmed ID: 23977159 The horizontal transmission of prion diseases has been well characterized in bovine spongiform encephalopathy (BSE), chronic wasting disease (CWD) of deer and elk and scrapie of sheep, and has been regarded as the primary mode of transmission. Few studies have monitored the possibility of vertical transmission occurring within an infected mother during pregnancy. To study the potential for and pathway of vertical transmission of CWD in the native cervid species, we used a small cervid model-the polyestrous breeding, indoor maintainable, Reeves' muntjac deer-and determined that the susceptibility and pathogenesis of CWD in these deer reproduce that in native mule and white-tailed deer. Moreover, we demonstrate here that CWD prions are transmitted from doe to fawn. Maternal CWD infection also appears to result in lower percentage of live birth offspring. In addition, evolving evidence from protein misfolding cyclic amplification (PMCA) assays on fetal tissues suggest that covert prion infection occurs in utero. Overall, our findings demonstrate that transmission of prions from mother to offspring can occur, and may be underestimated for all prion diseases.