Etienne Sibille Centre for Addiction and Mental Health (CAMH) Campbell Family Mental Health Research Institute Biography Publications Institution JoVE Articles Etienne Sibille has not added a biography. If you are Etienne Sibille and would like to personalize this page please email our Author Liaison for assistance. Publications Prophylactic Efficacy of Riluzole Against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models Complex Psychiatry. 2023 | Pubmed ID: 37101541 Robust Differences in Cortical Cell Type Proportions Across Healthy Human Aging Inferred Through Cross-dataset Transcriptome Analyses Neurobiology of Aging. May, 2023 | Pubmed ID: 36841202 Transcriptomic Congruence Analysis for Evaluating Model Organisms Proceedings of the National Academy of Sciences of the United States of America. Feb, 2023 | Pubmed ID: 36730203 Hippocampal α5-GABA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area Biological Psychiatry Global Open Science. Jan, 2023 | Pubmed ID: 36712569 Neurotrophic Effects of Potentiating Gaba-mediated Dendritic Inhibition Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2023 | Pubmed ID: 35995974 Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle The International Journal of Neuropsychopharmacology. Aug, 2022 | Pubmed ID: 35732272 Symptomatic and Neurotrophic Effects of GABAA Receptor Positive Allosteric Modulation in a Mouse Model of Chronic Stress Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Aug, 2022 | Pubmed ID: 35701547 Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the SgACC of Human Subjects With Depression Frontiers in Psychiatry. 2022 | Pubmed ID: 35280164 Molecular Origin of Somatostatin-positive Neuron Vulnerability Molecular Psychiatry. Apr, 2022 | Pubmed ID: 35145229 Reduced Inhibition in Depression Impairs Stimulus Processing in Human Cortical Microcircuits Cell Reports. Jan, 2022 | Pubmed ID: 35021088 Chronic Stress Induces Coordinated Cortical Microcircuit Cell-Type Transcriptomic Changes Consistent With Altered Information Processing Biological Psychiatry. May, 2022 | Pubmed ID: 34861977 Molecular Characterization of Depression Trait and State Molecular Psychiatry. Feb, 2022 | Pubmed ID: 34686766 Transcriptome-based Polygenic Score Links Depression-related Corticolimbic Gene Expression Changes to Sex-specific Brain Morphology and Depression Risk Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Dec, 2021 | Pubmed ID: 34588609 From Serendipity to Rational Drug Design in Brain Disorders: in Silico, In vitro, and In vivo Approaches Current Opinion in Pharmacology. Aug, 2021 | Pubmed ID: 34461562 Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex The International Journal of Neuropsychopharmacology. Oct, 2021 | Pubmed ID: 34346493 BDNF Controls GABAR Trafficking and Related Cognitive Processes Via Autophagic Regulation of P62 Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Aug, 2021 | Pubmed ID: 34341497 Reduced Anterior Cingulate Cortex Volume Induced by Chronic Stress Correlates with Increased Behavioral Emotionality and Decreased Synaptic Puncta Density Neuropharmacology. Jun, 2021 | Pubmed ID: 33864799 Estimating and Correcting for Off-Target Cellular Contamination in Brain Cell Type Specific RNA-Seq Data Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 33746712 Correction: Novel Polygenic Risk Score As a Translational Tool Linking Depression-related Changes in the Corticolimbic Transcriptome with Neural Face Processing and Anhedonic Symptoms Translational Psychiatry. Mar, 2021 | Pubmed ID: 33654052 Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression Biological Psychiatry. Jan, 2021 | Pubmed ID: 33648716 Genome-wide Analysis Suggests the Importance of Vascular Processes and Neuroinflammation in Late-life Antidepressant Response Translational Psychiatry. Feb, 2021 | Pubmed ID: 33589590 Transcriptional Markers of Excitation-inhibition Balance in Germ-free Mice Show Region-specific Dysregulation and Rescue After Bacterial Colonization Journal of Psychiatric Research. 03, 2021 | Pubmed ID: 33508544 Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation The International Journal of Neuropsychopharmacology. Jul, 2021 | Pubmed ID: 33438026 Differential and Spatial Expression Meta-analysis of Genes Identified in Genome-wide Association Studies of Depression Translational Psychiatry. Jan, 2021 | Pubmed ID: 33414381 Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation Cerebral Cortex (New York, N.Y. : 1991). Jan, 2021 | Pubmed ID: 33068001 Altered GABA-mediated Information Processing and Cognitive Dysfunctions in Depression and Other Brain Disorders Molecular Psychiatry. 01, 2021 | Pubmed ID: 32346158 Novel Polygenic Risk Score As a Translational Tool Linking Depression-related Changes in the Corticolimbic Transcriptome with Neural Face Processing and Anhedonic Symptoms Translational Psychiatry. Nov, 2020 | Pubmed ID: 33235204 Older Molecular Brain Age in Severe Mental Illness Molecular Psychiatry. Jul, 2020 | Pubmed ID: 32632206 Chronic Stress-induced Behaviors Correlate with Exacerbated Acute Stress-induced Cingulate Cortex and Ventral Hippocampus Activation Neuroscience. 08, 2020 | Pubmed ID: 32473277 Molecular and Cellular Evidence for Age by Disease Interactions: Updates and Path Forward The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry. 02, 2020 | Pubmed ID: 31285153 Major Depression and Enhanced Molecular Senescence Abnormalities in Young and Middle-aged Adults Translational Psychiatry. Aug, 2019 | Pubmed ID: 31434875 Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles Molecular Neuropsychiatry. Apr, 2019 | Pubmed ID: 31192221 Rate of Brain Aging and Are Synergistic Risk Factors for Alzheimer's Disease Life Science Alliance. Jun, 2019 | Pubmed ID: 31133613 Residual Avoidance: A New, Consistent and Repeatable Readout of Chronic Stress-induced Conflict Anxiety Reversible by Antidepressant Treatment Neuropharmacology. 07, 2019 | Pubmed ID: 31075295 Insight into Novel Treatment for Cognitive Dysfunctions Across Disorders ACS Chemical Neuroscience. May, 2019 | Pubmed ID: 30920790 Cell Type-Specific Gene Expression of Alpha 5 Subunit-Containing Gamma-Aminobutyric Acid Subtype A Receptors in Human and Mouse Frontal Cortex Molecular Neuropsychiatry. Feb, 2019 | Pubmed ID: 30815456 DNA Methylation in the Human Frontal Cortex Reveals a Putative Mechanism for Age-by-disease Interactions Translational Psychiatry. 01, 2019 | Pubmed ID: 30696804 The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression Biological Psychiatry. 03, 2019 | Pubmed ID: 30449530 The Relative Contributions of Cell-Dependent Cortical Microcircuit Aging to Cognition and Anxiety Biological Psychiatry. 02, 2019 | Pubmed ID: 30446205 No Interaction Between Polygenic Scores and Childhood Trauma in Predicting Suicide Attempt in Schizophrenia Progress in Neuro-psychopharmacology & Biological Psychiatry. Mar, 2019 | Pubmed ID: 30149093 Identification of a Novel Gene Regulating Amygdala-mediated Fear Extinction Molecular Psychiatry. 04, 2019 | Pubmed ID: 29311651 Synthesis of Chiral GABA Receptor Subtype Selective Ligands As Potential Agents to Treat Schizophrenia As Well As Depression ARKIVOC : Free Online Journal of Organic Chemistry. 2018 | Pubmed ID: 32774192 Ulk2 Controls Cortical Excitatory-inhibitory Balance Via Autophagic Regulation of P62 and GABAA Receptor Trafficking in Pyramidal Neurons Human Molecular Genetics. Sep, 2018 | Pubmed ID: 29893844 Expression of Dopamine D2 and D3 Receptors in the Human Retina Revealed by Positron Emission Tomography and Targeted Mass Spectrometry Experimental Eye Research. Oct, 2018 | Pubmed ID: 29883636 Reduced GABAergic Cortical Inhibition in Aging and Depression Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2018 | Pubmed ID: 29849055 Opposite Molecular Signatures of Depression in Men and Women Biological Psychiatry. 07, 2018 | Pubmed ID: 29548746 Shifting Priorities: Highly Conserved Behavioral and Brain Network Adaptations to Chronic Stress Across Species Translational Psychiatry. 01, 2018 | Pubmed ID: 29353879 Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder Biological Psychiatry. Jan, 2018 | Pubmed ID: 28935211 Genetic Risk for Schizophrenia and Psychosis in Alzheimer Disease Molecular Psychiatry. Apr, 2018 | Pubmed ID: 28461698 Increased Neuronal DNA/RNA Oxidation in the Frontal Cortex of Mice Subjected to Unpredictable Chronic Mild Stress Chronic Stress (Thousand Oaks, Calif.). Jan-Dec, 2017 | Pubmed ID: 29250610 Cross-Laboratory Analysis of Brain Cell Type Transcriptomes with Applications to Interpretation of Bulk Tissue Data ENeuro. Nov-Dec, 2017 | Pubmed ID: 29204516 Fluorescence-based Cell-specific Detection for Laser-capture Microdissection in Human Brain Scientific Reports. 10, 2017 | Pubmed ID: 29079825 Characterization of GABAergic Marker Expression in the Chronic Unpredictable Stress Model of Depression Chronic Stress (Thousand Oaks, Calif.). Feb, 2017 | Pubmed ID: 28835932 Resilient Protein Co-expression Network in Male Orbitofrontal Cortex Layer 2/3 During Human Aging Neurobiology of Aging. 10, 2017 | Pubmed ID: 28750307 Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives Biological Psychiatry. Oct, 2017 | Pubmed ID: 28697889 Reduced Somatostatin Expression or Somatostatin-Positive Gamma-Aminobutyric Acid Neurons: A Shared Pathology Across Brain Disorders Biological Psychiatry. 03, 2017 | Pubmed ID: 28190426 A Neural "Tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy Schizophrenia Bulletin. 07, 2017 | Pubmed ID: 28168302 Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults The American Journal of Psychiatry. May, 2017 | Pubmed ID: 28068779 Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry. 01, 2017 | Pubmed ID: 27856124 Decrease in Somatostatin-positive Cell Density in the Amygdala of Females with Major Depression Depression and Anxiety. 01, 2017 | Pubmed ID: 27557481 Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA Receptor Positive Allosteric Modulator Frontiers in Pharmacology. 2016 | Pubmed ID: 27920723 Age-dependent Increase in Kalirin-9 and Kalirin-12 Transcripts in Human Orbitofrontal Cortex The European Journal of Neuroscience. 10, 2016 | Pubmed ID: 27471199 Circulating Biosignatures of Late-life Depression (LLD): Towards a Comprehensive, Data-driven Approach to Understanding LLD Pathophysiology Journal of Psychiatric Research. 11, 2016 | Pubmed ID: 27447786 Predisposition to Treatment Response in Major Depressive Episode: A Peripheral Blood Gene Coexpression Network Analysis Journal of Psychiatric Research. 10, 2016 | Pubmed ID: 27438688 The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Dec, 2016 | Pubmed ID: 27417517 α5GABAA Receptor Deficiency Causes Autism-like Behaviors Annals of Clinical and Translational Neurology. May, 2016 | Pubmed ID: 27231709 Effects of Aging on Circadian Patterns of Gene Expression in the Human Prefrontal Cortex Proceedings of the National Academy of Sciences of the United States of America. Jan, 2016 | Pubmed ID: 26699485 Sigma-1 and N-Methyl-d-Aspartate Receptors: A Partnership with Beneficial Outcomes Molecular Neuropsychiatry. May, 2015 | Pubmed ID: 27602356 FRAS1-related Extracellular Matrix 3 (FREM3) Single-nucleotide Polymorphism Effects on Gene Expression, Amygdala Reactivity and Perceptual Processing Speed: An Accelerated Aging Pathway of Depression Risk Frontiers in Psychology. 2015 | Pubmed ID: 26441752 Molecular and Genetic Characterization of Depression: Overlap with Other Psychiatric Disorders and Aging Molecular Neuropsychiatry. May, 2015 | Pubmed ID: 26213687 Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2015 | Pubmed ID: 25881116 Elevated Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein (HCNP-pp) MRNA in the Amygdala in Major Depression Journal of Psychiatric Research. Apr, 2015 | Pubmed ID: 25819500 VSNL1 Co-Expression Networks in Aging Include Calcium Signaling, Synaptic Plasticity, and Alzheimer's Disease Pathways Frontiers in Psychiatry. 2015 | Pubmed ID: 25806004 Laminar and Cellular Analyses of Reduced Somatostatin Gene Expression in the Subgenual Anterior Cingulate Cortex in Major Depression Neurobiology of Disease. Jan, 2015 | Pubmed ID: 25315685 Sex Differences in Mood Disorders: Perspectives from Humans and Rodent Models Biology of Sex Differences. 2014 | Pubmed ID: 25520774 Cortical GABA Neurons and Self-focus in Depression: a Model Linking Cellular, Biochemical and Neural Network Findings Molecular Psychiatry. Sep, 2014 | Pubmed ID: 25237734 BS3 화학 가교 분석: 설치류 뇌의 세포 표면 GABAA 수용체 표현에 대한 만성 스트레스의 영향 평가 Akiko Sumitomo1, Runhao Zhou1,2, Thomas Prevot1,3, Etienne Sibille1,2,3, Toshifumi Tomoda1,3 1Centre for Addiction and Mental Health (CAMH), Campbell Family Mental Health Research Institute, 2Department of Pharmacology and Toxicology, University of Toronto, 3Department of Psychiatry, University of Toronto JoVE 65063 Neuroscience 마우스의 스트레스를 줄이는 취급 기술 Michael Marcotte1, Ashley Bernardo1,2, Nathaniel Linga3, Carmina A. Pérez-Romero4, Jean-Louis Guillou5, Etienne Sibille1,2,3, Thomas D. Prevot1,2 1Campbell Family Mental Health Research Institute of CAMH, 2Department of Psychiatry, University of Toronto, 3Department of Pharmacology and Toxicology, University of Toronto, 4Departamento de Investigación, Universidad Central de Queretaro, 5Centre National de la Recherche Scientifique, UMR 5287, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Université de Bordeaux JoVE 62593 Behavior
BS3 화학 가교 분석: 설치류 뇌의 세포 표면 GABAA 수용체 표현에 대한 만성 스트레스의 영향 평가 Akiko Sumitomo1, Runhao Zhou1,2, Thomas Prevot1,3, Etienne Sibille1,2,3, Toshifumi Tomoda1,3 1Centre for Addiction and Mental Health (CAMH), Campbell Family Mental Health Research Institute, 2Department of Pharmacology and Toxicology, University of Toronto, 3Department of Psychiatry, University of Toronto JoVE 65063 Neuroscience
마우스의 스트레스를 줄이는 취급 기술 Michael Marcotte1, Ashley Bernardo1,2, Nathaniel Linga3, Carmina A. Pérez-Romero4, Jean-Louis Guillou5, Etienne Sibille1,2,3, Thomas D. Prevot1,2 1Campbell Family Mental Health Research Institute of CAMH, 2Department of Psychiatry, University of Toronto, 3Department of Pharmacology and Toxicology, University of Toronto, 4Departamento de Investigación, Universidad Central de Queretaro, 5Centre National de la Recherche Scientifique, UMR 5287, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Université de Bordeaux JoVE 62593 Behavior
