Eugene O. Major Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke National Institutes of Health Biography Publications Institution JoVE Articles Eugene O. Major has not added a biography. If you are Eugene O. Major and would like to personalize this page please email our Author Liaison for assistance. Publications Human Immunodeficiency Virus Type 1 (HIV-1) Transactivator of Transcription Through Its Intact Core and Cysteine-Rich Domains Inhibits Wnt/β-Catenin Signaling in Astrocytes: Relevance to HIV Neuropathogenesis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2012 | Pubmed ID: 23152614 Changes in JC Virus-Specific T Cell Responses During Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy PLoS Pathogens. Nov, 2012 | Pubmed ID: 23144619 Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-induced Demyelinating Disease of the Human Brain Clinical Microbiology Reviews. Jul, 2012 | Pubmed ID: 22763635 Neurological Infections: Risks of Globalisation and New Drugs Lancet Neurology. Jan, 2012 | Pubmed ID: 22172615 Individuals Infected with JC Polyomavirus Do Not Present Detectable JC Virus DNA in Oropharyngeal Fluids The Journal of General Virology. Apr, 2012 | Pubmed ID: 22158878 The Link Between VLA-4 and JC Virus Reactivation Expert Review of Clinical Immunology. Jan, 2012 | Pubmed ID: 22149341 JC Virus Promoter/enhancers Contain TATA Box-associated Spi-B-binding Sites That Support Early Viral Gene Expression in Primary Astrocytes The Journal of General Virology. Mar, 2012 | Pubmed ID: 22071512 History and Current Concepts in the Pathogenesis of PML Cleveland Clinic Journal of Medicine. Nov, 2011 | Pubmed ID: 22123932 Natalizumab Treatment for Multiple Sclerosis: Updated Recommendations for Patient Selection and Monitoring Lancet Neurology. Aug, 2011 | Pubmed ID: 21777829 Taxonomical Developments in the Family Polyomaviridae Archives of Virology. Sep, 2011 | Pubmed ID: 21562881 IFN-gamma Mediates Enhancement of HIV Replication in Astrocytes by Inducing an Antagonist of the Beta-catenin Pathway (DKK1) in a STAT 3-dependent Manner Journal of Immunology (Baltimore, Md. : 1950). Jun, 2011 | Pubmed ID: 21562161 Inhibitory Interactions Between BK and JC Virus Among Kidney Transplant Recipients Journal of the American Society of Nephrology : JASN. May, 2011 | Pubmed ID: 21511831 CMX001 (1-O-hexadecyloxypropyl-cidofovir) Inhibits Polyomavirus JC Replication in Human Brain Progenitor-derived Astrocytes Antimicrobial Agents and Chemotherapy. May, 2011 | Pubmed ID: 21402853 Transcription Factor Spi-B Binds Unique Sequences Present in the Tandem Repeat Promoter/enhancer of JC Virus and Supports Viral Activity The Journal of General Virology. Dec, 2010 | Pubmed ID: 20826618 Hexadecyloxypropyl-cidofovir (CMX001) Suppresses JC Virus Replication in Human Fetal Brain SVG Cell Cultures Antimicrobial Agents and Chemotherapy. Nov, 2010 | Pubmed ID: 20823288 JC Virus Persistence Following Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients Treated with Natalizumab Annals of Neurology. Sep, 2010 | Pubmed ID: 20818792 Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication Rate Journal of Virology. Oct, 2010 | Pubmed ID: 20686041 Molecular Regulation of JC Virus Tropism: Insights into Potential Therapeutic Targets for Progressive Multifocal Leukoencephalopathy Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Sep, 2010 | Pubmed ID: 20401541 Progressive Multifocal Leukoencephalopathy in Patients on Immunomodulatory Therapies Annual Review of Medicine. 2010 | Pubmed ID: 19719397 Monoclonal Antibodies and Progressive Multifocal Leukoencephalopathy MAbs. Nov-Dec, 2009 | Pubmed ID: 20073129 Progressive Multifocal Leukoencephalopathy After Natalizumab Monotherapy The New England Journal of Medicine. Sep, 2009 | Pubmed ID: 19741229 Reemergence of PML in Natalizumab-treated Patients--new Cases, Same Concerns The New England Journal of Medicine. Sep, 2009 | Pubmed ID: 19741226 Monoclonal Antibody-associated Progressive Multifocal Leucoencephalopathy in Patients Treated with Rituximab, Natalizumab, and Efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project The Lancet Oncology. Aug, 2009 | Pubmed ID: 19647202 Progressive Multifocal Leukoencephalopathy After Rituximab Therapy in HIV-negative Patients: a Report of 57 Cases from the Research on Adverse Drug Events and Reports Project Blood. May, 2009 | Pubmed ID: 19264918 Glial Cell Type-specific Subcellular Localization of 14-3-3 Zeta: an Implication for JCV Tropism Glia. Jul, 2009 | Pubmed ID: 19062179 M- and T-tropic HIVs Promote Apoptosis in Rat Neurons Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2009 | Pubmed ID: 19034668 Response to Linberg Et Al. Natalizumab Alters Transcriptional Expression Profiles of Blood Cell Subpopulations of Multiple Sclerosis Patients Journal of Neuroimmunology. Nov, 2008 | Pubmed ID: 19117088 BK Virus Antibody Titers and Intensity of Infections After Renal Transplantation Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Oct, 2008 | Pubmed ID: 18676176 DNA-binding Transcription Factor NF-1A Negatively Regulates JC Virus Multiplication The Journal of General Virology. Jun, 2008 | Pubmed ID: 18474555 Neuropharmacology of HIV/AIDS Handbook of Clinical Neurology / Edited by P.J. Vinken and G.W. Bruyn. 2007 | Pubmed ID: 18808990 Evidence of Human Immunodeficiency Virus Type 1 Infection of Nestin-positive Neural Progenitors in Archival Pediatric Brain Tissue Journal of Neurovirology. Jun, 2007 | Pubmed ID: 17613718 Natalizumab Treatment for Multiple Sclerosis: Recommendations for Patient Selection and Monitoring Lancet Neurology. May, 2007 | Pubmed ID: 17434098 MEK1/2 Inhibitors Block Basal and Transforming Growth Factor 1beta1-stimulated JC Virus Multiplication Journal of Virology. Jun, 2007 | Pubmed ID: 17409139 Induction of Original Phenotype of Human Immortalized Chondrocytes: a Quantitative Gene Expression Analysis International Journal of Molecular Medicine. Jan, 2007 | Pubmed ID: 17143552 NeuroAIDS, Drug Abuse, and Inflammation: Building Collaborative Research Activities Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Dec, 2006 | Pubmed ID: 18040811 Complete Replication Cycle and Acquisition of Tegument in Nucleus of Human Herpesvirus 6A in Astrocytes and in T-cells Journal of Medical Virology. Dec, 2006 | Pubmed ID: 17063514 Viral Proteomics: a Promising Approach for Understanding JC Virus Tropism Proteomics. Oct, 2006 | Pubmed ID: 16991198 Interactions Between C-Jun, Nuclear Factor 1, and JC Virus Promoter Sequences: Implications for Viral Tropism Journal of Virology. Nov, 2006 | Pubmed ID: 16928756 Neural Progenitors and HIV-1-associated Central Nervous System Disease in Adults and Children Current HIV Research. Jul, 2006 | Pubmed ID: 16842084 JC Virus Can Infect Human Immune and Nervous System Progenitor Cells: Implications for Pathogenesis Advances in Experimental Medicine and Biology. 2006 | Pubmed ID: 16626042 Evaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy The New England Journal of Medicine. Mar, 2006 | Pubmed ID: 16510746 Astrocyte Differentiation Selectively Upregulates CCL2/monocyte Chemoattractant Protein-1 in Cultured Human Brain-derived Progenitor Cells Glia. Jan, 2006 | Pubmed ID: 16206198 Donor Origin of BK Virus in Renal Transplantation and Role of HLA C7 in Susceptibility to Sustained BK Viremia American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Sep, 2005 | Pubmed ID: 16095500 Variant-specific Tropism of Human Herpesvirus 6 in Human Astrocytes Journal of Virology. Aug, 2005 | Pubmed ID: 16014907 Herpes Simplex Virus Type 1 Enters Human Epidermal Keratinocytes, but Not Neurons, Via a PH-dependent Endocytic Pathway Journal of Virology. Jun, 2005 | Pubmed ID: 15919913 Investigation of Human Brain Tumors for the Presence of Polyomavirus Genome Sequences by Two Independent Laboratories International Journal of Cancer. Journal International Du Cancer. Feb, 2005 | Pubmed ID: 15499616 Nuclear Receptor Activation and Interaction with Morphine Journal of Neuroimmunology. Dec, 2004 | Pubmed ID: 15579281 Differential Effects of Interferon-gamma on the Expression of Cyclooxygenase-2 in High-grade Human Gliomas Versus Primary Astrocytes Journal of Neuroimmunology. Nov, 2004 | Pubmed ID: 15465602 Comparison of PCR-southern Hybridization and Quantitative Real-time PCR for the Detection of JC and BK Viral Nucleotide Sequences in Urine and Cerebrospinal Fluid Journal of Virological Methods. Nov, 2004 | Pubmed ID: 15381359 Human Immunodeficiency Virus Type 1 Infection of Human Brain-derived Progenitor Cells Journal of Virology. Jul, 2004 | Pubmed ID: 15220405 JC Virus Induces Nonapoptotic Cell Death of Human Central Nervous System Progenitor Cell-derived Astrocytes Journal of Virology. May, 2004 | Pubmed ID: 15078969 HIV-2 Derived Lentiviral Vectors: Gene Transfer in Parkinson's and Fabry Disease Models in Vitro Journal of Medical Virology. Oct, 2003 | Pubmed ID: 12938190 Analysis of the Excreted JC Virus Strains and Their Potential Oral Transmission Journal of Neurovirology. Aug, 2003 | Pubmed ID: 12907394 Brain-derived Neurotrophic Factor Inhibits Human Immunodeficiency Virus-1/gp120-mediated Cerebellar Granule Cell Death by Preventing Gp120 Internalization The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2003 | Pubmed ID: 12843275 Serum Antibodies to JC Virus, BK Virus, Simian Virus 40, and the Risk of Incident Adult Astrocytic Brain Tumors Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. May, 2003 | Pubmed ID: 12750243 Lineage Pathway of Human Brain Progenitor Cells Identified by JC Virus Susceptibility Annals of Neurology. May, 2003 | Pubmed ID: 12730998 Basic, Clinical, and Epidemiological Studies of Progressive Multifocal Leukoencephalopathy: Implications for Therapy Journal of Neurovirology. 2003 | Pubmed ID: 12709863 Advances in the Biology of JC Virus and Induction of Progressive Multifocal Leukoencephalopathy Journal of Neurovirology. Apr, 2003 | Pubmed ID: 12707854 Serological Cross-reactivities Between Antibodies to Simian Virus 40, BK Virus, and JC Virus Assessed by Virus-like-particle-based Enzyme Immunoassays Clinical and Diagnostic Laboratory Immunology. Mar, 2003 | Pubmed ID: 12626455 Intracellular Human Immunodeficiency Virus Tat Expression in Astrocytes Promotes Astrocyte Survival but Induces Potent Neurotoxicity at Distant Sites Via Axonal Transport The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12551932 Traffic of JC Virus from Sites of Initial Infection to the Brain: the Path to Progressive Multifocal Leukoencephalopathy The Journal of Infectious Diseases. Dec, 2002 | Pubmed ID: 12424695 Analysis of the Temporal Expression of Nestin in Human Fetal Brain Derived Neuronal and Glial Progenitor Cells Brain Research. Developmental Brain Research. Mar, 2002 | Pubmed ID: 11947939 HIV-1 and the Brain: Connections Between HIV-1-associated Dementia, Neuropathology and Neuroimmunology Microbes and Infection / Institut Pasteur. Mar, 2002 | Pubmed ID: 11909740 Indução direta de Neurais Human células-tronco de sangue periférico células progenitoras hematopoéticas Tongguang Wang1, Elliot Choi1, Maria Chiara G. Monaco2, Eugene O. Major2, Marie Medynets1, Avindra Nath1 1Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health JoVE 52298 Developmental Biology Progenitor derivado Sistema de Cultura oligodendroglial Cérebro Fetal Humano Maria Chiara G. Monaco1, Dragan Maric2, Alexandra Bandeian1, Emily Leibovitch1, Wan Yang1, Eugene O. Major1 1Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health JoVE 4274 Neuroscience
Indução direta de Neurais Human células-tronco de sangue periférico células progenitoras hematopoéticas Tongguang Wang1, Elliot Choi1, Maria Chiara G. Monaco2, Eugene O. Major2, Marie Medynets1, Avindra Nath1 1Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health JoVE 52298 Developmental Biology
Progenitor derivado Sistema de Cultura oligodendroglial Cérebro Fetal Humano Maria Chiara G. Monaco1, Dragan Maric2, Alexandra Bandeian1, Emily Leibovitch1, Wan Yang1, Eugene O. Major1 1Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health JoVE 4274 Neuroscience
