Ewan C. Goligher Toronto General Hospital Research Institute Biography Publications Institution JoVE Articles Ewan C. Goligher has not added a biography. If you are Ewan C. Goligher and would like to personalize this page please email our Author Liaison for assistance. Publications Lung and Diaphragm Protection During Mechanical Ventilation: Synchrony Matters Critical Care Medicine. Nov, 2023 | Pubmed ID: 37902352 Simvastatin in Critically Ill Patients with Covid-19 The New England Journal of Medicine. Oct, 2023 | Pubmed ID: 37888913 Phrenic Nerve Stimulation for Acute Respiratory Failure Respiratory Care. Oct, 2023 | Pubmed ID: 37875317 Proof of Concept for Continuous On-Demand Phrenic Nerve Stimulation to Prevent Diaphragm Disuse During Mechanical Ventilation (STIMULUS): A Phase 1 Clinical Trial American Journal of Respiratory and Critical Care Medicine. Nov, 2023 | Pubmed ID: 37642635 Driving Pressure: Pitfalls of Methods That Do Not Use Esophageal Pressure Measurement. Author's Reply Intensive Care Medicine. Sep, 2023 | Pubmed ID: 37466671 Heterogeneous Treatment Effects of Extracorporeal CO Removal in Acute Hypoxemic Respiratory Failure American Journal of Respiratory and Critical Care Medicine. Sep, 2023 | Pubmed ID: 37433221 Bringing Clinical Trials to the Bedside: Conditional Average Treatment Effects in the Balanced Solution Versus Saline in Intensive Care Study (BaSICS) Trial Annals of the American Thoracic Society. Jun, 2023 | Pubmed ID: 37261790 Driving Pressure: Applying the Concept at the Bedside Intensive Care Medicine. Aug, 2023 | Pubmed ID: 37191695 Reply to Fernández American Journal of Respiratory and Critical Care Medicine. Jul, 2023 | Pubmed ID: 37159944 Lung Recruitment Assessed by Electrical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 Acute Respiratory Distress Syndrome American Journal of Respiratory and Critical Care Medicine. Jul, 2023 | Pubmed ID: 37097986 Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 JAMA. Apr, 2023 | Pubmed ID: 36942550 Association of Days Alive and at Home at Day 90 After Intensive Care Unit Admission With Long-term Survival and Functional Status Among Mechanically Ventilated Patients JAMA Network Open. Mar, 2023 | Pubmed ID: 36929399 Diaphragm Neurostimulation Assisted Ventilation in Critically Ill Patients American Journal of Respiratory and Critical Care Medicine. May, 2023 | Pubmed ID: 36917765 Monitoring Respiratory Effort and Lung-distending Pressure Noninvasively During Mechanical Ventilation: Ready for Prime Time Anesthesiology. Mar, 2023 | Pubmed ID: 36749421 Linking Acute Physiology to Outcomes in the ICU: Challenges and Solutions for Research American Journal of Respiratory and Critical Care Medicine. Jun, 2023 | Pubmed ID: 36705985 Weaning from Mechanical Ventilation in Intensive Care Units Across 50 Countries (WEAN SAFE): a Multicentre, Prospective, Observational Cohort Study The Lancet. Respiratory Medicine. May, 2023 | Pubmed ID: 36693401 The Religious Character of Secular Arguments Supporting Euthanasia and What It Implies for Conscientious Practice in Medicine Theoretical Medicine and Bioethics. Feb, 2023 | Pubmed ID: 36449202 A Window Into the Future: The Diagnostic and Prognostic Utility of Respiratory Muscle Ultrasound in Optimizing Mechanical Ventilation Respiratory Care. Nov, 2022 | Pubmed ID: 36266056 Strategies for Lung- and Diaphragm-protective Ventilation in Acute Hypoxemic Respiratory Failure: a Physiological Trial Critical Care (London, England). Aug, 2022 | Pubmed ID: 36038890 Noninvasive and Invasive Mechanical Ventilation for Neurologic Disorders Handbook of Clinical Neurology. 2022 | Pubmed ID: 36031314 Phrenic Nerve Stimulation to Protect the Diaphragm, Lung, and Brain During Mechanical Ventilation Intensive Care Medicine. Oct, 2022 | Pubmed ID: 35688993 Validation of a Web-based Platform for Online Training in Point-of-Care Diaphragm Ultrasound ATS Scholar. Mar, 2022 | Pubmed ID: 35633997 Physiology Is Vital to Precision Medicine in Acute Respiratory Distress Syndrome and Sepsis American Journal of Respiratory and Critical Care Medicine. Jul, 2022 | Pubmed ID: 35442864 EXpert Consensus On Diaphragm UltraSonography in the Critically Ill (EXODUS): a Delphi Consensus Statement on the Measurement of Diaphragm Ultrasound-derived Parameters in a Critical Care Setting Critical Care (London, England). Apr, 2022 | Pubmed ID: 35395861 Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury Anesthesiology. May, 2022 | Pubmed ID: 35348581 Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis American Journal of Respiratory and Critical Care Medicine. Jun, 2022 | Pubmed ID: 35180042 Impact of Reverse Triggering Dyssynchrony During Lung-Protective Ventilation on Diaphragm Function: An Experimental Model American Journal of Respiratory and Critical Care Medicine. Mar, 2022 | Pubmed ID: 34941477 Noninvasive Respiratory Support Following Extubation in Critically Ill Adults: a Systematic Review and Network Meta-analysis Intensive Care Medicine. Feb, 2022 | Pubmed ID: 34825256 What Can We Learn From Monitoring Diaphragm Activity in Infants? Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Nov, 2021 | Pubmed ID: 34734896 Association of Different Positive End-expiratory Pressure Selection Strategies with All-cause Mortality in Adult Patients with Acute Respiratory Distress Syndrome Systematic Reviews. Aug, 2021 | Pubmed ID: 34384488 How Cutting-edge Trial Design Can Assess Outcomes Current Opinion in Critical Care. Oct, 2021 | Pubmed ID: 34334624 Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study Chest. Oct, 2021 | Pubmed ID: 34090872 Postextubation Respiratory Support: Of Clinical Trials and Clinical Decisions American Journal of Respiratory and Critical Care Medicine. Aug, 2021 | Pubmed ID: 33901412 Diaphragm Echodensity in Mechanically Ventilated Patients: a Description of Technique and Outcomes Critical Care (London, England). Feb, 2021 | Pubmed ID: 33593412 Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance American Journal of Respiratory and Critical Care Medicine. Jun, 2021 | Pubmed ID: 33439781 Association of Thoracic Computed Tomographic Measurements and Outcomes in Patients with Hematologic Malignancies Requiring Mechanical Ventilation Annals of the American Thoracic Society. Jul, 2021 | Pubmed ID: 33433272 Duration of Diaphragmatic Inactivity After Endotracheal Intubation of Critically Ill Patients Critical Care (London, England). Jan, 2021 | Pubmed ID: 33430930 Is Severe COVID-19 Pneumonia a Typical or Atypical Form of ARDS? And Does It Matter? Intensive Care Medicine. Jan, 2021 | Pubmed ID: 33237346 Clinical Trials in Critical Care: Can a Bayesian Approach Enhance Clinical and Scientific Decision Making? The Lancet. Respiratory Medicine. Feb, 2021 | Pubmed ID: 33227237 Response to Ventilator Adjustments for Predicting Acute Respiratory Distress Syndrome Mortality. Driving Pressure Versus Oxygenation Annals of the American Thoracic Society. May, 2021 | Pubmed ID: 33112644 Validity of Empirical Estimates of the Ratio of Dead Space to Tidal Volume in ARDS Respiratory Care. Apr, 2021 | Pubmed ID: 33082218 Comparing the Effects of Tidal Volume, Driving Pressure, and Mechanical Power on Mortality in Trials of Lung-Protective Mechanical Ventilation Respiratory Care. Feb, 2021 | Pubmed ID: 32843513 A Manifesto for the Future of ICU Trials Critical Care (London, England). Dec, 2020 | Pubmed ID: 33298134 Searching for the Optimal PEEP in Patients Without ARDS: High, Low, or in Between? JAMA. Dec, 2020 | Pubmed ID: 33295963 Clinical Strategies for Implementing Lung and Diaphragm-protective Ventilation: Avoiding Insufficient and Excessive Effort Intensive Care Medicine. Dec, 2020 | Pubmed ID: 33140181 Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study Critical Care Medicine. Dec, 2020 | Pubmed ID: 33044283 Anticipating and Managing Coagulopathy and Thrombotic Manifestations of Severe COVID-19 CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Oct, 2020 | Pubmed ID: 32816822 Anti-Thrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): Study Design and Methodology for an International, Adaptive Bayesian Randomized Controlled Trial Clinical Trials (London, England). Oct, 2020 | Pubmed ID: 32815416 Association of Mortality with Neuromuscular Blockade Differs According to Baseline Diaphragm Thickness American Journal of Respiratory and Critical Care Medicine. Dec, 2020 | Pubmed ID: 32717150 Monitoring Patient-ventilator Interaction by an End-expiratory Occlusion Maneuver Intensive Care Medicine. Dec, 2020 | Pubmed ID: 32623476 Lung- and Diaphragm-Protective Ventilation American Journal of Respiratory and Critical Care Medicine. Oct, 2020 | Pubmed ID: 32516052 Monitoring Patient Respiratory Effort During Mechanical Ventilation: Lung and Diaphragm-Protective Ventilation Critical Care (London, England). Mar, 2020 | Pubmed ID: 32204729 Airway Occlusion Pressure As an Estimate of Respiratory Drive and Inspiratory Effort During Assisted Ventilation American Journal of Respiratory and Critical Care Medicine. May, 2020 | Pubmed ID: 32097569 Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults JAMA Network Open. Feb, 2020 | Pubmed ID: 32074293 Editorial: Lung and Diaphragm-protective Ventilation: Setting New Concepts in Historical Context Current Opinion in Critical Care. Feb, 2020 | Pubmed ID: 31789946 Respiratory Drive in Critically Ill Patients. Pathophysiology and Clinical Implications American Journal of Respiratory and Critical Care Medicine. Jan, 2020 | Pubmed ID: 31437406 A Novel Non-invasive Method to Detect Excessively High Respiratory Effort and Dynamic Transpulmonary Driving Pressure During Mechanical Ventilation Critical Care (London, England). Nov, 2019 | Pubmed ID: 31694692 Determinants of the Effect of Extracorporeal Carbon Dioxide Removal in the SUPERNOVA Trial: Implications for Trial Design Intensive Care Medicine. Sep, 2019 | Pubmed ID: 31432216 Optimal Ventilator Strategies in Acute Respiratory Distress Syndrome Seminars in Respiratory and Critical Care Medicine. Feb, 2019 | Pubmed ID: 31060090 Lung- and Diaphragm-protective Ventilation in Acute Respiratory Distress Syndrome: Rationale and Challenges Anesthesiology. Apr, 2019 | Pubmed ID: 30844950 Withholding or Withdrawing Life Support Versus Physician-assisted Death: a Distinction with a Difference? Current Opinion in Anaesthesiology. Apr, 2019 | Pubmed ID: 30817393 Myotrauma in Mechanically Ventilated Patients Intensive Care Medicine. Jun, 2019 | Pubmed ID: 30741329 Diaphragm-protective Mechanical Ventilation Current Opinion in Critical Care. Feb, 2019 | Pubmed ID: 30531536 Diaphragmatic Myotrauma: a Mediator of Prolonged Ventilation and Poor Patient Outcomes in Acute Respiratory Failure The Lancet. Respiratory Medicine. Jan, 2019 | Pubmed ID: 30455078 Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial JAMA. Dec, 2018 | Pubmed ID: 30347031 Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes (Video) | JoVE Catherine A. Bellissimo1, Idunn S. Morris2,3,4, Jenna Wong1, Ewan C. Goligher1,2,3,5 1Toronto General Hospital Research Institute, 2Interdepartmental Division of Critical Care Medicine, University of Toronto, 3Department of Physiology, Faculty of Medicine, University of Toronto, 4Deparatment of Intensive Care Medicine, Nepean Hospital, 5Division of Respirology, Department of Medicine, University Health Network JoVE 65431 Medicine
Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes (Video) | JoVE Catherine A. Bellissimo1, Idunn S. Morris2,3,4, Jenna Wong1, Ewan C. Goligher1,2,3,5 1Toronto General Hospital Research Institute, 2Interdepartmental Division of Critical Care Medicine, University of Toronto, 3Department of Physiology, Faculty of Medicine, University of Toronto, 4Deparatment of Intensive Care Medicine, Nepean Hospital, 5Division of Respirology, Department of Medicine, University Health Network JoVE 65431 Medicine
