Flávio Reis Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine University of Coimbra Biography Publications Institution JoVE Articles Flávio Reis has not added a biography. If you are Flávio Reis and would like to personalize this page please email our Author Liaison for assistance. Publications Are Gut Dysbiosis, Barrier Disruption, and Endotoxemia Related to Adipose Tissue Dysfunction in Metabolic Disorders? Overview of the Mechanisms Involved Internal and Emergency Medicine. Apr, 2023 | Pubmed ID: 37014495 TNFR2 As a Potential Biomarker for Early Detection and Progression of CKD Biomolecules. Mar, 2023 | Pubmed ID: 36979469 Gut Microbiota Dysbiosis and Cardiovascular Disease - The Chicken and the Egg Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology. Mar, 2023 | Pubmed ID: 36893843 Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis Frontiers in Medicine. 2022 | Pubmed ID: 35692536 Defining Milestones for the Study of Remyelination Using the Cuprizone Mouse Model: How Early is Early? Multiple Sclerosis and Related Disorders. Jul, 2022 | Pubmed ID: 35597080 Inflammatory Biomarkers in Staging of Chronic Kidney Disease: Elevated TNFR2 Levels Accompanies Renal Function Decline Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Jun, 2022 | Pubmed ID: 35471601 The Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD International Journal of Molecular Sciences. Mar, 2022 | Pubmed ID: 35328704 Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics Nutrients. Nov, 2021 | Pubmed ID: 34959746 Editorial: Combating Redox Imbalance-Associated Complications With Natural Products Frontiers in Pharmacology. 2021 | Pubmed ID: 34899360 Unhealthy Lifestyles, Environment, Well-being and Health Capability in Rural Neighbourhoods: a Community-based Cross-sectional Study BMC Public Health. Sep, 2021 | Pubmed ID: 34488709 Blueberry As an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression Antioxidants (Basel, Switzerland). Jul, 2021 | Pubmed ID: 34439410 Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular Disease Risk in Chronic Kidney Disease? Biomedicines. May, 2021 | Pubmed ID: 34065648 A Selective P53 Activator and Anticancer Agent to Improve Colorectal Cancer Therapy Cell Reports. Apr, 2021 | Pubmed ID: 33852837 Assessing Scientific Soundness and Translational Value of Animal Studies on DPP4 Inhibitors for Treating Type 2 Diabetes Mellitus Biology. Feb, 2021 | Pubmed ID: 33669354 Lactation As a Programming Window for Metabolic Syndrome European Journal of Clinical Investigation. May, 2021 | Pubmed ID: 33350459 Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update Microorganisms. Dec, 2020 | Pubmed ID: 33379162 New Potential Biomarkers for Chronic Kidney Disease Management-A Review of the Literature International Journal of Molecular Sciences. Dec, 2020 | Pubmed ID: 33375198 Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats Pharmaceutics. Nov, 2020 | Pubmed ID: 33202669 Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches Microorganisms. Oct, 2020 | Pubmed ID: 33019592 Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy Antioxidants (Basel, Switzerland). Aug, 2020 | Pubmed ID: 32759750 Diet-induced Rodent Models of Obesity-related Metabolic Disorders-A Guide to a Translational Perspective Obesity Reviews : an Official Journal of the International Association for the Study of Obesity. Dec, 2020 | Pubmed ID: 32691524 ACE2 Imbalance As a Key Player for the Poor Outcomes in COVID-19 Patients with Age-related Comorbidities - Role of Gut Microbiota Dysbiosis Ageing Research Reviews. Sep, 2020 | Pubmed ID: 32683039 Crescent-Like Lesions As an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet Nutrients. Mar, 2020 | Pubmed ID: 32218109 Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy Nutrients. Jan, 2020 | Pubmed ID: 31963709 The Yin and Yang Faces of the Mitochondrial Deacetylase Sirtuin 3 in Age-related Disorders Ageing Research Reviews. Jan, 2020 | Pubmed ID: 31740222 Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases Trends in Pharmacological Sciences. Dec, 2019 | Pubmed ID: 31704173 Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency Nutrients. Sep, 2019 | Pubmed ID: 31540270 SLMP53-2 Restores Wild-Type-Like Function to Mutant P53 Through Hsp70: Promising Activity in Hepatocellular Carcinoma Cancers. Aug, 2019 | Pubmed ID: 31405179 The Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Improves Oxidative Stress and Ameliorates Glomerular Lesions in a Rat Model of Type 1 Diabetes Life Sciences. Oct, 2019 | Pubmed ID: 31398418 Development of a Healthy Lifestyle Assessment Toolkit for the General Public Frontiers in Medicine. 2019 | Pubmed ID: 31316985 The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index Oxidative Medicine and Cellular Longevity. 2019 | Pubmed ID: 30911344 MTOR Signaling in Cardiometabolic Disease, Cancer, and Aging 2018 Oxidative Medicine and Cellular Longevity. 2019 | Pubmed ID: 30863483 Hepcidin in Chronic Kidney Disease Anemia Vitamins and Hormones. 2019 | Pubmed ID: 30798815 Diabetic Gut Microbiota Dysbiosis As an Inflammaging and Immunosenescence Condition That Fosters Progression of Retinopathy and Nephropathy Biochimica Et Biophysica Acta. Molecular Basis of Disease. Jul, 2019 | Pubmed ID: 30287404 Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes Frontiers in Physiology. 2018 | Pubmed ID: 30705633 Therapeutic Use of MTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges Oxidative Medicine and Cellular Longevity. 2018 | Pubmed ID: 30510618 Subtle Thinning of Retinal Layers Without Overt Vascular and Inflammatory Alterations in a Rat Model of Prediabetes Molecular Vision. 2018 | Pubmed ID: 29853770 Influence of the 6-month Physical Activity Programs on Renal Function in Obese Boys Pediatric Research. May, 2018 | Pubmed ID: 29638229 Discovery of a Small-molecule Protein Kinase Cδ-selective Activator with Promising Application in Colon Cancer Therapy Cell Death & Disease. 01, 2018 | Pubmed ID: 29348560 Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes Journal of Diabetes Research. 2017 | Pubmed ID: 29098166 Therapeutic Strategies Targeting Oxidative Stress to Improve Dyslipidemia and Left Ventricular Hypertrophy Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology. Sep, 2017 | Pubmed ID: 28826936 MTOR Signaling in Cardiometabolic Disease, Cancer, and Aging Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 28770023 Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet Nutrients. Jun, 2017 | Pubmed ID: 28635632 Recent Advances and Challenges of MTOR Inhibitors Use in the Treatment of Patients with Tuberous Sclerosis Complex Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 28386314 DIMP53-1: a Novel Small-molecule Dual Inhibitor of P53-MDM2/X Interactions with Multifunctional P53-dependent Anticancer Properties Molecular Oncology. 06, 2017 | Pubmed ID: 28296148 Solid Lipid Nanoparticles As Oral Delivery Systems of Phenolic Compounds: Overcoming Pharmacokinetic Limitations for Nutraceutical Applications Critical Reviews in Food Science and Nutrition. Jun, 2017 | Pubmed ID: 26192708 Therapeutic and Nutraceutical Potential of Rosmarinic Acid-Cytoprotective Properties and Pharmacokinetic Profile Critical Reviews in Food Science and Nutrition. Jun, 2017 | Pubmed ID: 26114303 Natural Killer Cell-based Adoptive Immunotherapy Eradicates and Drives Differentiation of Chemoresistant Bladder Cancer Stem-like Cells BMC Medicine. Oct, 2016 | Pubmed ID: 27769244 Rapamycin Negatively Impacts Insulin Signaling, Glucose Uptake and Uncoupling Protein-1 in Brown Adipocytes Biochimica Et Biophysica Acta. Dec, 2016 | Pubmed ID: 27686967 Safety Profile of Solid Lipid Nanoparticles Loaded with Rosmarinic Acid for Oral Use: in Vitro and Animal Approaches International Journal of Nanomedicine. 2016 | Pubmed ID: 27536103 Recombinant Human Erythropoietin-induced Erythropoiesis Regulates Hepcidin Expression over Iron Status in the Rat Blood Cells, Molecules & Diseases. Jul, 2016 | Pubmed ID: 27282570 Pathological and Molecular Mechanisms Underlying Resistance to Recombinant Human Erythropoietin Therapy in the Remnant Kidney Rat Model of Chronic Kidney Disease Associated Anemia Biochimie. Jun, 2016 | Pubmed ID: 27039028 Liver Iron is a Major Regulator of Hepcidin Gene Expression Via BMP/SMAD Pathway in a Rat Model of Chronic Renal Failure Under Treatment with High RHuEPO Doses BioFactors (Oxford, England). May, 2016 | Pubmed ID: 26990350 Impaired Renal Endothelial Nitric Oxide Synthase and Reticulocyte Production As Modulators of Hypertension Induced by RHuEPO in the Rat Life Sciences. Apr, 2016 | Pubmed ID: 26924494 Renal Risk-benefit Determinants of Recombinant Human Erythropoietin Therapy in the Remnant Kidney Rat Model - Hypertension, Anaemia, Inflammation and Drug Dose Clinical and Experimental Pharmacology & Physiology. Mar, 2016 | Pubmed ID: 26889660 Comparison of Endogenous GHB Concentrations in Blood and Hair in Death Cases with Emphasis on the Post Mortem Interval International Journal of Legal Medicine. Jul, 2016 | Pubmed ID: 26846768 A Fast and Reliable Method for GHB Quantitation in Whole Blood by GC-MS/MS (TQD) for Forensic Purposes Journal of Pharmaceutical and Biomedical Analysis. Feb, 2016 | Pubmed ID: 26678181 Iron Therapy in Chronic Kidney Disease: Recent Changes, Benefits and Risks Blood Reviews. Jan, 2016 | Pubmed ID: 26342303 Resistance to Recombinant Human Erythropoietin Therapy in a Rat Model of Chronic Kidney Disease Associated Anemia International Journal of Molecular Sciences. Dec, 2015 | Pubmed ID: 26712750 Functional and Molecular Characterization of Cancer Stem-like Cells in Bladder Cancer: a Potential Signature for Muscle-invasive Tumors Oncotarget. Nov, 2015 | Pubmed ID: 26452033 The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class? Journal of Diabetes Research. 2015 | Pubmed ID: 26075286 Cyclosporine A-induced Nephrotoxicity is Ameliorated by Dose Reduction and Conversion to Sirolimus in the Rat Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society. Apr, 2015 | Pubmed ID: 25903959 Iron-hepcidin Dysmetabolism, Anemia and Renal Hypoxia, Inflammation and Fibrosis in the Remnant Kidney Rat Model PloS One. 2015 | Pubmed ID: 25867633 Gamma-hydroxybutyric Acid Endogenous Production and Post-mortem Behaviour - the Importance of Different Biological Matrices, Cut-off Reference Values, Sample Collection and Storage Conditions Journal of Forensic and Legal Medicine. Oct, 2014 | Pubmed ID: 25287794 Conversion to Sirolimus Ameliorates Cyclosporine-induced Nephropathy in the Rat: Focus on Serum, Urine, Gene, and Protein Renal Expression Biomarkers BioMed Research International. 2014 | Pubmed ID: 24971338 Cyclosporine A Enhances Gluconeogenesis While Sirolimus Impairs Insulin Signaling in Peripheral Tissues After 3 Weeks of Treatment Biochemical Pharmacology. Sep, 2014 | Pubmed ID: 24960264 Transition from Cyclosporine-induced Renal Dysfunction to Nephrotoxicity in an in Vivo Rat Model International Journal of Molecular Sciences. May, 2014 | Pubmed ID: 24853130 Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals Mediators of Inflammation. 2014 | Pubmed ID: 24817793 Dipeptidyl Peptidase-IV Inhibition Prevents Blood-retinal Barrier Breakdown, Inflammation and Neuronal Cell Death in the Retina of Type 1 Diabetic Rats Biochimica Et Biophysica Acta. Sep, 2014 | Pubmed ID: 24769045 Short and Long Term in Vivo Effects of Cyclosporine A and Sirolimus on Genes and Proteins Involved in Lipid Metabolism in Wistar Rats Metabolism: Clinical and Experimental. May, 2014 | Pubmed ID: 24656168 Sitagliptin Prevents Aggravation of Endocrine and Exocrine Pancreatic Damage in the Zucker Diabetic Fatty Rat - Focus on Amelioration of Metabolic Profile and Tissue Cytoprotective Properties Diabetology & Metabolic Syndrome. Mar, 2014 | Pubmed ID: 24650557 Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c And/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid TheScientificWorldJournal. 2013 | Pubmed ID: 24319364 Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: a Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin Mediators of Inflammation. 2013 | Pubmed ID: 24282340 Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations Disease Markers. 2013 | Pubmed ID: 24167352 Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer BioMed Research International. 2013 | Pubmed ID: 23865049 Diabetes Abrogates Sex Differences and Aggravates Cardiometabolic Risk in Postmenopausal Women Cardiovascular Diabetology. Apr, 2013 | Pubmed ID: 23570342 Early Cardiac Changes in a Rat Model of Prediabetes: Brain Natriuretic Peptide Overexpression Seems to Be the Best Marker Cardiovascular Diabetology. Mar, 2013 | Pubmed ID: 23497124 Regular Physical Exercise As a Strategy to Improve Antioxidant and Anti-inflammatory Status: Benefits in Type 2 Diabetes Mellitus Oxidative Medicine and Cellular Longevity. 2012 | Pubmed ID: 22928086 Endocannabinoid System in Cardiovascular Disorders - New Pharmacotherapeutic Opportunities Journal of Pharmacy & Bioallied Sciences. Jul, 2011 | Pubmed ID: 21966155 Regular Physical Exercise Training Assists in Preventing Type 2 Diabetes Development: Focus on Its Antioxidant and Anti-inflammatory Properties Cardiovascular Diabetology. Jan, 2011 | Pubmed ID: 21276212 Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) Mediators of Inflammation. 2010 | Pubmed ID: 20652060 The Unsolved Cyclosporine-induced Kidney Injury: is Paricalcitol a Feasible New Renoprotective Option? Kidney International. Jun, 2010 | Pubmed ID: 20508662 Anti-inflammatory, Anti-proliferative and Antioxidant Profiles of Selective Cyclooxygenase-2 Inhibition As Chemoprevention for Rat Bladder Carcinogenesis Cancer Biology & Therapy. Sep, 2009 | Pubmed ID: 19571668 Impairment of Vascular and Platelet Levels of Nitric Oxide and Cyclic Guanosine-3',5'-monophosphate in Cyclosporin A-induced Hypertensive Rats Fundamental & Clinical Pharmacology. Feb, 2003 | Pubmed ID: 12588629 Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment (Video) | JoVE Karina Garcia1,2,3,4, André Alves1,2,3, Teresa M. Ribeiro-Rodrigues1,2,3, Flávio Reis1,2,3, Sofia Viana1,2,3,4 1Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 2Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3Clinical Academic Center of Coimbra (CACC), 4Polytechnic Institute of Coimbra, Coimbra Health School JoVE 65206 Biochemistry
Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment (Video) | JoVE Karina Garcia1,2,3,4, André Alves1,2,3, Teresa M. Ribeiro-Rodrigues1,2,3, Flávio Reis1,2,3, Sofia Viana1,2,3,4 1Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 2Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3Clinical Academic Center of Coimbra (CACC), 4Polytechnic Institute of Coimbra, Coimbra Health School JoVE 65206 Biochemistry