Gabriel C. Lander

Publications

• Succinylation of a KEAP1 Sensor Lysine Promotes NRF2 Activation
  Cell Chemical Biology. Aug, 2023  |   Pubmed ID: 37619563
• Structural Basis for a Degenerate TRNA Identity Code and the Evolution of Bimodal Specificity in Human Mitochondrial TRNA Recognition
  Nature Communications. Aug, 2023  |   Pubmed ID: 37558671
• DELE1 Oligomerization Promotes Integrated Stress Response Activation
  Nature Structural & Molecular Biology. Aug, 2023  |   Pubmed ID: 37550454
• Succinylation of a KEAP1 Sensor Lysine Promotes NRF2 Activation
  BioRxiv : the Preprint Server for Biology. May, 2023  |   Pubmed ID: 37215033
• Molecular Glue CELMoD Compounds Are Regulators of Cereblon Conformation
  Science (New York, N.Y.). Nov, 2022  |   Pubmed ID: 36378961
• Structure of the Hepatitis C Virus E1E2 Glycoprotein Complex
  Science (New York, N.Y.). Oct, 2022  |   Pubmed ID: 36264808
• Structural Basis for Shape-selective Recognition and Aminoacylation of a D-armless Human Mitochondrial TRNA
  Nature Communications. Aug, 2022  |   Pubmed ID: 36042193
• Coupling of Distant ATPase Domains in the Circadian Clock Protein KaiC
  Nature Structural & Molecular Biology. Aug, 2022  |   Pubmed ID: 35864165
• The YΦ Motif Defines the Structure-activity Relationships of Human 20S Proteasome Activators
  Nature Communications. Mar, 2022  |   Pubmed ID: 35264557
• Allosteric Differences Dictate GroEL Complementation Of E. coli
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2022  |   Pubmed ID: 35199390
• Cryo-EM Structure of Hexameric Yeast Lon Protease (PIM1) Highlights the Importance of Conserved Structural Elements
  The Journal of Biological Chemistry. Mar, 2022  |   Pubmed ID: 35143841
• A Case for Glycerol As an Acceptable Additive for Single-particle CryoEM Samples
  Acta Crystallographica. Section D, Structural Biology. Jan, 2022  |   Pubmed ID: 34981768
• Conquer by Cryo-EM Without Physically Dividing
  Biochemical Society Transactions. Nov, 2021  |   Pubmed ID: 34709401
• Structural Basis for PiRNA Targeting
  Nature. Sep, 2021  |   Pubmed ID: 34471284
• Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation
  Nature Communications. May, 2021  |   Pubmed ID: 34050165
• A Guided Approach for Subtomogram Averaging of Challenging Macromolecular Assemblies
  Journal of Structural Biology: X. 2020  |   Pubmed ID: 33319208
• Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis
  Biophysical Journal. Oct, 2020  |   Pubmed ID: 32919493
• Sub-2 Angstrom Resolution Structure Determination Using Single-particle Cryo-EM at 200 keV
  Journal of Structural Biology: X. 2020  |   Pubmed ID: 32647824
• How Low Can We Go? Structure Determination of Small Biological Complexes Using Single-particle Cryo-EM
  Current Opinion in Structural Biology. Oct, 2020  |   Pubmed ID: 32599507
• Structural Basis for Distinct Operational Modes and Protease Activation in AAA+ Protease Lon
  Science Advances. May, 2020  |   Pubmed ID: 32490208
• AcrIF9 Tethers Non-sequence Specific DsDNA to the CRISPR RNA-guided Surveillance Complex
  Nature Communications. Jun, 2020  |   Pubmed ID: 32483187
• Author Correction: An Allosteric Network in Spastin Couples Multiple Activities Required for Microtubule Severing
  Nature Structural & Molecular Biology. Apr, 2020  |   Pubmed ID: 32203494
• Dynamics at the Serine Loop Underlie Differential Affinity of Cryptochromes for CLOCK:BMAL1 to Control Circadian Timing
  ELife. Feb, 2020  |   Pubmed ID: 32101164
• The Molecular Principles Governing the Activity and Functional Diversity of AAA+ Proteins
  Nature Reviews. Molecular Cell Biology. Jan, 2020  |   Pubmed ID: 31754261
• Specific Lid-base Contacts in the 26s Proteasome Control the Conformational Switching Required for Substrate Degradation
  ELife. Nov, 2019  |   Pubmed ID: 31778111
• Current Outcomes when Optimizing 'standard' Sample Preparation for Single-particle Cryo-EM
  Journal of Microscopy. Oct, 2019  |   Pubmed ID: 31553060
• Visualizing Structural Transitions of Ligand-dependent Gating of the TRPM2 Channel
  Nature Communications. Aug, 2019  |   Pubmed ID: 31431622
• Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease
  Molecular Cell. Sep, 2019  |   Pubmed ID: 31327635
• An Allosteric Network in Spastin Couples Multiple Activities Required for Microtubule Severing
  Nature Structural & Molecular Biology. Aug, 2019  |   Pubmed ID: 31285604
• Setting the Dynein Motor in Motion: New Insights from Electron Tomography
  The Journal of Biological Chemistry. Sep, 2019  |   Pubmed ID: 31285262
• Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry
  Molecular Cell. Apr, 2019  |   Pubmed ID: 30872121
• High-resolution Structure Determination of Sub-100 kDa Complexes Using Conventional Cryo-EM
  Nature Communications. Mar, 2019  |   Pubmed ID: 30833564
• A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality
  Structure (London, England : 1993). Feb, 2019  |   Pubmed ID: 30449687
• The Rod-shaped ATG2A-WIPI4 Complex Tethers Membranes in Vitro
  Contact (Thousand Oaks (Ventura County, Calif.)). 2018  |   Pubmed ID: 30766969
• Conformational Ensemble of the Human TRPV3 Ion Channel
  Nature Communications. Nov, 2018  |   Pubmed ID: 30429472
• Substrate-engaged 26 Proteasome Structures Reveal Mechanisms for ATP-hydrolysis-driven Translocation
  Science (New York, N.Y.). Nov, 2018  |   Pubmed ID: 30309908
• Insights into Autophagosome Biogenesis from Structural and Biochemical Analyses of the ATG2A-WIPI4 Complex
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2018  |   Pubmed ID: 30185561
• Cryo-EM Structure of a Mitochondrial Calcium Uniporter
  Science (New York, N.Y.). Aug, 2018  |   Pubmed ID: 29954988
• Exploring Applications of Crowdsourcing to Cryo-EM
  Journal of Structural Biology. Jul, 2018  |   Pubmed ID: 29486249
• Author Correction: Cryo-electron Tomography Reveals That Dynactin Recruits a Team of Dyneins for Processive Motility
  Nature Structural & Molecular Biology. Apr, 2018  |   Pubmed ID: 29476122
• Cryo-electron Tomography Reveals That Dynactin Recruits a Team of Dyneins for Processive Motility
  Nature Structural & Molecular Biology. Mar, 2018  |   Pubmed ID: 29416113
• The Peroxisomal AAA-ATPase Pex1/Pex6 Unfolds Substrates by Processive Threading
  Nature Communications. Jan, 2018  |   Pubmed ID: 29321502
• Structure of the Cold- and Menthol-sensing Ion Channel TRPM8
  Science (New York, N.Y.). Jan, 2018  |   Pubmed ID: 29217583
• Structure of the Mitochondrial Inner Membrane AAA+ Protease YME1 Gives Insight into Substrate Processing
  Science (New York, N.Y.). Nov, 2017  |   Pubmed ID: 29097521
• Cryo-electron Microscopy Structure of the Lysosomal Calcium-permeable Channel TRPML3
  Nature. Oct, 2017  |   Pubmed ID: 29019979
• Achieving Better-than-3-Å Resolution by Single-particle Cryo-EM at 200 KeV
  Nature Methods. Nov, 2017  |   Pubmed ID: 28991891
• The Endoplasmic Reticulum HSP40 Co-chaperone ERdj3/DNAJB11 Assembles and Functions As a Tetramer
  The EMBO Journal. Aug, 2017  |   Pubmed ID: 28655754
• Cas1 and the Csy Complex Are Opposing Regulators of Cas2/3 Nuclease Activity
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2017  |   Pubmed ID: 28438998
• Structure Reveals Mechanisms of Viral Suppressors That Intercept a CRISPR RNA-Guided Surveillance Complex
  Cell. Mar, 2017  |   Pubmed ID: 28340349
• What's the Key to Unlocking the Proteasome's Gate?
  Structure (London, England : 1993). Dec, 2016  |   Pubmed ID: 27926830
• Isolation of Yeast Complex IV in Native Lipid Nanodiscs
  Biochimica Et Biophysica Acta. Dec, 2016  |   Pubmed ID: 27620332
• A Novel Cereblon Modulator Recruits GSPT1 to the CRL4(CRBN) Ubiquitin Ligase
  Nature. 07, 2016  |   Pubmed ID: 27338790
• Cryo-electron Microscopy Structure of the TRPV2 Ion Channel
  Nature Structural & Molecular Biology. Feb, 2016  |   Pubmed ID: 26779611
• Atomic Structure of the 26S Proteasome Lid Reveals the Mechanism of Deubiquitinase Inhibition
  ELife. Jan, 2016  |   Pubmed ID: 26744777
• Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex
  Biophysical Journal. Oct, 2015  |   Pubmed ID: 26488657
• Site-specific Labeling of Proteins for Electron Microscopy
  Journal of Structural Biology. Nov, 2015  |   Pubmed ID: 26409249
• Ubp6 Deubiquitinase Controls Conformational Dynamics and Substrate Degradation of the 26S Proteasome
  Nature Structural & Molecular Biology. Sep, 2015  |   Pubmed ID: 26301997
• Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22
  Journal of Molecular Biology. Oct, 2015  |   Pubmed ID: 26301600
• Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases
  Cell. May, 2015  |   Pubmed ID: 25959773
• Structural Organization of the Dynein-dynactin Complex Bound to Microtubules
  Nature Structural & Molecular Biology. Apr, 2015  |   Pubmed ID: 25751425
• The Pex1/Pex6 Complex is a Heterohexameric AAA+ Motor with Alternating and Highly Coordinated Subunits
  Journal of Molecular Biology. Mar, 2015  |   Pubmed ID: 25659908
• Solid-to-fluid-like DNA Transition in Viruses Facilitates Infection
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014  |   Pubmed ID: 25271319
• DNA Bending-induced Phase Transition of Encapsidated Genome in Phage λ
  Nucleic Acids Research. Apr, 2013  |   Pubmed ID: 23449219
• Capsomer Dynamics and Stabilization in the T = 12 Marine Bacteriophage SIO-2 and Its Procapsid Studied by CryoEM
  Structure (London, England : 1993). Mar, 2012  |   Pubmed ID: 22405008
• Peering Down the Barrel of a Bacteriophage Portal: the Genome Packaging and Release Valve in P22
  Structure (London, England : 1993). Apr, 2011  |   Pubmed ID: 21439834
• Subunits Fold at Position-dependent Rates During Maturation of a Eukaryotic RNA Virus
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010  |   Pubmed ID: 20660783
• An Automated Procedure for Detecting Protein Folds from Sub-nanometer Resolution Electron Density
  Journal of Structural Biology. Jun, 2010  |   Pubmed ID: 20026407
• A Toolbox for Ab Initio 3-D Reconstructions in Single-particle Electron Microscopy
  Journal of Structural Biology. Mar, 2010  |   Pubmed ID: 20018246
• The P22 Tail Machine at Subnanometer Resolution Reveals the Architecture of an Infection Conduit
  Structure (London, England : 1993). Jun, 2009  |   Pubmed ID: 19523897
• Drosophila A Virus is an Unusual RNA Virus with a T=3 Icosahedral Core and Permuted RNA-dependent RNA Polymerase
  The Journal of General Virology. Sep, 2009  |   Pubmed ID: 19474243
• Ab Initio Maximum Likelihood Reconstruction from Cryo Electron Microscopy Images of an Infectious Virion of the Tailed Bacteriophage P22 and Maximum Likelihood Versions of Fourier Shell Correlation Appropriate for Measuring Resolution of Spherical or Cylindrical Objects
  Journal of Structural Biology. Sep, 2009  |   Pubmed ID: 19457456
• Appion: an Integrated, Database-driven Pipeline to Facilitate EM Image Processing
  Journal of Structural Biology. Apr, 2009  |   Pubmed ID: 19263523
• Bacteriophage Lambda Stabilization by Auxiliary Protein GpD: Timing, Location, and Mechanism of Attachment Determined by Cryo-EM
  Structure (London, England : 1993). Sep, 2008  |   Pubmed ID: 18786402
• Assembly Architecture and DNA Binding of the Bacteriophage P22 Terminase Small Subunit
  Journal of Molecular Biology. Nov, 2008  |   Pubmed ID: 18775728
• A Test-bed for Optimizing High-resolution Single Particle Reconstructions
  Journal of Structural Biology. Jul, 2008  |   Pubmed ID: 18534866
• Polyvalent Display of Heme on Hepatitis B Virus Capsid Protein Through Coordination to Hexahistidine Tags
  Chemistry & Biology. May, 2008  |   Pubmed ID: 18482703
• Automated CryoEM Data Acquisition and Analysis of 284742 Particles of GroEL
  Journal of Structural Biology. Sep, 2006  |   Pubmed ID: 16762565
• The Structure of an Infectious P22 Virion Shows the Signal for Headful DNA Packaging
  Science (New York, N.Y.). Jun, 2006  |   Pubmed ID: 16709746
• Exploring Icosahedral Virus Structures with VIPER
  Nature Reviews. Microbiology. Oct, 2005  |   Pubmed ID: 16205712