Gabriele Kaminski Schierle Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology University of Cambridge Biography Publications Institution JoVE Articles Gabriele Kaminski Schierle has not added a biography. If you are Gabriele Kaminski Schierle and would like to personalize this page please email our Author Liaison for assistance. Publications A Waveguide Imaging Platform for Live-cell TIRF Imaging of Neurons over Large Fields of View Journal of Biophotonics. Feb, 2020 | Pubmed ID: 32067356 Observation of High-temperature Macromolecular Confinement in Lyophilised Protein Formulations Using Terahertz Spectroscopy International Journal of Pharmaceutics: X. Dec, 2019 | Pubmed ID: 31517287 Mitochondrial Degradation of Amyloidogenic Proteins - A New Perspective for Neurodegenerative Diseases Progress in Neurobiology. 10, 2019 | Pubmed ID: 31301323 The Role of Water in Amyloid Aggregation Kinetics Current Opinion in Structural Biology. 10, 2019 | Pubmed ID: 31299481 Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging ACS Chemical Biology. Jul, 2019 | Pubmed ID: 31246415 Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres Pharmaceutics. Jun, 2019 | Pubmed ID: 31226751 Intrinsically Aggregation-prone Proteins Form Amyloid-like Aggregates and Contribute to Tissue Aging in ELife. May, 2019 | Pubmed ID: 31050339 The Cellular Environment Affects Monomeric α-Synuclein Structure Trends in Biochemical Sciences. 05, 2019 | Pubmed ID: 30527975 Structural Progression of Amyloid-β Arctic Mutant Aggregation in Cells Revealed by Multiparametric Imaging The Journal of Biological Chemistry. 02, 2019 | Pubmed ID: 30504224 Live-cell Super-resolution Microscopy Reveals a Primary Role for Diffusion in Polyglutamine-driven Aggresome Assembly The Journal of Biological Chemistry. 01, 2019 | Pubmed ID: 30401748 Opal-like Multicolor Appearance of Self-Assembled Photonic Array ACS Applied Materials & Interfaces. Jun, 2018 | Pubmed ID: 29842782 Different Structural Conformers of Monomeric α-Synuclein Identified After Lyophilizing and Freezing Analytical Chemistry. 06, 2018 | Pubmed ID: 29750859 FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions Cell. Apr, 2018 | Pubmed ID: 29677515 An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures Frontiers in Cellular Neuroscience. 2018 | Pubmed ID: 29556177 C-terminal Calcium Binding of α-synuclein Modulates Synaptic Vesicle Interaction Nature Communications. 02, 2018 | Pubmed ID: 29459792 Biophotonics of Native Silk Fibrils Macromolecular Bioscience. Apr, 2018 | Pubmed ID: 29377575 Imaging Aβ(1-42) Fibril Elongation Reveals Strongly Polarised Growth and Growth Incompetent States Physical Chemistry Chemical Physics : PCCP. Oct, 2017 | Pubmed ID: 29026905 α-Synuclein - Regulator of Exocytosis, Endocytosis, or Both? Trends in Cell Biology. 07, 2017 | Pubmed ID: 28259601 Super-resolution Imaging of Alpha-synuclein Polymorphisms and Their Potential Role in Neurodegeneration Integrative Biology : Quantitative Biosciences from Nano to Macro. 03, 2017 | Pubmed ID: 28180219 A Computational Study on How Structure Influences the Optical Properties in Model Crystal Structures of Amyloid Fibrils Physical Chemistry Chemical Physics : PCCP. Feb, 2017 | Pubmed ID: 28111679 Fluorescence Self-Quenching from Reporter Dyes Informs on the Structural Properties of Amyloid Clusters Formed in Vitro and in Cells Nano Letters. 01, 2017 | Pubmed ID: 28073262 Structural Basis of Synaptic Vesicle Assembly Promoted by α-synuclein Nature Communications. 09, 2016 | Pubmed ID: 27640673 Probing Amyloid Protein Aggregation with Optical Superresolution Methods: from the Test Tube to Models of Disease Neurophotonics. Oct, 2016 | Pubmed ID: 27413767 Nanoscopic Insights into Seeding Mechanisms and Toxicity of α-synuclein Species in Neurons Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26993805 Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures Journal of the American Chemical Society. Mar, 2016 | Pubmed ID: 26824778 Optical Super-Resolution Imaging of β-Amyloid Aggregation In Vitro and In Vivo: Method and Techniques Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26235063 CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation PLoS Biology. Apr, 2015 | Pubmed ID: 25875822 Highly Potent Soluble Amyloid-β Seeds in Human Alzheimer Brain but Not Cerebrospinal Fluid Brain : a Journal of Neurology. Nov, 2014 | Pubmed ID: 25212850 Direct Observations of Amyloid β Self-assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1-40) and Aβ(1-42) Aggregation Chemistry & Biology. Jun, 2014 | Pubmed ID: 24856820 Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics Via Two-color Super-resolution Microscopy Nano Letters. Jan, 2014 | Pubmed ID: 24303845 Extracellular Monomeric Tau Protein is Sufficient to Initiate the Spread of Tau Protein Pathology The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24235150 A Label-free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence Chembiochem : a European Journal of Chemical Biology. May, 2013 | Pubmed ID: 23592254 Lifetime Imaging of a Fluorescent Protein Sensor Reveals Surprising Stability of ER Thiol Redox The Journal of Cell Biology. Apr, 2013 | Pubmed ID: 23589496 Protein Amyloids Develop an Intrinsic Fluorescence Signature During Aggregation The Analyst. Apr, 2013 | Pubmed ID: 23420088 Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme PloS One. 2012 | Pubmed ID: 23166837 ALS Mutations in FUS Cause Neuronal Dysfunction and Death in Caenorhabditis Elegans by a Dominant Gain-of-function Mechanism Human Molecular Genetics. Jan, 2012 | Pubmed ID: 21949354 Intrinsically Disordered Proteins As Molecular Shields Molecular BioSystems. Jan, 2012 | Pubmed ID: 21909508 In Situ Measurements of the Formation and Morphology of Intracellular β-amyloid Fibrils by Super-resolution Fluorescence Imaging Journal of the American Chemical Society. Aug, 2011 | Pubmed ID: 21793568 HomoFRET Fluorescence Anisotropy Imaging As a Tool to Study Molecular Self-assembly in Live Cells Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Feb, 2011 | Pubmed ID: 21344590 A FRET Sensor for Non-invasive Imaging of Amyloid Formation in Vivo Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Feb, 2011 | Pubmed ID: 21308945 Catalytic and Chaperone-like Functions in an Intrinsically Disordered Protein Associated with Desiccation Tolerance Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20805515 Charakterisierung von Amyloidstrukturen im Altern C. Elegans mit Fluoreszenz-Lebensdauer-Bildgebung Maria Lucia Pigazzini*1,2, Christian Gallrein*1, Manuel Iburg*1, Gabriele Kaminski Schierle3, Janine Kirstein1,4 1Leibniz Research Institute for Molecular Pharmacology im Forschungsverbund Berlin, 2NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin, 3Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, 4Cell Biology, University of Bremen JoVE 61004 Biochemistry
Charakterisierung von Amyloidstrukturen im Altern C. Elegans mit Fluoreszenz-Lebensdauer-Bildgebung Maria Lucia Pigazzini*1,2, Christian Gallrein*1, Manuel Iburg*1, Gabriele Kaminski Schierle3, Janine Kirstein1,4 1Leibniz Research Institute for Molecular Pharmacology im Forschungsverbund Berlin, 2NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin, 3Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, 4Cell Biology, University of Bremen JoVE 61004 Biochemistry
