Gal Bitan Department of Neurology David Geffen School of Medicine Biography Publications Institution JoVE Articles Gal Bitan has not added a biography. If you are Gal Bitan and would like to personalize this page please email our Author Liaison for assistance. Publications Modulating Self-Assembly of Amyloidogenic Proteins As a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms ChemMedChem. Feb, 2012 | Pubmed ID: 22323134 A Two-Step Strategy for Structure-Activity Relationship Studies of N-Methylated Aβ42 C-Terminal Fragments As Aβ42 Toxicity Inhibitors ChemMedChem. Feb, 2012 | Pubmed ID: 22307963 Aβ(39-42) Modulates Aβ Oligomerization but Not Fibril Formation Biochemistry. Jan, 2012 | Pubmed ID: 22129303 C-terminal Tetrapeptides Inhibit Aβ42-induced Neurotoxicity Primarily Through Specific Interaction at the N-terminus of Aβ42 Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22087474 Induction of Methionine-sulfoxide Reductases Protects Neurons from Amyloid β-protein Insults in Vitro and in Vivo Biochemistry. Dec, 2011 | Pubmed ID: 22059533 Lysine-specific Molecular Tweezers Are Broad-spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins Journal of the American Chemical Society. Oct, 2011 | Pubmed ID: 21916458 Rational Design of β-sheet Ligands Against Aβ42-induced Toxicity Journal of the American Chemical Society. Mar, 2011 | Pubmed ID: 21381732 Surprising Toxicity and Assembly Behaviour of Amyloid β-protein Oxidized to Sulfone The Biochemical Journal. Jan, 2011 | Pubmed ID: 21044048 Mechanistic Investigation of the Inhibition of Abeta42 Assembly and Neurotoxicity by Abeta42 C-terminal Fragments Biochemistry. Aug, 2010 | Pubmed ID: 20568734 Despite Its Role in Assembly, Methionine 35 is Not Necessary for Amyloid Beta-protein Toxicity Journal of Neurochemistry. Jun, 2010 | Pubmed ID: 20345758 Biophysical Characterization of Abeta42 C-terminal Fragments: Inhibitors of Abeta42 Neurotoxicity Biochemistry. Feb, 2010 | Pubmed ID: 20050679 Amyloid-β Protein Oligomerization and the Importance of Tetramers and Dodecamers in the Aetiology of Alzheimer's Disease Nature Chemistry. Jul, 2009 | Pubmed ID: 20703363 RNA Aptamers Generated Against Oligomeric Abeta40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity PloS One. 2009 | Pubmed ID: 19901993 Amino Acid Position-specific Contributions to Amyloid Beta-protein Oligomerization The Journal of Biological Chemistry. Aug, 2009 | Pubmed ID: 19567875 The Structure of Abeta42 C-terminal Fragments Probed by a Combined Experimental and Theoretical Study Journal of Molecular Biology. Mar, 2009 | Pubmed ID: 19356595 C-terminal Peptides Coassemble into Abeta42 Oligomers and Protect Neurons Against Abeta42-induced Neurotoxicity Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18779585 Dendrimeric Abeta1-15 is an Effective Immunogen in Wildtype and APP-tg Mice Neurobiology of Aging. Jun, 2007 | Pubmed ID: 16725229 Structural Study of Metastable Amyloidogenic Protein Oligomers by Photo-induced Cross-linking of Unmodified Proteins Methods in Enzymology. 2006 | Pubmed ID: 17046399 Early Diagnostics and Therapeutics for Alzheimer's Disease--how Early Can We Get There? Expert Review of Neurotherapeutics. Sep, 2006 | Pubmed ID: 17009917 Elucidating Amyloid Beta-protein Folding and Assembly: A Multidisciplinary Approach Accounts of Chemical Research. Sep, 2006 | Pubmed ID: 16981680 Amyloid Beta-protein Monomer Structure: a Computational and Experimental Study Protein Science : a Publication of the Protein Society. Mar, 2006 | Pubmed ID: 16501222 En Route to Early Diagnosis of Alzheimer's Disease--are We There Yet? Trends in Biotechnology. Nov, 2005 | Pubmed ID: 16165236 Neurotoxic Protein Oligomers--what You See is Not Always What You Get Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2005 | Pubmed ID: 16011984 Determination of Peptide Oligomerization State Using Rapid Photochemical Crosslinking Methods in Molecular Biology (Clifton, N.J.). 2005 | Pubmed ID: 15980592 Preparation of Aggregate-free, Low Molecular Weight Amyloid-beta for Assembly and Toxicity Assays Methods in Molecular Biology (Clifton, N.J.). 2005 | Pubmed ID: 15980591 Amyloid Beta-protein: Monomer Structure and Early Aggregation States of Abeta42 and Its Pro19 Alloform Journal of the American Chemical Society. Feb, 2005 | Pubmed ID: 15713083 Rapid Photochemical Cross-linking--a New Tool for Studies of Metastable, Amyloidogenic Protein Assemblies Accounts of Chemical Research. Jun, 2004 | Pubmed ID: 15196045 A Molecular Switch in Amyloid Assembly: Met35 and Amyloid Beta-protein Oligomerization Journal of the American Chemical Society. Dec, 2003 | Pubmed ID: 14664580 Increased T Cell Reactivity to Amyloid Beta Protein in Older Humans and Patients with Alzheimer Disease The Journal of Clinical Investigation. Aug, 2003 | Pubmed ID: 12897209 Elucidation of Primary Structure Elements Controlling Early Amyloid Beta-protein Oligomerization The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12840029 Amyloid Beta -protein (Abeta) Assembly: Abeta 40 and Abeta 42 Oligomerize Through Distinct Pathways Proceedings of the National Academy of Sciences of the United States of America. Jan, 2003 | Pubmed ID: 12506200 Polyglutamine Repeat Length-dependent Proteolysis of Huntingtin Neurobiology of Disease. Oct, 2002 | Pubmed ID: 12460551 Paradigm Shifts in Alzheimer's Disease and Other Neurodegenerative Disorders: the Emerging Role of Oligomeric Assemblies Journal of Neuroscience Research. Sep, 2002 | Pubmed ID: 12210822 Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids The Journal of Organic Chemistry. Jan, 1997 | Pubmed ID: 11671417 Amyloid β प्रोटीन, अल्जाइमर रोग की प्रेरणा का एजेंट के लिए Aptamers का चयन Farid Rahimi1, Gal Bitan1,2,3 1Department of Neurology, David Geffen School of Medicine, 2Molecular Biology Institute, University of California, Los Angeles, 3Brain Research Institute, University of California, Los Angeles JoVE 1955 Neuroscience फोटो प्रेरित पार से जोड़ने असंशोधित प्रोटीन (पीआईसीयूपी) Amyloidogenic पेप्टाइड्स लागू करने के लिए Farid Rahimi1, Panchanan Maiti1, Gal Bitan2,3 1Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, 3Department of Neurology, University of California, Los Angeles JoVE 1071 Biology
Amyloid β प्रोटीन, अल्जाइमर रोग की प्रेरणा का एजेंट के लिए Aptamers का चयन Farid Rahimi1, Gal Bitan1,2,3 1Department of Neurology, David Geffen School of Medicine, 2Molecular Biology Institute, University of California, Los Angeles, 3Brain Research Institute, University of California, Los Angeles JoVE 1955 Neuroscience
फोटो प्रेरित पार से जोड़ने असंशोधित प्रोटीन (पीआईसीयूपी) Amyloidogenic पेप्टाइड्स लागू करने के लिए Farid Rahimi1, Panchanan Maiti1, Gal Bitan2,3 1Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, 3Department of Neurology, University of California, Los Angeles JoVE 1071 Biology
