Gerald B. Pier Channing Laboratory, Department of Medicine, Brigham and Women's Hospital Harvard Medical School Biography Publications Institution JoVE Articles Gerald B. Pier has not added a biography. If you are Gerald B. Pier and would like to personalize this page please email our Author Liaison for assistance. Publications Poly-N-Acetyl-β-(1-6)-Glucosamine Is a Target for Protective Immunity Against Acinetobacter Baumannii Infections Infection and Immunity. Feb, 2012 | Pubmed ID: 22104104 NMR and Conformational Studies of Linear and Cyclic Oligo-(1→6)-β-D-glucosamines Carbohydrate Research. Nov, 2011 | Pubmed ID: 21945383 Refers To: J.-P. Rasigade, N. Sicot, F. Laurent, G. Lina, F. Vandenesch, J. Etienne, A History of Panton-Valentine Leukocidin (PVL)-associated Infection Protects Against Death in PVL-associated Pneumonia, Vaccine 29 (25) (2011) 4185-4186 Vaccine. Aug, 2011 | Pubmed ID: 21821077 Efficacy of a Conjugate Vaccine Containing Polymannuronic Acid and Flagellin Against Experimental Pseudomonas Aeruginosa Lung Infection in Mice Infection and Immunity. Aug, 2011 | Pubmed ID: 21628521 Synthesis of Five Nona-β-(1→6)-d-glucosamines with Various Patterns of N-acetylation Corresponding to the Fragments of Exopolysaccharide of Staphylococcus Aureus Carbohydrate Research. May, 2011 | Pubmed ID: 21474120 Mucosal Vaccination with a Multivalent, Live-attenuated Vaccine Induces Multifactorial Immunity Against Pseudomonas Aeruginosa Acute Lung Infection Infection and Immunity. Mar, 2011 | Pubmed ID: 21149583 Utility of in Vivo Transcription Profiling for Identifying Pseudomonas Aeruginosa Genes Needed for Gastrointestinal Colonization and Dissemination PloS One. 2010 | Pubmed ID: 21170272 High Levels of Antibody to Panton-valentine Leukocidin Are Not Associated with Resistance to Staphylococcus Aureus-associated Skin and Soft-tissue Infection Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Nov, 2010 | Pubmed ID: 20946065 Animal and Human Antibodies to Distinct Staphylococcus Aureus Antigens Mutually Neutralize Opsonic Killing and Protection in Mice The Journal of Clinical Investigation. Sep, 2010 | Pubmed ID: 20739753 Lack of Correlation Between Pulmonary Disease and Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Cystic Fibrosis: a Case Report Journal of Medical Case Reports. 2010 | Pubmed ID: 20420703 Inhibition of Macrophage Migration Inhibitory Factor Ameliorates Ocular Pseudomonas Aeruginosa-induced Keratitis PLoS Pathogens. Mar, 2010 | Pubmed ID: 20361053 Alveolar Inflammation in Cystic Fibrosis Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. May, 2010 | Pubmed ID: 20347403 Is Exposure to Mercury a Driving Force for the Carriage of Antibiotic Resistance Genes? Journal of Medical Microbiology. Jul, 2010 | Pubmed ID: 20339018 Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children The New England Journal of Medicine. Feb, 2010 | Pubmed ID: 20175297 Antibody-mediated Enhancement of Community-acquired Methicillin-resistant Staphylococcus Aureus Infection Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133867 Evaluation of Flagella and Flagellin of Pseudomonas Aeruginosa As Vaccines Infection and Immunity. Feb, 2010 | Pubmed ID: 19995892 Caveolin-1 Modifies the Immunity to Pseudomonas Aeruginosa Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 19949109 Synthetic {beta}-(1->6)-linked N-acetylated and Nonacetylated Oligoglucosamines Used to Produce Conjugate Vaccines for Bacterial Pathogens Infection and Immunity. Feb, 2010 | Pubmed ID: 19948836 Analysis of Acquisition of Pseudomonas Aeruginosa Gastrointestinal Mucosal Colonization and Horizontal Transmission in a Murine Model The Journal of Infectious Diseases. Jan, 2010 | Pubmed ID: 19938976 Role of Neutrophils, MyD88-mediated Neutrophil Recruitment, and Complement in Antibody-mediated Defense Against Pseudomonas Aeruginosa Keratitis Investigative Ophthalmology & Visual Science. Apr, 2010 | Pubmed ID: 19892865 Inescapable Need for Neutrophils As Mediators of Cellular Innate Immunity to Acute Pseudomonas Aeruginosa Pneumonia Infection and Immunity. Dec, 2009 | Pubmed ID: 19805527 The PgaABCD Locus of Acinetobacter Baumannii Encodes the Production of Poly-beta-1-6-N-acetylglucosamine, Which is Critical for Biofilm Formation Journal of Bacteriology. Oct, 2009 | Pubmed ID: 19633088 Inactivation of the RhlA Gene in Pseudomonas Aeruginosa Prevents Rhamnolipid Production, Disabling the Protection Against Polymorphonuclear Leukocytes APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Jul, 2009 | Pubmed ID: 19594494 IL1B Polymorphisms Modulate Cystic Fibrosis Lung Disease Pediatric Pulmonology. Jun, 2009 | Pubmed ID: 19431193 Cystic Fibrosis Transmembrane Conductance Regulator and Caveolin-1 Regulate Epithelial Cell Internalization of Pseudomonas Aeruginosa American Journal of Physiology. Cell Physiology. Aug, 2009 | Pubmed ID: 19386787 First Synthesis of Pentasaccharide Glycoform I of the Outer Core Region of the Pseudomonas Aeruginosa Lipopolysaccharide The Journal of Organic Chemistry. Nov, 2008 | Pubmed ID: 18842026 IL-17 is a Critical Component of Vaccine-induced Protection Against Lung Infection by Lipopolysaccharide-heterologous Strains of Pseudomonas Aeruginosa Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18802100 On the Greatly Exaggerated Reports of the Death of Infectious Diseases Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Oct, 2008 | Pubmed ID: 18800937 Prophylactic and Therapeutic Efficacy of a Fully Human Immunoglobulin G1 Monoclonal Antibody to Pseudomonas Aeruginosa Alginate in Murine Keratitis Infection Infection and Immunity. Oct, 2008 | Pubmed ID: 18644881 ClpXP Proteases Positively Regulate Alginate Overexpression and Mucoid Conversion in Pseudomonas Aeruginosa Microbiology (Reading, England). Jul, 2008 | Pubmed ID: 18599839 Dropping Acid to Help Cystic Fibrosis Nature Medicine. Apr, 2008 | Pubmed ID: 18391932 Predictors of Mucoid Pseudomonas Colonization in Cystic Fibrosis Patients Pediatric Pulmonology. May, 2008 | Pubmed ID: 18361452 Disruption of CFTR-dependent Lipid Rafts Reduces Bacterial Levels and Corneal Disease in a Murine Model of Pseudomonas Aeruginosa Keratitis Investigative Ophthalmology & Visual Science. Mar, 2008 | Pubmed ID: 18326723 Wall Teichoic Acids Are Dispensable for Anchoring the PNAG Exopolysaccharide to the Staphylococcus Aureus Cell Surface Microbiology (Reading, England). Mar, 2008 | Pubmed ID: 18310032 Mucosal Damage and Neutropenia Are Required for Candida Albicans Dissemination PLoS Pathogens. Feb, 2008 | Pubmed ID: 18282097 Airway Epithelial Control of Pseudomonas Aeruginosa Infection in Cystic Fibrosis Trends in Molecular Medicine. Mar, 2008 | Pubmed ID: 18262467 Vaccines and Immunotherapy Against Pseudomonas Aeruginosa Vaccine. Feb, 2008 | Pubmed ID: 18242792 Relationship of the Lipopolysaccharide Structure of Yersinia Pestis to Resistance to Antimicrobial Factors Advances in Experimental Medicine and Biology. 2007 | Pubmed ID: 17966406 Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells Science (New York, N.Y.). Jul, 2007 | Pubmed ID: 17615361 Molecular Basis for Preferential Protective Efficacy of Antibodies Directed to the Poorly Acetylated Form of Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine Infection and Immunity. Jul, 2007 | Pubmed ID: 17470540 Pseudomonas Aeruginosa Lipopolysaccharide: a Major Virulence Factor, Initiator of Inflammation and Target for Effective Immunity International Journal of Medical Microbiology : IJMM. Sep, 2007 | Pubmed ID: 17466590 Protection Against Escherichia Coli Infection by Antibody to the Staphylococcus Aureus Poly-N-acetylglucosamine Surface Polysaccharide Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17446272 Effect of Deletion of the LpxM Gene on Virulence and Vaccine Potential of Yersinia Pestis in Mice Journal of Medical Microbiology. Apr, 2007 | Pubmed ID: 17374882 Intranasal Immunization with Heterologously Expressed Polysaccharide Protects Against Multiple Pseudomonas Aeruginosa Infections Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360574 Resistance to Pseudomonas Aeruginosa Chronic Lung Infection Requires Cystic Fibrosis Transmembrane Conductance Regulator-modulated Interleukin-1 (IL-1) Release and Signaling Through the IL-1 Receptor Infection and Immunity. Apr, 2007 | Pubmed ID: 17283089 Is Pseudomonas Aeruginosa Exotoxin A a Good Carrier Protein for Conjugate Vaccines? Human Vaccines. Mar-Apr, 2007 | Pubmed ID: 17268204 Inflammatory Markers of Lung Disease in Adult Patients with Cystic Fibrosis Pediatric Pulmonology. Mar, 2007 | Pubmed ID: 17245735 Synthesis of Beta-(1-->6)-linked Glucosamine Oligosaccharides Corresponding to Fragments of the Bacterial Surface Polysaccharide Poly-N-acetylglucosamine Carbohydrate Research. Feb, 2007 | Pubmed ID: 16952342 Conserved and Variable Structural Features in the Lipopolysaccharide of Pseudomonas Aeruginosa Journal of Endotoxin Research. 2006 | Pubmed ID: 17254386 Airway Epithelial (nasal) Cell Monolayers Used to Study Pseudomonas Aeruginosa Invasion Are Hyperpolarized and Not Representative of the Human Airway Epithelium Infection and Immunity. Dec, 2006 | Pubmed ID: 17116966 Comparative Antibody-mediated Phagocytosis of Staphylococcus Epidermidis Cells Grown in a Biofilm or in the Planktonic State Infection and Immunity. Aug, 2006 | Pubmed ID: 16861673 Characterization of the Opsonic and Protective Activity Against Staphylococcus Aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-acetylglucosamine Infection and Immunity. May, 2006 | Pubmed ID: 16622211 A Live-attenuated Pseudomonas Aeruginosa Vaccine Elicits Outer Membrane Protein-specific Active and Passive Protection Against Corneal Infection Infection and Immunity. Feb, 2006 | Pubmed ID: 16428743 Structures of the Core Oligosaccharide and O-units in the R- and SR-type Lipopolysaccharides of Reference Strains of Pseudomonas Aeruginosa O-serogroups FEMS Immunology and Medical Microbiology. Feb, 2006 | Pubmed ID: 16420601 Effects of Growth in the Presence of Subinhibitory Concentrations of Dicloxacillin on Staphylococcus Epidermidis and Staphylococcus Haemolyticus Biofilms Applied and Environmental Microbiology. Dec, 2005 | Pubmed ID: 16332862 The Role of Epitope Specificity in the Human Opsonic Antibody Response to the Staphylococcal Surface Polysaccharide Poly N-acetyl Glucosamine The Journal of Infectious Diseases. Dec, 2005 | Pubmed ID: 16267775 Intraspecies and Temperature-dependent Variations in Susceptibility of Yersinia Pestis to the Bactericidal Action of Serum and to Polymyxin B Infection and Immunity. Nov, 2005 | Pubmed ID: 16239530 Poly-N-acetylglucosamine Production in Staphylococcus Aureus is Essential for Virulence in Murine Models of Systemic Infection Infection and Immunity. Oct, 2005 | Pubmed ID: 16177366 Influence of Cystic Fibrosis Transmembrane Conductance Regulator on Gene Expression in Response to Pseudomonas Aeruginosa Infection of Human Bronchial Epithelial Cells Infection and Immunity. Oct, 2005 | Pubmed ID: 16177360 Comparative Opsonic and Protective Activities of Staphylococcus Aureus Conjugate Vaccines Containing Native or Deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine Infection and Immunity. Oct, 2005 | Pubmed ID: 16177353 Nonmucoid Pseudomonas Aeruginosa Expresses Alginate in the Lungs of Patients with Cystic Fibrosis and in a Mouse Model The Journal of Infectious Diseases. Aug, 2005 | Pubmed ID: 15995954 Comparative Assessment of Antibiotic Susceptibility of Coagulase-negative Staphylococci in Biofilm Versus Planktonic Culture As Assessed by Bacterial Enumeration or Rapid XTT Colorimetry The Journal of Antimicrobial Chemotherapy. Aug, 2005 | Pubmed ID: 15980094 The Relationship Between Inhibition of Bacterial Adhesion to a Solid Surface by Sub-MICs of Antibiotics and Subsequent Development of a Biofilm Research in Microbiology. Jun-Jul, 2005 | Pubmed ID: 15950124 Use of Confocal Microscopy to Analyze the Rate of Vancomycin Penetration Through Staphylococcus Aureus Biofilms Antimicrobial Agents and Chemotherapy. Jun, 2005 | Pubmed ID: 15917548 Cold Temperature-induced Modifications to the Composition and Structure of the Lipopolysaccharide of Yersinia Pestis Carbohydrate Research. Jul, 2005 | Pubmed ID: 15907814 Quantitative Analysis of Adhesion and Biofilm Formation on Hydrophilic and Hydrophobic Surfaces of Clinical Isolates of Staphylococcus Epidermidis Research in Microbiology. May, 2005 | Pubmed ID: 15862449 Virulence of Pseudomonas Aeruginosa in a Murine Model of Gastrointestinal Colonization and Dissemination in Neutropenia Infection and Immunity. Apr, 2005 | Pubmed ID: 15784570 Temperature-dependent Variations and Intraspecies Diversity of the Structure of the Lipopolysaccharide of Yersinia Pestis Biochemistry. Feb, 2005 | Pubmed ID: 15683257 Hypoxia Increases Corneal Cell Expression of CFTR Leading to Increased Pseudomonas Aeruginosa Binding, Internalization, and Initiation of Inflammation Investigative Ophthalmology & Visual Science. Nov, 2004 | Pubmed ID: 15505057 Comparative Evaluation of Coagulase-negative Staphylococci (CoNS) Adherence to Acrylic by a Static Method and a Parallel-plate Flow Dynamic Method Research in Microbiology. Nov, 2004 | Pubmed ID: 15501653 Human Monoclonal Antibodies to Pseudomonas Aeruginosa Alginate That Protect Against Infection by Both Mucoid and Nonmucoid Strains Journal of Immunology (Baltimore, Md. : 1950). Nov, 2004 | Pubmed ID: 15494518 The GalU Gene of Pseudomonas Aeruginosa is Required for Corneal Infection and Efficient Systemic Spread Following Pneumonia but Not for Infection Confined to the Lung Infection and Immunity. Jul, 2004 | Pubmed ID: 15213167 Intraspecific Diversity of Yersinia Pestis Clinical Microbiology Reviews. Apr, 2004 | Pubmed ID: 15084509 The Teicoplanin-associated Locus Regulator (TcaR) and the Intercellular Adhesin Locus Regulator (IcaR) Are Transcriptional Inhibitors of the Ica Locus in Staphylococcus Aureus Journal of Bacteriology. Apr, 2004 | Pubmed ID: 15060048 Biologic Properties and Vaccine Potential of the Staphylococcal Poly-N-acetyl Glucosamine Surface Polysaccharide Vaccine. Feb, 2004 | Pubmed ID: 15040940 Meeting Summary: Possibilities for Active and Passive Vaccination Against Opportunistic Infections Vaccine. Feb, 2004 | Pubmed ID: 15040930 Assessment of the Role of Antibiotics and Enterococcal Virulence Factors in a Mouse Model of Extraintestinal Translocation Critical Care Medicine. Feb, 2004 | Pubmed ID: 14758165 Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells is Required for Pseudomonas Aeruginosa-induced Cellular Activation Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14688350 Promises and Pitfalls of Pseudomonas Aeruginosa Lipopolysaccharide As a Vaccine Antigen Carbohydrate Research. Nov, 2003 | Pubmed ID: 14670716 Transcription of Quorum-sensing System Genes in Clinical and Environmental Isolates of Pseudomonas Aeruginosa Journal of Bacteriology. Dec, 2003 | Pubmed ID: 14645283 Structure of the Lipopolysaccharide of Pseudomonas Aeruginosa O-12 with a Randomly O-acetylated Core Region Carbohydrate Research. Sep, 2003 | Pubmed ID: 12932374 Pseudomonas Aeruginosa Activates Cl- Channels in Host Epithelial Cells Pflügers Archiv : European Journal of Physiology. Oct, 2003 | Pubmed ID: 12920599 Structure of the Biological Repeating Unit of the O-antigen of Pseudomonas Aeruginosa Immunotype 4 Containing Both 2-acetamido-2,6-dideoxy-D-glucose and 2-acetamido-2,6-dideoxy-D-galactose Carbohydrate Research. Aug, 2003 | Pubmed ID: 12892948 Pseudomonas Aeruginosa-induced Apoptosis is Defective in Respiratory Epithelial Cells Expressing Mutant Cystic Fibrosis Transmembrane Conductance Regulator American Journal of Respiratory Cell and Molecular Biology. Aug, 2003 | Pubmed ID: 12878584 Construction and Characterization of a Pseudomonas Aeruginosa Mucoid Exopolysaccharide-alginate Conjugate Vaccine Infection and Immunity. Jul, 2003 | Pubmed ID: 12819072 Identification of a 5-nucleotide Sequence That Controls Expression of the Ica Locus in Staphylococcus Aureus and Characterization of the DNA-binding Properties of IcaR Molecular Microbiology. May, 2003 | Pubmed ID: 12753184 Isolation, Structural Characterization, and Immunological Evaluation of a High-molecular-weight Exopolysaccharide from Staphylococcus Aureus Carbohydrate Research. Apr, 2003 | Pubmed ID: 12681914 Protection Against Fatal Pseudomonas Aeruginosa Pneumonia in Mice After Nasal Immunization with a Live, Attenuated AroA Deletion Mutant Infection and Immunity. Mar, 2003 | Pubmed ID: 12595463 Hypersusceptibility of Cystic Fibrosis Mice to Chronic Pseudomonas Aeruginosa Oropharyngeal Colonization and Lung Infection Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12578988 Salmonella Enterica Serovar Typhi Modulates Cell Surface Expression of Its Receptor, the Cystic Fibrosis Transmembrane Conductance Regulator, on the Intestinal Epithelium Infection and Immunity. Nov, 2002 | Pubmed ID: 12379722 Immunochemical Properties of the Staphylococcal Poly-N-acetylglucosamine Surface Polysaccharide Infection and Immunity. Aug, 2002 | Pubmed ID: 12117954 CFTR is a Pattern Recognition Molecule That Extracts Pseudomonas Aeruginosa LPS from the Outer Membrane into Epithelial Cells and Activates NF-kappa B Translocation Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 11997458 Structural Studies on the Core and the O-polysaccharide Repeating Unit of Pseudomonas Aeruginosa Immunotype 1 Lipopolysaccharide European Journal of Biochemistry / FEBS. Apr, 2002 | Pubmed ID: 11985598 Lung Infections Associated with Cystic Fibrosis Clinical Microbiology Reviews. Apr, 2002 | Pubmed ID: 11932230 Construction and Characterization of a Live, Attenuated AroA Deletion Mutant of Pseudomonas Aeruginosa As a Candidate Intranasal Vaccine Infection and Immunity. Mar, 2002 | Pubmed ID: 11854239 CFTR Mutations and Host Susceptibility to Pseudomonas Aeruginosa Lung Infection Current Opinion in Microbiology. Feb, 2002 | Pubmed ID: 11834374 Isolatie van RNA Pseudomonas aeruginosa Kolonisatie van de muizen Maagdarmkanaal Eduardo Lopez-Medina1, Megan M. Neubauer1, Gerald B. Pier2, Andrew Y. Koh3 1Department of Pediatrics, University of Texas Southwestern Medical Center, 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 3Department of Pediatrics and Microbiology, University of Texas Southwestern Medical Center JoVE 3293 Immunology and Infection
Isolatie van RNA Pseudomonas aeruginosa Kolonisatie van de muizen Maagdarmkanaal Eduardo Lopez-Medina1, Megan M. Neubauer1, Gerald B. Pier2, Andrew Y. Koh3 1Department of Pediatrics, University of Texas Southwestern Medical Center, 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 3Department of Pediatrics and Microbiology, University of Texas Southwestern Medical Center JoVE 3293 Immunology and Infection