Guy Lippens

Publications

• The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 27975251
• Molecular Dynamics Simulation of Tau Peptides for the Investigation of Conformational Changes Induced by Specific Phosphorylation Patterns
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 27975243
• A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52
  Biochemistry. Sep, 2016  |   Pubmed ID: 27641460
• NMR Meets Tau: Insights into Its Function and Pathology
  Biomolecules. Jun, 2016  |   Pubmed ID: 27338491
• Studying Intrinsically Disordered Proteins Under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy
  Angewandte Chemie (International Ed. in English). Jun, 2016  |   Pubmed ID: 27159340
• Characterization of Neuronal Tau Protein As a Target of Extracellular Signal-regulated Kinase
  The Journal of Biological Chemistry. Apr, 2016  |   Pubmed ID: 26858248
• Tau Phosphorylation Regulates the Interaction Between BIN1's SH3 Domain and Tau's Proline-rich Domain
  Acta Neuropathologica Communications. Sep, 2015  |   Pubmed ID: 26395440
• Catalytic Site Inhibition of Insulin-degrading Enzyme by a Small Molecule Induces Glucose Intolerance in Mice
  Nature Communications. Sep, 2015  |   Pubmed ID: 26394692
• A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication
  The Journal of Biological Chemistry. Jul, 2015  |   Pubmed ID: 26085105
• The FK506-binding Protein FKBP52 in Vitro Induces Aggregation of Truncated Tau Forms with Prion-like Behavior
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2015  |   Pubmed ID: 25888602
• A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein
  Angewandte Chemie (International Ed. in English). Jun, 2015  |   Pubmed ID: 25881502
• Nuclear Magnetic Resonance Spectroscopy Characterization of Interaction of Tau with DNA and Its Regulation by Phosphorylation
  Biochemistry. Feb, 2015  |   Pubmed ID: 25623359
• Tau Monoclonal Antibody Generation Based on Humanized Yeast Models: Impact on Tau Oligomerization and Diagnostics
  The Journal of Biological Chemistry. Feb, 2015  |   Pubmed ID: 25540200
• H/D Exchange of a (15)N Labelled Tau Fragment As Measured by a Simple Relax-EXSY Experiment
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Oct, 2014  |   Pubmed ID: 25462944
• Phosphorylation in Intrinsically Disordered Regions Regulates the Activity of Neurogenin2
  BMC Biochemistry. Nov, 2014  |   Pubmed ID: 25374254
• Mechanism of Tau-promoted Microtubule Assembly As Probed by NMR Spectroscopy
  Journal of the American Chemical Society. Sep, 2014  |   Pubmed ID: 25162583
• Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein
  Biochemistry. May, 2014  |   Pubmed ID: 24708343
• Immunophilin FKBP52 Induces Tau-P301L Filamentous Assembly in Vitro and Modulates Its Activity in a Model of Tauopathy
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014  |   Pubmed ID: 24623856
• A Functional Fragment of Tau Forms Fibers Without the Need for an Intermolecular Cysteine Bridge
  Biochemical and Biophysical Research Communications. Mar, 2014  |   Pubmed ID: 24502945
• Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice
  PloS One. 2013  |   Pubmed ID: 24376810
• Dissociation Kinetics of a Binary Complex in Solution by Protein Displacement
  Angewandte Chemie (International Ed. in English). Nov, 2013  |   Pubmed ID: 24123878
• A New Strategy for Sequential Assignment of Intrinsically Unstructured Proteins Based on 15N Single Isotope Labelling
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Nov, 2013  |   Pubmed ID: 24018100
• Unraveling a Phosphorylation Event in a Folded Protein by NMR Spectroscopy: Phosphorylation of the Pin1 WW Domain by PKA
  Journal of Biomolecular NMR. Apr, 2013  |   Pubmed ID: 23456038
• Tau Pathology Modulates Pin1 Post-translational Modifications and May Be Relevant As Biomarker
  Neurobiology of Aging. Mar, 2013  |   Pubmed ID: 22926167
• Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A
  The Journal of Biological Chemistry. Dec, 2012  |   Pubmed ID: 23152499
• Cell Signaling, Post-translational Protein Modifications and NMR Spectroscopy
  Journal of Biomolecular NMR. Nov, 2012  |   Pubmed ID: 23011410
• Post-translational Modification: Nature's Escape from Genetic Imprisonment and the Basis for Dynamic Information Encoding
  Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Nov-Dec, 2012  |   Pubmed ID: 22899623
• Towards Understanding the Phosphorylation Code of Tau
  Biochemical Society Transactions. Aug, 2012  |   Pubmed ID: 22817719
• Differential Contribution of the Repeats to Heparin Binding of HBHA, a Major Adhesin of Mycobacterium Tuberculosis
  PloS One. 2012  |   Pubmed ID: 22403657
• Structural Activation of the Transcriptional Repressor EthR from Mycobacterium Tuberculosis by Single Amino Acid Change Mimicking Natural and Synthetic Ligands
  Nucleic Acids Research. Apr, 2012  |   Pubmed ID: 22156370
• Structural Characterization by Nuclear Magnetic Resonance of the Impact of Phosphorylation in the Proline-rich Region of the Disordered Tau Protein
  Proteins. Feb, 2012  |   Pubmed ID: 22072628
• Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy
  ACS Medicinal Chemistry Letters. Jun, 2011  |   Pubmed ID: 24900335
• Characterization of the AT180 Epitope of Phosphorylated Tau Protein by a Combined Nuclear Magnetic Resonance and Fluorescence Spectroscopy Approach
  Biochemical and Biophysical Research Communications. Sep, 2011  |   Pubmed ID: 21871442
• Glycerol and Glycerol Carbonate As Ultraviscous Solvents for Mixture Analysis by NMR
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Sep, 2011  |   Pubmed ID: 21802324
• Systematic Identification of Tubulin-interacting Fragments of the Microtubule-associated Protein Tau Leads to a Highly Efficient Promoter of Microtubule Assembly
  The Journal of Biological Chemistry. Sep, 2011  |   Pubmed ID: 21757739
• Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau
  PloS One. 2011  |   Pubmed ID: 21731772
• Molecular Basis for an Ancient Partnership Between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2
  Biochemistry. Aug, 2011  |   Pubmed ID: 21714498
• Substrate Recognition by the POTRA Domains of TpsB Transporter FhaC
  Molecular Microbiology. Jul, 2011  |   Pubmed ID: 21542859
• Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic Alpha-helical Propensity and is a Substrate of Cyclophilin A
  The Journal of Biological Chemistry. Jun, 2011  |   Pubmed ID: 21489988
• Comparative Analysis of Erk Phosphorylation Suggests a Mixed Strategy for Measuring Phospho-form Distributions
  Molecular Systems Biology. Apr, 2011  |   Pubmed ID: 21487401
• Mice Lacking Phosphatase PP2A Subunit PR61/B'delta (Ppp2r5d) Develop Spatially Restricted Tauopathy by Deregulation of CDK5 and GSK3beta
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011  |   Pubmed ID: 21482799
• Oleuropein and Derivatives from Olives As Tau Aggregation Inhibitors
  Neurochemistry International. May, 2011  |   Pubmed ID: 21333710
• Identification of O-GlcNAc Sites Within Peptides of the Tau Protein and Their Impact on Phosphorylation
  Molecular BioSystems. May, 2011  |   Pubmed ID: 21327254
• Intermolecular Interaction Studies Using Small Volumes
  Magnetic Resonance in Chemistry : MRC. Jan, 2011  |   Pubmed ID: 21162136
• DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-trans Isomerisation in Domain II of NS5A
  PloS One. Oct, 2010  |   Pubmed ID: 21060866
• Spectroscopic Studies of GSK3{beta} Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-terminal Domain of Apolipoprotein E
  The Journal of Biological Chemistry. Oct, 2010  |   Pubmed ID: 20679343
• NMR Spectroscopy of the Neuronal Tau Protein: Normal Function and Implication in Alzheimer's Disease
  Biochemical Society Transactions. Aug, 2010  |   Pubmed ID: 20658994
• Microtubule and MAPs: Thermodynamics of Complex Formation by AUC, ITC, Fluorescence, and NMR
  Methods in Cell Biology. 2010  |   Pubmed ID: 20466148
• The Domain 2 of the HCV NS5A Protein is Intrinsically Unstructured
  Protein and Peptide Letters. Aug, 2010  |   Pubmed ID: 20450484
• Structural Basis for the Non-immunosuppressive Character of the Cyclosporin A Analogue Debio 025
  Biochemistry. Jun, 2010  |   Pubmed ID: 20423153
• Fluorescent BODIPY-based Zn(II) Complex As a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer's Disease Patients
  Journal of the American Chemical Society. May, 2009  |   Pubmed ID: 19368380
• Hepatitis C Virus NS5A Protein is a Substrate for the Peptidyl-prolyl Cis/trans Isomerase Activity of Cyclophilins A and B
  The Journal of Biological Chemistry. May, 2009  |   Pubmed ID: 19297321
• Selective Backbone Labelling of ILV Methyl Labelled Proteins
  Journal of Biomolecular NMR. Apr, 2009  |   Pubmed ID: 19288066
• Domain 3 of Non-structural Protein 5A from Hepatitis C Virus is Natively Unfolded
  Biochemical and Biophysical Research Communications. Apr, 2009  |   Pubmed ID: 19249289
• Alzheimer Disease Specific Phosphoepitopes of Tau Interfere with Assembly of Tubulin but Not Binding to Microtubules
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2009  |   Pubmed ID: 19074508
• Graphical Interpretation of Boolean Operators for Protein NMR Assignments
  Journal of Biomolecular NMR. Sep, 2008  |   Pubmed ID: 18762868
• The Talin Rod IBS2 Alpha-helix Interacts with the Beta3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges
  The Journal of Biological Chemistry. Aug, 2008  |   Pubmed ID: 18577523
• Sandwich-ELISE NMR: Reducing the Sample Volume of NMR Samples
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jul, 2008  |   Pubmed ID: 18455452
• NMR Observation of Tau in Xenopus Oocytes
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jun, 2008  |   Pubmed ID: 18378475
• Measurement of Amyloid Fibril Length Distributions by Inclusion of Rotational Motion in Solution NMR Diffusion Measurements
  Angewandte Chemie (International Ed. in English). 2008  |   Pubmed ID: 18350531
• Microinjection of Recombinant O-GlcNAc Transferase Potentiates Xenopus Oocytes M-phase Entry
  Biochemical and Biophysical Research Communications. May, 2008  |   Pubmed ID: 18298951
• Tau Aggregation in Alzheimer's Disease: What Role for Phosphorylation?
  Prion. Jan-Mar, 2007  |   Pubmed ID: 19164903
• Contribution of Rotational Diffusion to Pulsed Field Gradient Diffusion Measurements
  The Journal of Chemical Physics. Sep, 2007  |   Pubmed ID: 17887855
• Structural and Functional Characterization of the Interaction Between Cyclophilin B and a Heparin-derived Oligosaccharide
  The Journal of Biological Chemistry. Nov, 2007  |   Pubmed ID: 17855358
• NMR Investigation of the Interaction Between the Neuronal Protein Tau and the Microtubules
  Biochemistry. Mar, 2007  |   Pubmed ID: 17311412
• Structural Impact of Heparin Binding to Full-length Tau As Studied by NMR Spectroscopy
  Biochemistry. Oct, 2006  |   Pubmed ID: 17029411
• Selective Intracellular Accumulation of the Major Metabolite Issued from the Activation of the Prodrug Ethionamide in Mycobacteria
  The Journal of Antimicrobial Chemotherapy. Oct, 2006  |   Pubmed ID: 16895935
• New DEFT Sequences for the Acquisition of One-dimensional Carbon NMR Spectra of Small Unlabelled Molecules
  Magnetic Resonance in Chemistry : MRC. Oct, 2006  |   Pubmed ID: 16883554
• ELISE NMR: Experimental Liquid Sealing of NMR Samples
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Aug, 2006  |   Pubmed ID: 16709462
• Arabidopsis PASTICCINO2 is an Antiphosphatase Involved in Regulation of Cyclin-dependent Kinase A
  The Plant Cell. Jun, 2006  |   Pubmed ID: 16698944
• Pin1 Allows for Differential Tau Dephosphorylation in Neuronal Cells
  Molecular and Cellular Neurosciences. May-Jun, 2006  |   Pubmed ID: 16697218
• NMR Analysis of a Tau Phosphorylation Pattern
  Journal of the American Chemical Society. Mar, 2006  |   Pubmed ID: 16536530
• Studying the Natively Unfolded Neuronal Tau Protein by Solution NMR Spectroscopy
  Protein and Peptide Letters. 2006  |   Pubmed ID: 16515451
• Regions of Tau Implicated in the Paired Helical Fragment Core As Defined by NMR
  Chembiochem : a European Journal of Chemical Biology. Oct, 2005  |   Pubmed ID: 16196016
• Control of Protein-protein Interactions: Structure-based Discovery of Low Molecular Weight Inhibitors of the Interactions Between Pin1 WW Domain and Phosphopeptides
  Journal of Medicinal Chemistry. Jul, 2005  |   Pubmed ID: 16033261
• High-resolution Magic Angle Spinning NMR of the Neuronal Tau Protein Integrated in Alzheimer's-like Paired Helical Fragments
  Journal of the American Chemical Society. Jul, 2005  |   Pubmed ID: 16028903
• Regulation of Pin1 Peptidyl-prolyl Cis/trans Isomerase Activity by Its WW Binding Module on a Multi-phosphorylated Peptide of Tau Protein
  FEBS Letters. Aug, 2005  |   Pubmed ID: 16024016
• Monitoring of the Ethionamide Pro-drug Activation in Mycobacteria by (1)H High Resolution Magic Angle Spinning NMR
  Biochemical and Biophysical Research Communications. Jun, 2005  |   Pubmed ID: 15850780
• Development of a High-resolution Magic-angle Spinning Nuclear Magnetic Resonance Identity Assay of the Capsular Polysaccharide from Haemophilus Influenzae Type B Present in Cetavlon Precipitate
  Analytical Biochemistry. Mar, 2005  |   Pubmed ID: 15707931
• Practical Aspects of Shimming a High Resolution Magic Angle Spinning Probe
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Mar, 2005  |   Pubmed ID: 15705516
• Accepting Its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein
  Chembiochem : a European Journal of Chemical Biology. Dec, 2004  |   Pubmed ID: 15532033
• Characterization of the Arabidopsis Thaliana Arath;CDC25 Dual-specificity Tyrosine Phosphatase
  Biochemical and Biophysical Research Communications. Sep, 2004  |   Pubmed ID: 15336525
• A Small CDC25 Dual-specificity Tyrosine-phosphatase Isoform in Arabidopsis Thaliana
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004  |   Pubmed ID: 15329414
• Structural Analysis of Escherichia Coli OpgG, a Protein Required for the Biosynthesis of Osmoregulated Periplasmic Glucans
  Journal of Molecular Biology. Sep, 2004  |   Pubmed ID: 15313617
• The Peptidyl Prolyl Cis/trans-isomerase Pin1 Recognizes the Phospho-Thr212-Pro213 Site on Tau
  Biochemistry. Feb, 2004  |   Pubmed ID: 14967043
• Proline-directed Random-coil Chemical Shift Values As a Tool for the NMR Assignment of the Tau Phosphorylation Sites
  Chembiochem : a European Journal of Chemical Biology. Jan, 2004  |   Pubmed ID: 14695515
• Cobatoxin 1 from Centruroides Noxius Scorpion Venom: Chemical Synthesis, Three-dimensional Structure in Solution, Pharmacology and Docking on K+ Channels
  The Biochemical Journal. Jan, 2004  |   Pubmed ID: 14498829
• Neurofibrillary Degeneration of the Alzheimer-type: an Alternate Pathway to Neuronal Apoptosis?
  Biochemical Pharmacology. Oct, 2003  |   Pubmed ID: 14555242
• Restricted Linear Least Square Treatment Processing of Heteronuclear Spectra of Biomolecules Using the ANAFOR Strategy
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Apr, 2003  |   Pubmed ID: 12713967
• HRMAS NMR Observation of Beta-sheet Secondary Structure on a Water Swollen Solid Support
  Journal of Peptide Science : an Official Publication of the European Peptide Society. Jan, 2003  |   Pubmed ID: 12587882
• Pin1: a Therapeutic Target in Alzheimer Neurodegeneration
  Journal of Molecular Neuroscience : MN. Dec, 2002  |   Pubmed ID: 12540053
• Fine-tuned Characterization at the Solid/solution Interface of Organotin Compounds Grafted Onto Cross-linked Polystyrene by Using High-resolution MAS NMR Spectroscopy
  Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2002  |   Pubmed ID: 12203323
• Resin Dynamics Contributes to the NMR Line Broadening of Organic Molecules Grafted Onto a Polystyrene Resin
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jun, 2002  |   Pubmed ID: 12165259
• Assignment of the 1H, 13C and 15N Resonances and Secondary Structure of the Monomeric P13suc1 Protein of Saccharomyces Pombe
  Journal of Biomolecular NMR. Jun, 2002  |   Pubmed ID: 12153042
• Solution Structure of the Single-domain Prolyl Cis/trans Isomerase PIN1At from Arabidopsis Thaliana
  Journal of Molecular Biology. Jul, 2002  |   Pubmed ID: 12079389
• Osmoregulated Periplasmic Glucans of the Free-living Photosynthetic Bacterium Rhodobacter Sphaeroides
  European Journal of Biochemistry. May, 2002  |   Pubmed ID: 12027884
• Solution NMR Study of the Monomeric Form of P13suc1 Protein Sheds Light on the Hinge Region Determining the Affinity for a Phosphorylated Substrate
  The Journal of Biological Chemistry. Apr, 2002  |   Pubmed ID: 11812792
• Solid-phase Enolate Chemistry Investigated Using HR-MAS NMR Spectroscopy
  The Journal of Organic Chemistry. Jan, 2002  |   Pubmed ID: 11798327