Hong Zan Department of Microbiology, Immunology and Molecular Genetics University of Texas Long School of Medicine at San Antonio Biography Publications Institution JoVE Articles Hong Zan has not added a biography. If you are Hong Zan and would like to personalize this page please email our Author Liaison for assistance. Publications Rad52 Competes with Ku70/Ku86 for Binding to S-region DSB Ends to Modulate Antibody Class-switch DNA Recombination Nature Communications. Feb, 2017 | Pubmed ID: 28176781 Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus Journal of Immunology (Baltimore, Md. : 1950). Nov, 2016 | Pubmed ID: 27742832 Editorial: Epigenetics of B Cells and Antibody Responses Frontiers in Immunology. 2015 | Pubmed ID: 26793194 Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Frontiers in Immunology. 2015 | Pubmed ID: 26697022 Genome-Wide Analysis Reveals Selective Modulation of MicroRNAs and MRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation Frontiers in Immunology. 2015 | Pubmed ID: 26697020 Histone Deacetylase Inhibitors Upregulate B Cell MicroRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014 | Pubmed ID: 25392531 Epigenetics in Lupus Autoimmunity. Jun, 2014 | Pubmed ID: 24826881 MicroRNAs in Lupus Autoimmunity. Jun, 2014 | Pubmed ID: 24826805 Combinatorial H3K9acS10ph Histone Modification in IgH Locus S Regions Targets 14-3-3 Adaptors and AID to Specify Antibody Class-switch DNA Recombination Cell Reports. Nov, 2013 | Pubmed ID: 24209747 Epigenetics of the Antibody Response Trends in Immunology. Sep, 2013 | Pubmed ID: 23643790 Regulation of Aicda Expression and AID Activity Autoimmunity. Mar, 2013 | Pubmed ID: 23181381 Rev1 Recruits Ung to Switch Regions and Enhances Du Glycosylation for Immunoglobulin Class Switch DNA Recombination Cell Reports. Nov, 2012 | Pubmed ID: 23140944 Immunoglobulin Class-switch DNA Recombination: Induction, Targeting and Beyond Nature Reviews. Immunology. Jun, 2012 | Pubmed ID: 22728528 B Cell TLRs and Induction of Immunoglobulin Class-switch DNA Recombination Frontiers in Bioscience (Landmark Edition). Jun, 2012 | Pubmed ID: 22652800 BCR-signalling Synergizes with TLR-signalling for Induction of AID and Immunoglobulin Class-switching Through the Non-canonical NF-κB Pathway Nature Communications. Apr, 2012 | Pubmed ID: 22473011 Viral Kinetics of Enterovirus 71 in Human Abdomyosarcoma Cells World Journal of Gastroenterology. Sep, 2011 | Pubmed ID: 22039330 AID Dysregulation in Lupus-prone MRL/Fas(lpr/lpr) Mice Increases Class Switch DNA Recombination and Promotes Interchromosomal C-Myc/IgH Loci Translocations: Modulation by HoxC4 Autoimmunity. Dec, 2011 | Pubmed ID: 21585311 Endonuclease G Plays a Role in Immunoglobulin Class Switch DNA Recombination by Introducing Double-strand Breaks in Switch Regions Molecular Immunology. Jan, 2011 | Pubmed ID: 21111482 Three Fatal Cases of Pandemic 2009 Influenza A Virus Infection in Shenzhen Are Associated with Cytokine Storm Respiratory Physiology & Neurobiology. Jan, 2011 | Pubmed ID: 21075220 Estrogen Receptors Bind to and Activate the HOXC4/HoxC4 Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation The Journal of Biological Chemistry. Nov, 2010 | Pubmed ID: 20855884 Specific Cross-reaction of Anti-dsDNA Antibody with Platelet Integrin GPIIIa49-66 Autoimmunity. Dec, 2010 | Pubmed ID: 20828249 14-3-3 Adaptor Proteins Recruit AID to 5'-AGCT-3'-rich Switch Regions for Class Switch Recombination Nature Structural & Molecular Biology. Sep, 2010 | Pubmed ID: 20729863 Toll-like Receptors and B-cell Receptors Synergize to Induce Immunoglobulin Class-switch DNA Recombination: Relevance to Microbial Antibody Responses Critical Reviews in Immunology. 2010 | Pubmed ID: 20370617 HoxC4 Binds to the Promoter of the Cytidine Deaminase AID Gene to Induce AID Expression, Class-switch DNA Recombination and Somatic Hypermutation Nature Immunology. May, 2009 | Pubmed ID: 19363484 Lupus-prone MRL/faslpr/lpr Mice Display Increased AID Expression and Extensive DNA Lesions, Comprising Deletions and Insertions, in the Immunoglobulin Locus: Concurrent Upregulation of Somatic Hypermutation and Class Switch DNA Recombination Autoimmunity. Feb, 2009 | Pubmed ID: 19156553 AID- and Ung-dependent Generation of Staggered Double-strand DNA Breaks in Immunoglobulin Class Switch DNA Recombination: a Post-cleavage Role for AID Molecular Immunology. Nov, 2008 | Pubmed ID: 18760480 A Role for DRAK2 in the Germinal Center Reaction and the Antibody Response Autoimmunity. Aug, 2008 | Pubmed ID: 18568639 Regulation of Aicda Expression and AID Activity: Relevance to Somatic Hypermutation and Class Switch DNA Recombination Critical Reviews in Immunology. 2007 | Pubmed ID: 18197815 DNA Replication to Aid Somatic Hypermutation Advances in Experimental Medicine and Biology. 2007 | Pubmed ID: 17338180 DNA Repair in Antibody Somatic Hypermutation Trends in Immunology. Jul, 2006 | Pubmed ID: 16737852 A Role for the MutL Mismatch Repair Mlh3 Protein in Immunoglobulin Class Switch DNA Recombination and Somatic Hypermutation Journal of Immunology (Baltimore, Md. : 1950). May, 2006 | Pubmed ID: 16622010 Biased DA/dT Somatic Hypermutation As Regulated by the Heavy Chain Intronic IEmu Enhancer and 3'Ealpha Enhancers in Human Lymphoblastoid B Cells Molecular Immunology. Apr, 2006 | Pubmed ID: 16412510 The Translesion DNA Polymerase Theta Plays a Dominant Role in Immunoglobulin Gene Somatic Hypermutation The EMBO Journal. Nov, 2005 | Pubmed ID: 16222339 DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation Annals of the New York Academy of Sciences. Jun, 2005 | Pubmed ID: 16014529 Class Switching and Myc Translocation: How Does DNA Break? Nature Immunology. Nov, 2004 | Pubmed ID: 15496946 Immunoglobulin Somatic Hypermutation: Double-strand DNA Breaks, AID and Error-prone DNA Repair Journal of Clinical Immunology. Jul, 2003 | Pubmed ID: 12959216 AID-dependent Generation of Resected Double-strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation Immunity. Jun, 2003 | Pubmed ID: 12818155 Selective Inhibition of Class Switching to IgG and IgE by Recruitment of the HoxC4 and Oct-1 Homeodomain Proteins and Ku70/Ku86 to Newly Identified ATTT Cis-elements The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12672812 Ongoing in Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2002 | Pubmed ID: 12444172 Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin V(H)DJ(H) Gene Diversification The Journal of Experimental Medicine. Sep, 2002 | Pubmed ID: 12208878 Genoma-ancha análisis de inhibidor de HDAC mediada por modulación de microRNAs y mRNAs en células B inducida por recombinación del ADN someterse a interruptor de clase y diferenciación de células plasmáticas Helia N. Sanchez1, Tian Shen1,2, Dawn Garcia1,3, Zhao Lai1,3, Paolo Casali1, Hong Zan1 1Department of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine at San Antonio, 2Xiangya School of Medicine, Cental South University, 3Greehey Children’s Cancer Research Institute, University of Texas Long School of Medicine at San Antonio JoVE 55135 Immunology and Infection
Genoma-ancha análisis de inhibidor de HDAC mediada por modulación de microRNAs y mRNAs en células B inducida por recombinación del ADN someterse a interruptor de clase y diferenciación de células plasmáticas Helia N. Sanchez1, Tian Shen1,2, Dawn Garcia1,3, Zhao Lai1,3, Paolo Casali1, Hong Zan1 1Department of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine at San Antonio, 2Xiangya School of Medicine, Cental South University, 3Greehey Children’s Cancer Research Institute, University of Texas Long School of Medicine at San Antonio JoVE 55135 Immunology and Infection
