Horst Kessler Department of Chemistry Technische Universität München Biography Publications Institution JoVE Articles Horst Kessler has not added a biography. If you are Horst Kessler and would like to personalize this page please email our Author Liaison for assistance. Publications A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins Scientific Reports. Jan, 2017 | Pubmed ID: 28074920 In Vivo PET Imaging of the Cancer Integrin αvβ6 Using (68)Ga-Labeled Cyclic RGD Nonapeptides Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Apr, 2017 | Pubmed ID: 27980050 Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer Neoplasia (New York, N.Y.). Jan, 2017 | Pubmed ID: 27940248 Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing Journal of Medicinal Chemistry. Nov, 2016 | Pubmed ID: 27753493 αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating Angewandte Chemie (International Ed. in English). Jun, 2016 | Pubmed ID: 27258759 Solution Structure and Binding Specificity of the P63 DNA Binding Domain Scientific Reports. May, 2016 | Pubmed ID: 27225672 Variation of Specific Activities of 68Ga-Aquibeprin and 68Ga-Avebetrin Enables Selective PET Imaging of Different Expression Levels of Integrins α5β1 and αvβ3 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Oct, 2016 | Pubmed ID: 27151985 The Influence of Different Metal-chelate Conjugates of Pentixafor on the CXCR4 Affinity EJNMMI Research. Dec, 2016 | Pubmed ID: 27112767 Non-invasive Assessment of Inter-and Intrapatient Variability of Integrin Expression in Metastasized Prostate Cancer by PET Oncotarget. May, 2016 | Pubmed ID: 27058620 Selective Binding and Lateral Clustering of α5β1 and αvβ3 Integrins: Unraveling the Spatial Requirements for Cell Spreading and Focal Adhesion Assembly Cell Adhesion & Migration. Sep, 2016 | Pubmed ID: 27003228 Substrate Engagement of Integrins α5β1 and αvβ3 is Necessary, but Not Sufficient, for High Directional Persistence in Migration on Fibronectin Scientific Reports. Mar, 2016 | Pubmed ID: 26987342 Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity Angewandte Chemie (International Ed. in English). Jan, 2016 | Pubmed ID: 26663700 Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands Angewandte Chemie (International Ed. in English). Jan, 2016 | Pubmed ID: 26663660 Complementary, Selective PET Imaging of Integrin Subtypes α5β1 and αvβ3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Mar, 2016 | Pubmed ID: 26635338 In Vivo Biokinetic and Metabolic Characterization of the ⁶⁸Ga-labelled α5β1-selective Peptidomimetic FR366 European Journal of Nuclear Medicine and Molecular Imaging. May, 2016 | Pubmed ID: 26497698 Caveolin-1-negative Head and Neck Squamous Cell Carcinoma Primary Tumors Display Increased Epithelial to Mesenchymal Transition and Prometastatic Properties Oncotarget. Dec, 2015 | Pubmed ID: 26474461 Cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? Chemistry (Weinheim an Der Bergstrasse, Germany). Oct, 2015 | Pubmed ID: 26337831 Minimal Synthetic Cells to Study Integrin-mediated Adhesion Angewandte Chemie (International Ed. in English). Oct, 2015 | Pubmed ID: 26257266 Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors Journal of Medicinal Chemistry. Aug, 2015 | Pubmed ID: 26218460 Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions Advanced Materials (Deerfield Beach, Fla.). Jul, 2015 | Pubmed ID: 25981929 Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-mediated Transport Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2015 | Pubmed ID: 25917866 Hsp90 Regulates the Dynamics of Its Cochaperone Sti1 and the Transfer of Hsp70 Between Modules Nature Communications. Apr, 2015 | Pubmed ID: 25851214 Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging Theranostics. 2015 | Pubmed ID: 25825601 Mimicking Bone Extracellular Matrix: Integrin-binding Peptidomimetics Enhance Osteoblast-like Cells Adhesion, Proliferation, and Differentiation on Titanium Colloids and Surfaces. B, Biointerfaces. Apr, 2015 | Pubmed ID: 25637448 Direct Prediction of Residual Dipolar Couplings of Small Molecules in a Stretched Gel by Stochastic Molecular Dynamics Simulations Magnetic Resonance in Chemistry : MRC. Mar, 2015 | Pubmed ID: 25612077 Interface Immobilization Chemistry of CRGD-based Peptides Regulates Integrin Mediated Cell Adhesion Advanced Functional Materials. Feb, 2014 | Pubmed ID: 25810710 Receptor-bound Conformation of Cilengitide Better Represented by Its Solution-state Structure Than the Solid-state Structure Chemistry (Weinheim an Der Bergstrasse, Germany). Oct, 2014 | Pubmed ID: 25251673 Cytoplasmic Salt Bridge Formation in Integrin αvß3 Stabilizes Its Inactive State Affecting Integrin-mediated Cell Biological Effects Cellular Signalling. Nov, 2014 | Pubmed ID: 25041847 Protein Folding by Interaction Structure (London, England : 1993). Jul, 2014 | Pubmed ID: 25007223 Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides Journal of Medicinal Chemistry. Jul, 2014 | Pubmed ID: 24949551 Single Cell Tracking Assay Reveals an Opposite Effect of Selective Small Non-peptidic α5β1 or αvβ3/β5 Integrin Antagonists in U87MG Glioma Cells Biochimica Et Biophysica Acta. May, 2014 | Pubmed ID: 24810979 The Integrin Ligand C(RGDf(NMe)Nal) Reduces Neointimal Hyperplasia in a Polymer-free Drug-eluting Stent System ChemMedChem. Jul, 2014 | Pubmed ID: 24706601 Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of (68)Ga-NOPO-c(RGDfK) Molecular Pharmaceutics. May, 2014 | Pubmed ID: 24669840 Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity Journal of Medicinal Chemistry. Apr, 2014 | Pubmed ID: 24654918 Investigation of Early Cell-surface Interactions of Human Mesenchymal Stem Cells on Nanopatterned β-type Titanium-niobium Alloy Surfaces Interface Focus. Feb, 2014 | Pubmed ID: 24501674 PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis JACC. Cardiovascular Imaging. Feb, 2014 | Pubmed ID: 24412187 The Cyclic Cystine Ladder of Theta-defensins As a Stable, Bifunctional Scaffold: A Proof-of-concept Study Using the Integrin-binding RGD Motif Chembiochem : a European Journal of Chemical Biology. Feb, 2014 | Pubmed ID: 24382674 Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3 Angewandte Chemie (International Ed. in English). Oct, 2013 | Pubmed ID: 24115324 Integrin Modulators: a Patent Review Expert Opinion on Therapeutic Patents. Oct, 2013 | Pubmed ID: 24050747 Tumor Targeting Via Integrin Ligands Frontiers in Oncology. Aug, 2013 | Pubmed ID: 24010121 Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: a New Tool for the Measurement of Cell Traction Forces Transmitted Through αvβ3- or α5β1-integrins Advanced Materials (Deerfield Beach, Fla.). Nov, 2013 | Pubmed ID: 23913640 A Molecular Toolkit for the Functionalization of Titanium-based Biomaterials That Selectively Control Integrin-mediated Cell Adhesion Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2013 | Pubmed ID: 23744802 The Glycophorin A Transmembrane Sequence Within Integrin αvβ3 Creates a Non-signaling Integrin with Low Basal Affinity That is Strongly Adhesive Under Force Journal of Molecular Biology. Aug, 2013 | Pubmed ID: 23727145 Comparison of Cyclic RGD Peptides for αvβ3 Integrin Detection in a Rat Model of Myocardial Infarction EJNMMI Research. May, 2013 | Pubmed ID: 23663426 A Cyclen-based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates Chemistry (Weinheim an Der Bergstrasse, Germany). Jun, 2013 | Pubmed ID: 23613345 Biselectivity of IsoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control Through Flanking Amino Acids Journal of Medicinal Chemistry. Feb, 2013 | Pubmed ID: 23362923 Functionalizing αvβ3- or α5β1-selective Integrin Antagonists for Surface Coating: a Method to Discriminate Integrin Subtypes in Vitro Angewandte Chemie (International Ed. in English). Jan, 2013 | Pubmed ID: 23345131 FOSL1 Controls the Assembly of Endothelial Cells into Capillary Tubes by Direct Repression of αv and β3 Integrin Transcription Molecular and Cellular Biology. Mar, 2013 | Pubmed ID: 23319049 Orthogonally Protected Artificial Amino Acid As Tripod Ligand for Automated Peptide Synthesis and Labeling with [(99m)Tc(OH(2))(3)(CO)(3)](+) Bioconjugate Chemistry. Jan, 2013 | Pubmed ID: 23237229 N-methylation of Peptides and Proteins: an Important Element for Modulating Biological Functions Angewandte Chemie (International Ed. in English). Jan, 2013 | Pubmed ID: 23161799 The Regulatory Domain Stabilizes the P53 Tetramer by Intersubunit Contacts with the DNA Binding Domain Journal of Molecular Biology. Jan, 2013 | Pubmed ID: 23103206 Behavior of Primary Human Osteoblasts on Trimmed and Sandblasted Ti6Al4V Surfaces Functionalized with Integrin αvβ3-selective Cyclic RGD Peptides Journal of Biomedical Materials Research. Part A. Jan, 2013 | Pubmed ID: 22826207 In Support of the BMRB Nature Structural & Molecular Biology. Sep, 2012 | Pubmed ID: 22955930 A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity Angewandte Chemie (International Ed. in English). Aug, 2012 | Pubmed ID: 22760863 Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified Journal of the American Chemical Society. Jul, 2012 | Pubmed ID: 22737969 Cell Adhesion and Proliferation on RGD-modified Recombinant Spider Silk Proteins Biomaterials. Oct, 2012 | Pubmed ID: 22727466 Guiding Plant Virus Particles to Integrin-displaying Cells Nanoscale. Jun, 2012 | Pubmed ID: 22585108 Cyclic Aza-peptide Integrin Ligand Synthesis and Biological Activity The Journal of Organic Chemistry. Jun, 2012 | Pubmed ID: 22582818 68Ga-NODAGA-RGD is a Suitable Substitute for (18)F-Galacto-RGD and Can Be Produced with High Specific Activity in a CGMP/GRP Compliant Automated Process Nuclear Medicine and Biology. Aug, 2012 | Pubmed ID: 22444238 Solid-phase-assisted Synthesis of Targeting Peptide-PEG-oligo(ethane Amino)amides for Receptor-mediated Gene Delivery Organic & Biomolecular Chemistry. Apr, 2012 | Pubmed ID: 22407126 Synthesis of N-methylated Cyclic Peptides Nature Protocols. Feb, 2012 | Pubmed ID: 22322216 Polymer-free Immobilization of a Cyclic RGD Peptide on a Nitinol Stent Promotes Integrin-dependent Endothelial Coverage of Strut Surfaces Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Apr, 2012 | Pubmed ID: 22278946 The Architecture of Functional Modules in the Hsp90 Co-chaperone Sti1/Hop The EMBO Journal. Mar, 2012 | Pubmed ID: 22227520 Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-dependent Adhesion Site Journal of Medicinal Chemistry. Jan, 2012 | Pubmed ID: 22185640 Synthesis and Conformational Analysis of Efrapeptins Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2012 | Pubmed ID: 22147615 N-Methylated Sst2 Selective Somatostatin Cyclic Peptide Analogue As a Potent Candidate for Treating Neurogenic Inflammation ACS Medicinal Chemistry Letters. Jul, 2011 | Pubmed ID: 24900340 Spectroscopically Well-characterized RGD Optical Probe As a Prerequisite for Lifetime-gated Tumor Imaging Molecular Imaging. Dec, 2011 | Pubmed ID: 22201538 PET of CXCR4 Expression by a (68)Ga-labeled Highly Specific Targeted Contrast Agent Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2011 | Pubmed ID: 22045709 Increasing αvβ3 Selectivity of the Anti-angiogenic Drug Cilengitide by N-methylation Angewandte Chemie (International Ed. in English). Sep, 2011 | Pubmed ID: 21948451 Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4 Journal of Medicinal Chemistry. Nov, 2011 | Pubmed ID: 21905730 Structural Analysis of the Interaction Between Hsp90 and the Tumor Suppressor Protein P53 Nature Structural & Molecular Biology. Sep, 2011 | Pubmed ID: 21892170 Introducing Lasso Peptides As Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist Angewandte Chemie (International Ed. in English). Sep, 2011 | Pubmed ID: 21812076 Telethonin Deficiency is Associated with Maladaptation to Biomechanical Stress in the Mammalian Heart Circulation Research. Sep, 2011 | Pubmed ID: 21799151 PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand ChemMedChem. Oct, 2011 | Pubmed ID: 21780290 PET Imaging of Integrin αVβ3 Expression Theranostics. Jan, 2011 | Pubmed ID: 21547152 Impact of Local Versus Global Ligand Density on Cellular Adhesion Nano Letters. Apr, 2011 | Pubmed ID: 21425841 The Effect of Multiple N-methylation on Intestinal Permeability of Cyclic Hexapeptides Molecular Pharmaceutics. Apr, 2011 | Pubmed ID: 21375270 Stable Functionalized PEGylated Quantum Dots Micelles with a Controlled Stoichiometry Chemical Communications (Cambridge, England). Jan, 2011 | Pubmed ID: 21103558 NCO-sP(EO-stat-PO) Surface Coatings Preserve Biochemical Properties of RGD Peptides International Journal of Molecular Medicine. Jan, 2011 | Pubmed ID: 21069259 PH-dependent Dimerization and Salt-dependent Stabilization of the N-terminal Domain of Spider Dragline Silk--implications for Fiber Formation Angewandte Chemie (International Ed. in English). Jan, 2011 | Pubmed ID: 21064058 Improvement of Drug-like Properties of Peptides: the Somatostatin Paradigm Expert Opinion on Drug Discovery. Jul, 2010 | Pubmed ID: 22823205 Cilengitide: the First Anti-angiogenic Small Molecule Drug Candidate Design, Synthesis and Clinical Evaluation Anti-cancer Agents in Medicinal Chemistry. Dec, 2010 | Pubmed ID: 21269250 Stimulation of Cell Adhesion at Nanostructured Teflon Interfaces Advanced Materials (Deerfield Beach, Fla.). Dec, 2010 | Pubmed ID: 20972983 Optimized Measurement Temperature Gives Access to the Solution Structure of a 49 KDa Homohexameric β-propeller Journal of the American Chemical Society. Nov, 2010 | Pubmed ID: 20961124 Conformational Control of Integrin-subtype Selectivity in IsoDGR Peptide Motifs: a Biological Switch Angewandte Chemie (International Ed. in English). Nov, 2010 | Pubmed ID: 20957712 Polymeric Substrates with Tunable Elasticity and Nanoscopically Controlled Biomolecule Presentation Langmuir : the ACS Journal of Surfaces and Colloids. Oct, 2010 | Pubmed ID: 20831282 Hsp12 is an Intrinsically Unstructured Stress Protein That Folds Upon Membrane Association and Modulates Membrane Function Molecular Cell. Aug, 2010 | Pubmed ID: 20797624 Multiple N-methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype HMC1R Selectivity: Pharmacological and Conformational Studies Journal of the American Chemical Society. Jun, 2010 | Pubmed ID: 20496895 A Conserved Spider Silk Domain Acts As a Molecular Switch That Controls Fibre Assembly Nature. May, 2010 | Pubmed ID: 20463741 The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2010 | Pubmed ID: 20358563 Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1 Molecular Cell. Feb, 2010 | Pubmed ID: 20159554 BclxL Changes Conformation Upon Binding to Wild-type but Not Mutant P53 DNA Binding Domain The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19955567 Cell Interactions with Hierarchically Structured Nano-patterned Adhesive Surfaces Soft Matter. Jan, 2009 | Pubmed ID: 21686049 Hsp90 is Regulated by a Switch Point in the C-terminal Domain EMBO Reports. Oct, 2009 | Pubmed ID: 19696785 The Transmembrane Structure of Integrin AlphaIIbbeta3: Significance for Signal Transduction Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19598189 An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies Molecular Cell. Jun, 2009 | Pubmed ID: 19524537 Prolonged Stability by Cyclization: Macrocyclic Phosphino Dipeptide Isostere Inhibitors of Beta-secretase (BACE1) Bioorganic & Medicinal Chemistry Letters. Aug, 2009 | Pubmed ID: 19523824 Ligands for Mapping Alphavbeta3-integrin Expression in Vivo Accounts of Chemical Research. Jul, 2009 | Pubmed ID: 19489579 The HSP90 Binding Mode of a Radicicol-like E-oxime Determined by Docking, Binding Free Energy Estimations, and NMR 15N Chemical Shifts Biophysical Chemistry. Aug, 2009 | Pubmed ID: 19482409 Imaging of Integrin Alpha(v)beta(3) Expression in Patients with Malignant Glioma by [18F] Galacto-RGD Positron Emission Tomography Neuro-oncology. Dec, 2009 | Pubmed ID: 19401596 New Perspective in Peptide Chemistry by N-alkylation Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19400173 Highly Selective Cyclic Hexapeptides Antagonist of GPIIb-IIIa by Multiple N-methylation Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19400163 Making Double-minded Peptides Strong-willed? The Side Chain Impact on the Backbone Conformation of N-methylated Cyclic Pentapeptides Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19400138 Development of a Small Molecule Peptidomimetic Affinity Ligand for Efficient Purification of the Large Protein Factor VIII Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19400135 N-methylated Cyclic Pentapeptides As Template Structures Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19400115 Solid-phase Synthesis of Phosphinic Dipepetide Isosteres and Beta Amino Acids Via Activated N-terminal Acrylamides Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 19400072 Breaking the Dogma of the Metal-coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS to Tune Potency and Selectivity Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19343753 Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion Nano Letters. Mar, 2009 | Pubmed ID: 19206508 Interaction of Human Heat Shock Protein 70 with Tumor-associated Peptides Biological Chemistry. Apr, 2009 | Pubmed ID: 19199830 The State of the Art of Chemical Biology Chembiochem : a European Journal of Chemical Biology. Jan, 2009 | Pubmed ID: 19115274 Can N-methylated Amino Acids Serve As Substitutes for Prolines in Conformational Design of Cyclic Pentapeptides? Journal of Peptide Science : an Official Publication of the European Peptide Society. Mar, 2009 | Pubmed ID: 18985637 Perspectives on NMR in Drug Discovery: a Technique Comes of Age Nature Reviews. Drug Discovery. Sep, 2008 | Pubmed ID: 19172689 Deuterated Polymer Gels for Measuring Anisotropic NMR Parameters with Strongly Reduced Artefacts Chemical Communications (Cambridge, England). Nov, 2008 | Pubmed ID: 19009060 The Solution Structure of BMPR-IA Reveals a Local Disorder-to-order Transition Upon BMP-2 Binding Biochemistry. Nov, 2008 | Pubmed ID: 18937504 The Structure of a Folding Intermediate Provides Insight into Differences in Immunoglobulin Amyloidogenicity Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18768806 Cooperativity in Adhesion Cluster Formation During Initial Cell Adhesion Biophysical Journal. Dec, 2008 | Pubmed ID: 18689459 N-methylation of Peptides: a New Perspective in Medicinal Chemistry Accounts of Chemical Research. Oct, 2008 | Pubmed ID: 18636716 Cell Adhesion and Polarisation on Molecularly Defined Spacing Gradient Surfaces of Cyclic RGDfK Peptide Patches European Journal of Cell Biology. Sep, 2008 | Pubmed ID: 18572273 Induction of Cell Polarization and Migration by a Gradient of Nanoscale Variations in Adhesive Ligand Spacing Nano Letters. Jul, 2008 | Pubmed ID: 18558788 Rational Design of Highly Active and Selective Ligands for the Alpha5beta1 Integrin Receptor Chembiochem : a European Journal of Chemical Biology. Jun, 2008 | Pubmed ID: 18481343 Isothiocyanate-functionalized RGD Peptides for Tailoring Cell-adhesive Surface Patterns Biomaterials. Jul, 2008 | Pubmed ID: 18433862 Biophysics: the Sweetest Candy for the Virus Nature. Apr, 2008 | Pubmed ID: 18421340 The CLIP/CLAP-HSQC: Pure Absorptive Spectra for the Measurement of One-bond Couplings Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jun, 2008 | Pubmed ID: 18411067 Chemical Conjugation of Linear and Cyclic RGD Moieties to a Recombinant Elastin-mimetic Polypeptide--a Versatile Approach Towards Bioactive Protein Hydrogels Macromolecular Bioscience. Jun, 2008 | Pubmed ID: 18350537 Phosphorus NMR Spectroscopy As a Versatile Tool for Compound Library Screening Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18311739 Improving Oral Bioavailability of Peptides by Multiple N-methylation: Somatostatin Analogues Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18297660 Assessment of Alphavbeta3 Integrin Expression After Myocardial Infarction by Positron Emission Tomography Cardiovascular Research. May, 2008 | Pubmed ID: 18256073 Conformational Preference and Potential Templates of N-methylated Cyclic Pentaalanine Peptides Chemistry (Weinheim an Der Bergstrasse, Germany). 2008 | Pubmed ID: 18080261 Development and Evaluation of Peptidic Ligands Targeting Tumour-associated Urokinase Plasminogen Activator Receptor (uPAR) for Use in Alpha-emitter Therapy for Disseminated Ovarian Cancer European Journal of Nuclear Medicine and Molecular Imaging. Jan, 2008 | Pubmed ID: 17891393 Multiple N-methylation by a Designed Approach Enhances Receptor Selectivity Journal of Medicinal Chemistry. Nov, 2007 | Pubmed ID: 17973471 J-ONLY-TOCSY: Efficient Suppression of RDC-induced Transfer in Homonuclear TOCSY Experiments Using JESTER-1-derived Multiple Pulse Sequences Journal of Magnetic Resonance (San Diego, Calif. : 1997). Dec, 2007 | Pubmed ID: 17936049 Specific Integrin Labeling in Living Cells Using Functionalized Nanocrystals Small (Weinheim an Der Bergstrasse, Germany). Sep, 2007 | Pubmed ID: 17705315 Design and Chemical Synthesis of Integrin Ligands Methods in Enzymology. 2007 | Pubmed ID: 17697896 Protein Repellent Properties of Covalently Attached PEG Coatings on Nanostructured SiO(2)-based Interfaces Biomaterials. Nov, 2007 | Pubmed ID: 17697710 Development of a Peptidomimetic Ligand for Efficient Isolation and Purification of Factor VIII Via Affinity Chromatography Journal of Medicinal Chemistry. Sep, 2007 | Pubmed ID: 17691762 NMR-based Screening: a Powerful Tool in Fragment-based Drug Discovery The Analyst. Jul, 2007 | Pubmed ID: 17657909 The RGD Motif in Fibronectin is Essential for Development but Dispensable for Fibril Assembly The Journal of Cell Biology. Jul, 2007 | Pubmed ID: 17591922 Synthesis of Novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic Acid (DOTA) Derivatives for Chemoselective Attachment to Unprotected Polyfunctionalized Compounds Chemistry (Weinheim an Der Bergstrasse, Germany). 2007 | Pubmed ID: 17503419 Synthesis and Biological Evaluation of Phosphino Dipeptide Isostere Inhibitor of Human Beta-secretase (BACE1) Bioorganic & Medicinal Chemistry. Jun, 2007 | Pubmed ID: 17433698 Mimicking Cellular Environments by Nanostructured Soft Interfaces Nano Letters. May, 2007 | Pubmed ID: 17394372 Probing Integrin Selectivity: Rational Design of Highly Active and Selective Ligands for the Alpha5beta1 and Alphavbeta3 Integrin Receptor Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17394271 Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin Ligands Biophysical Journal. Apr, 2007 | Pubmed ID: 17277192 J-Spectroscopy in the Presence of Residual Dipolar Couplings: Determination of One-bond Coupling Constants and Scalable Resolution Journal of Biomolecular NMR. Mar, 2007 | Pubmed ID: 17235497 Influence of the Internal Disulfide Bridge on the Folding Pathway of the CL Antibody Domain Journal of Molecular Biology. Jan, 2007 | Pubmed ID: 17112539 N-methylated Cyclic Pentaalanine Peptides As Template Structures Journal of the American Chemical Society. Nov, 2006 | Pubmed ID: 17117868 The Conformation of Cyclo(-D-Pro-Ala4-) As a Model for Cyclic Pentapeptides of the DL4 Type Journal of the American Chemical Society. Oct, 2006 | Pubmed ID: 17044709 P53--a Natural Cancer Killer: Structural Insights and Therapeutic Concepts Angewandte Chemie (International Ed. in English). Oct, 2006 | Pubmed ID: 16983711 Efficient Enantioselective Synthesis of Condensed and Aromatic-ring-substituted Tyrosine Derivatives The Journal of Organic Chemistry. Jul, 2006 | Pubmed ID: 16839142 Inter-domain Orientation and Motions in VAT-N Explored by Residual Dipolar Couplings and 15N Backbone Relaxation Magnetic Resonance in Chemistry : MRC. Jul, 2006 | Pubmed ID: 16826545 Positron Emission Tomography Using [18F]Galacto-RGD Identifies the Level of Integrin Alpha(v)beta3 Expression in Man Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2006 | Pubmed ID: 16818691 Binding of Small Mono- and Oligomeric Integrin Ligands to Membrane-embedded Integrins Monitored by Surface Plasmon-enhanced Fluorescence Spectroscopy Analytical Chemistry. Jul, 2006 | Pubmed ID: 16808462 Synthesis and Stereochemical Assignment of DNA Spore Photoproduct Analogues Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2006 | Pubmed ID: 16789031 Solid-phase Synthesis of 1,3-azole-based Peptides and Peptidomimetics Organic Letters. May, 2006 | Pubmed ID: 16706540 Growth Promoting in Vitro Effect of Synthetic Cyclic RGD-peptides on Human Osteoblast-like Cells Attached to Cancellous Bone International Journal of Molecular Medicine. Jun, 2006 | Pubmed ID: 16685410 Characterization of Human Saposins by NMR Spectroscopy Biochemistry. Apr, 2006 | Pubmed ID: 16618109 Lateral Spacing of Integrin Ligands Influences Cell Spreading and Focal Adhesion Assembly European Journal of Cell Biology. Apr, 2006 | Pubmed ID: 16546564 Cellular Unbinding Forces of Initial Adhesion Processes on Nanopatterned Surfaces Probed with Magnetic Tweezers Nano Letters. Mar, 2006 | Pubmed ID: 16522030 Intrinsic Inhibition of the Hsp90 ATPase Activity The Journal of Biological Chemistry. Apr, 2006 | Pubmed ID: 16461354 WT P53, but Not Tumor-derived Mutants, Bind to Bcl2 Via the DNA Binding Domain and Induce Mitochondrial Permeabilization The Journal of Biological Chemistry. Mar, 2006 | Pubmed ID: 16443602 The Holo-form of the Nucleotide Binding Domain of the KdpFABC Complex from Escherichia Coli Reveals a New Binding Mode The Journal of Biological Chemistry. Apr, 2006 | Pubmed ID: 16354672 Benzylprotected Aromatic Phosphonic Acids for Anchoring Peptides on Titanium Bioorganic & Medicinal Chemistry Letters. Jan, 2006 | Pubmed ID: 16256349 3-Substituted Indolizine-1-carbonitrile Derivatives As Phosphatase Inhibitors Bioorganic & Medicinal Chemistry Letters. Jan, 2006 | Pubmed ID: 16236508 Optimized Selective N-methylation of Peptides on Solid Support Journal of Peptide Science : an Official Publication of the European Peptide Society. Mar, 2006 | Pubmed ID: 16189816 Prokaryotic Kdp-ATPase: Recent Insights into the Structure and Function of KdpB Journal of Molecular Microbiology and Biotechnology. 2005 | Pubmed ID: 16645309 Molecular Targeting with Peptides or Peptide-polymer Conjugates: Just a Question of Size? Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Dec, 2005 | Pubmed ID: 16330555 Photoswitched Cell Adhesion on Surfaces with RGD Peptides Journal of the American Chemical Society. Nov, 2005 | Pubmed ID: 16287297 Titanium Implant Materials with Improved Biocompatibility Through Coating with Phosphonate-anchored Cyclic RGD Peptides Chembiochem : a European Journal of Chemical Biology. Nov, 2005 | Pubmed ID: 16206226 Structure Refinement of Cyclosporin A in Chloroform by Using RDCs Measured in a Stretched PDMS-gel Chembiochem : a European Journal of Chemical Biology. Sep, 2005 | Pubmed ID: 16138307 Diffusion NMR Spectroscopy: Folding and Aggregation of Domains in P53 Chembiochem : a European Journal of Chemical Biology. Sep, 2005 | Pubmed ID: 16138303 Cooperative Binding of P53 to DNA: Regulation by Protein-protein Interactions Through a Double Salt Bridge Angewandte Chemie (International Ed. in English). Aug, 2005 | Pubmed ID: 16035029 Ligand Binding Analysis for Human Alpha5beta1 Integrin: Strategies for Designing New Alpha5beta1 Integrin Antagonists Journal of Medicinal Chemistry. Jun, 2005 | Pubmed ID: 15974570 Convenient Synthesis of N-methylamino Acids Compatible with Fmoc Solid-phase Peptide Synthesis The Journal of Organic Chemistry. Jun, 2005 | Pubmed ID: 15960522 Orientational Properties of Stretched Polystyrene Gels in Organic Solvents and the Suppression of Their Residual 1H NMR Signals Journal of the American Chemical Society. May, 2005 | Pubmed ID: 15853354 Stretched Gelatin Gels As Chiral Alignment Media for the Discrimination of Enantiomers by NMR Spectroscopy Angewandte Chemie (International Ed. in English). May, 2005 | Pubmed ID: 15834848 Structure-activity Relationship Studies Optimizing the Antiproliferative Activity of Novel Cyclic Somatostatin Analogues Containing a Restrained Cyclic Beta-amino Acid Journal of Medicinal Chemistry. Apr, 2005 | Pubmed ID: 15828830 Noninvasive Visualization of the Activated Alphavbeta3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD PLoS Medicine. Mar, 2005 | Pubmed ID: 15783258 NMR Studies Reveal Structural Differences Between the Gallium and Yttrium Complexes of DOTA-D-Phe1-Tyr3-octreotide Journal of Medicinal Chemistry. Mar, 2005 | Pubmed ID: 15743193 Stretched Poly(vinyl Acetate) Gels As NMR Alignment Media for the Measurement of Residual Dipolar Couplings in Polar Organic Solvents Angewandte Chemie (International Ed. in English). Jan, 2005 | Pubmed ID: 15624159 ADAM15 Decreases Integrin Alphavbeta3/vitronectin-mediated Ovarian Cancer Cell Adhesion and Motility in an RGD-dependent Fashion The International Journal of Biochemistry & Cell Biology. Mar, 2005 | Pubmed ID: 15618016 Improving Implant Materials by Coating with Nonpeptidic, Highly Specific Integrin Ligands Angewandte Chemie (International Ed. in English). Dec, 2004 | Pubmed ID: 15593169 Stretched Poly(dimethylsiloxane) Gels As NMR Alignment Media for Apolar and Weakly Polar Organic Solvents: an Ideal Tool for Measuring RDCs at Low Molecular Concentrations Journal of the American Chemical Society. Nov, 2004 | Pubmed ID: 15535672 Inter-domain Motions of the N-domain of the KdpFABC Complex, a P-type ATPase, Are Not Driven by ATP-induced Conformational Changes Journal of Molecular Biology. Oct, 2004 | Pubmed ID: 15364580 Solution Structure of Escherichia Coli Par10: The Prototypic Member of the Parvulin Family of Peptidyl-prolyl Cis/trans Isomerases Protein Science : a Publication of the Protein Society. Sep, 2004 | Pubmed ID: 15322281 Human Integrin Alphavbeta5: Homology Modeling and Ligand Binding Journal of Medicinal Chemistry. Aug, 2004 | Pubmed ID: 15293989 A Computational Model of Transmembrane Integrin Clustering Structure (London, England : 1993). Jun, 2004 | Pubmed ID: 15274930 1H, 13C and 15N Resonance Assignment of the Nucleotide Binding Domain of KdpB from Escherichia Coli Journal of Biomolecular NMR. Jul, 2004 | Pubmed ID: 15213457 A Structural Model of EmrE, a Multi-drug Transporter from Escherichia Coli Biophysical Journal. Jun, 2004 | Pubmed ID: 15189838 First (18)F-labeled Tracer Suitable for Routine Clinical Imaging of Sst Receptor-expressing Tumors Using Positron Emission Tomography Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2004 | Pubmed ID: 15173065 Two-step Methodology for High-yield Routine Radiohalogenation of Peptides: (18)F-labeled RGD and Octreotide Analogs Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2004 | Pubmed ID: 15136641 NMR Studies on the Substrate-binding Domains of the Thermosome: Structural Plasticity in the Protrusion Region Journal of Molecular Biology. Feb, 2004 | Pubmed ID: 15095983 Activation of Integrin Function by Nanopatterned Adhesive Interfaces Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Mar, 2004 | Pubmed ID: 15067875 Backbone 1H, 15N and 13C Resonance Assignments of Alpha-ADT and Beta-ADT Journal of Biomolecular NMR. Jun, 2004 | Pubmed ID: 15014236 An Easy and Scalable Method for the Partial Alignment of Organic Molecules for Measuring Residual Dipolar Couplings Angewandte Chemie (International Ed. in English). Feb, 2004 | Pubmed ID: 14983442 Combination of an SRC Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2004 | Pubmed ID: 14977859 Expression of the GM2-activator Protein in the Methylotrophic Yeast Pichia Pastoris, Purification, Isotopic Labeling, and Biophysical Characterization Protein Expression and Purification. Mar, 2004 | Pubmed ID: 14766311 Evidence for Hetero-association of Transmembrane Helices of Integrins FEBS Letters. Jan, 2004 | Pubmed ID: 14741377 [18F]Galacto-RGD: Synthesis, Radiolabeling, Metabolic Stability, and Radiation Dose Estimates Bioconjugate Chemistry. Jan-Feb, 2004 | Pubmed ID: 14733584 Synthesis and Structure-activity Relationship of Mannose-based Peptidomimetics Selectively Blocking Integrin Alpha4beta7 Binding to Mucosal Addressin Cell Adhesion Molecule-1 Journal of Medicinal Chemistry. Dec, 2003 | Pubmed ID: 14667228 New Oxazole-based Peptidomimetics: Useful Building Blocks for the Synthesis of Orthogonally Protected Macrocyclic Scaffolds Organic Letters. Nov, 2003 | Pubmed ID: 14627385 Docking Studies on Alphavbeta3 Integrin Ligands: Pharmacophore Refinement and Implications for Drug Design Journal of Medicinal Chemistry. Oct, 2003 | Pubmed ID: 14521404 Kişiye özel Prekürsorler tarafından Modifikasyon ve Guanidin Grubu işlevselleştirilmesi Tobias G. Kapp*1, Maximilian Fottner*1, Horst Kessler1 1Department of Chemistry, Technische Universität München JoVE 54873 Biochemistry
Kişiye özel Prekürsorler tarafından Modifikasyon ve Guanidin Grubu işlevselleştirilmesi Tobias G. Kapp*1, Maximilian Fottner*1, Horst Kessler1 1Department of Chemistry, Technische Universität München JoVE 54873 Biochemistry