Ihor R. Lemischka Department of Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Ihor R. Lemischka has not added a biography. If you are Ihor R. Lemischka and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Cancer with Pluripotent Stem Cells Trends in Cancer. Sep, 2016 | Pubmed ID: 27722205 A Dual Molecular Analogue Tuner for Dissecting Protein Function in Mammalian Cells Nature Communications. May, 2016 | Pubmed ID: 27230261 Emerging Modeling Concepts and Solutions in Stem Cell Research Current Topics in Developmental Biology. 2016 | Pubmed ID: 26970649 Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells Developmental Cell. Mar, 2016 | Pubmed ID: 26954547 Converting Cell Fates: Generating Hematopoietic Stem Cells De Novo Via Transcription Factor Reprogramming Annals of the New York Academy of Sciences. Apr, 2016 | Pubmed ID: 26748878 Making a Hematopoietic Stem Cell Trends in Cell Biology. Mar, 2016 | Pubmed ID: 26526106 Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia Cell Reports. Oct, 2015 | Pubmed ID: 26456833 Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms That Control Self-Renewal Stem Cell Reports. Aug, 2015 | Pubmed ID: 26267829 Distribution Analyzer, a Methodology for Identifying and Clustering Outlier Conditions from Single-cell Distributions, and Its Application to a Nanog Reporter RNAi Screen BMC Bioinformatics. Jul, 2015 | Pubmed ID: 26198214 Tbx3 Controls Dppa3 Levels and Exit from Pluripotency Toward Mesoderm Stem Cell Reports. Jul, 2015 | Pubmed ID: 26095607 Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming Cell Stem Cell. Jun, 2015 | Pubmed ID: 25936917 Modeling Familial Cancer with Induced Pluripotent Stem Cells Cell. Apr, 2015 | Pubmed ID: 25860607 NetExplore: a Web Server for Modeling Small Network Motifs Bioinformatics (Oxford, England). Jun, 2015 | Pubmed ID: 25637559 A Genome-wide RNAi Screen Identifies Opposing Functions of Snai1 and Snai2 on the Nanog Dependency in Reprogramming Molecular Cell. Oct, 2014 | Pubmed ID: 25240402 Construction and Validation of a Regulatory Network for Pluripotency and Self-renewal of Mouse Embryonic Stem Cells PLoS Computational Biology. Aug, 2014 | Pubmed ID: 25122140 Genomic Editing Tools to Model Human Diseases with Isogenic Pluripotent Stem Cells Stem Cells and Development. Nov, 2014 | Pubmed ID: 25075441 'From Blood to Blood': De-differentiation of Hematopoietic Progenitors to Stem Cells The EMBO Journal. Jul, 2014 | Pubmed ID: 24907133 "There Will Be Blood" from Fibroblasts Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 24335410 Expression of Podocalyxin Separates the Hematopoietic and Vascular Potentials of Mouse Embryonic Stem Cell-derived Mesoderm Stem Cells (Dayton, Ohio). Jan, 2014 | Pubmed ID: 24022884 Epigenetic Roles of MLL Oncoproteins Are Dependent on NF-κB Cancer Cell. Oct, 2013 | Pubmed ID: 24054986 Statistical Mechanics of Pluripotency Cell. Aug, 2013 | Pubmed ID: 23911316 Patterning Pluripotency in Embryonic Stem Cells Stem Cells (Dayton, Ohio). Sep, 2013 | Pubmed ID: 23843329 ESCAPE: Database for Integrating High-content Published Data Collected from Human and Mouse Embryonic Stem Cells Database : the Journal of Biological Databases and Curation. 2013 | Pubmed ID: 23794736 Induction of a Hemogenic Program in Mouse Fibroblasts Cell Stem Cell. Aug, 2013 | Pubmed ID: 23770078 SETD6 Monomethylates H2AZ on Lysine 7 and is Required for the Maintenance of Embryonic Stem Cell Self-renewal Epigenetics. Feb, 2013 | Pubmed ID: 23324626 Nanog-dependent Feedback Loops Regulate Murine Embryonic Stem Cell Heterogeneity Nature Cell Biology. Nov, 2012 | Pubmed ID: 23103910 Zfp281 Mediates Nanog Autorepression Through Recruitment of the NuRD Complex and Inhibits Somatic Cell Reprogramming Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 22988117 Reprogramming Cell Fates: Insights from Combinatorial Approaches Annals of the New York Academy of Sciences. Aug, 2012 | Pubmed ID: 22901251 Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling Cell Stem Cell. Aug, 2012 | Pubmed ID: 22862944 Combining Competition Assays with Genetic Complementation Strategies to Dissect Mouse Embryonic Stem Cell Self-renewal and Pluripotency Nature Protocols. Mar, 2012 | Pubmed ID: 22441292 KrasG12D-induced IKK2/β/NF-κB Activation by IL-1α and P62 Feedforward Loops is Required for Development of Pancreatic Ductal Adenocarcinoma Cancer Cell. Jan, 2012 | Pubmed ID: 22264792 Wnt-inhibitory Factor 1 Dysregulation of the Bone Marrow Niche Exhausts Hematopoietic Stem Cells Blood. Sep, 2011 | Pubmed ID: 21652676 Stem Cells and Reprogramming: Breaking the Epigenetic Barrier? Trends in Pharmacological Sciences. Jul, 2011 | Pubmed ID: 21621281 Single Transcription Factor Reprogramming of Hair Follicle Dermal Papilla Cells to Induced Pluripotent Stem Cells Stem Cells (Dayton, Ohio). Jun, 2011 | Pubmed ID: 21563278 Wdr5 Mediates Self-renewal and Reprogramming Via the Embryonic Stem Cell Core Transcriptional Network Cell. Apr, 2011 | Pubmed ID: 21477851 Induced Pluripotent Stem Cell-derived Cardiomyocytes As Models for Genetic Cardiovascular Disorders Current Opinion in Cardiology. May, 2011 | Pubmed ID: 21451408 Generation of Anterior Foregut Endoderm from Human Embryonic and Induced Pluripotent Stem Cells Nature Biotechnology. Mar, 2011 | Pubmed ID: 21358635 Prdm16 is a Physiologic Regulator of Hematopoietic Stem Cells Blood. May, 2011 | Pubmed ID: 21343612 Hemp, an Mbt Domain-containing Protein, Plays Essential Roles in Hematopoietic Stem Cell Function and Skeletal Formation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21252303 Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells PLoS Computational Biology. Dec, 2010 | Pubmed ID: 21187909 SVM Classifier to Predict Genes Important for Self-renewal and Pluripotency of Mouse Embryonic Stem Cells BMC Systems Biology. Dec, 2010 | Pubmed ID: 21176149 Toward a Complete in Silico, Multi-layered Embryonic Stem Cell Regulatory Network Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Nov-Dec, 2010 | Pubmed ID: 20890967 Exploration of Self-renewal and Pluripotency in ES Cells Using RNAi Methods in Enzymology. 2010 | Pubmed ID: 20699150 Patient-specific Induced Pluripotent Stem-cell-derived Models of LEOPARD Syndrome Nature. Jun, 2010 | Pubmed ID: 20535210 Hooking Up with Oct4 Cell Stem Cell. Apr, 2010 | Pubmed ID: 20362529 GATE: Software for the Analysis and Visualization of High-dimensional Time Series Expression Data Bioinformatics (Oxford, England). Jan, 2010 | Pubmed ID: 19892805 Delayed Differentiation in Embryonic Stem Cells and Mesodermal Progenitors in the Absence of CtBP2 Mechanisms of Development. Jan-Feb, 2010 | Pubmed ID: 19825414 Systems-level Dynamic Analyses of Fate Change in Murine Embryonic Stem Cells Nature. Nov, 2009 | Pubmed ID: 19924215 Smarcc1/Baf155 Couples Self-renewal Gene Repression with Changes in Chromatin Structure in Mouse Embryonic Stem Cells Stem Cells (Dayton, Ohio). Dec, 2009 | Pubmed ID: 19785031 Systems Biology of Stem Cell Fate and Cellular Reprogramming Nature Reviews. Molecular Cell Biology. Oct, 2009 | Pubmed ID: 19738627 Bmi-1 Cooperates with Foxg1 to Maintain Neural Stem Cell Self-renewal in the Forebrain Genes & Development. Mar, 2009 | Pubmed ID: 19270157 Alternative Induced Pluripotent Stem Cell Characterization Criteria for in Vitro Applications Cell Stem Cell. Mar, 2009 | Pubmed ID: 19265656 A Genomewide Functional Network for the Laboratory Mouse PLoS Computational Biology. 2008 | Pubmed ID: 18818725 ShRNA Knockdown of Bmi-1 Reveals a Critical Role for P21-Rb Pathway in NSC Self-renewal During Development Cell Stem Cell. Jun, 2007 | Pubmed ID: 18371338 Dissecting Self-renewal in Stem Cells with RNA Interference Nature. Aug, 2006 | Pubmed ID: 16767105 The Timing of Cortical Neurogenesis is Encoded Within Lineages of Individual Progenitor Cells Nature Neuroscience. Jun, 2006 | Pubmed ID: 16680166 Delivery of Short Hairpin RNAs--triggers of Gene Silencing--into Mouse Embryonic Stem Cells Nature Methods. May, 2006 | Pubmed ID: 16628211 Genomewide Gain-of-function Genetic Screen Identifies Functionally Active Genes in Mouse Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16621925 Stem Cells and Their Niches Science (New York, N.Y.). Mar, 2006 | Pubmed ID: 16574858 Alternative Splicing Increases Complexity of Stem Cell Transcriptome Cell Cycle (Georgetown, Tex.). Feb, 2006 | Pubmed ID: 16479168 Diversification of Stem Cell Molecular Repertoire by Alternative Splicing Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16183747 Stem Cell Biology: a View Toward the Future Annals of the New York Academy of Sciences. Jun, 2005 | Pubmed ID: 15958706 "Tie-ing" Down the Hematopoietic Niche Cell. Jul, 2004 | Pubmed ID: 15260982 Stem Cells: Interactive Niches Nature. Oct, 2003 | Pubmed ID: 14574394 A Stem Cell Molecular Signature Science (New York, N.Y.). Oct, 2002 | Pubmed ID: 12228721 A Molecular Profile of a Hematopoietic Stem Cell Niche Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12226475 A Genetic and Genomic Analysis Identifies a Cluster of Genes Associated with Hematopoietic Cell Turnover Blood. Sep, 2002 | Pubmed ID: 12200366 Cells for Repair: Breakout Session Summary Annals of the New York Academy of Sciences. Jun, 2002 | Pubmed ID: 12081862 प्रतिलेखन कारक के साथ माउस भ्रूणीय Fibroblasts Reprogramming एक Hemogenic कार्यक्रम प्रेरित करने के लिए Michael G. Daniel1,2,3, Carlos-Filipe Pereira4, Jeffrey M. Bernitz1,2,3, Ihor R. Lemischka1,3,5, Kateri Moore1,3 1Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 2The Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, 3Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 4Center for Neuroscience and Cell Biology, University of Coimbra, 5Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai Developmental Biology
प्रतिलेखन कारक के साथ माउस भ्रूणीय Fibroblasts Reprogramming एक Hemogenic कार्यक्रम प्रेरित करने के लिए Michael G. Daniel1,2,3, Carlos-Filipe Pereira4, Jeffrey M. Bernitz1,2,3, Ihor R. Lemischka1,3,5, Kateri Moore1,3 1Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 2The Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, 3Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 4Center for Neuroscience and Cell Biology, University of Coimbra, 5Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai Developmental Biology
