Ingeborg Friehs Department of Cardiac Surgery, Boston Children’s Hospital Harvard Medical School Biography Publications Institution JoVE Articles Ingeborg Friehs has not added a biography. If you are Ingeborg Friehs and would like to personalize this page please email our Author Liaison for assistance. Publications Case Report: Active Clinical Manifestation of Endocardial Fibroelastosis in Adolescence in a Patient with Mitral and Aortic Obstruction-histologic Presence of Endothelial-to-mesenchymal Transformation Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 36531727 Endothelial-to-Mesenchymal Transition As Underlying Mechanism for the Formation of Double-Chambered Right Ventricle Pediatric Cardiology. Jun, 2022 | Pubmed ID: 35084525 Mechanical Strain Triggers Endothelial-to-mesenchymal Transition of the Endocardium in the Immature Heart Pediatric Research. Sep, 2022 | Pubmed ID: 34837068 Human Endothelial Colony-forming Cells Provide Trophic Support for Pluripotent Stem Cell-derived Cardiomyocytes Via Distinctively High Expression of Neuregulin-1 Angiogenesis. Jan, 2021 | Pubmed ID: 33454888 Autogenous Mitochondria Transplantation for Treatment of Right Heart Failure The Journal of Thoracic and Cardiovascular Surgery. Aug, 2020 | Pubmed ID: 32919774 Flow Disturbances and the Development of Endocardial Fibroelastosis The Journal of Thoracic and Cardiovascular Surgery. Feb, 2020 | Pubmed ID: 31668539 Flow Disturbances and Progression of Endocardial Fibroelastosis - a Case Report Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Sep - Oct, 2019 | Pubmed ID: 31150840 Alloreactivity and Allorecognition of Syngeneic and Allogeneic Mitochondria Mitochondrion. 05, 2019 | Pubmed ID: 29588218 A Growth-Accommodating Implant for Paediatric Applications Nature Biomedical Engineering. 2017 | Pubmed ID: 29900036 Treating a 20 Mm Hg Gradient Alleviates Myocardial Hypertrophy in Experimental Aortic Coarctation The Journal of Surgical Research. Oct, 2017 | Pubmed ID: 28985849 Vascular Endothelial Growth Factor Prevents Endothelial-to-Mesenchymal Transition In Hypertrophy The Annals of Thoracic Surgery. Sep, 2017 | Pubmed ID: 28483153 Myocardial Rescue with Autologous Mitochondrial Transplantation in a Porcine Model of Ischemia/reperfusion The Journal of Thoracic and Cardiovascular Surgery. 04, 2017 | Pubmed ID: 27938904 Pilomotor Function is Impaired in Patients with Parkinson's Disease: A Study of the Adrenergic Axon-reflex Response and Autonomic Functions Parkinsonism & Related Disorders. Oct, 2016 | Pubmed ID: 27569843 Development of a Vascularized Heterotopic Neonatal Rat Heart Transplantation Model European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes. 2016 | Pubmed ID: 27544776 Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection PloS One. 2016 | Pubmed ID: 27500955 A Light-reflecting Balloon Catheter for Atraumatic Tissue Defect Repair Science Translational Medicine. Sep, 2015 | Pubmed ID: 26400910 Distention of the Immature Left Ventricle Triggers Development of Endocardial Fibroelastosis: An Animal Model of Endocardial Fibroelastosis Introducing Morphopathological Features of Evolving Fetal Hypoplastic Left Heart Syndrome BioMed Research International. 2015 | Pubmed ID: 26064914 Endocardial Fibroelastosis is Caused by Aberrant Endothelial to Mesenchymal Transition Circulation Research. Feb, 2015 | Pubmed ID: 25587097 Pressure Overload Induces IL-18 and IL-18R Expression, but Markedly Suppresses IL-18BP Expression in a Rabbit Model. IL-18 Potentiates TNF-α-induced Cardiomyocyte Death Journal of Molecular and Cellular Cardiology. Oct, 2014 | Pubmed ID: 25108227 A Blood-resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects Science Translational Medicine. Jan, 2014 | Pubmed ID: 24401941 Pressure-overload Hypertrophy of the Developing Heart Reveals Activation of Divergent Gene and Protein Pathways in the Left and Right Ventricular Myocardium American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2013 | Pubmed ID: 23262132 A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer Advanced Materials (Deerfield Beach, Fla.). Feb, 2013 | Pubmed ID: 23239051 An Animal Model of Endocardial Fibroelastosis The Journal of Surgical Research. Jun, 2013 | Pubmed ID: 22938709 Endogenous Angiogenesis Inhibitors Prevent Adaptive Capillary Growth in Left Ventricular Pressure Overload Hypertrophy The Annals of Thoracic Surgery. Nov, 2012 | Pubmed ID: 22795062 Up-regulation of Soluble Vascular Endothelial Growth Factor Receptor-1 Prevents Angiogenesis in Hypertrophied Myocardium Cardiovascular Research. Feb, 2011 | Pubmed ID: 20935166 Electron Transport Chain Dysfunction in Neonatal Pressure-overload Hypertrophy Precedes Cardiomyocyte Apoptosis Independent of Oxidative Stress The Journal of Thoracic and Cardiovascular Surgery. Jun, 2010 | Pubmed ID: 20038480 Development of Left Ventricular Diastolic Dysfunction with Preservation of Ejection Fraction During Progression of Infant Right Ventricular Hypertrophy Circulation. Heart Failure. Nov, 2009 | Pubmed ID: 19919985 Myocyte Apoptosis Occurs Early During the Development of Pressure-overload Hypertrophy in Infant Myocardium The Journal of Thoracic and Cardiovascular Surgery. Jun, 2009 | Pubmed ID: 19464448 Proteasome Inhibition in Hypertrophied Myocardium American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2008 | Pubmed ID: 18708439 Inhibition of Glycogen Synthase Kinase-3beta Improves Tolerance to Ischemia in Hypertrophied Hearts The Annals of Thoracic Surgery. Jul, 2007 | Pubmed ID: 17588398 Age-dependent Expression of VEGF Isoforms and Receptors in the Rabbit Anterior Cruciate Ligament Biochimica Et Biophysica Acta. Jul, 2007 | Pubmed ID: 17459591 Dopamine Induces Postischemic Cardiomyocyte Apoptosis in Vivo: an Effect Ameliorated by Propofol The Annals of Thoracic Surgery. Dec, 2006 | Pubmed ID: 17126134 Vascular Endothelial Growth Factor Prevents Apoptosis and Preserves Contractile Function in Hypertrophied Infant Heart Circulation. Jul, 2006 | Pubmed ID: 16820588 Cardiac Conduction Through Engineered Tissue The American Journal of Pathology. Jul, 2006 | Pubmed ID: 16816362 Vascular Endothelial Growth Factor Delays Onset of Failure in Pressure-overload Hypertrophy Through Matrix Metalloproteinase Activation and Angiogenesis Basic Research in Cardiology. May, 2006 | Pubmed ID: 16369727 Cyclosporin A but Not FK-506 Protects Against Dopamine-induced Apoptosis in the Stunned Heart The Annals of Thoracic Surgery. May, 2005 | Pubmed ID: 15854943 Impaired Insulin-signaling in Hypertrophied Hearts Contributes to Ischemic Injury Biochemical and Biophysical Research Communications. May, 2005 | Pubmed ID: 15845351 Promoting Angiogenesis Protects Severely Hypertrophied Hearts from Ischemic Injury The Annals of Thoracic Surgery. Jun, 2004 | Pubmed ID: 15172254 Postnatal Increase in Insulin-sensitive Glucose Transporter Expression is Associated with Improved Recovery of Postischemic Myocardial Function The Journal of Thoracic and Cardiovascular Surgery. Jul, 2003 | Pubmed ID: 12878964 Noninvasive Serial Evaluation of Myocardial Mechanics in Pressure Overload Hypertrophy of Rabbit Myocardium Herz. Feb, 2003 | Pubmed ID: 12616321 Increased Susceptibility of Hypertrophied Hearts to Ischemic Injury The Annals of Thoracic Surgery. Feb, 2003 | Pubmed ID: 12607712 Improving Results of the Modified Fontan Operation in Patients with Heterotaxy Syndrome The Annals of Thoracic Surgery. Dec, 2002 | Pubmed ID: 12643382 Dopamine Treatment of Postischemic Contractile Dysfunction Rapidly Induces Calcium-dependent Pro-apoptotic Signaling Circulation. Sep, 2002 | Pubmed ID: 12354748 Protective Effects of Protein Kinase C During Myocardial Ischemia Require Activation of Phosphatidyl-inositol Specific Phospholipase C The Annals of Thoracic Surgery. Apr, 2002 | Pubmed ID: 11998814 Outcome After Reconstruction of Discontinuous Pulmonary Arteries The Journal of Thoracic and Cardiovascular Surgery. Feb, 2002 | Pubmed ID: 11828283 A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition (Video) | JoVE Gregor Gierlinger1, Lavinia Rech1, Sitaram M. Emani1, Pedro J. del Nido1, Ingeborg Friehs1 1Department of Cardiac Surgery, Boston Children’s Hospital, Harvard Medical School JoVE 65426 Medicine
A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition (Video) | JoVE Gregor Gierlinger1, Lavinia Rech1, Sitaram M. Emani1, Pedro J. del Nido1, Ingeborg Friehs1 1Department of Cardiac Surgery, Boston Children’s Hospital, Harvard Medical School JoVE 65426 Medicine
