Irena Levitan Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy University of Illinois at Chicago Biography Publications Institution JoVE Articles Irena Levitan has not added a biography. If you are Irena Levitan and would like to personalize this page please email our Author Liaison for assistance. Publications Shear-Stress Sensitive Inwardly-Rectifying K Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019 | Pubmed ID: 31145841 Comparative Docking Analysis of Cholesterol Analogs to Ion Channels to Discriminate Between Stereospecific Binding Vs. Stereospecific Response Channels (Austin, Tex.). Dec, 2019 | Pubmed ID: 31033379 Endothelial Stiffening in Dyslipidemia Aging. Jan, 2019 | Pubmed ID: 30674709 Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K Channels Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30649756 Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-induced Degradation of the Endothelial Glycocalyx American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2019 | Pubmed ID: 30632766 Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms Hypertension (Dallas, Tex. : 1979). Feb, 2019 | Pubmed ID: 30624988 Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus Current Topics in Membranes. 2018 | Pubmed ID: 30243442 Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules Biophysical Journal. 10, 2018 | Pubmed ID: 30205899 Comparative Analysis of Endothelial Cell and Sub-endothelial Cell Elastic Moduli in Young and Aged Mice: Role of CD36 Journal of Biomechanics. 07, 2018 | Pubmed ID: 29954596 Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K Channels Journal of the American Heart Association. 03, 2018 | Pubmed ID: 29502106 Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force Biophysical Journal. 02, 2018 | Pubmed ID: 29490252 Proatherogenic Flow Increases Endothelial Stiffness Via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins Arteriosclerosis, Thrombosis, and Vascular Biology. 01, 2018 | Pubmed ID: 29025707 Differential Effects of Sterols on Ion Channels: Stereospecific Binding Vs Stereospecific Response Current Topics in Membranes. 2017 | Pubmed ID: 28863819 OxLDL Induces Endothelial Cell Proliferation Via Rho/ROCK/Akt/p27 Signaling: Opposite Effects of OxLDL and Cholesterol Loading American Journal of Physiology. Cell Physiology. Sep, 2017 | Pubmed ID: 28701359 Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids Biophysical Journal. Jan, 2017 | Pubmed ID: 28122218 Orthogonal Lipid Sensors Identify Transbilayer Asymmetry of Plasma Membrane Cholesterol Nature Chemical Biology. 03, 2017 | Pubmed ID: 28024150 Inwardly Rectifying K Channels Are Major Contributors to Flow-induced Vasodilatation in Resistance Arteries The Journal of Physiology. 04, 2017 | Pubmed ID: 27859264 Paradoxical Impact of Cholesterol on Lipid Packing and Cell Stiffness Frontiers in Bioscience (Landmark Edition). 06, 2016 | Pubmed ID: 27100504 Oxidized LDL Signals Through Rho-GTPase to Induce Endothelial Cell Stiffening and Promote Capillary Formation Journal of Lipid Research. 05, 2016 | Pubmed ID: 26989083 Cholesterol Increases the Open Probability of Cardiac KACh Currents Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26196595 Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2 Computational and Structural Biotechnology Journal. Sep, 2014 | Pubmed ID: 25408847 Silencing of Kir2 Channels by Caveolin-1: Cross-talk with Cholesterol The Journal of Physiology. Sep, 2014 | Pubmed ID: 25038242 Cholesterol Binding to Ion Channels Frontiers in Physiology. 2014 | Pubmed ID: 24616704 Upregulated Copper Transporters in Hypoxia-induced Pulmonary Hypertension PloS One. 2014 | Pubmed ID: 24614111 Oxidized Low-density Lipoprotein Alters the Effect of Matrix Stiffness on the Formation of Endothelial Networks and Capillary Lumens Pulmonary Circulation. Sep, 2013 | Pubmed ID: 24618546 Identification of Novel Cholesterol-binding Regions in Kir2 Channels The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24019518 Cholesterol Sensitivity of KIR2.1 Depends on Functional Inter-links Between the N and C Termini Channels (Austin, Tex.). Jul-Aug, 2013 | Pubmed ID: 23807091 Regulation of Ion Channels by Membrane Lipids Comprehensive Physiology. Jan, 2012 | Pubmed ID: 23728970 Ferne Zytosolische Rückstände Vermitteln Einen Bidirektionalen Molekularen Schalter, Der Die Modulation Der Kir-Kanäle Durch Cholesterin Und PI (4,5) P2 Zu Steuert The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22995912 OxLDL Und Substrat Steifigkeit Fördern Neutrophil Seelenwanderung Durch Verbesserte Endothelial Zellen Kontraktilität Und ICAM-1 Journal of Biomechanics. Jun, 2012 | Pubmed ID: 22560286 Die Rolle Der Oxysterols Kontrolle über Endothelial Steifigkeit Journal of Lipid Research. Jul, 2012 | Pubmed ID: 22496390 Neue Mechanismen Der Pulmonalen Arteriellen Hypertonie: Rolle Ca²⁺ Zu Signalisieren American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2012 | Pubmed ID: 22245772 Hypercholesterinämie Induziert Bis-Regulierung Von KACh Kardiale Ströme über Einen Mechanismus Unabhängig Von Phosphatidylinositol-4, 5-bisphosphat Und Gβγ The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22174416 Neuartige Rolle Der P66Shc in ROS-abhängige VEGF Signalisierung Und Angiogenesis in Endothelzellen American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2012 | Pubmed ID: 22101521 Cholesterin Abbau Ermöglicht Recovery Von Hypotonischen Zelle Schwellung in CHO-Zellen Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2011 | Pubmed ID: 22179012 Cholesterin Regelt Prokaryotischen Kir-Kanal Durch Direkte Bindung an Kanal-Protein Biochimica Et Biophysica Acta. Oct, 2011 | Pubmed ID: 21798234 Auswirkungen Von OxLDL Auf Cholesterin-Rich Membran Flößen Journal of Lipids. 2011 | Pubmed ID: 21490811 Milzbrand Letale Faktor Aktiviert K(+)-Kanäle, Um IL-1β Sekretion in Makrophagen Induzieren Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21421849 Cholesterin-Empfindlichkeit Des KIR2.1 Wird Durch Einen Gürtel Von Rückständen Um Die Zytosolische Pore Gesteuert Biophysical Journal. Jan, 2011 | Pubmed ID: 21244834 Änderung Der Zellulären Cholesteringehalt Betrifft Zugkraft, Adhäsion Und Zelle Zu Verbreiten Cellular and Molecular Bioengineering. Jun, 2010 | Pubmed ID: 21461187 OxLDL-induzierte Abnahme Der Lipid-Reihenfolge Der Membran-Domains Ist Umgekehrt Mit Endothelial Steifigkeit Und Netzwerk Bildung Korreliert American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20410437 Cholesterin Und Ionen-Kanäle Sub-cellular Biochemistry. 2010 | Pubmed ID: 20213557 Vergleichende Analyse Der Cholesterin-Empfindlichkeit Der Kir-Kanäle: Rolle Der CD-Schleife Channels (Austin, Tex.). Jan-Feb, 2010 | Pubmed ID: 19923917 Oxidierte LDL: Vielfalt, Von Anerkennung Und Pathophysiologie Antioxidants & Redox Signaling. Jul, 2010 | Pubmed ID: 19888833 Direkte Regulierung Prokaryotischen Kir-Kanal Von Cholesterin The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19740741 Cholesterin Und Kir-Kanäle IUBMB Life. Aug, 2009 | Pubmed ID: 19548316 Kennung Einer C-Terminus-Domäne, Die Kritisch Für Die Anfälligkeit Des Kir2.1 Für Cholesterin Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416905 Endothelial Aktin Und Zelle Steifigkeit Wird Durch Substrat Steifigkeit in 2D Und 3D Moduliert Journal of Biomechanics. May, 2009 | Pubmed ID: 19356760 OxLDL Erleichtert Fluss Induziert Neuausrichtung Der Aortalen Endothelzellen American Journal of Physiology. Cell Physiology. Aug, 2008 | Pubmed ID: 18562483 Lipid Rafts Im Membran-Zytoskeletts Interaktionen Und Kontrolle Der Zellulären Biomechanik: Aktionen Von OxLDL Antioxidants & Redox Signaling. Sep, 2007 | Pubmed ID: 17576163 Die Beeinträchtigung Der Zellulären Cholesterin Membran-Zytoskeletts Adhäsion Journal of Cell Science. Jul, 2007 | Pubmed ID: 17550968 Einsatz Von Cyclodextrinen, Plasmamembran Cholesteringehalt Zu Manipulieren: Nachweis, Missverständnisse Und Strategien Zu Steuern Biochimica Et Biophysica Acta. Jun, 2007 | Pubmed ID: 17493580 Hypercholesterinämie Unterdrückt Kir-Kanäle in Schweinen Knochenmark-Vorläuferzellen, Die In-vivo Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17482574 Beziehung Zwischen Kir2.1/Kir2.3-Aktivität Und Ihren Verteilungen Zwischen Cholesterin-Arm Und Reich Cholesterin Membran-Domänen American Journal of Physiology. Cell Physiology. Jul, 2007 | Pubmed ID: 17459945 Hypercholesterinämie Unterdrückt Einwärtsgleichrichtenden K + Kanäle in Aorten Endothel in Vitro Und in Vivo Circulation Research. Apr, 2006 | Pubmed ID: 16556870 OxLDL Erhöht Endothelial Steifigkeit, Streitkräfteaufwuchs Und Netzwerkbildung Journal of Lipid Research. Apr, 2006 | Pubmed ID: 16418538 Funktionaler Ausdruck Mit Kir2.x in Menschlichen Endothelzellen Aorta: Die Dominierende Rolle Der Kir2.2 American Journal of Physiology. Cell Physiology. Nov, 2005 | Pubmed ID: 15958527 Cholesterin-Empfindlichkeit Und Lipid Raft Targeting Kir2.1 Kanäle Biophysical Journal. Dec, 2004 | Pubmed ID: 15465867 Cholesterin Abbau Erhöht Die Steifigkeit Der Membran Der Aortalen Endothelzellen Biophysical Journal. Nov, 2004 | Pubmed ID: 15347591 Plasmamembran Oberfläche Erhöht Mit Tonisch Dehnung Der Alveolaren Epithelzellen American Journal of Respiratory Cell and Molecular Biology. Aug, 2004 | Pubmed ID: 15016618 Empfindlichkeit Des Volume-regulierten Anion Strom Der Cholesterin Strukturverwandte The Journal of General Physiology. Jan, 2004 | Pubmed ID: 14699079 Schubspannung Erhöht Ausdruck Eines KATP-Kanals in Ratten Und Rindern Pulmonalen Vaskulären Endothelzellen American Journal of Physiology. Cell Physiology. Oct, 2003 | Pubmed ID: 12826604 Modulation Der Endothelial Nach Innen-Gleichrichter K + Aktuelle Durch Optische Isomere Von Cholesterin Biophysical Journal. Dec, 2002 | Pubmed ID: 12496090 Doppelte Wirkung Der Flüssigkeit Scherspannung Auf Volume-regulierten Anion Aktuelle in Bovine Aorten Endothelzellen American Journal of Physiology. Cell Physiology. Apr, 2002 | Pubmed ID: 11880259 Elektrophysiologische Aufnahmen von einzelzelligen Ionenströmen unter genau definiertem Scherspannung Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 Immunology and Infection Mikropipette Aspiration von Substrat-attached Cells zu schätzen Zelle Stiffness Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 Bioengineering
Elektrophysiologische Aufnahmen von einzelzelligen Ionenströmen unter genau definiertem Scherspannung Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 Immunology and Infection
Mikropipette Aspiration von Substrat-attached Cells zu schätzen Zelle Stiffness Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 Bioengineering