Jürgen Götz Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute The University of Queensland Biography Publications Institution JoVE Articles Jürgen Götz has not added a biography. If you are Jürgen Götz and would like to personalize this page please email our Author Liaison for assistance. Publications Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery Stem Cell Reports. 05, 2020 | Pubmed ID: 32275861 PTEN Activation Contributes to Neuronal and Synaptic Engulfment by Microglia in Tauopathy Acta Neuropathologica. Jul, 2020 | Pubmed ID: 32236736 Cell-specific Non-canonical Amino Acid Labelling Identifies Changes in the De Novo Proteome During Memory Formation ELife. Jan, 2020 | Pubmed ID: 31904341 Mitochondria Modulatory Effects of New TSPO Ligands in a Cellular Model of Tauopathies Journal of Neuroendocrinology. 01, 2020 | Pubmed ID: 31536662 Experimental Models of Tauopathy - From Mechanisms to Therapies Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 32096051 The Blood-brain Barrier: Physiology and Strategies for Drug Delivery Advanced Drug Delivery Reviews. Nov, 2019 | Pubmed ID: 31790711 The Search for Improved Animal Models of Alzheimer's Disease and Novel Strategies for Therapeutic Intervention Future Medicinal Chemistry. 08, 2019 | Pubmed ID: 31517531 Scanning Ultrasound in the Absence of Blood-brain Barrier Opening is Not Sufficient to Clear β-amyloid Plaques in the APP23 Mouse Model of Alzheimer's Disease Brain Research Bulletin. 11, 2019 | Pubmed ID: 31400496 Repeated Ultrasound Treatment of Tau Transgenic Mice Clears Neuronal Tau by Autophagy and Improves Behavioral Functions Theranostics. 2019 | Pubmed ID: 31281511 Decreased Synthesis of Ribosomal Proteins in Tauopathy Revealed by Non-canonical Amino Acid Labelling The EMBO Journal. 07, 2019 | Pubmed ID: 31268600 Ultrasound-mediated Blood-brain Barrier Opening Enhances Delivery of Therapeutically Relevant Formats of a Tau-specific Antibody Scientific Reports. 06, 2019 | Pubmed ID: 31239479 Tauopathy in Veterans with Long-term Posttraumatic Stress Disorder and Traumatic Brain Injury European Journal of Nuclear Medicine and Molecular Imaging. May, 2019 | Pubmed ID: 30617964 Disease-associated Tau Impairs Mitophagy by Inhibiting Parkin Translocation to Mitochondria The EMBO Journal. 02, 2019 | Pubmed ID: 30538104 Molecular Pathogenesis of the Tauopathies Annual Review of Pathology. 01, 2019 | Pubmed ID: 30355155 Multimodal Analysis of Aged Wild-type Mice Exposed to Repeated Scanning Ultrasound Treatments Demonstrates Long-term Safety Theranostics. 2018 | Pubmed ID: 30613294 Local Oxidative Damage in the Soma and Dendrites Quarantines Neuronal Mitochondria at the Site of Insult IScience. Aug, 2018 | Pubmed ID: 30240605 Rodent Models for Alzheimer Disease Nature Reviews. Neuroscience. 10, 2018 | Pubmed ID: 30194347 Modeling Ultrasound Propagation Through Material of Increasing Geometrical Complexity Ultrasonics. Nov, 2018 | Pubmed ID: 29909121 Pyk2 is a Novel Tau Tyrosine Kinase That is Regulated by the Tyrosine Kinase Fyn Journal of Alzheimer's Disease : JAD. 2018 | Pubmed ID: 29782321 Establishing Sheep As an Experimental Species to Validate Ultrasound-mediated Blood-brain Barrier Opening for Potential Therapeutic Interventions Theranostics. 2018 | Pubmed ID: 29721100 Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies Journal of Alzheimer's Disease : JAD. 2018 | Pubmed ID: 29562514 Exosomes Taken Up by Neurons Hijack the Endosomal Pathway to Spread to Interconnected Neurons Acta Neuropathologica Communications. 02, 2018 | Pubmed ID: 29448966 A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles Journal of Alzheimer's Disease : JAD. 2018 | Pubmed ID: 29332046 Retiring the Term FTDP-17 As MAPT Mutations Are Genetic Forms of Sporadic Frontotemporal Tauopathies Brain : a Journal of Neurology. 02, 2018 | Pubmed ID: 29253099 Amyloid-β and Tau Complexity - Towards Improved Biomarkers and Targeted Therapies Nature Reviews. Neurology. Jan, 2018 | Pubmed ID: 29242522 Shedding Light on Mitophagy in Neurons: What is the Evidence for PINK1/Parkin Mitophagy in Vivo? Cellular and Molecular Life Sciences : CMLS. 04, 2018 | Pubmed ID: 29085955 A Corticostriatal Deficit Promotes Temporal Distortion of Automatic Action in Ageing ELife. 10, 2017 | Pubmed ID: 29058672 Tau-based Therapies in Neurodegeneration: Opportunities and Challenges Nature Reviews. Drug Discovery. Dec, 2017 | Pubmed ID: 28983098 Ultrasound As a Treatment Modality for Neurological Diseases The Medical Journal of Australia. 06, 2017 | Pubmed ID: 28918723 Somatodendritic Accumulation of Tau in Alzheimer's Disease is Promoted by Fyn-mediated Local Protein Translation The EMBO Journal. 11, 2017 | Pubmed ID: 28864542 The Amyloid-β Oligomer Aβ*56 Induces Specific Alterations in Neuronal Signaling That Lead to Tau Phosphorylation and Aggregation Science Signaling. May, 2017 | Pubmed ID: 28487416 Combined Effects of Scanning Ultrasound and a Tau-specific Single Chain Antibody in a Tau Transgenic Mouse Model Brain : a Journal of Neurology. May, 2017 | Pubmed ID: 28379300 Accelerated Aging Exacerbates a Pre-existing Pathology in a Tau Transgenic Mouse Model Aging Cell. Apr, 2017 | Pubmed ID: 28160413 Hyperphosphorylated Tau Causes Reduced Hippocampal CA1 Excitability by Relocating the Axon Initial Segment Acta Neuropathologica. 05, 2017 | Pubmed ID: 28091722 Mouse Models of Frontotemporal Dementia: A Comparison of Phenotypes with Clinical Symptomatology Neuroscience and Biobehavioral Reviews. Mar, 2017 | Pubmed ID: 28088537 Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice PloS One. 2016 | Pubmed ID: 27727310 Munc18-1 is a Molecular Chaperone for α-synuclein, Controlling Its Self-replicating Aggregation The Journal of Cell Biology. Sep, 2016 | Pubmed ID: 27597756 Special Issue on 'Cytoskeletal Proteins in Health and Neurodegenerative Disease' Brain Research Bulletin. 09, 2016 | Pubmed ID: 27506280 Motor Cortical Function Determines Prognosis in Sporadic ALS Neurology. Aug, 2016 | Pubmed ID: 27402895 Mobility and Subcellular Localization of Endogenous, Gene-edited Tau Differs from That of Over-expressed Human Wild-type and P301L Mutant Tau Scientific Reports. 07, 2016 | Pubmed ID: 27378256 Quantitative Imaging of Cholinergic Interneurons Reveals a Distinctive Spatial Organization and a Functional Gradient Across the Mouse Striatum PloS One. 2016 | Pubmed ID: 27314496 Tau Physiology and Pathomechanisms in Frontotemporal Lobar Degeneration Journal of Neurochemistry. 08, 2016 | Pubmed ID: 27306859 Glutamate Receptors in Alzheimer's Disease: Mechanisms and Therapies Neural Plasticity. 2016 | Pubmed ID: 27293907 A Local Insult of Okadaic Acid in Wild-type Mice Induces Tau Phosphorylation and Protein Aggregation in Anatomically Distinct Brain Regions Acta Neuropathologica Communications. Mar, 2016 | Pubmed ID: 27037086 Extracellular Vesicles Isolated from the Brains of RTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner The Journal of Biological Chemistry. Jun, 2016 | Pubmed ID: 27030011 Ultrasound Treatment of Neurological Diseases--current and Emerging Applications Nature Reviews. Neurology. Mar, 2016 | Pubmed ID: 26891768 Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26861879 Impulsivity, Decreased Social Exploration, and Executive Dysfunction in a Mouse Model of Frontotemporal Dementia Neurobiology of Learning and Memory. Apr, 2016 | Pubmed ID: 26827932 Sex Hormone-related Neurosteroids Differentially Rescue Bioenergetic Deficits Induced by Amyloid-β or Hyperphosphorylated Tau Protein Cellular and Molecular Life Sciences : CMLS. Jan, 2016 | Pubmed ID: 26198711 FTD and ALS--translating Mouse Studies into Clinical Trials Nature Reviews. Neurology. Jun, 2015 | Pubmed ID: 25939274 What We Can Learn from Animal Models About Cerebral Multi-morbidity Alzheimer's Research & Therapy. 2015 | Pubmed ID: 25810783 Scanning Ultrasound Removes Amyloid-β and Restores Memory in an Alzheimer's Disease Mouse Model Science Translational Medicine. Mar, 2015 | Pubmed ID: 25761889 Pseudophosphorylation of Tau at Distinct Epitopes or the Presence of the P301L Mutation Targets the Microtubule-associated Protein Tau to Dendritic Spines Biochimica Et Biophysica Acta. May, 2015 | Pubmed ID: 25558816 Tau Aggregation and Its Interplay with Amyloid-β Acta Neuropathologica. Feb, 2015 | Pubmed ID: 25492702 Connecting the Dots Between Tau Dysfunction and Neurodegeneration Trends in Cell Biology. Jan, 2015 | Pubmed ID: 25172552 Bio-orthogonal Labeling As a Tool to Visualize and Identify Newly Synthesized Proteins in Caenorhabditis Elegans Nature Protocols. Sep, 2014 | Pubmed ID: 25167056 Granulovacuolar Degeneration and Unfolded Protein Response in Mouse Models of Tauopathy and Aβ Amyloidosis Neurobiology of Disease. Nov, 2014 | Pubmed ID: 25073087 Premature Lethality, Hyperactivity, and Aberrant Phosphorylation in Transgenic Mice Expressing a Constitutively Active Form of Fyn Frontiers in Molecular Neuroscience. 2014 | Pubmed ID: 24860422 Visualizing the Microtubule-associated Protein Tau in the Nucleus Science China. Life Sciences. Apr, 2014 | Pubmed ID: 24643416 Altered Proteostasis in Aging and Heat Shock Response in C. Elegans Revealed by Analysis of the Global and De Novo Synthesized Proteome Cellular and Molecular Life Sciences : CMLS. Sep, 2014 | Pubmed ID: 24458371 March Separate, Strike Together--role of Phosphorylated TAU in Mitochondrial Dysfunction in Alzheimer's Disease Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 24051203 Profiling Murine Tau with 0N, 1N and 2N Isoform-specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus PloS One. 2013 | Pubmed ID: 24386422 Lessons from Two Prevalent Amyloidoses-what Amylin and Aβ Have in Common Frontiers in Aging Neuroscience. 2013 | Pubmed ID: 23964237 What Renders TAU Toxic Frontiers in Neurology. 2013 | Pubmed ID: 23772223 Glutamate Metabolism is Impaired in Transgenic Mice with Tau Hyperphosphorylation Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2013 | Pubmed ID: 23340677 Alzheimer's Disease Models and Functional Genomics-How Many Needles Are There in the Haystack? Frontiers in Physiology. 2012 | Pubmed ID: 22934069 Tau Promotes Neurodegeneration Via DRP1 Mislocalization in Vivo Neuron. Aug, 2012 | Pubmed ID: 22920254 Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship Molecular Neurobiology. Aug, 2012 | Pubmed ID: 22678467 Levering af antistoffer i hjernen ved hjælp af fokuseret scanning ultralyd Gerhard Leinenga1, Liviu-Gabriel Bodea1, Wee Kiat Koh1, Rebecca M. Nisbet1, Jürgen Götz1 1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland JoVE 61372 Neuroscience
Levering af antistoffer i hjernen ved hjælp af fokuseret scanning ultralyd Gerhard Leinenga1, Liviu-Gabriel Bodea1, Wee Kiat Koh1, Rebecca M. Nisbet1, Jürgen Götz1 1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland JoVE 61372 Neuroscience