James K. Chen Department of Chemical and Systems Biology Stanford University Biography Publications Institution JoVE Articles James K. Chen has not added a biography. If you are James K. Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Spatiotemporal Resolution of the Ntla Transcriptome in Axial Mesoderm Development Nature Chemical Biology. 2012 | Pubmed ID: 22286130 Roles of Hedgehog Pathway Components and Retinoic Acid Signalling in Specifying Zebrafish Ventral Spinal Cord Neurons Development (Cambridge, England). Dec, 2011 | Pubmed ID: 22069186 Hedgehog and Retinoic Acid Signaling Cooperate to Promote Motoneurogenesis in Zebrafish Development (Cambridge, England). Dec, 2011 | Pubmed ID: 22069185 Neuropilins Are Positive Regulators of Hedgehog Signal Transduction Genes & Development. Nov, 2011 | Pubmed ID: 22051878 A Small-molecule Smoothened Agonist Prevents Glucocorticoid-induced Neonatal Cerebellar Injury Science Translational Medicine. Oct, 2011 | Pubmed ID: 22013124 A Crucial Requirement for Hedgehog Signaling in Small Cell Lung Cancer Nature Medicine. 2011 | Pubmed ID: 21983857 Spatiotemporal Control of Embryonic Gene Expression Using Caged Morpholinos Methods in Cell Biology. 2011 | Pubmed ID: 21924162 Chemical 'Jekyll and Hyde's: Small-molecule Inhibitors of Developmental Signaling Pathways Chemical Society Reviews. Aug, 2011 | Pubmed ID: 21505654 Synthetic Strategies for Studying Embryonic Development Chemistry & Biology. Jun, 2010 | Pubmed ID: 20609409 Oligonucleotide-based Tools for Studying Zebrafish Development Zebrafish. Mar, 2010 | Pubmed ID: 20392138 Controlling Destiny Through Chemistry: Small-molecule Regulators of Cell Fate ACS Chemical Biology. Jan, 2010 | Pubmed ID: 20000447 Versatile Synthesis and Rational Design of Caged Morpholinos Journal of the American Chemical Society. Sep, 2009 | Pubmed ID: 19708646 Small-molecule Inhibitors Reveal Multiple Strategies for Hedgehog Pathway Blockade Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666565 Germ Cell Migration in Zebrafish is Cyclopamine-sensitive but Smoothened-independent Developmental Biology. Apr, 2009 | Pubmed ID: 19389352 Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19366682 The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19222062 A Small Molecule That Binds Hedgehog and Blocks Its Signaling in Human Cells Nature Chemical Biology. Mar, 2009 | Pubmed ID: 19151731 Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics Zebrafish. Oct, 2008 | Pubmed ID: 20798783 The Decoupling of Smoothened from Galphai Proteins Has Little Effect on Gli3 Protein Processing and Hedgehog-regulated Chick Neural Tube Patterning Developmental Biology. Sep, 2008 | Pubmed ID: 18590719 Chemical Technologies for Probing Embryonic Development Chemical Society Reviews. Jul, 2008 | Pubmed ID: 18568156 Fish 'n Clicks Nature Chemical Biology. Jul, 2008 | Pubmed ID: 18560429 Gene Regulation Technologies in Zebrafish Molecular BioSystems. Apr, 2008 | Pubmed ID: 18354783 Light-controlled Gene Silencing in Zebrafish Embryos Nature Chemical Biology. Oct, 2007 | Pubmed ID: 17717538 Small-molecule Regulation of Zebrafish Gene Expression Nature Chemical Biology. Mar, 2007 | Pubmed ID: 17237798 Smoothened Signal Transduction is Promoted by G Protein-coupled Receptor Kinase 2 Molecular and Cellular Biology. Oct, 2006 | Pubmed ID: 16908539 Purmorphamine Activates the Hedgehog Pathway by Targeting Smoothened Nature Chemical Biology. Jan, 2006 | Pubmed ID: 16408088 Activity-dependent Internalization of Smoothened Mediated by Beta-arrestin 2 and GRK2 Science (New York, N.Y.). Dec, 2004 | Pubmed ID: 15618519 Inhibition of Hedgehog Signaling by Direct Binding of Cyclopamine to Smoothened Genes & Development. Nov, 2002 | Pubmed ID: 12414725 Small Molecule Modulation of Smoothened Activity Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12391318 Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade Science (New York, N.Y.). Aug, 2002 | Pubmed ID: 12202832 Lineage Маркировка данио рерио Клетки с лазерной Uncagable Fluorescein Декстран Joshua A. Clanton1, Ilya A. Shestopalov2, James K. Chen2, Joshua T. Gamse1 1Department of Biological Sciences, Vanderbilt University, 2Department of Chemical and Systems Biology, Stanford University JoVE 2672 Biology
Lineage Маркировка данио рерио Клетки с лазерной Uncagable Fluorescein Декстран Joshua A. Clanton1, Ilya A. Shestopalov2, James K. Chen2, Joshua T. Gamse1 1Department of Biological Sciences, Vanderbilt University, 2Department of Chemical and Systems Biology, Stanford University JoVE 2672 Biology