James L. McGrath Department of Biomedical Engineering University of Rochester Biography Publications Institution JoVE Articles James L. McGrath has not added a biography. If you are James L. McGrath and would like to personalize this page please email our Author Liaison for assistance. Publications High Levels of Endothelial ICAM-1 Prohibit Natalizumab Mediated Abrogation of CD4 T Cell Arrest on the Inflamed BBB Under Flow in Vitro Journal of Neuroinflammation. May, 2023 | Pubmed ID: 37221552 A Computer Vision Approach for Analyzing Label Free Leukocyte Trafficking Dynamics on a Microvascular Mimetic Frontiers in Immunology. 2023 | Pubmed ID: 37033977 Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device International Journal of Molecular Sciences. Mar, 2023 | Pubmed ID: 36982697 A Tissue Chip with Integrated Digital Immunosensors: In Situ Brain Endothelial Barrier Cytokine Secretion Monitoring Biosensors & Bioelectronics. Mar, 2023 | Pubmed ID: 36603283 A Photonic Biosensor-integrated Tissue Chip Platform for Real-time Sensing of Lung Epithelial Inflammatory Markers Lab on a Chip. Jan, 2023 | Pubmed ID: 36594179 Sourcing Cells for Models of Human Vascular Barriers of Inflammation Frontiers in Medical Technology. 2022 | Pubmed ID: 36483299 The Modular µSiM Reconfigured: Integration of Microfluidic Capabilities to Study In Vitro Barrier Tissue Models Under Flow Advanced Healthcare Materials. Aug, 2022 | Pubmed ID: 35953453 The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro Advanced Healthcare Materials. Jul, 2022 | Pubmed ID: 35899801 Molecular Mechanisms Underlying the Heterogeneous Barrier Responses of Two Primary Endothelial Cell Types to Sphingosine-1-phosphate European Journal of Cell Biology. 2022 | Pubmed ID: 35605366 Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery Frontiers in Bioengineering and Biotechnology. 2022 | Pubmed ID: 35360391 Real Time Imaging of Single Extracellular Vesicle PH Regulation in a Microfluidic Cross-flow Filtration Platform Communications Biology. Jan, 2022 | Pubmed ID: 35013561 Rapid and Specific Detection of Intact Viral Particles Using Functionalized Microslit Silicon Membranes As a Fouling-based Sensor The Analyst. Jan, 2022 | Pubmed ID: 34933322 Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis Frontiers in Microbiology. 2021 | Pubmed ID: 34484165 Brain Endothelial Tricellular Junctions As Novel Sites for T Cell Diapedesis Across the Blood-brain Barrier Journal of Cell Science. Apr, 2021 | Pubmed ID: 33912914 Silicon Nanomembrane Filtration and Imaging for the Evaluation of Microplastic Entrainment Along a Municipal Water Delivery Route Sustainability. Dec, 2020 | Pubmed ID: 36938128 Studies of Transendothelial Migration for Biological and Drug Discovery Frontiers in Medical Technology. 2020 | Pubmed ID: 35047883 Endothelial Cell Apicobasal Polarity Coordinates Distinct Responses to Luminally Versus Abluminally Delivered TNF-α in a Microvascular Mimetic Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2020 | Pubmed ID: 33164044 Identification of Penicillin Binding Protein 4 (PBP4) As a Critical Factor for Staphylococcus Aureus Bone Invasion During Osteomyelitis in Mice PLoS Pathogens. 10, 2020 | Pubmed ID: 33091079 Free Standing, Large-Area Silicon Nitride Membranes for High Toxin Clearance in Blood Surrogate for Small-Format Hemodialysis Membranes. Jun, 2020 | Pubmed ID: 32517263 Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions Cellular and Molecular Bioengineering. Apr, 2020 | Pubmed ID: 32175026 Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis Advanced Healthcare Materials. Feb, 2020 | Pubmed ID: 31943849 Ultrathin Silicon Membranes for Optical Analysis of Nanoparticle Translocation Across a Human Blood-Brain Barrier Model ACS Nano. Jan, 2020 | Pubmed ID: 31914314 Development of Isoporous Microslit Silicon Nitride Membranes for Sterile Filtration Applications Biotechnology and Bioengineering. Mar, 2020 | Pubmed ID: 31784974 Entropic Trapping of DNA with a Nanofiltered Nanopore ACS Applied Nano Materials. Aug, 2019 | Pubmed ID: 32577609 Monolithic Fabrication of NPN/SiN Dual Membrane Cavity for Nanopore-based DNA Sensing Advanced Materials Interfaces. Jul, 2019 | Pubmed ID: 32577337 An in Vitro Platform for Elucidating the Molecular Genetics of S. Aureus Invasion of the Osteocyte Lacuno-canalicular Network During Chronic Osteomyelitis Nanomedicine : Nanotechnology, Biology, and Medicine. 10, 2019 | Pubmed ID: 31247310 Ultrathin Dual-Scale Nano- and Microporous Membranes for Vascular Transmigration Models Small (Weinheim an Der Bergstrasse, Germany). Feb, 2019 | Pubmed ID: 30632319 A Silicon Nanomembrane Platform for the Visualization of Immune Cell Trafficking Across the Human Blood-brain Barrier Under Flow Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2019 | Pubmed ID: 30565961 Protein Separation and Hemocompatibility of Nitride Membranes in Microfluidic Filtration Systems Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Jul, 2018 | Pubmed ID: 30441657 TEM Tomography of Pores with Application to Computational Nanoscale Flows in Nanoporous Silicon Nitride (NPN) Membranes. Jun, 2018 | Pubmed ID: 29865242 Ultrathin Nanoporous Membranes for Insulator-based Dielectrophoresis Nanotechnology. Jun, 2018 | Pubmed ID: 29528846 Finite Element Modeling to Analyze TEER Values Across Silicon Nanomembranes Biomedical Microdevices. Jan, 2018 | Pubmed ID: 29305767 DNA Translocations Through Nanopores Under Nanoscale Preconfinement Nano Letters. Feb, 2018 | Pubmed ID: 29087723 Modification of Nanoporous Silicon Nitride with Stable and Functional Organic Monolayers Chemistry of Materials : a Publication of the American Chemical Society. Mar, 2017 | Pubmed ID: 29651199 Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. May, 2017 | Pubmed ID: 27933662 Nanoporous Membrane Robustness / Stability in Small Form Factor Microfluidic Filtration System Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Aug, 2016 | Pubmed ID: 28268711 Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis Membranes. Dec, 2015 | Pubmed ID: 26729179 Influence of Silicon Dioxide Capping Layers on Pore Characteristics in Nanocrystalline Silicon Membranes Nanotechnology. Feb, 2015 | Pubmed ID: 25590751 Endothelial Vacuolization Induced by Highly Permeable Silicon Membranes Acta Biomaterialia. Nov, 2014 | Pubmed ID: 25072618 Highly Permeable Silicon Membranes for Shear Free Chemotaxis and Rapid Cell Labeling Lab on a Chip. Jul, 2014 | Pubmed ID: 24850320 Highly Porous Silicon Membranes Fabricated from Silicon Nitride/silicon Stacks Small (Weinheim an Der Bergstrasse, Germany). Jul, 2014 | Pubmed ID: 24623562 Ultrathin Silicon Membranes for Wearable Dialysis Advances in Chronic Kidney Disease. Nov, 2013 | Pubmed ID: 24206603 High-performance, Low-voltage Electroosmotic Pumps with Molecularly Thin Silicon Nanomembranes Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24167263 Dynamics of Adhesion Molecule Domains on Neutrophil Membranes: Surfing the Dynamic Cell Topography European Biophysics Journal : EBJ. Dec, 2013 | Pubmed ID: 24113789 Opposing Roles for RhoH GTPase During T-cell Migration and Activation Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22689994 LC/LC-MS/MS of an Innovative Prostate Human Epithelial Cancer (PHEC) in Vitro Model System Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Apr, 2012 | Pubmed ID: 22425387 Robust Antigen-specific Humoral Immune Responses to Sublingually Delivered Adenoviral Vectors Encoding HIV-1 Env: Association with Mucoadhesion and Efficient Penetration of the Sublingual Barrier Vaccine. Sep, 2011 | Pubmed ID: 21801777 High-performance Separation of Nanoparticles with Ultrathin Porous Nanocrystalline Silicon Membranes ACS Nano. Nov, 2010 | Pubmed ID: 21043434 Pore Size Control of Ultrathin Silicon Membranes by Rapid Thermal Carbonization Nano Letters. Oct, 2010 | Pubmed ID: 20839831 Ion-selective Permeability of an Ultrathin Nanoporous Silicon Membrane As Probed by Scanning Electrochemical Microscopy Using Micropipet-supported ITIES Tips Analytical Chemistry. Sep, 2010 | Pubmed ID: 20690617 Image Correlation Microscopy for Uniform Illumination Journal of Microscopy. Jan, 2010 | Pubmed ID: 20055917 Activated Integrin VLA-4 Localizes to the Lamellipodia and Mediates T Cell Migration on VCAM-1 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19542447 Recombinant Human Activated Protein C Inhibits Integrin-mediated Neutrophil Migration Blood. Apr, 2009 | Pubmed ID: 19244161 The Influence of Protein Adsorption on Nanoparticle Association with Cultured Endothelial Cells Biomaterials. Feb, 2009 | Pubmed ID: 19012960 Membrane Mobility of Beta2 Integrins and Rolling Associated Adhesion Molecules in Resting Neutrophils Biophysical Journal. Nov, 2008 | Pubmed ID: 18689449 A Structure-permeability Relationship of Ultrathin Nanoporous Silicon Membrane: a Comparison with the Nuclear Envelope Journal of the American Chemical Society. Apr, 2008 | Pubmed ID: 18324815 Cell Spreading: the Power to Simplify Current Biology : CB. May, 2007 | Pubmed ID: 17502086 Relationships Between Actin Regulatory Mechanisms and Measurable State Variables Annals of Biomedical Engineering. Jun, 2007 | Pubmed ID: 17380395 Charge- and Size-based Separation of Macromolecules Using Ultrathin Silicon Membranes Nature. Feb, 2007 | Pubmed ID: 17301789 Sheet Migration by Wounded Monolayers As an Emergent Property of Single-cell Dynamics Journal of Cell Science. Mar, 2007 | Pubmed ID: 17298977 Evidence for Actin Cytoskeleton-dependent and -independent Pathways for RelA/p65 Nuclear Translocation in Endothelial Cells The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17158457 Metallization of Surface-attached Actin Networks Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2006 | Pubmed ID: 17946467 Microtubule Mechanics: a Little Flexibility Goes a Long Way Current Biology : CB. Sep, 2006 | Pubmed ID: 16979547 Cell Mechanics: FilaminA Leads the Way Current Biology : CB. May, 2006 | Pubmed ID: 16682340 Binding Between Particles and Proteins in Extracts: Implications for Microrheology and Toxicity Acta Biomaterialia. May, 2005 | Pubmed ID: 16701809 Dynein Motility: Four Heads Are Better Than Two Current Biology : CB. Dec, 2005 | Pubmed ID: 16332531 Actin Motility: Staying on Track Takes a Little More Effort Current Biology : CB. Nov, 2004 | Pubmed ID: 15530387 Formin' New Ideas About Actin Filament Generation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15466701 The Role of Substrate Curvature in Actin-based Pushing Forces Current Biology : CB. Jun, 2004 | Pubmed ID: 15203003 Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems Mehran Mansouri1, Aidan R. Hughes1, Lauren A. Audi1, Anna E. Carter1, Justin A. Vidas1, James L. McGrath2, Vinay V. Abhyankar1 1Department of Biomedical Engineering, Rochester Institute of Technology, 2Department of Biomedical Engineering, University of Rochester JoVE 66090 Bioengineering Advancing the Use of Tissue Chip Technology for Studying Human Tissues (Video) | JoVE Molly C. McCloskey1, Pelin Kasap2, Michelle Trempel1, Louis P. Widom3, Julia Kuebel1, Kaihua Chen1, Thomas R. Gaborski3, Britta Engelhardt2, James L. McGrath1 1Department of Biomedical Engineering, University of Rochester, 2Theodor Kocher Institute, University of Bern, 3Department of Biomedical Engineering, Rochester Institute of Technology JoVE 65258 Bioengineering
Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems Mehran Mansouri1, Aidan R. Hughes1, Lauren A. Audi1, Anna E. Carter1, Justin A. Vidas1, James L. McGrath2, Vinay V. Abhyankar1 1Department of Biomedical Engineering, Rochester Institute of Technology, 2Department of Biomedical Engineering, University of Rochester JoVE 66090 Bioengineering
Advancing the Use of Tissue Chip Technology for Studying Human Tissues (Video) | JoVE Molly C. McCloskey1, Pelin Kasap2, Michelle Trempel1, Louis P. Widom3, Julia Kuebel1, Kaihua Chen1, Thomas R. Gaborski3, Britta Engelhardt2, James L. McGrath1 1Department of Biomedical Engineering, University of Rochester, 2Theodor Kocher Institute, University of Bern, 3Department of Biomedical Engineering, Rochester Institute of Technology JoVE 65258 Bioengineering
