James Shorter

Publications

• Counteracting Semen-mediated Enhancement of HIV Infection and Enveloped Virus Infection by a Lysine-specific Molecular Tweezer
  AIDS Research and Human Retroviruses. Oct, 2014  |   Pubmed ID: 25357741
• Suramin Inhibits Hsp104 ATPase and Disaggregase Activity
  PloS One. 2014  |   Pubmed ID: 25299406
• Specific Aromatic Foldamers Potently Inhibit Spontaneous and Seeded Aβ42 and Aβ43 Fibril Assembly
  The Biochemical Journal. Nov, 2014  |   Pubmed ID: 25142005
• Potentiated Hsp104 Variants Suppress Toxicity of Diverse Neurodegenerative Disease-linked Proteins
  Disease Models & Mechanisms. Oct, 2014  |   Pubmed ID: 25062688
• A Cellular System That Degrades Misfolded Proteins and Protects Against Neurodegeneration
  Molecular Cell. Jul, 2014  |   Pubmed ID: 24882209
• Reversing Deleterious Protein Aggregation with Re-engineered Protein Disaggregases
  Cell Cycle (Georgetown, Tex.). May, 2014  |   Pubmed ID: 24694655
• ALS-associated Mutation FUS-R521C Causes DNA Damage and RNA Splicing Defects
  The Journal of Clinical Investigation. Mar, 2014  |   Pubmed ID: 24509083
• Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
  Cell. Jan, 2014  |   Pubmed ID: 24439375
• Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation
  The Journal of Biological Chemistry. Jan, 2014  |   Pubmed ID: 24280225
• Disease Mutations in the Prion-like Domains of HnRNPA1 and HnRNPA2/B1 Introduce Potent Steric Zippers That Drive Excess RNP Granule Assembly
  Rare Diseases (Austin, Tex.). 2013  |   Pubmed ID: 25002999
• The Metazoan Protein Disaggregase and Amyloid Depolymerase System: Hsp110, Hsp70, Hsp40, and Small Heat Shock Proteins
  Prion. Nov-Dec, 2013  |   Pubmed ID: 24401655
• Hsp104 Suppresses Polyglutamine-induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model
  PLoS Genetics. 2013  |   Pubmed ID: 24039611
• Fission Yeast Does Not Age Under Favorable Conditions, but Does So After Stress
  Current Biology : CB. Oct, 2013  |   Pubmed ID: 24035542
• Stress Granules As Crucibles of ALS Pathogenesis
  The Journal of Cell Biology. Apr, 2013  |   Pubmed ID: 23629963
• Mutations in Prion-like Domains in HnRNPA2B1 and HnRNPA1 Cause Multisystem Proteinopathy and ALS
  Nature. Mar, 2013  |   Pubmed ID: 23455423
• The Surprising Role of Amyloid Fibrils in HIV Infection
  Biology. 2012  |   Pubmed ID: 24832047
• Hsp104 Drives "protein-only" Positive Selection of Sup35 Prion Strains Encoding Strong [PSI(+)]
  Chemistry & Biology. Nov, 2012  |   Pubmed ID: 23177195
• Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients
  Cell. Nov, 2012  |   Pubmed ID: 23141537
• Inhibition of RNA Lariat Debranching Enzyme Suppresses TDP-43 Toxicity in ALS Disease Models
  Nature Genetics. Dec, 2012  |   Pubmed ID: 23104007
• RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration
  Neurology Research International. 2012  |   Pubmed ID: 22919483
• Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans
  PLoS Biology. 2012  |   Pubmed ID: 22723742
• Evaluating the Role of the FUS/TLS-related Gene EWSR1 in Amyotrophic Lateral Sclerosis
  Human Molecular Genetics. Apr, 2012  |   Pubmed ID: 22454397
• The Tip of the Iceberg: RNA-binding Proteins with Prion-like Domains in Neurodegenerative Disease
  Brain Research. Jun, 2012  |   Pubmed ID: 22445064
• The Elusive Middle Domain of Hsp104 and ClpB: Location and Function
  Biochimica Et Biophysica Acta. Jan, 2012  |   Pubmed ID: 21843558
• A Yeast Functional Screen Predicts New Candidate ALS Disease Genes
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011  |   Pubmed ID: 22065782
• The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-free System
  PloS One. 2011  |   Pubmed ID: 22022600
• RNA-binding Proteins with Prion-like Domains in ALS and FTLD-U
  Prion. Jul, 2011  |   Pubmed ID: 21847013
• Shock and Awe: Unleashing the Heat Shock Response to Treat Huntington Disease
  The Journal of Clinical Investigation. Aug, 2011  |   Pubmed ID: 21785212
• Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
  PLoS Biology. Apr, 2011  |   Pubmed ID: 21541367
• Countering Amyloid Polymorphism and Drug Resistance with Minimal Drug Cocktails
  Prion. Oct-Dec, 2010  |   Pubmed ID: 20935457
• Emergence and Natural Selection of Drug-resistant Prions
  Molecular BioSystems. Jul, 2010  |   Pubmed ID: 20422111
• Prion-like Disorders: Blurring the Divide Between Transmissibility and Infectivity
  Journal of Cell Science. Apr, 2010  |   Pubmed ID: 20356930
• Applying Hsp104 to Protein-misfolding Disorders
  Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Feb, 2010  |   Pubmed ID: 20130674
• A Synergistic Small-molecule Combination Directly Eradicates Diverse Prion Strain Structures
  Nature Chemical Biology. Dec, 2009  |   Pubmed ID: 19915541
• N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils
  The Journal of Biological Chemistry. Dec, 2009  |   Pubmed ID: 19840945
• TDP-43 is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
  The Journal of Biological Chemistry. Jul, 2009  |   Pubmed ID: 19465477
• Motor Mechanism for Protein Threading Through Hsp104
  Molecular Cell. Apr, 2009  |   Pubmed ID: 19362537
• Prion Proteostasis: Hsp104 Meets Its Supporting Cast
  Prion. Oct-Dec, 2008  |   Pubmed ID: 19242125
• The Mad2 Partial Unfolding Model: Regulating Mitosis Through Mad2 Conformational Switching
  The Journal of Cell Biology. Dec, 2008  |   Pubmed ID: 19029339
• Hsp104, Hsp70 and Hsp40 Interplay Regulates Formation, Growth and Elimination of Sup35 Prions
  The EMBO Journal. Oct, 2008  |   Pubmed ID: 18833196
• A PDZ-binding Motif Controls Basolateral Targeting of Syndecan-1 Along the Biosynthetic Pathway in Polarized Epithelial Cells
  Traffic (Copenhagen, Denmark). Nov, 2008  |   Pubmed ID: 18764819
• Hsp104 Antagonizes Alpha-synuclein Aggregation and Reduces Dopaminergic Degeneration in a Rat Model of Parkinson Disease
  The Journal of Clinical Investigation. Sep, 2008  |   Pubmed ID: 18704197
• Escaping Amyloid Fate
  Nature Structural & Molecular Biology. Jun, 2008  |   Pubmed ID: 18523464
• Direct and Selective Elimination of Specific Prions and Amyloids by 4,5-dianilinophthalimide and Analogs
  Proceedings of the National Academy of Sciences of the United States of America. May, 2008  |   Pubmed ID: 18480256
• Hsp110 Chaperones Regulate Prion Formation and Propagation in S. Cerevisiae by Two Discrete Activities
  PloS One. 2008  |   Pubmed ID: 18335038
• The Parkinson's Disease Protein Alpha-synuclein Disrupts Cellular Rab Homeostasis
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008  |   Pubmed ID: 18162536
• Hsp104: a Weapon to Combat Diverse Neurodegenerative Disorders
  Neuro-Signals. 2008  |   Pubmed ID: 18097161
• Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-remodeling Factor Hsp104
  Cell. Dec, 2007  |   Pubmed ID: 18160044
• Prime Time for Alpha-synuclein
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2007  |   Pubmed ID: 17344380
• Asymmetric Deceleration of ClpB or Hsp104 ATPase Activity Unleashes Protein-remodeling Activity
  Nature Structural & Molecular Biology. Feb, 2007  |   Pubmed ID: 17259993
• Destruction or Potentiation of Different Prions Catalyzed by Similar Hsp104 Remodeling Activities
  Molecular Cell. Aug, 2006  |   Pubmed ID: 16885031
• Prions As Adaptive Conduits of Memory and Inheritance
  Nature Reviews. Genetics. Jun, 2005  |   Pubmed ID: 15931169
• A Cryptic Rab1-binding Site in the P115 Tethering Protein
  The Journal of Biological Chemistry. Jul, 2005  |   Pubmed ID: 15878873
• Navigating the ClpB Channel to Solution
  Nature Structural & Molecular Biology. Jan, 2005  |   Pubmed ID: 15689967
• Hsp104 Catalyzes Formation and Elimination of Self-replicating Sup35 Prion Conformers
  Science (New York, N.Y.). Jun, 2004  |   Pubmed ID: 15155912
• A Direct Role for GRASP65 As a Mitotically Regulated Golgi Stacking Factor
  The EMBO Journal. Jul, 2003  |   Pubmed ID: 12839990
• Golgi Architecture and Inheritance
  Annual Review of Cell and Developmental Biology. 2002  |   Pubmed ID: 12142281
• Sequential SNARE Disassembly and GATE-16-GOS-28 Complex Assembly Mediated by Distinct NSF Activities Drives Golgi Membrane Fusion
  The Journal of Cell Biology. Jun, 2002  |   Pubmed ID: 12070132
• Sequential Tethering of Golgins and Catalysis of SNAREpin Assembly by the Vesicle-tethering Protein P115
  The Journal of Cell Biology. Apr, 2002  |   Pubmed ID: 11927603