Jan Wollenhaupt Macromolecular Crystallography Helmholtz-Zentrum Berlin Biography Publications Institution JoVE Articles Jan Wollenhaupt Jan Wollenhaupt is a postdoc in the Macromolecular Crystallography group at the BESSY II synchrotron.He achieved his PhD in biochemistry at the Free University Berlin. There he studied protein-RNA complexes via X-ray crystallography and complementary biophysical techniques in the lab of Markus Wahl and first came in touch with crystallographic fragment screening (CFS). He then became a postdoc in the synchrotron MX group of Manfred Weiss at the Helmholtz-Zentrum Berlin and gained additional experience in the drug design group of Gerhard Klebe in Marburg. Jan Wollenhaupt's research focus is on improvement on CFS workflows, advancing of fragment hits to higher potency as well as on modulation of protein-protein interactions. At the Helmholtz-Zentrum Berlin, he is responsible for the support of CFS user campaigns. Publications Insulin Polymorphism Induced by Two Polyphenols: New Crystal Forms and Advances in Macromolecular Powder Diffraction Acta Crystallographica. Section D, Structural Biology. Nov, 2020 | Pubmed ID: 33135678 F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening Structure (London, England : 1993). 06, 2020 | Pubmed ID: 32413289 Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2 Biophysical Journal. 02, 2018 | Pubmed ID: 29490241 Interplay of Cis- and Trans-regulatory Mechanisms in the Spliceosomal RNA Helicase Brr2 Cell Cycle (Georgetown, Tex.). Jan, 2017 | Pubmed ID: 27880071 Helmholtz-Zentrum Berlin'de Kristalografik Parça Taraması için İş Akışı ve Araçlar Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry
Helmholtz-Zentrum Berlin'de Kristalografik Parça Taraması için İş Akışı ve Araçlar Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry
