Janis Kuka

Publications

• Imitation of β-lactam Binding Enables Broad-spectrum Metallo-β-lactamase Inhibitors
  Nature Chemistry. Jan, 2022  |   Pubmed ID: 34903857
• Antibacterial Activity of Apramycin at Acidic PH Warrants Wide Therapeutic Window in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis
  EBioMedicine. Nov, 2021  |   Pubmed ID: 34740109
• Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage
  Free Radical Biology & Medicine. 12, 2021  |   Pubmed ID: 34728372
• Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
  Oxidative Medicine and Cellular Longevity. 2021  |   Pubmed ID: 34367467
• -Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs
  ACS Medicinal Chemistry Letters. Nov, 2020  |   Pubmed ID: 33214822
• Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia
  Journal of Cellular and Molecular Medicine. 10, 2020  |   Pubmed ID: 32896106
• Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice
  Scientific Reports. 09, 2020  |   Pubmed ID: 32884086
• Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload
  Cardiovascular Drugs and Therapy. 12, 2020  |   Pubmed ID: 32424653
• Excretion of the Polymyxin Derivative NAB739 in Murine Urine
  Antibiotics (Basel, Switzerland). Mar, 2020  |   Pubmed ID: 32230751
• Skull Fractures Induce Neuroinflammation and Worsen Outcomes After Closed Head Injury in Mice
  Journal of Neurotrauma. 01, 2020  |   Pubmed ID: 31441378
• Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues
  Scientific Reports. 12, 2017  |   Pubmed ID: 29235526
• Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice
  BioFactors (Oxford, England). Sep, 2017  |   Pubmed ID: 28759135
• Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB
  Basic & Clinical Pharmacology & Toxicology. Aug, 2017  |   Pubmed ID: 28244203
• Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria
  The Biochemical Journal. 05, 2016  |   Pubmed ID: 26936967
• Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity
  Pharmacological Research. 11, 2016  |   Pubmed ID: 26850121
• Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance
  Pharmacological Research. 11, 2016  |   Pubmed ID: 26621248
• Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae
  The Journal of Biological Chemistry. Aug, 2015  |   Pubmed ID: 26187464
• Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis
  Vascular Pharmacology. Sep, 2015  |   Pubmed ID: 25989106
• Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation
  Life Sciences. Nov, 2014  |   Pubmed ID: 25301199
• Expression and Purification of Active, Stabilized Trimethyllysine Hydroxylase
  Protein Expression and Purification. 12, 2014  |   Pubmed ID: 25220864
• Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria
  Molecular and Cellular Biochemistry. Oct, 2014  |   Pubmed ID: 24878991
• Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size
  Pharmacological Research. Jul, 2014  |   Pubmed ID: 24836867
• Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats
  Magnesium Research. Jan-Mar, 2014  |   Pubmed ID: 24827813
• The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State
  Metabolism: Clinical and Experimental. Jan, 2014  |   Pubmed ID: 24140100
• Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion
  Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013  |   Pubmed ID: 23525500
• Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples
  Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013  |   Pubmed ID: 23202591
• A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function
  Cardiovascular Toxicology. Dec, 2012  |   Pubmed ID: 22539084
• The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine
  Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012  |   Pubmed ID: 21903968
• Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats
  Pharmacological Reports : PR. 2011  |   Pubmed ID: 21857086
• Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers
  The Journal of Pharmacy and Pharmacology. Sep, 2011  |   Pubmed ID: 21827492
• Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism
  Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009  |   Pubmed ID: 19912061
• Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats
  Basic & Clinical Pharmacology & Toxicology. Dec, 2009  |   Pubmed ID: 19663820
• Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats
  British Journal of Pharmacology. Aug, 2009  |   Pubmed ID: 19594753
• Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart
  Cardiovascular Drugs and Therapy. Aug, 2009  |   Pubmed ID: 19536647
• Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart
  Life Sciences. Oct, 2008  |   Pubmed ID: 18801379